EKS-RAN-00380
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00380
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src448.19.9E-135270519250
StatusUnreviewed
Ensembl ProteinENSRNOP00000012739
UniProt AccessionQ9JJ10;
Protein Name
Protein Synonyms/Alias Neuronal C-SRC tyrosine-specific protein kinase; Proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene, isoform CRA_a;
Gene NameSrc
Gene Synonyms/Alias Src; rCG_32093;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000009495ENSRNOP00000012739ENSRNOT00000012739
OrganismRattus norvegicus
Functional Description
Protein Length536
Protein Sequence
(FASTA)
MGSNKSKPKD ASQRRRSLEP AENVHGAGGA FPASQTPSKP ASADGHRGPN AAFVPPAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTEGD 120
WWLAHSLSTG QTGYIPSNYV APSDSIQAEE WYFGKITRRE SERLLLNAEN PRGTFLVRES 180
ETTKGAYCLS VSDFDNAKGL NVKHYKIRKL DSGGFYITSR TQFNSLQQLV AYYSKHADGL 240
CHRLTTVCPT SKPQTQGLAK DAWEIPRESL RLEVKLGQGC FGEVWMGTWN GTTRVAIKTL 300
KPGTMSPEAF LQEAQVMKKL RHEKLVQLYA VVSEEPIYIV TEYMNKGSLL DFLKGETGKY 360
LRLPQLVDMS AQIASGMAYV ERMNYVHRDL RAANILVGEN LVCKVADFGL ARLIEDNEYT 420
ARQGAKFPIK WTAPEAALYG RFTIKSDVWS FGILLTELTT KGRVPYPGMV NREVLDQVER 480
GYRMPCPPEC PESLHDLMCQ CWRKEPEERP TFEYLQAFLE DYFTSTEPQY QPGENL 536
Nucleotide Sequence
(FASTA)
ATGGGCAGCA ACAAGAGCAA GCCCAAGGAC GCCAGCCAGA GGCGCCGCAG CCTGGAGCCC 60
GCGGAGAACG TGCATGGGGC AGGTGGCGCC TTCCCTGCCT CACAGACACC AAGCAAGCCT 120
GCCTCCGCCG ATGGCCACCG CGGGCCCAAT GCCGCCTTTG TGCCCCCCGC GGCCGCCGAG 180
CCCAAGCTCT TCGGAGGCTT CAACTCCTCG GACACTGTCA CCTCCCCACA AAGGGCGGGG 240
CCTCTGGCAG GTGGGGTGAC TACCTTTGTG GCCCTCTATG ACTATGAGTC ACGGACAGAG 300
ACTGACCTGT CCTTCAAGAA AGGGGAGCGG CTGCAGATTG TCAATAACAC AGAGGGAGAC 360
TGGTGGCTGG CACACTCGCT GAGCACCGGA CAGACCGGTT ACATCCCCAG TAACTATGTG 420
GCGCCCTCCG ACTCCATCCA GGCTGAGGAG TGGTACTTTG GCAAGATCAC TAGACGGGAA 480
TCAGAGCGGC TACTTCTCAA CGCCGAGAAC CCCAGAGGGA CCTTCCTCGT GAGGGAGAGT 540
GAGACCACAA AAGGTGCCTA CTGCCTCTCT GTATCCGACT TTGACAATGC CAAGGGCCTA 600
AATGTGAAAC ACTACAAGAT CCGGAAACTG GACAGTGGCG GATTCTACAT CACCTCCCGC 660
ACGCAATTCA ACAGCCTGCA GCAGCTTGTG GCTTACTACT CCAAACATGC TGATGGCCTG 720
TGTCACCGTC TCACTACCGT GTGTCCCACA TCCAAGCCTC AGACCCAGGG CCTGGCCAAG 780
GATGCGTGGG AGATCCCCCG GGAGTCCCTG CGGCTGGAGG TCAAGCTGGG CCAGGGTTGC 840
TTCGGAGAGG TGTGGATGGG GACCTGGAAC GGCACCACGA GGGTTGCCAT CAAAACCCTG 900
AAGCCAGGCA CCATGTCTCC AGAGGCCTTC CTGCAGGAGG CCCAAGTCAT GAAGAAACTG 960
AGGCATGAGA AGCTGGTGCA GCTGTATGCC GTGGTGTCAG AAGAACCCAT TTACATTGTG 1020
ACAGAGTACA TGAACAAGGG GAGTCTGCTG GACTTTCTCA AGGGGGAAAC GGGCAAATAC 1080
TTGCGGCTAC CCCAGCTGGT GGACATGTCT GCTCAGATTG CTTCAGGCAT GGCCTATGTG 1140
GAGCGGATGA ACTATGTGCA CCGGGACCTC CGAGCCGCCA ATATCCTGGT TGGCGAGAAC 1200
CTGGTGTGCA AAGTGGCCGA CTTTGGGCTG GCCCGGCTCA TAGAGGACAA CGAATACACA 1260
GCTCGGCAAG GTGCCAAATT CCCCATCAAG TGGACCGCCC CTGAAGCGGC TCTGTATGGC 1320
AGGTTCACCA TCAAGTCGGA CGTGTGGTCC TTTGGAATCC TGCTGACTGA GCTCACCACT 1380
AAGGGCAGAG TGCCCTATCC TGGGATGGTG AACCGAGAGG TGCTGGACCA GGTAGAGCGG 1440
GGCTACCGGA TGCCTTGTCC CCCCGAGTGC CCTGAGTCCC TGCATGACCT CATGTGCCAG 1500
TGCTGGCGGA AGGAGCCTGA GGAGCGGCCC ACCTTCGAGT ACCTGCAGGC CTTCCTGGAG 1560
GACTACTTTA CGTCCACGGA GCCGCAGTAC CAGCCCGGGG AGAACCTATA G 1611
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly
Q: 270   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  329
         68999*******************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd++aq+a+Gmay+e++n++hr
Q: 330   AVVSE-EPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHR  388
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv
Q: 389   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  448
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee
Q: 449   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  508
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 509   RPTFEYLQAFL  519
         *******9876
Domain Sequence
(FASTA)
LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60
AVVSEEPIYI VTEYMNKGSL LDFLKGETGK YLRLPQLVDM SAQIASGMAY VERMNYVHRD 120
LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180
SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240
PTFEYLQAFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00340
EKS-ANC-00356
EKS-BOT-00366
EKS-CAJ-00371
EKS-CAF-00367
EKS-CAP-00399
EKS-CII-00206
EKS-CIS-00121
EKS-DAR-00747
EKS-DIO-00054
EKS-EQC-00357
EKS-FEC-00354
EKS-GAG-00310
EKS-GAA-00450
EKS-GOG-00366
EKS-HOS-00372
EKS-ICT-00347
EKS-LAC-00383
EKS-LOA-00375
EKS-MAM-00366
EKS-MEG-00302
EKS-MIM-00048
EKS-MOD-00355
EKS-MUM-00398
EKS-MUP-00360
EKS-MYL-00367
EKS-NOL-00334
EKS-ORN-00475
EKS-ORC-00344
EKS-ORL-00435
EKS-OTG-00369
EKS-PAT-00346
EKS-PES-00326
EKS-POA-00356
EKS-SAH-00337
EKS-SUS-00323
EKS-TAG-00439
EKS-TAR-00470
EKS-TEN-00465
EKS-XET-00482
EKS-XIM-00463
Gene Ontology
GO:0005901; C:caveola
GO:0005770; C:late endosome
GO:0005764; C:lysosome
GO:0005743; C:mitochondrial inner membrane
GO:0005524; F:ATP binding
GO:0020037; F:heme binding
GO:0004713; F:protein tyrosine kinase activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0016477; P:cell migration
GO:0030900; P:forebrain development
GO:0007243; P:intracellular protein kinase cascade
GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway
GO:0048477; P:oogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway
GO:0070555; P:response to interleukin-1
GO:0060065; P:uterus development
KEGG
rno:83805;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013