EKS-RAN-00089

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00089

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	443.0	9.0E-133	2153	2477	325

Status

Reviewed

Ensembl Protein

ENSRNOP00000014167

UniProt Accession

P42346;

Protein Name

Serine/threonine-protein kinase mTOR

Protein Synonyms/Alias

FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin target protein 1; RAPT1;

Gene Name

Mtor

Gene Synonyms/Alias

Mtor; Frap1, Raft1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000009615	ENSRNOP00000014167	ENSRNOT00000014167

Organism

Rattus norvegicus

Functional Description

Serine/threonine protein kinase which is a centralregulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B and the inhibitor of translation initiation PDCD4. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 a RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-757', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro- survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho- type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-421'.

Protein Length

2549

Protein Sequence
(FASTA)

MLGTGPATAT AGAATSSNVS VLQQFASGLK SRNEETRAKA AKELQHYVTM ELREMSQEES 60

TRFYDQLNHH IFELVSSSDA NERKGGILAI ASLIGVEGGN STRIGRFANY LRNLLPSSDP 120

VVMEMASKAI GRLAMAGDTF TAEYVEFEVK RALEWLGADR NEGRRHAAVL VLRELAISVP 180

TFFFQQVQPF FDNIFVAVWD PKQAIREGAV AALRACLILT TQREPKEMQK PQWYRHTFEE 240

AEKGFDETLA KEKGMNRDDR IHGALLILNE LVRISSMEGE RLREEMEEIT QQQLVHDKYC 300

KDLMGFGTKP RHITPFTSFQ AVQPQQSNAL VGLLGYSSHQ GLMGFGASPS PTKSTLVESR 360

CCRDLMEEKF DQVCQWVLKC RSSKNSLIQM TILNLLPRLA AFRPSAFTDT QYLQDTMNHV 420

LSCVKKEKER TAAFQALGLL SVAVRSEFKV YLPRVLDIIR AALPPKDFAH KRQKTVQVDA 480

TVFTCISMLA RAMGPGIQQD IKELLEPMLA VGLSPALTAV LYDLSRQIPQ LKKDIQDGLL 540

KMLSLVLMHK PLRHPGMPKG LAHQLASPGL TTLPEASDVA SITLALRTLG SFEFEGHSLT 600

QFVRHCADHF LNSEHKEIRM EAARTCSRLL TPSIHLISGH AHVVSQTAVQ VVADVLSKLL 660

VVGITDPDPD IRYCVLASLD ERFDAHLAQA ENLQALFVAL NDQVFEIREL AICTVGRLSS 720

MNPAFVMPFL RKMLIQILTE LEHSGIGRIK EQSARMLGHL VSNAPRLIRP YMEPILKALI 780

LKLKDPDPDP NPGVINNVLA TIGELAQVSG LEMRKWVDEL FVIIMDMLQD SSLLAKRQVA 840

LWTLGQLVAS TGYVVEPYRK YPTLLEVLLN FLKTEQNQGT RREAIRVLGL LGALDPYKHK 900

VNIGMIDQSR DASAVSLSES KSSQDSSDYS TSEMLVNMGN LPLDEFYPAV SMVALMRIFR 960

DQSLSHHHTM VVQAITFIFK SLGLKCVQFL PQVMPTFLNV IRVCDGAIRE FLFQQLGMLV 1020

SFVKSHIRPY MDEIVTLMRE FWVMNTSIQS TIILLIEQIV VALGGEFKLY LPQLIPHMLR 1080

VFMHDNSQGR IVSIKLLAAI QLFGANLDDY LHLLLPPIVK LFDAPEVPLP SRKAALETVD 1140

RLTESLDFTD YASRIIHPIV RTLDQSPELR STAMDTLSSL VFQLGKKYQI FIPMVNKVLV 1200

RHRINHQRYD VLICRIVKGY TLADEEEDPL IYQHRMLRSS QGDALASGPV ETGPMKKLHV 1260

STINLQKAWG AARRVSKDDW LEWLRRLSLE LLKDSSSPSL RSCWALAQAY NPMARDLFNA 1320

AFVSCWSELN EDQQDELIRS IELALTSQDI AEVTQTLLNL AEFMEHSDKG PLPLRDDNGI 1380

VLLGERAAKC RAYAKALHYK ELEFQKGPTP AILESLISIN NKLQQPEAAS GVLEYAMKHF 1440

GELEIQATWY EKLHEWEDAL VAYDKKMDTN KDDPELMLGR MRCLEALGEW GQLHQQCCEK 1500

WTLVNDETQA KMARMAAAAA WGLGQWDSME EYTCMIPRDT HDGAFYRAVL ALHQDLFSLA 1560

QQCIDKARDL LDAELTAMAG ESYSRAYGAM VSCHMLSELE EVIQYKLVPE RREIIRQIWW 1620

ERLQGCQRIV EDWQKILMVR SLVVSPHEDM RTWLKYASLC GKSGRLALAH KTLVLLLGVD 1680

PSRQLDHPLP TVHPQVTYAY MKNMWKSARK IDAFQHMQHF VQTMQQQAQH AIATEDQQHK 1740

QELHKLMARC FLKLGEWQLN LQGINESTIP KVLQYYSAAT EHDRSWYKAW HAWAVMNFEA 1800

VLHYKHQNQA RDEKKKLRHA SGANITNATT TATTAASAAA ATSTEGSNSE SEAESNESSP 1860

TPSPLQKKVT EDLSKTLLLY TVPAVQGFFR SISLSRGNNL QDTLRVLTLW FDYGHWPDVN 1920

EALVEGVKAI QIDTWLQVIP QLIARIDTPR PLVGRLIHQL LTDIGRYHPQ ALIYPLTVAS 1980

KSTTTARHNA ANKILKNMCE HSNTLVQQAM MVSEELIRVA ILWHEMWHEG LEEASRLYFG 2040

ERNVKGMFEV LEPLHAMMER GPQTLKETSF NQAYGRDLME AQEWCRKYMK SGNVKDLTQA 2100

WDLYYHVFRR ISKQLPQLTS LELQYVSPKL LMCRDLELAV PGTYDPNQPI IRIQSIAPSL 2160

QVITSKQRPR KLTLMGSNGH EFVFLLKGHE DLRQDERVMQ LFGLVNTLLA NDPTSLRKNL 2220

SIQRYAVIPL STNSGLIGWV PHCDTLHALI RDYREKKKIL LNIEHRIMLR MAPDYDHLTL 2280

MQKVEVFEHA VNNTAGDDLA KLLWLKSPSS EVWFDRRTNY TRSLAVMSMV GYILGLGDRH 2340

PSNLMLDRLS GKILHIDFGD CFEVAMTREK FPEKIPFRLT RMLTNAMEVT GLDGNYRTTC 2400

HTVMEVLREH KDSVMAVLEA FVYDPLLNWR LMDTNAKGNK RSRTRTDSYS AGQSVEILDG 2460

VELGEPAHKK TGTTVPESIH SFIGDGLVKP EALNKKAIQI INRVRDKLTG RDFSHDDTLD 2520

VPTQVELLIK QATSHENLCQ CYIGWCPFW 2549

Nucleotide Sequence
(FASTA)

ATGCTTGGGA CAGGCCCTGC CACGGCCACC GCCGGTGCCG CCACATCTAG CAACGTGAGC 60

GTTCTGCAGC AGTTCGCCAG TGGGCTGAAG AGCCGGAATG AGGAGACCAG GGCCAAAGCA 120

GCCAAGGAGC TCCAGCACTA TGTCACCATG GAACTTCGAG AGATGAGTCA GGAGGAGTCT 180

ACTCGCTTCT ATGACCAGCT GAACCATCAC ATTTTTGAAC TGGTTTCCAG CTCAGACGCC 240

AATGAGAGGA AGGGTGGCAT CTTGGCCATT GCCAGCCTCA TTGGAGTGGA AGGTGGGAAT 300

TCCACCAGGA TTGGCAGATT TGCCAACTAC CTTCGGAACC TCCTCCCCTC AAGTGATCCA 360

GTTGTCATGG AGATGGCATC CAAGGCCATT GGCCGCCTTG CAATGGCAGG GGACACTTTC 420

ACTGCTGAGT ATGTGGAGTT TGAAGTGAAG CGAGCCTTGG AGTGGCTGGG TGCTGACCGA 480

AATGAGGGCC GGAGACATGC AGCTGTCCTC GTTCTCCGTG AGCTGGCCAT CAGCGTCCCC 540

ACCTTCTTCT TCCAGCAAGT TCAGCCCTTC TTTGACAACA TTTTTGTGGC TGTGTGGGAC 600

CCCAAGCAGG CCATCCGTGA AGGAGCTGTG GCTGCCCTTC GTGCCTGTCT GATTCTTACC 660

ACGCAGCGGG AGCCGAAGGA GATGCAGAAG CCTCAGTGGT ACAGGCACAC ATTTGAAGAA 720

GCAGAGAAAG GTTTTGATGA GACCCTGGCC AAAGAGAAGG GTATGAACCG AGATGATCGA 780

ATCCACGGGG CCTTGCTGAT CCTCAACGAG CTCGTCCGAA TCAGCAGCAT GGAGGGAGAG 840

CGTCTGAGAG AGGAGATGGA GGAAATCACC CAGCAGCAGC TGGTACATGA CAAGTACTGC 900

AAAGACCTAA TGGGCTTTGG GACAAAGCCT CGGCACATCA CTCCCTTCAC CAGCTTCCAG 960

GCTGTGCAGC CCCAGCAGTC AAACGCCTTG GTGGGACTGC TGGGGTACAG CTCCCACCAA 1020

GGCCTAATGG GGTTTGGGGC TTCCCCCAGC CCTACAAAGT CCACTCTGGT GGAAAGCCGT 1080

TGTTGCAGAG ACTTGATGGA AGAGAAATTT GATCAGGTGT GCCAGTGGGT GCTGAAATGT 1140

AGGAGCAGCA AGAACTCACT GATCCAAATG ACAATCCTTA ATCTGTTGCC CCGCTTGGCT 1200

GCATTCCGAC CGTCTGCCTT CACAGATACC CAGTACCTGC AAGACACCAT GAACCATGTC 1260

CTGAGCTGTG TCAAGAAGGA AAAGGAACGG ACCGCAGCGT TCCAGGCCCT AGGGCTGCTT 1320

TCTGTGGCGG TGAGGTCCGA GTTTAAGGTC TACCTGCCCC GAGTACTTGA CATCATCCGA 1380

GCAGCCCTGC CTCCAAAGGA CTTTGCCCAC AAGAGGCAGA AAACTGTGCA GGTGGATGCC 1440

ACAGTGTTCA CGTGCATCAG CATGCTGGCG CGGGCCATGG GGCCAGGCAT CCAGCAGGAC 1500

ATCAAGGAGC TGCTGGAGCC CATGTTGGCA GTGGGCCTGA GCCCTGCGCT CACTGCTGTG 1560

CTCTATGACC TGAGCCGGCA GATTCCGCAG CTGAAGAAAG ATATTCAGGA CGGGCTTCTG 1620

AAGATGCTGT CCCTGGTCCT TATGCACAAA CCCCTGCGGC ACCCGGGCAT GCCCAAAGGC 1680

CTGGCCCACC AGCTGGCCTC CCCAGGTCTT ACCACCCTCC CTGAGGCCAG CGACGTGGCC 1740

AGCATCACTC TTGCCCTTCG AACTCTCGGC AGCTTTGAAT TTGAAGGCCA CTCTCTGACC 1800

CAGTTCGTCC GACACTGCGC AGATCATTTC CTGAACAGTG AGCACAAGGA GATCCGCATG 1860

GAAGCAGCCC GCACCTGCTC CCGCCTGCTC ACACCCTCCA TCCACCTCAT CAGCGGCCAT 1920

GCCCATGTGG TTAGCCAGAC CGCAGTGCAA GTGGTAGCAG ATGTGCTCAG CAAGCTGCTT 1980

GTGGTCGGCA TAACAGATCC TGATCCTGAT ATCCGCTACT GTGTCTTGGC CTCCCTGGAT 2040

GAGCGCTTCG ATGCCCACTT GGCCCAGGCA GAAAACTTAC AAGCTCTGTT TGTGGCTCTG 2100

AATGACCAGG TCTTTGAGAT CCGAGAGCTG GCCATCTGCA CTGTGGGCCG ACTCAGTAGC 2160

ATGAACCCAG CCTTTGTCAT GCCTTTCCTG CGCAAGATGC TCATCCAGAT TTTGACAGAG 2220

CTGGAGCACA GTGGCATTGG GAGAATCAAG GAGCAGAGTG CCCGCATGCT GGGGCACCTG 2280

GTCTCCAATG CCCCCCGCCT CATCCGCCCC TATATGGAGC CTATTCTGAA GGCTTTAATT 2340

TTGAAACTCA AAGATCCAGA CCCTGACCCA AACCCGGGCG TGATCAATAA CGTGTTGGCC 2400

ACTATAGGAG AACTGGCTCA GGTTAGCGGC CTGGAGATGA GGAAGTGGGT GGACGAGCTC 2460

TTTGTCATCA TCATGGACAT GCTGCAGGAC TCCTCTCTTC TGGCCAAAAG ACAGGTGGCT 2520

TTGTGGACCC TGGGACAGTT GGTGGCCAGT ACTGGCTACG TGGTGGAGCC CTACAGGAAG 2580

TACCCCACTC TGCTTGAAGT GCTGCTGAAT TTTCTGAAGA CGGAGCAGAA CCAGGGCACT 2640

CGGAGAGAGG CCATCCGAGT GTTAGGGCTC CTCGGGGCTT TGGACCCCTA CAAGCACAAA 2700

GTGAACATCG GCATGATTGA CCAGTCCCGA GATGCTTCTG CTGTCAGCCT GTCAGAATCC 2760

AAGTCAAGTC AAGATTCCTC TGACTACAGC ACCAGTGAAA TGCTGGTCAA CATGGGAAAC 2820

CTGCCACTGG ACGAGTTCTA CCCCGCCGTG TCCATGGTGG CCTTGATGCG GATCTTCCGA 2880

GACCAGTCCC TCTCTCACCA CCACACCATG GTGGTTCAGG CCATCACCTT CATCTTCAAG 2940

TCCCTGGGGC TCAAGTGTGT GCAGTTCCTG CCCCAGGTCA TGCCCACGTT CCTTAACGTC 3000

ATCCGAGTCT GTGATGGGGC CATCCGGGAA TTTCTGTTCC AGCAGCTGGG AATGCTGGTG 3060

TCCTTTGTGA AGAGCCACAT CCGTCCCTAC ATGGATGAAA TAGTCACCCT CATGAGAGAA 3120

TTTTGGGTCA TGAACACCTC AATCCAGAGC ACAATCATTC TTCTCATTGA GCAAATCGTG 3180

GTGGCTCTTG GAGGTGAATT TAAGCTCTAC CTGCCCCAGC TGATCCCACA CATGCTGCGT 3240

GTCTTCATGC ATGACAACAG CCAGGGCCGC ATAGTCTCCA TCAAGCTGTT AGCAGCGATC 3300

CAGCTGTTTG GCGCCAACCT GGATGACTAT CTGCACTTGT TGTTGCCTCC GATCGTGAAA 3360

TTGTTTGATG CCCCTGAAGT TCCACTGCCG TCGAGAAAGG CAGCGTTGGA GACAGTGGAC 3420

CGCCTGACAG AGTCCCTGGA TTTCACTGAC TATGCCTCCC GCATCATTCA CCCGATTGTT 3480

CGCACGCTAG ACCAGAGCCC AGAGCTGCGC TCCACAGCCA TGGACACCCT GTCTTCACTT 3540

GTGTTTCAAC TAGGGAAGAA GTACCAGATC TTCATTCCAA TGGTGAATAA AGTCCTTGTG 3600

CGACACCGGA TCAATCACCA GCGCTACGAC GTGCTGATCT GCAGAATCGT CAAGGGGTAC 3660

ACGCTTGCTG ATGAAGAAGA AGACCCTTTG ATTTACCAGC ATCGAATGCT AAGGAGCAGC 3720

CAGGGAGATG CCCTGGCCAG TGGACCAGTT GAAACAGGAC CCATGAAGAA ACTGCATGTC 3780

AGCACCATCA ACCTCCAAAA GGCCTGGGGA GCTGCCAGAA GGGTCTCCAA GGACGACTGG 3840

CTGGAGTGGC TGCGACGCTT GAGTCTGGAG CTGCTGAAGG ATTCCTCATC ACCTTCCCTG 3900

CGCTCATGCT GGGCCCTGGC CCAGGCCTAC AACCCCATGG CCAGGGATCT CTTCAACGCT 3960

GCGTTTGTGT CCTGCTGGTC TGAACTGAAT GAAGACCAAC AAGATGAGCT CATCAGGAGC 4020

ATTGAGTTGG CTCTCACTTC TCAAGACATT GCTGAAGTCA CACAAACCCT CTTGAACTTG 4080

GCTGAGTTCA TGGAGCACAG TGACAAGGGC CCCCTACCAC TGAGAGATGA CAATGGCATC 4140

GTGCTGTTGG GTGAGAGAGC TGCCAAGTGC CGGGCATATG CCAAAGCACT ACACTACAAA 4200

GAGCTGGAGT TCCAGAAGGG GCCCACGCCT GCCATACTTG AGTCCCTCAT CAGCATTAAT 4260

AATAAACTGC AGCAGCCTGA GGCAGCGTCC GGGGTGTTAG AGTACGCCAT GAAACACTTC 4320

GGAGAGCTGG AGATCCAGGC CACCTGGTAT GAGAAGTTGC ATGAGTGGGA GGACGCCCTT 4380

GTGGCCTACG ACAAGAAGAT GGACACGAAC AAGGATGACC CAGAGCTGAT GCTGGGCCGC 4440

ATGCGCTGTC TCGAGGCCTT GGGAGAATGG GGCCAGCTTC ATCAGCAGTG CTGTGAAAAG 4500

TGGACTCTGG TTAATGACGA GACCCAGGCT AAGATGGCCC GGATGGCTGC TGCAGCAGCA 4560

TGGGGTTTAG GTCAGTGGGA CAGCATGGAG GAGTACACCT GTATGATTCC TCGGGATACT 4620

CACGATGGAG CATTCTACAG AGCAGTGTTG GCACTGCATC AGGATCTCTT CTCCTTGGCT 4680

CAACAGTGCA TTGACAAGGC CAGGGACCTG CTGGACGCCG AGCTGACTGC CATGGCAGGG 4740

GAGAGCTACA GCCGAGCCTA TGGGGCCATG GTTTCTTGCC ACATGCTGTC CGAGCTGGAG 4800

GAGGTTATCC AGTACAAACT CGTCCCGGAG CGACGGGAGA TCATCCGCCA GATCTGGTGG 4860

GAGAGACTGC AGGGCTGCCA GCGTATTGTA GAGGACTGGC AGAAAATCCT CATGGTCCGG 4920

TCCCTTGTGG TCAGCCCTCA CGAGGACATG AGAACCTGGC TCAAGTACGC AAGCCTGTGT 4980

GGCAAGAGCG GCAGACTGGC TCTTGCTCAT AAAACCTTAG TGTTGCTCTT GGGAGTTGAT 5040

CCATCTCGGC AACTTGACCA TCCTCTGCCA ACAGTTCACC CTCAAGTGAC CTATGCCTAC 5100

ATGAAAAACA TGTGGAAAAG CGCTCGGAAG ATTGATGCCT TCCAGCACAT GCAGCACTTT 5160

GTGCAGACCA TGCAGCAGCA GGCCCAGCAC GCCATTGCCA CAGAGGACCA GCAGCACAAG 5220

CAGGAGCTGC ATAAGCTCAT GGCCAGGTGT TTTCTGAAAC TTGGGGAGTG GCAGCTGAAC 5280

CTCCAGGGCA TCAACGAGAG CACCATCCCC AAGGTGCTAC AGTACTACAG TGCTGCCACA 5340

GAGCATGACC GCAGCTGGTA TAAGGCTTGG CACGCATGGG CAGTGATGAA CTTTGAAGCC 5400

GTGCTACACT ACAAACATCA GAACCAAGCC CGCGATGAGA AGAAGAAACT GCGCCATGCC 5460

AGCGGGGCCA ACATCACCAA TGCCACCACC ACTGCCACCA CCGCTGCCTC CGCTGCCGCT 5520

GCCACCAGCA CAGAGGGCAG CAACAGTGAA AGTGAAGCCG AGAGCAATGA GAGCAGCCCC 5580

ACCCCGTCCC CTCTGCAGAA GAAGGTCACT GAGGATTTGT CCAAAACCCT CTTGTTGTAC 5640

ACTGTCCCTG CTGTCCAAGG CTTCTTCCGT TCTATCTCCT TGTCGAGAGG CAACAACCTC 5700

CAGGATACAC TCAGAGTCCT CACCTTGTGG TTTGATTATG GTCACTGGCC AGATGTCAAT 5760

GAAGCCCTGG TGGAAGGGGT GAAGGCCATA CAGATTGACA CTTGGTTACA GGTTATACCT 5820

CAGCTCATTG CAAGAATTGA CACGCCCAGA CCCTTGGTGG GCCGGCTCAT TCACCAGCTC 5880

CTCACAGATA TTGGTCGGTA CCACCCACAG GCCCTCATCT ACCCCCTGAC GGTGGCTTCT 5940

AAGTCTACCA CCACAGCCCG TCACAATGCA GCCAACAAGA TCCTGAAGAA CATGTGCGAG 6000

CACAGCAACA CGCTAGTCCA GCAGGCCATG ATGGTGAGTG AAGAGCTGAT TCGAGTAGCC 6060

ATCCTCTGGC ATGAGATGTG GCATGAAGGC CTAGAAGAGG CCTCTCGCTT GTACTTTGGG 6120

GAGAGGAACG TCAAAGGCAT GTTTGAGGTG CTGGAGCCCC TGCATGCTAT GATGGAACGC 6180

GGTCCCCAGA CCCTGAAGGA AACGTCCTTT AATCAGGCAT ATGGTCGAGA TTTAATGGAG 6240

GCACAAGAAT GGTGCCGAAA GTACATGAAA TCAGGGAACG TCAAGGACCT CACCCAAGCC 6300

TGGGACCTCT ACTATCACGT GTTCAGACGG ATCTCCAAGC AGCTACCACA GCTCACATCC 6360

CTGGAGCTGC AGTATGTGTC CCCCAAACTT TTGATGTGCA GAGACCTTGA ATTGGCTGTG 6420

CCAGGAACAT ATGACCCCAA CCAGCCAATC ATTCGCATTC AGTCCATAGC CCCGTCTTTG 6480

CAAGTCATCA CATCCAAGCA GAGGCCTCGG AAGCTGACCC TGATGGGCAG CAATGGGCAC 6540

GAGTTTGTTT TCCTCCTGAA AGGCCATGAA GATCTGCGGC AGGACGAGCG AGTGATGCAG 6600

CTCTTTGGCC TGGTGAACAC ACTCCTAGCC AATGACCCAA CTTCTCTTCG AAAGAACCTC 6660

AGCATCCAGA GATACGCCGT CATTCCTCTG TCCACCAACT CGGGCCTGAT TGGCTGGGTG 6720

CCCCACTGTG ACACGCTGCA TGCCCTCATC CGGGACTACA GAGAGAAGAA GAAGATCCTG 6780

CTGAACATCG AGCACCGCAT CATGCTGCGG ATGGCTCCTG ACTATGACCA CCTGACTCTG 6840

ATGCAGAAGG TGGAGGTGTT TGAGCATGCT GTCAACAACA CAGCCGGGGA TGACCTGGCC 6900

AAGCTGCTGT GGCTGAAAAG CCCCAGCTCA GAGGTGTGGT TTGACCGAAG AACCAATTAT 6960

ACTCGCTCCC TGGCTGTCAT GTCCATGGTT GGATACATTT TAGGCCTTGG AGACAGGCAC 7020

CCATCCAACC TGATGCTGGA CCGGCTGAGT GGAAAGATCC TGCACATTGA CTTTGGGGAC 7080

TGCTTTGAGG TTGCTATGAC CAGAGAGAAA TTTCCAGAAA AGATTCCATT TAGACTAACA 7140

AGAATGTTGA CCAATGCTAT GGAGGTTACC GGTCTCGATG GCAACTATAG AACCACATGC 7200

CACACAGTGA TGGAGGTGCT TCGGGAGCAC AAGGACAGTG TCATGGCTGT GCTAGAAGCC 7260

TTTGTCTATG ACCCTCTGCT GAATTGGAGG CTGATGGACA CAAATGCCAA AGGCAACAAG 7320

CGGTCCCGAA CCAGGACAGA CTCCTATTCT GCAGGCCAGT CAGTAGAAAT TTTGGACGGT 7380

GTAGAACTTG GAGAACCAGC CCATAAGAAA ACAGGGACCA CTGTGCCAGA ATCCATCCAT 7440

TCTTTCATTG GAGATGGTTT GGTGAAACCA GAAGCCTTAA ACAAGAAAGC TATTCAGATT 7500

ATTAACAGGG TTCGAGATAA GCTCACTGGT CGGGATTTCT CTCATGATGA CACTTTGGAT 7560

GTTCCAACCC AAGTGGAACT GCTTATCAAG CAAGCGACAT CTCATGAGAA CCTCTGCCAG 7620

TGCTACATTG GCTGGTGTCC TTTCTGGTAA 7650

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i+++++++++++skq+p+kl+l+Gs+g+e+++L+kg+eDlrqderv+qlf+lvNtlLa+d

Q: 2153  IQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLAND  2212

         899*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +++ r++L+i++y+V+plst+sgli+wv+++++L++l+++++ekk++ll+        ++

Q: 2213  PTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLN-------IEH  2265

         *************************************************9.......9**

S: 121   stvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrsl  178

         +++ +++p+++hl+l+  +evf+++++n ++ d l+kll+ k+ps+e+wf++r++ytrsl

Q: 2266  RIMLRMAPDYDHLTLMqkVEVFEHAVNN-TAGDDLAKLLWLKSPSSEVWFDRRTNYTRSL  2324

         ****************************.999****************************

S: 179   AvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrniv  238

         Av+s+vgyiLgLgdrh++nl++d+ +g+++hidfg +fe a+t++k+pek+PFRLTr+++

Q: 2325  AVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLT  2384

         ************************************************************

S: 239   nalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeela  298

         na++vtg++G++r +c++v++vlre+k++++++Le+f+ydpl++w+ ++++ k+++++++

Q: 2385  NAMEVTGLDGNYRTTCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNAKGNKRSRT  2444

         ************************************************************

S: 299   ekakaealkikkllskvekaenavatrdlllle  331

         ++++++a +++++l++ve +e+a+++++++++e

Q: 2445  RTDSYSAGQSVEILDGVELGEPAHKKTGTTVPE  2477

         ****************************99987

Domain Sequence
(FASTA)

IQSIAPSLQV ITSKQRPRKL TLMGSNGHEF VFLLKGHEDL RQDERVMQLF GLVNTLLAND 60

PTSLRKNLSI QRYAVIPLST NSGLIGWVPH CDTLHALIRD YREKKKILLN IEHRIMLRMA 120

PDYDHLTLMQ KVEVFEHAVN NTAGDDLAKL LWLKSPSSEV WFDRRTNYTR SLAVMSMVGY 180

ILGLGDRHPS NLMLDRLSGK ILHIDFGDCF EVAMTREKFP EKIPFRLTRM LTNAMEVTGL 240

DGNYRTTCHT VMEVLREHKD SVMAVLEAFV YDPLLNWRLM DTNAKGNKRS RTRTDSYSAG 300

QSVEILDGVE LGEPAHKKTG TTVPE 325

Keyword

Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; Golgi apparatus; Kinase; Lysosome; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005789	; C:endoplasmic reticulum membrane
GO:0000139	; C:Golgi membrane
GO:0005764	; C:lysosome
GO:0005741	; C:mitochondrial outer membrane
GO:0070438	; C:mTOR-FKBP12-rapamycin complex
GO:0005634	; C:nucleus
GO:0016605	; C:PML body
GO:0031931	; C:TORC1 complex
GO:0005524	; F:ATP binding
GO:0008144	; F:drug binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043022	; F:ribosome binding
GO:0001030	; F:RNA polymerase III type 1 promoter DNA binding
GO:0001031	; F:RNA polymerase III type 2 promoter DNA binding
GO:0001032	; F:RNA polymerase III type 3 promoter DNA binding
GO:0030030	; P:cell projection organization
GO:0071456	; P:cellular response to hypoxia
GO:0031669	; P:cellular response to nutrient levels
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0007281	; P:germ cell development
GO:0010507	; P:negative regulation of autophagy
GO:0045792	; P:negative regulation of cell size
GO:0016242	; P:negative regulation of macroautophagy
GO:0051534	; P:negative regulation of NFAT protein import into nucleus
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010592	; P:positive regulation of lamellipodium assembly
GO:0046889	; P:positive regulation of lipid biosynthetic process
GO:0050731	; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0051496	; P:positive regulation of stress fiber assembly
GO:0045945	; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727	; P:positive regulation of translation
GO:0046777	; P:protein autophosphorylation
GO:0043610	; P:regulation of carbohydrate utilization
GO:0031998	; P:regulation of fatty acid beta-oxidation
GO:0005979	; P:regulation of glycogen biosynthetic process
GO:0045859	; P:regulation of protein kinase activity
GO:0032314	; P:regulation of Rac GTPase activity
GO:0032095	; P:regulation of response to food
GO:0043200	; P:response to amino acid stimulus
GO:0032868	; P:response to insulin stimulus
GO:0031529	; P:ruffle organization
GO:0031929	; P:TOR signaling cascade

KEGG

rno:56718

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR024585	; DUF3385_TOR.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR009076	; Rapamycin-bd_dom.
IPR026683	; TOR/Smg1.

Pfam

PF11865	; DUF3385; 1.
PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08771	; Rapamycin_bind; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013