EKS-RAN-00271
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00271
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl557.16.1E-168242493252
StatusUnreviewed
Ensembl ProteinENSRNOP00000012617
UniProt AccessionE9PT20;
Protein Name
Protein Synonyms/Alias Protein Abl1;
Gene NameAbl1
Gene Synonyms/Alias Abl1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000009371ENSRNOP00000012617ENSRNOT00000012617
ENSRNOG00000009371ENSRNOP00000042940ENSRNOT00000043661
OrganismRattus norvegicus
Functional Description
Protein Length1124
Protein Sequence
(FASTA)
MLEICLKLVG CKSKKGLSSS SSCYLEEALQ RPVASDFEPQ GLSEAARWNS KENLLAGPSE 60
NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC EAQTKNGQGW VPSNYITPVN 120
SLEKHSWYHG PVSRNAAEYL LSSGINGSFL VRESESSPGQ RSISLRYEGR VYHYRINTAS 180
DGKLYVSSES RFNTLAELVH HHSTVADGLI TTLHYPAPKR NKPTIYGVSP NYDKWEMERT 240
DITMKHKLGG GQYGEVYEGV WKKYSLTVAV KTLKEDTMEV EEFLKEAAVM KEIKHPNLVQ 300
LLGVCTREPP FYIITEFMTY GNLLDYLREC NRQEVSAVVL LYMATQISSA MEYLEKKNFI 360
HRDLAARNCL VGENHLVKVA DFGLSRLMTG DTYTAHAGAK FPIKWTAPES LAYNKFSIKS 420
DVWAFGVLLW EIATYGMSPY PGIDLSQVYE LLEKDYRMER PEGCPEKVYE LMRACWQWNP 480
SDRPSFAEIH QAFETMFQES SISDEVEKEL GKRGMRGAAG STLQAPELPT KTRTCRKTAE 540
QKDAPDALEL LHTKGLGESD ALDSEPAVSP LLPRKERGPP DGSLNEDERL LPKDKKTNLF 600
SALIKKKKKM APTPPKRSSS FREMDGQSER RGASEDDGRE ISNGPPALTS DAVEPTKSPK 660
ASNGAGVPNG AFREPGNSGF RSPHVWKKSS TLTSSRLAAA EEESGLSSSK RFLRSCSASC 720
MPHGVRDTEW RSVTLPRDLP SAGKQFDSST FGGHKSEKPA LPRKRTSESR SEQVAKSTAT 780
PPPRLVKKTE EAAEDVFKDT ESSPGSSPPS LTPKLLRRQV PASPSSGPSH KDEATKGNAS 840
GMGTPATAEP AAPSNKAGLS KASSEEPRAR RHKHSSESPG RDKGRLSKLK PAPPPPPSST 900
GKAGKPAQSP SQDVAGEAGG ATKTKCTSLS VDAVNSDPTK AGQPGEGLRK SVPPSVPKPQ 960
SATKPPGTPT SPVSTPSTAP APSPLAGDQQ PSSAAFIPLI STRVSLRKTR QPPERIASGT 1020
ITKGVVLDST EALCLAISRN SEQMASHSAV LEAGKNLYTF CVSYVDSIQQ MRNKFAFREA 1080
INKLESNLRE LQICPATASS GPAATQDFSK LLSSVKEISD IVRR 1124
Nucleotide Sequence
(FASTA)
ATGTTGGAGA TCTGCTTGAA GTTGGTGGGC TGCAAATCCA AGAAGGGGCT CTCTTCGTCC 60
TCCAGCTGCT ACCTAGAAGA AGCCCTGCAG AGGCCAGTGG CCTCTGACTT TGAGCCCCAG 120
GGTCTCAGCG AAGCAGCTCG ATGGAACTCC AAGGAAAACC TTCTTGCTGG GCCCAGCGAA 180
AATGACCCCA ACCTTTTTGT GGCACTCTAT GATTTTGTGG CCAGTGGAGA CAACACTCTC 240
AGCATCACTA AAGGCGAGAA GCTCCGGGTC TTAGGTTATA ATCACAATGG GGAGTGGTGT 300
GAAGCCCAAA CGAAAAATGG CCAAGGATGG GTCCCAAGCA ACTACATCAC CCCTGTCAAC 360
AGCCTGGAGA AGCACTCCTG GTATCACGGG CCCGTGTCTC GAAACGCTGC AGAGTACCTG 420
CTGAGCAGTG GGATCAACGG CAGCTTCTTA GTTCGGGAGA GCGAGAGCAG CCCGGGCCAG 480
AGGTCCATCT CGCTGCGGTA TGAAGGGAGG GTGTACCACT ACAGGATCAA CACTGCCTCT 540
GATGGCAAGC TCTACGTCTC CTCGGAGAGC CGCTTCAACA CTCTGGCCGA GTTAGTTCAC 600
CATCATTCCA CTGTGGCTGA CGGGCTCATC ACCACACTGC ACTACCCAGC TCCCAAGCGC 660
AACAAGCCCA CCATCTACGG CGTGTCCCCC AACTATGACA AGTGGGAAAT GGAGCGCACA 720
GACATCACCA TGAAGCACAA GCTGGGCGGA GGCCAGTACG GGGAGGTGTA CGAGGGCGTC 780
TGGAAGAAGT ACAGCCTCAC TGTGGCCGTG AAGACCCTGA AGGAGGACAC CATGGAGGTG 840
GAGGAGTTCC TGAAGGAAGC CGCAGTGATG AAGGAGATCA AGCACCCTAA CCTGGTGCAG 900
CTGCTAGGGG TGTGTACCCG GGAACCTCCG TTCTACATCA TCACCGAGTT CATGACCTAT 960
GGGAACCTGC TGGACTACCT GAGGGAATGT AACCGGCAGG AGGTGAGCGC TGTGGTGCTG 1020
CTCTACATGG CCACACAGAT CTCATCAGCC ATGGAGTACC TGGAGAAGAA GAACTTCATC 1080
CACAGAGACC TTGCTGCCCG GAACTGCCTG GTAGGGGAAA ACCACTTGGT GAAGGTGGCT 1140
GATTTTGGCC TAAGCAGGTT GATGACAGGG GACACCTACA CAGCCCATGC TGGAGCCAAG 1200
TTCCCCATCA AGTGGACTGC ACCCGAGAGC CTGGCCTATA ACAAGTTCTC CATCAAGTCG 1260
GACGTCTGGG CATTTGGAGT ATTGCTCTGG GAAATTGCTA CCTATGGCAT GTCACCTTAC 1320
CCGGGAATTG ACCTGTCTCA GGTTTATGAG CTGCTGGAAA AAGACTACCG CATGGAGCGC 1380
CCGGAAGGCT GCCCAGAGAA AGTCTACGAA CTCATGCGAG CATGTTGGCA GTGGAACCCC 1440
TCTGATCGGC CCTCCTTTGC TGAAATCCAT CAAGCCTTTG AAACCATGTT CCAGGAGTCC 1500
AGCATCTCAG ACGAGGTGGA GAAGGAGCTG GGGAAACGAG GCATGAGAGG AGCCGCCGGG 1560
AGCACCCTGC AGGCCCCAGA GCTGCCCACC AAGACCAGAA CCTGCAGGAA AACCGCTGAG 1620
CAGAAAGATG CACCTGACGC CCTGGAACTG CTCCACACGA AGGGCCTGGG CGAAAGCGAC 1680
GCACTGGACA GTGAACCTGC TGTATCACCA CTGCTTCCTC GGAAAGAGCG TGGGCCCCCG 1740
GACGGCAGCC TAAATGAAGA TGAGCGTCTC CTCCCCAAAG ACAAAAAGAC CAACCTGTTC 1800
AGCGCCTTGA TCAAGAAGAA GAAGAAAATG GCGCCGACGC CCCCTAAGCG CAGCAGTTCC 1860
TTCCGAGAGA TGGATGGCCA GTCAGAACGC AGAGGGGCTA GTGAGGATGA CGGCCGGGAA 1920
ATCAGCAATG GGCCACCAGC TCTCACCTCA GATGCAGTAG AGCCTACCAA GTCCCCAAAG 1980
GCCAGCAATG GGGCTGGCGT CCCCAATGGA GCCTTCCGGG AGCCAGGCAA CTCGGGCTTC 2040
CGCTCTCCCC ATGTGTGGAA GAAGAGCAGC ACACTGACCA GCAGCCGCCT CGCTGCTGCT 2100
GAAGAGGAGA GTGGCCTCAG TTCCAGTAAG CGCTTCCTGC GCTCCTGCTC GGCCTCCTGC 2160
ATGCCCCATG GGGTTAGGGA CACTGAGTGG CGGTCAGTCA CGCTGCCTCG GGACCTGCCG 2220
TCTGCTGGTA AGCAGTTTGA CTCTTCCACC TTTGGAGGGC ACAAAAGTGA AAAGCCAGCT 2280
CTGCCTCGGA AACGCACCAG TGAGAGCAGG TCTGAGCAGG TGGCCAAAAG CACAGCGACA 2340
CCCCCTCCTC GGCTGGTGAA GAAGACTGAG GAGGCCGCCG AAGATGTCTT CAAAGACACG 2400
GAATCCAGCC CTGGCTCCAG CCCTCCCAGC TTGACCCCCA AACTCCTCCG TAGGCAGGTC 2460
CCTGCCTCCC CCTCCTCTGG CCCCTCTCAC AAGGACGAGG CCACCAAGGG CAATGCCTCG 2520
GGCATGGGGA CTCCTGCCAC TGCAGAGCCA GCAGCCCCCA GCAACAAAGC GGGCCTCAGC 2580
AAGGCCTCCT CCGAGGAGCC CCGTGCAAGG AGACACAAGC ACAGCTCGGA GTCCCCAGGG 2640
AGAGACAAGG GGCGGCTGTC CAAGCTCAAG CCGGCCCCGC CACCTCCGCC CTCCTCCACA 2700
GGGAAAGCAG GGAAGCCTGC ACAGAGCCCC AGCCAAGATG TGGCTGGGGA GGCAGGTGGG 2760
GCCACCAAGA CAAAATGCAC AAGTCTGTCT GTGGATGCTG TGAACAGTGA CCCCACCAAG 2820
GCTGGCCAGC CTGGAGAAGG ACTGAGAAAA TCTGTGCCCC CATCTGTGCC AAAGCCTCAG 2880
TCAGCTACTA AGCCACCGGG GACCCCCACC AGCCCGGTCT CCACCCCCTC CACAGCGCCA 2940
GCACCTTCAC CCCTGGCTGG GGACCAGCAG CCATCTTCTG CTGCCTTCAT CCCCCTCATA 3000
TCAACCCGTG TGTCTCTTCG AAAGACCCGA CAGCCGCCAG AGCGCATCGC CAGTGGCACC 3060
ATCACCAAGG GTGTGGTTCT GGACAGTACT GAGGCCCTGT GCCTTGCCAT CTCCCGGAAC 3120
TCGGAGCAGA TGGCCAGCCA CAGTGCTGTG CTGGAGGCGG GCAAGAACCT GTACACATTC 3180
TGTGTGAGCT ACGTGGACTC TATCCAGCAG ATGAGGAACA AGTTTGCCTT CCGCGAGGCT 3240
ATCAACAAGC TGGAGAGCAA CCTCCGAGAG CTGCAGATCT GCCCTGCGAC AGCCTCCAGT 3300
GGGCCAGCGG CCACACAAGA CTTCAGCAAG CTGCTTAGCT CTGTGAAGGA GATCAGCGAC 3360
ATTGTCCGGA GGTAG 3375
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 242   ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  301
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvctreppfyiitefm+ygnlldylre++r+ev+avvllymatqissameylekknfih
Q: 302   LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIH  361
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen+lvkvadfglsrlm++dtytahagakfpikwtapeslaynkfsiksd
Q: 362   RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD  421
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvyellek+yrmerpegcp+kvyelmracw+w+ps
Q: 422   VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPS  481
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfaeihqa+
Q: 482   DRPSFAEIHQAF  493
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVSAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS 240
DRPSFAEIHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00228
EKS-BOT-00257
EKS-CAE-00214
EKS-CAF-00245
EKS-DAR-00593
EKS-EQC-00230
EKS-GAG-00198
EKS-GOG-00256
EKS-HOS-00245
EKS-LAC-00270
EKS-LOA-00268
EKS-MAM-00261
EKS-MYL-00237
EKS-ORA-00227
EKS-ORC-00244
EKS-OTG-00264
EKS-PES-00229
EKS-SAH-00243
EKS-TAR-00332
EKS-XET-00314
Gene Ontology
GO:0005730; C:nucleolus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0071901; P:negative regulation of protein serine/threonine kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0051353; P:positive regulation of oxidoreductase activity
GO:0051726; P:regulation of cell cycle
GO:2001020; P:regulation of response to DNA damage stimulus
GO:0042770; P:signal transduction in response to DNA damage
KEGG
rno:311860;
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013