EKS-RAN-00232

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00232

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	403.6	4.4E-121	37	321	285

Status

Reviewed

Ensembl Protein

ENSRNOP00000061535

UniProt Accession

Q4G050;

Protein Name

MAP kinase-interacting serine/threonine-protein kinase 1

Protein Synonyms/Alias

MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1;

Gene Name

Mknk1

Gene Synonyms/Alias

Mknk1; Mnk1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000010381	ENSRNOP00000061535	ENSRNOT00000067655

Organism

Rattus norvegicus

Functional Description

May play a role in the response to environmental stressand cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap (By similarity).

Protein Length

413

Protein Sequence
(FASTA)

MGSSEPLPIV DSDKRRKKKR KTRATDSLPG KFEDVYQLTS ELLGEGAYAK VQGAVSLQSG 60

KEYAVKIIEK QAGHSRSRVF REVETLYQCQ GNRNILELIE FFEDDTRFYL VFEKLQGGSI 120

LAHIQKRKHF NELEASRVVR DVATALDFLH TKGIAHRDLK PENILCESPE KVSPVKICDF 180

DLGSGVKLNN SCTPITTPEL TTPCGSAEYM APEVVEVFRD EATFYDKRCD LWSLGVVLYI 240

MLSGYPPFVG HCGADCGWDR GEVCRMCQNK LFESIQEGKY EFPDKDWAHI STEAKDLISK 300

LLVRDAKQRL SAAQVLQHPW VQGQAPERGL PTPQVLQRNS STMDLTLFAA EAIALNRQLS 360

QHEENELAEE HEALAEGLCS MKLSPPSKSR LARRRALAHA GREANSCSTP AGL 413

Nucleotide Sequence
(FASTA)

ATGGGCAGCA GTGAGCCCCT TCCCATCGTG GATAGTGACA AGAGGAGAAA GAAGAAGCGT 60

AAGACCCGGG CCACCGACTC TCTGCCAGGG AAGTTTGAAG ACGTGTACCA GCTGACCTCA 120

GAATTGCTGG GAGAAGGAGC CTATGCCAAA GTCCAGGGTG CCGTGAGCCT GCAGAGTGGC 180

AAAGAGTATG CAGTCAAAAT CATCGAGAAG CAAGCAGGAC ACAGTCGAAG CCGAGTATTC 240

CGTGAGGTGG AGACGTTGTA CCAGTGTCAA GGAAACAGGA ACATTTTGGA GCTGATTGAA 300

TTCTTTGAAG ATGACACACG ATTTTACTTG GTCTTTGAGA AATTGCAAGG AGGCTCCATC 360

CTAGCACACA TCCAGAAGCG GAAGCACTTC AATGAGCTAG AAGCCAGCAG AGTGGTGCGG 420

GATGTCGCCA CTGCCCTTGA TTTCCTGCAT ACTAAAGGCA TTGCTCACCG TGATCTGAAG 480

CCAGAAAACA TATTGTGCGA ATCTCCAGAA AAGGTGTCTC CGGTGAAAAT TTGTGACTTT 540

GACTTGGGCA GTGGAGTAAA ATTGAACAAC TCCTGCACTC CCATAACCAC ACCAGAGCTG 600

ACCACTCCAT GCGGCTCTGC AGAGTATATG GCACCTGAGG TGGTGGAGGT CTTTAGGGAC 660

GAGGCTACTT TCTATGACAA GCGCTGTGAC CTGTGGAGCC TGGGTGTGGT CCTCTACATC 720

ATGCTGAGTG GCTACCCCCC CTTTGTAGGT CACTGTGGGG CTGACTGCGG CTGGGACCGG 780

GGAGAGGTAT GCAGGATGTG CCAGAACAAG CTGTTCGAAA GCATCCAGGA AGGCAAATAC 840

GAGTTTCCCG ACAAAGACTG GGCTCACATC TCCACCGAGG CCAAAGACCT CATCTCTAAG 900

CTCCTGGTTC GAGATGCGAA GCAGAGACTC AGCGCTGCCC AAGTTCTGCA GCATCCATGG 960

GTGCAAGGGC AAGCTCCAGA AAGGGGACTC CCCACGCCGC AAGTCCTTCA GAGAAACAGC 1020

AGCACCATGG ACTTGACACT CTTCGCAGCT GAGGCCATTG CCCTCAACCG CCAGCTGTCT 1080

CAGCATGAAG AGAATGAACT GGCTGAGGAA CACGAGGCCC TAGCCGAGGG CCTCTGCTCC 1140

ATGAAGCTGT CCCCTCCATC CAAATCTCGC CTGGCACGAA GGCGAGCCCT GGCCCACGCT 1200

GGCCGAGAAG CAAACTCTTG TTCCACACCC GCAGGGCTCT GA 1242

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghkniv  55

         +lt+e+lGeG+++kv+ +v+ ++g++ya+ki+     ++r++v+reve+++q++g++ni+

Q: 37    QLTSELLGEGAYAKVQGAVSLQSGKEYAVKIIekqagHSRSRVFREVETLYQCQGNRNIL  96

         5799********************************************************

S: 56    elidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         eli++fe    d++r++lv+ekl+GG++l++iq+rk+f+e eas+vv+d+a+al+flh+k

Q: 97    ELIEFFE----DDTRFYLVFEKLQGGSILAHIQKRKHFNELEASRVVRDVATALDFLHTK  152

         *******....*************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaket.eee........eelktpcltaeyva  166

         +iahrDlkpen+L+es+ek++pvk+cDf+l++++   +        +el+tpc++aey+a

Q: 153   GIAHRDLKPENILCESPEKVSPVKICDFDLGSGVkL-NnsctpittPELTTPCGSAEYMA  211

         ********************************9952.345899999**************

S: 167   PevleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskkl  215

         Pev+e++++ea++ydk+CDlWslGv+lyi+l+GypPf++++g           r++++kl

Q: 212   PEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGadcgwdrgevcRMCQNKL  271

         *****************************************99*****************

S: 216   keriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         +e+iqegkyefP+++W+++s+eakdli+klL+rd+k+rl++++vl+hpwv

Q: 272   FESIQEGKYEFPDKDWAHISTEAKDLISKLLVRDAKQRLSAAQVLQHPWV  321

         *************************************************8

Domain Sequence
(FASTA)

QLTSELLGEG AYAKVQGAVS LQSGKEYAVK IIEKQAGHSR SRVFREVETL YQCQGNRNIL 60

ELIEFFEDDT RFYLVFEKLQ GGSILAHIQK RKHFNELEAS RVVRDVATAL DFLHTKGIAH 120

RDLKPENILC ESPEKVSPVK ICDFDLGSGV KLNNSCTPIT TPELTTPCGS AEYMAPEVVE 180

VFRDEATFYD KRCDLWSLGV VLYIMLSGYP PFVGHCGADC GWDRGEVCRM CQNKLFESIQ 240

EGKYEFPDKD WAHISTEAKD LISKLLVRDA KQRLSAAQVL QHPWV 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Translation regulation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006417	; P:regulation of translation

KEGG

rno:500526

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013