Tag | Content |
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EKPD ID | EKS-RAN-00225 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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STE/STE7 | 386.3 | 9.0E-116 | 69 | 361 | 293 |
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Status | Reviewed |
Ensembl Protein | ENSRNOP00000013933 |
UniProt Accession | Q01986; Q5EBD5; |
Protein Name | Dual specificity mitogen-activated protein kinase kinase 1 |
Protein Synonyms/Alias | MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; |
Gene Name | Map2k1 |
Gene Synonyms/Alias | Map2k1; Mek1, Prkmk1; |
Ensembl Information | |
Organism | Rattus norvegicus |
Functional Description | Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator- activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. |
Protein Length | 393 |
Protein Sequence (FASTA) | MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 60 | GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE 120 | CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 180 | REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 240 | SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELLFGCQVE GDAAETPPRP RTPGRPLSSY 300 | GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF 360 | IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA ASI 393 |
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Nucleotide Sequence (FASTA) | ATGCCCAAGA AGAAGCCGAC GCCCATCCAG CTGAACCCGG CCCCCGATGG CTCCGCGGTT 60 | AACGGGACCA GCTCGGCCGA GACCAACCTG GAGGCCTTGC AGAAGAAGCT GGAGGAGCTG 120 | GAGCTGGACG AGCAGCAGCG GAAGCGCCTT GAGGCCTTTC TGACGCAGAA GCAGAAGGTG 180 | GGAGAGTTGA AGGATGATGA CTTTGAGAAG ATCAGTGAAC TGGGGGCTGG CAATGGTGGA 240 | GTGGTGTTCA AGGTCTCCCA CAAGCCATCT GGCCTGGTTA TGGCTAGGAA GCTAATTCAC 300 | CTGGAGATCA AACCCGCAAT CCGGAACCAG ATCATCCGGG AGCTGCAGGT GCTGCATGAG 360 | TGCAACTCCC CGTACATAGT GGGCTTCTAC GGGGCCTTCT ACAGTGACGG CGAGATCAGC 420 | ATCTGCATGG AGCACATGGA TGGTGGGTCC TTGGATCAAG TGCTGAAGAA AGCTGGAAGA 480 | ATTCCTGAGC AAATTTTAGG AAAAGTCAGC ATCGCTGTGA TAAAAGGCCT GACATATCTA 540 | CGAGAGAAGC ACAAGATTAT GCACAGAGAT GTCAAGCCTT CCAACATTCT AGTGAACTCA 600 | CGTGGGGAGA TCAAACTCTG CGATTTTGGG GTCAGCGGGC AGCTAATTGA CTCCATGGCC 660 | AACTCCTTCG TGGGAACAAG GTCCTACATG TCGCCTGAGA GACTCCAGGG GACTCACTAC 720 | TCTGTGCAGT CGGACATCTG GAGCATGGGG CTCTCTCTGG TGGAGATGGC AGTTGGAAGA 780 | TACCCCATTC CTCCTCCTGA TGCCAAGGAG CTGGAGCTGC TGTTTGGATG CCAGGTGGAA 840 | GGAGACGCGG CCGAAACGCC ACCCAGGCCA AGGACCCCTG GGAGGCCCCT CAGCTCATAT 900 | GGAATGGATA GCCGACCTCC CATGGCAATT TTTGAGTTGT TGGATTACAT CGTCAATGAG 960 | CCTCCTCCAA AACTGCCCAG TGGAGTATTC AGTCTGGAAT TTCAGGATTT TGTGAATAAG 1020 | TGCTTAATAA AGAACCCTGC AGAGAGAGCA GATCTGAAGC AGCTCATGGT ACATGCTTTC 1080 | ATCAAGAGAT CTGATGCCGA GGAGGTAGAC TTCGCAGGCT GGCTCTGCTC CACCATTGGG 1140 | CTTAACCAGC CCAGCACACC AACCCACGCT GCCAGCATCT GA 1182 |
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Domain Profile | S: 2 ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv 61 | ek++elGaGnggvV kv+hk+sg ++a+K i+leik+++++qi+rel+vl+++ nspyiv | Q: 69 EKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV 127 | 799**************************************************.****** |
| S: 62 kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek 121 | +fyGaf+s+g++sicme+mdg+sld+vlkk ++ripe++lgk+++av+k+l+yl+ek | Q: 128 GFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREK 183 | *****************************9....8************************* |
| S: 122 lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv 181 | +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv | Q: 184 HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV 242 | ******************************************************.***** |
| S: 182 ksdvWslGltlvelatgrypyeklke.................................. 207 | +sd+Ws+Gl+lve+a+gryp++++++ | Q: 243 QSDIWSMGLSLVEMAVGRYPIPPPDAkelellfgcqvegdaaetpprprtpgrplssygm 302 | ************************999********************************* |
| S: 208 .......ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhafi 259 | i+ell++ivne+ppklp+ fs efq+fv+kCl+k+++eR++lk+l+ hafi | Q: 303 dsrppmaIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI 361 | *********************************************************97 |
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Domain Sequence (FASTA) | EKISELGAGN GGVVFKVSHK PSGLVMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60 | FYGAFYSDGE ISICMEHMDG GSLDQVLKKA GRIPEQILGK VSIAVIKGLT YLREKHKIMH 120 | RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180 | MGLSLVEMAV GRYPIPPPDA KELELLFGCQ VEGDAAETPP RPRTPGRPLS SYGMDSRPPM 240 | AIFELLDYIV NEPPPKLPSG VFSLEFQDFV NKCLIKNPAE RADLKQLMVH AFI 293 |
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Keyword | ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |