EKS-RAN-00385
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00385
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src429.64.4E-129252500249
StatusReviewed
Ensembl ProteinENSRNOP00000013779
UniProt AccessionQ6P6U0; Q63206;
Protein NameTyrosine-protein kinase Fgr
Protein Synonyms/Alias Proto-oncogene c-Fgr; p55-Fgr;
Gene NameFgr
Gene Synonyms/Alias Fgr;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000009912ENSRNOP00000013779ENSRNOT00000013778
OrganismRattus norvegicus
Functional DescriptionNon-receptor tyrosine-protein kinase that transmitssignals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2 (By similarity). Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Protein Length517
Protein Sequence
(FASTA)
MGCVFCKKLE PAPKEDVGLE GDFRSQGAEE RYYPDPTQGR SSSISPQPIS PAFLNVGNIR 60
SVSGTGVTIF VALYDYEART GDDLTFTKGE KFHILNNTEY DWWEARSLSS GRTGYVPSNY 120
VAPVDSIQAE EWYFGKISRK DAERQLLSDG NPQGAFLIRE SETTKGAYSL SIRDWDQNRG 180
DHIKHYKIRK LDMGGYYITT RAQFESVQDL VRHYMEVNDG LCYLLTAPCM VMKPQTLGLA 240
KDAWEIDRNS IALDRRLGTG CFGDVWLGTW NCSTKVAVKT LKPGTMSPKA FLEEAQIMKL 300
LRHDKLVQLY AVVSEEPIYI VTEFMCYGSL LDFLKDRKGH NLMLPNLVDM AAQVAEGMAY 360
MERMNYIHRD LRAANILVGE HLICKIADFG LARLIVDDEY NPQQGTKFPI KWTAPEAALF 420
GRFTVKSDVW SFGILLTELI TKGRVPYPGM NNREVLEQVE HGYHMPCPPG CPVSLYEVME 480
QTWRLDPEER PTFEYLQSFL EDYFTSTEPQ YQPGDQT 517
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTTCTGCAA GAAGTTAGAG CCTGCACCCA AGGAGGATGT TGGCCTGGAA 60
GGGGACTTCC GGAGCCAAGG CGCTGAAGAA CGCTATTACC CTGACCCTAC TCAAGGCCGG 120
TCTTCGTCCA TCTCGCCTCA GCCCATCAGC CCTGCTTTCC TTAATGTTGG CAACATAAGA 180
AGCGTCTCTG GGACGGGAGT GACCATATTC GTCGCCCTGT ATGACTATGA GGCCAGGACA 240
GGGGATGACC TCACCTTCAC CAAAGGCGAG AAGTTCCACA TCCTGAACAA TACGGAGTAT 300
GACTGGTGGG AGGCTAGGTC CCTGAGCTCC GGACGCACGG GCTATGTTCC CAGCAACTAT 360
GTGGCTCCCG TGGATTCCAT CCAGGCTGAA GAGTGGTACT TCGGAAAGAT CAGCAGAAAG 420
GATGCAGAGA GGCAGCTTCT CTCCGATGGC AACCCTCAAG GGGCCTTTCT CATTCGGGAA 480
AGCGAGACCA CCAAAGGTGC CTACTCCCTG TCCATCCGTG ACTGGGACCA GAACAGAGGC 540
GACCACATAA AGCATTACAA GATCCGAAAG CTGGACATGG GTGGCTACTA CATCACCACG 600
CGGGCCCAGT TCGAATCCGT GCAGGACCTG GTGCGGCACT ACATGGAAGT GAATGACGGT 660
CTATGCTACT TGCTCACGGC ACCCTGTATG GTCATGAAGC CCCAGACTCT AGGCCTGGCT 720
AAGGATGCCT GGGAGATCGA CCGTAACTCC ATAGCACTTG ACCGCAGGCT GGGCACCGGC 780
TGCTTTGGAG ACGTGTGGCT GGGCACGTGG AACTGTAGCA CAAAGGTGGC AGTGAAAACG 840
CTGAAGCCAG GCACCATGTC GCCGAAGGCC TTCCTGGAGG AGGCACAGAT CATGAAACTG 900
CTGAGGCACG ACAAGCTGGT GCAGCTGTAC GCGGTGGTGT CAGAGGAACC CATTTATATT 960
GTGACAGAGT TCATGTGCTA TGGTAGCTTG CTGGATTTCC TAAAGGATCG AAAGGGTCAC 1020
AACTTGATGC TGCCCAATCT AGTGGACATG GCTGCCCAGG TAGCAGAGGG CATGGCCTAC 1080
ATGGAGCGCA TGAACTATAT CCACCGAGAC CTGAGAGCAG CCAACATCCT GGTGGGGGAA 1140
CATCTAATAT GCAAGATCGC TGACTTTGGG TTGGCACGCC TCATAGTGGA TGATGAGTAC 1200
AACCCCCAAC AAGGAACCAA GTTTCCCATC AAGTGGACAG CCCCAGAGGC TGCTCTCTTT 1260
GGCAGATTCA CTGTCAAATC AGACGTGTGG TCCTTTGGGA TTCTGCTCAC TGAACTGATC 1320
ACCAAGGGCA GAGTTCCATA CCCAGGTATG AACAACCGGG AAGTGTTGGA ACAGGTAGAG 1380
CACGGCTACC ACATGCCATG CCCTCCGGGA TGCCCAGTAT CCCTGTATGA GGTCATGGAG 1440
CAGACCTGGC GTCTGGATCC AGAGGAGAGG CCCACCTTTG AGTACCTGCA GTCTTTCCTG 1500
GAAGACTATT TCACCTCCAC AGAACCACAG TATCAGCCCG GAGACCAGAC ATAG 1554
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61
          l ++lG+G+fG+vwlg+w+ s+kvavktlk+gt+sp+afleeaqi+k lrh+klv+lya
Q: 252   ALDRRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYA  311
         6889********************************************************
S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121
         vvse ePiyivte+m  Gslldflk+++g++l lp+lvd+aaqvaeGmay+e++n+ihrd
Q: 312   VVSE-EPIYIVTEFMCYGSLLDFLKDRKGHNLMLPNLVDMAAQVAEGMAYMERMNYIHRD  370
         ***9.*******************************************************
S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181
         l+a+n+lvge+l++k+adfGlarli ddey++++g+k+PikWtaPea+ +g+ft+ksdvW
Q: 371   LRAANILVGEHLICKIADFGLARLIVDDEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVW  430
         ************************************************************
S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241
         sfGillte++tkG+vPypGm+n+evleqve+gy++p+p  cp +lye+++++w+ dpeer
Q: 431   SFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPVSLYEVMEQTWRLDPEER  490
         ************************************************************
S: 242   Ptfetlqevl  251
         Ptfe+lq++l
Q: 491   PTFEYLQSFL  500
         *******986
Domain Sequence
(FASTA)
ALDRRLGTGC FGDVWLGTWN CSTKVAVKTL KPGTMSPKAF LEEAQIMKLL RHDKLVQLYA 60
VVSEEPIYIV TEFMCYGSLL DFLKDRKGHN LMLPNLVDMA AQVAEGMAYM ERMNYIHRDL 120
RAANILVGEH LICKIADFGL ARLIVDDEYN PQQGTKFPIK WTAPEAALFG RFTVKSDVWS 180
FGILLTELIT KGRVPYPGMN NREVLEQVEH GYHMPCPPGC PVSLYEVMEQ TWRLDPEERP 240
TFEYLQSFL 249
KeywordATP-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Immunity; Innate immunity; Kinase; Lipoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Proto-oncogene; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>
EKS-AIM-00344
EKS-BOT-00371
EKS-CAJ-00374
EKS-CAF-00373
EKS-CAP-00403
EKS-EQC-00362
EKS-FEC-00357
EKS-GOG-00361
EKS-ICT-00349
EKS-LOA-00379
EKS-MAM-00370
EKS-MUM-00402
EKS-MUP-00364
EKS-NOL-00341
EKS-ORA-00323
EKS-ORC-00348
EKS-OTG-00373
EKS-PAT-00350
EKS-POA-00360
EKS-SAH-00341
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0005829; C:cytosol
GO:0005743; C:mitochondrial inner membrane
GO:0005758; C:mitochondrial intermembrane space
GO:0005886; C:plasma membrane
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0034987; F:immunoglobulin receptor binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0001784; F:phosphotyrosine binding
GO:0019901; F:protein kinase binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0045087; P:innate immune response
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
KEGG
rno:79113;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013