| Tag | Content |
|---|
| EKPD ID | EPS-RAN-00019 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 60.6 | 1.9E-16 | 168 | 243 | 76 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000013584 |
| UniProt Accession | P0C089; |
| Protein Name | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 |
| Protein Synonyms/Alias | Protein-tyrosine phosphatase mitochondrial 1; |
| Gene Name | Ptpmt1 |
| Gene Synonyms/Alias | Ptpmt1; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Lipid phosphatase which dephosphorylatesphosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (By similarity). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. |
| Protein Length | 251 |
Protein Sequence
(FASTA) | | MVPVPGSPGP ASDGGDSASE SREASGGPQL SSSASFSRWL TASSEAGGWP LRLAGWGGMA 60 | | ASAWLEAGLA RVLFYPTLLY TVFRGRVGGP AHRDWYHRID HTVLLGALPL RSMTRRLVLD 120 | | ENVRGVITMN EEYETRFLCN TSKEWKNVGV EQLRLSTVDM TGVPTLANLH RGVQFALKYQ 180 | | SLGQCVYVHC KAGRSRSATM VAAYLIQVHN WSPEEAIEAI AKIRSHISIR PSQLEILKEF 240 | | HKEIAARAAK N 251 |
|
Nucleotide Sequence
(FASTA) | | ATGGTTCCTG TCCCGGGATC CCCCGGGCCT GCCTCTGACG GCGGGGACTC AGCTTCGGAG 60 | | AGTCGGGAGG CATCAGGTGG CCCGCAGCTC TCGTCCTCTG CGTCCTTCTC GCGGTGGCTG 120 | | ACCGCGAGCT CCGAAGCGGG TGGCTGGCCG CTGCGCTTGG CGGGGTGGGG CGGGATGGCG 180 | | GCGTCCGCGT GGCTGGAGGC CGGCCTGGCC CGGGTGCTCT TCTACCCGAC GCTGCTCTAC 240 | | ACAGTGTTCC GGGGGAGGGT GGGCGGCCCG GCGCACCGCG ATTGGTACCA CCGCATCGAC 300 | | CACACAGTGC TGCTGGGCGC GCTGCCGCTG AGGAGCATGA CGCGCCGGCT GGTACTGGAC 360 | | GAGAACGTGC GCGGAGTGAT CACTATGAAC GAGGAGTACG AGACCAGATT CCTGTGCAAC 420 | | ACCTCGAAGG AATGGAAGAA TGTGGGAGTT GAGCAGCTAC GGCTCAGCAC AGTCGACATG 480 | | ACTGGAGTCC CCACCTTGGC CAACCTCCAC AGAGGAGTCC AGTTTGCTCT CAAGTACCAG 540 | | TCCCTGGGCC AGTGTGTCTA CGTGCATTGT AAGGCTGGTC GATCCAGAAG TGCCACAATG 600 | | GTGGCAGCCT ATCTGATTCA GGTACACAAC TGGAGCCCAG AGGAGGCTAT AGAAGCTATC 660 | | GCCAAAATCC GGTCACACAT CTCCATCAGG CCCAGCCAGT TGGAAATTCT CAAAGAGTTC 720 | | CACAAGGAGA TTGCTGCAAG GGCAGCAAAG AACTAA 756 |
|
| Domain Profile | S: 71 yfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAieavkrkrpsi 130 | +++ ++f + ++ g+ v+vHC+aG sRSat+v aYL++v+++s ++Aiea+ + r++i | Q: 168 NLHRGVQFALKYQSLGQCVYVHCKAGRSRSATMVAAYLIQVHNWSPEEAIEAIAKIRSHI 227 | 444555555556888999****************************************** |
| S: 131 epnegfleQLlelekk 146 | + + +le L e+ k+ | Q: 228 SIRPSQLEILKEFHKE 243 | ***********99886 |
|
Domain Sequence
(FASTA) | | NLHRGVQFAL KYQSLGQCVY VHCKAGRSRS ATMVAAYLIQ VHNWSPEEAI EAIAKIRSHI 60 | | SIRPSQLEIL KEFHKE 76 |
|
| Keyword | Complete proteome; Hydrolase; Lipid biosynthesis; Lipid metabolism; Membrane; Mitochondrion; Mitochondrion inner membrane; Phospholipid biosynthesis; Phospholipid metabolism; Protein phosphatase; Reference proteome; Transit peptide. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | | GO:0005743 | ; C:mitochondrial inner membrane | | GO:0005739 | ; C:mitochondrion | | GO:0008962 | ; F:phosphatidylglycerophosphatase activity | | GO:0004439 | ; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | | GO:0004725 | ; F:protein tyrosine phosphatase activity | | GO:0008138 | ; F:protein tyrosine/serine/threonine phosphatase activity | | GO:0032049 | ; P:cardiolipin biosynthetic process | | GO:0046855 | ; P:inositol phosphate dephosphorylation | | GO:0035335 | ; P:peptidyl-tyrosine dephosphorylation |
|
| KEGG | |
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| Pfam | |
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| Prints | |
| Created Date | 20-Feb-2013 |