Tag | Content |
---|
EKPD ID | EKS-RAN-00385 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
---|
TK/Src | 429.6 | 4.4E-129 | 252 | 500 | 249 |
|
Status | Reviewed |
Ensembl Protein | ENSRNOP00000013779 |
UniProt Accession | Q6P6U0; Q63206; |
Protein Name | Tyrosine-protein kinase Fgr |
Protein Synonyms/Alias | Proto-oncogene c-Fgr; p55-Fgr; |
Gene Name | Fgr |
Gene Synonyms/Alias | Fgr; |
Ensembl Information | |
Organism | Rattus norvegicus |
Functional Description | Non-receptor tyrosine-protein kinase that transmitssignals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2 (By similarity). Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. |
Protein Length | 517 |
Protein Sequence (FASTA) | MGCVFCKKLE PAPKEDVGLE GDFRSQGAEE RYYPDPTQGR SSSISPQPIS PAFLNVGNIR 60 | SVSGTGVTIF VALYDYEART GDDLTFTKGE KFHILNNTEY DWWEARSLSS GRTGYVPSNY 120 | VAPVDSIQAE EWYFGKISRK DAERQLLSDG NPQGAFLIRE SETTKGAYSL SIRDWDQNRG 180 | DHIKHYKIRK LDMGGYYITT RAQFESVQDL VRHYMEVNDG LCYLLTAPCM VMKPQTLGLA 240 | KDAWEIDRNS IALDRRLGTG CFGDVWLGTW NCSTKVAVKT LKPGTMSPKA FLEEAQIMKL 300 | LRHDKLVQLY AVVSEEPIYI VTEFMCYGSL LDFLKDRKGH NLMLPNLVDM AAQVAEGMAY 360 | MERMNYIHRD LRAANILVGE HLICKIADFG LARLIVDDEY NPQQGTKFPI KWTAPEAALF 420 | GRFTVKSDVW SFGILLTELI TKGRVPYPGM NNREVLEQVE HGYHMPCPPG CPVSLYEVME 480 | QTWRLDPEER PTFEYLQSFL EDYFTSTEPQ YQPGDQT 517 |
|
Nucleotide Sequence (FASTA) | ATGGGCTGTG TGTTCTGCAA GAAGTTAGAG CCTGCACCCA AGGAGGATGT TGGCCTGGAA 60 | GGGGACTTCC GGAGCCAAGG CGCTGAAGAA CGCTATTACC CTGACCCTAC TCAAGGCCGG 120 | TCTTCGTCCA TCTCGCCTCA GCCCATCAGC CCTGCTTTCC TTAATGTTGG CAACATAAGA 180 | AGCGTCTCTG GGACGGGAGT GACCATATTC GTCGCCCTGT ATGACTATGA GGCCAGGACA 240 | GGGGATGACC TCACCTTCAC CAAAGGCGAG AAGTTCCACA TCCTGAACAA TACGGAGTAT 300 | GACTGGTGGG AGGCTAGGTC CCTGAGCTCC GGACGCACGG GCTATGTTCC CAGCAACTAT 360 | GTGGCTCCCG TGGATTCCAT CCAGGCTGAA GAGTGGTACT TCGGAAAGAT CAGCAGAAAG 420 | GATGCAGAGA GGCAGCTTCT CTCCGATGGC AACCCTCAAG GGGCCTTTCT CATTCGGGAA 480 | AGCGAGACCA CCAAAGGTGC CTACTCCCTG TCCATCCGTG ACTGGGACCA GAACAGAGGC 540 | GACCACATAA AGCATTACAA GATCCGAAAG CTGGACATGG GTGGCTACTA CATCACCACG 600 | CGGGCCCAGT TCGAATCCGT GCAGGACCTG GTGCGGCACT ACATGGAAGT GAATGACGGT 660 | CTATGCTACT TGCTCACGGC ACCCTGTATG GTCATGAAGC CCCAGACTCT AGGCCTGGCT 720 | AAGGATGCCT GGGAGATCGA CCGTAACTCC ATAGCACTTG ACCGCAGGCT GGGCACCGGC 780 | TGCTTTGGAG ACGTGTGGCT GGGCACGTGG AACTGTAGCA CAAAGGTGGC AGTGAAAACG 840 | CTGAAGCCAG GCACCATGTC GCCGAAGGCC TTCCTGGAGG AGGCACAGAT CATGAAACTG 900 | CTGAGGCACG ACAAGCTGGT GCAGCTGTAC GCGGTGGTGT CAGAGGAACC CATTTATATT 960 | GTGACAGAGT TCATGTGCTA TGGTAGCTTG CTGGATTTCC TAAAGGATCG AAAGGGTCAC 1020 | AACTTGATGC TGCCCAATCT AGTGGACATG GCTGCCCAGG TAGCAGAGGG CATGGCCTAC 1080 | ATGGAGCGCA TGAACTATAT CCACCGAGAC CTGAGAGCAG CCAACATCCT GGTGGGGGAA 1140 | CATCTAATAT GCAAGATCGC TGACTTTGGG TTGGCACGCC TCATAGTGGA TGATGAGTAC 1200 | AACCCCCAAC AAGGAACCAA GTTTCCCATC AAGTGGACAG CCCCAGAGGC TGCTCTCTTT 1260 | GGCAGATTCA CTGTCAAATC AGACGTGTGG TCCTTTGGGA TTCTGCTCAC TGAACTGATC 1320 | ACCAAGGGCA GAGTTCCATA CCCAGGTATG AACAACCGGG AAGTGTTGGA ACAGGTAGAG 1380 | CACGGCTACC ACATGCCATG CCCTCCGGGA TGCCCAGTAT CCCTGTATGA GGTCATGGAG 1440 | CAGACCTGGC GTCTGGATCC AGAGGAGAGG CCCACCTTTG AGTACCTGCA GTCTTTCCTG 1500 | GAAGACTATT TCACCTCCAC AGAACCACAG TATCAGCCCG GAGACCAGAC ATAG 1554 |
|
Domain Profile | S: 2 klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya 61 | l ++lG+G+fG+vwlg+w+ s+kvavktlk+gt+sp+afleeaqi+k lrh+klv+lya | Q: 252 ALDRRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYA 311 | 6889******************************************************** |
| S: 62 vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd 121 | vvse ePiyivte+m Gslldflk+++g++l lp+lvd+aaqvaeGmay+e++n+ihrd | Q: 312 VVSE-EPIYIVTEFMCYGSLLDFLKDRKGHNLMLPNLVDMAAQVAEGMAYMERMNYIHRD 370 | ***9.******************************************************* |
| S: 122 laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW 181 | l+a+n+lvge+l++k+adfGlarli ddey++++g+k+PikWtaPea+ +g+ft+ksdvW | Q: 371 LRAANILVGEHLICKIADFGLARLIVDDEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVW 430 | ************************************************************ |
| S: 182 sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer 241 | sfGillte++tkG+vPypGm+n+evleqve+gy++p+p cp +lye+++++w+ dpeer | Q: 431 SFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPVSLYEVMEQTWRLDPEER 490 | ************************************************************ |
| S: 242 Ptfetlqevl 251 | Ptfe+lq++l | Q: 491 PTFEYLQSFL 500 | *******986 |
|
Domain Sequence (FASTA) | ALDRRLGTGC FGDVWLGTWN CSTKVAVKTL KPGTMSPKAF LEEAQIMKLL RHDKLVQLYA 60 | VVSEEPIYIV TEFMCYGSLL DFLKDRKGHN LMLPNLVDMA AQVAEGMAYM ERMNYIHRDL 120 | RAANILVGEH LICKIADFGL ARLIVDDEYN PQQGTKFPIK WTAPEAALFG RFTVKSDVWS 180 | FGILLTELIT KGRVPYPGMN NREVLEQVEH GYHMPCPPGC PVSLYEVMEQ TWRLDPEERP 240 | TFEYLQSFL 249 |
|
Keyword | ATP-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Immunity; Innate immunity; Kinase; Lipoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Proto-oncogene; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |