EKS-RAN-00235

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00235

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	388.7	1.3E-116	56	307	252

Status

Unreviewed

Ensembl Protein

ENSRNOP00000014395

UniProt Accession

F1M836;

Protein Name

Protein Synonyms/Alias

MAP/microtubule affinity-regulating kinase 3;

Gene Name

Mark3

Gene Synonyms/Alias

Mark3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000010330	ENSRNOP00000014395	ENSRNOT00000014395

Organism

Rattus norvegicus

Functional Description

Protein Length

797

Protein Sequence
(FASTA)

MSTRTPLPTV NERDTENHIS HGDGRQEVTS RTGRSGARCR NSIASCADEQ PHIGNYRLLK 60

TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKRIVHRDLK 180

AENLLLDADM NIKIADFGFS NEFTVGSKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240

VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPVKRGTLEQ 300

IMKDRWINAG HEEEELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 360

YLLLGRKSAE LDASDSSSSS NLSLAKVRPS SDLSNSTGQS PHHKGQRSVS SSQKQRRYSD 420

HAGPAIPSVV AYPKRSQTST ADSDLKEDGV PSRKSGSSAV GGKGIAPASP MLGNASNPNK 480

ADIPERKKSP AVPSSNAASG GMTRRNTYVC SERCAADRHS VIQNGKESSL TEVFAYAASP 540

ASLCATSTCR LRHQRSMSVS ASGHPKMVLP PIDSEGDTFK AITTPDQRTP VASTHSISSA 600

TTPDRIRFPR GTASRSTFHG QPRERRTATY NGPPASPSLS HEATPLSQTR SRGSTNLFSK 660

LTSKLTRRLP TEYERNGRYE GSSRNVSSEQ KDENREAKPR SLRFTWSMKT TSSMDPSDMM 720

REIRKVLDAN TCDYEQRERF LLFCVHGDGH AESLVQWEME VCKLPRLSLN GVRFKRISGT 780

SIAFKNIASK IANELKL 797

Nucleotide Sequence
(FASTA)

ATGTCCACTA GGACCCCTTT GCCAACGGTG AATGAACGAG ACACTGAAAA CCACATTTCA 60

CATGGAGATG GGAGGCAAGA AGTCACCTCC CGCACCGGGC GCTCTGGAGC TCGGTGTAGA 120

AACTCAATAG CTTCCTGTGC AGATGAACAG CCTCATATTG GAAACTACAG ACTATTGAAA 180

ACAATCGGCA AGGGGAACTT TGCAAAAGTG AAATTGGCGA GACACATCCT CACAGGCAGA 240

GAGGTTGCAA TAAAGATAAT TGACAAAACT CAGTTGAATC CAACAAGTCT ACAGAAGCTC 300

TTCAGAGAAG TAAGAATAAT GAAGATTTTA AATCACCCAA ACATAGTGAA ATTGTTCGAG 360

GTCATTGAAA CGGAAAAAAC ACTCTACTTA ATCATGGAAT ATGCAAGTGG AGGTGAAGTA 420

TTTGACTATT TGGTTGCACA TGGAAGAATG AAGGAAAAAG AAGCAAGAGC TAAGTTTAGA 480

CAGATTGTGT CCGCAGTACA GTATTGCCAC CAAAAACGGA TCGTTCACAG AGACCTCAAG 540

GCTGAAAATC TGTTATTAGA TGCGGATATG AACATTAAAA TAGCAGATTT TGGTTTTAGC 600

AATGAATTTA CTGTTGGCAG TAAACTAGAC ACGTTTTGTG GTAGTCCTCC ATATGCAGCC 660

CCTGAGCTCT TCCAGGGCAA GAAGTATGAC GGGCCGGAAG TGGACGTGTG GAGTCTCGGC 720

GTCATTCTGT ACACCCTAGT CAGTGGGTCA CTTCCCTTTG ATGGTCAGAA CCTGAAGGAA 780

CTGAGAGAGA GAGTCCTCCG AGGGAAGTAC AGAATCCCTT TCTACATGTC CACAGACTGT 840

GAGAACCTTC TCAAGCGCTT CCTGGTGCTG AACCCAGTTA AACGCGGCAC TCTGGAGCAA 900

ATCATGAAGG ACAGGTGGAT CAATGCAGGT CATGAGGAAG AGGAGCTTAA GCCATTTGTC 960

GAACCAGAAC TAGACATCTC AGACCAGAAG AGAATAGATA TTATGGTGGG AATGGGATAT 1020

TCCCAAGAAG AAATACAAGA ATCTCTTAGT AAAATGAAAT ACGATGAAAT CACAGCGACG 1080

TACTTGTTAC TGGGGAGGAA GTCTGCAGAG CTGGACGCTA GTGACTCCAG TTCTAGCAGC 1140

AACCTTTCAC TTGCTAAGGT GCGGCCAAGC AGTGACCTCA GCAATAGCAC TGGCCAGTCT 1200

CCTCATCACA AAGGGCAGAG GAGTGTGTCT TCAAGTCAGA AGCAGAGACG GTACAGTGAC 1260

CACGCTGGAC CAGCTATTCC TTCAGTTGTG GCATATCCGA AGAGGAGTCA GACCAGCACT 1320

GCAGATAGTG ACCTCAAAGA AGATGGAGTT CCCTCCCGAA AATCAGGCAG CAGTGCTGTA 1380

GGAGGAAAGG GGATTGCCCC TGCCAGTCCC ATGCTTGGGA ATGCAAGCAA TCCCAATAAA 1440

GCTGATATTC CCGAGCGCAA GAAAAGCCCT GCTGTCCCCA GTAGTAATGC AGCATCTGGT 1500

GGGATGACTC GGAGGAACAC TTACGTGTGC AGTGAGAGAT GTGCAGCGGA CAGACATTCA 1560

GTGATTCAGA ACGGCAAAGA AAGCAGCCTG ACAGAAGTGT TCGCTTACGC AGCTAGCCCT 1620

GCCTCACTCT GTGCCACATC TACCTGTCGG CTGAGACATC AGAGGTCGAT GTCCGTGTCA 1680

GCCTCTGGGC ACCCCAAGAT GGTGTTACCT CCAATAGACA GTGAAGGAGA TACCTTCAAG 1740

GCTATCACCA CTCCAGATCA GAGGACTCCA GTTGCTTCTA CACACAGTAT TAGCAGTGCG 1800

ACAACCCCAG ATCGCATCCG CTTCCCAAGG GGCACAGCCA GCCGTAGCAC TTTCCACGGG 1860

CAGCCTCGAG AGCGGCGAAC CGCAACATAT AATGGCCCCC CAGCCTCACC CAGCTTGTCC 1920

CATGAAGCCA CACCGCTGTC CCAGACGCGA AGCAGAGGCT CCACTAATCT TTTTAGCAAA 1980

CTAACTTCTA AACTCACCAG AAGACTTCCA ACTGAATATG AGAGGAACGG GAGATATGAG 2040

GGCTCAAGTC GCAATGTATC TTCGGAACAA AAGGATGAGA ACAGAGAGGC CAAACCTCGG 2100

TCCCTGCGCT TCACCTGGAG CATGAAAACC ACTAGTTCCA TGGATCCCAG TGACATGATG 2160

CGGGAGATCC GCAAAGTGCT GGACGCCAAT ACCTGCGACT ATGAGCAGAG GGAGCGCTTC 2220

CTGCTCTTCT GTGTCCATGG CGACGGGCAC GCTGAGAGCC TGGTGCAGTG GGAGATGGAA 2280

GTCTGTAAGC TGCCAAGACT GTCTCTGAAT GGGGTCCGGT TTAAGCGGAT ATCAGGGACA 2340

TCCATCGCTT TCAAAAACAT TGCTTCCAAA ATTGCCAACG AGCTAAAGCT GTAA 2394

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 56    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  115

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lyl++eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 116   VKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIV  175

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 176   HRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  235

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 236   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKR  295

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 296   GTLEQIMKDRWI  307

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETE KTLYLIMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKRIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPVKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013