EKS-RAN-00173
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00173
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/SRPK870.54.6E-26279679601
StatusUnreviewed
Ensembl ProteinENSRNOP00000059855
UniProt AccessionB1WBT4;
Protein Name
Protein Synonyms/Alias Protein Srpk2; SFRS protein kinase 2; Serine/arginine-rich protein specific kinase 2 (Predicted), isoform CRA_b;
Gene NameSrpk2
Gene Synonyms/Alias Srpk2; Srpk2_predicted; rCG_24322;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000010601ENSRNOP00000059855ENSRNOT00000063994
OrganismRattus norvegicus
Functional Description
Protein Length681
Protein Sequence
(FASTA)
MSVNSEKSSS SERPEPQQKA PLVPPPPPPP PPPPLPDPVP PEPEEEILGS DDEEQEDPAD 60
YCKGGYHPVK IGDLFNGRYH VIRKLGWGHF STVWLCWDMQ GKRFVAMKVV KSAQHYTETA 120
LDEIKLLKCV RESDPSDPNK DMVVQLIDDF KISGMNGIHV CMVFEVLGHH LLKWIIKSNY 180
QGLPVRCVKS IIRQVLQGLD YLHSKCKIIH TDIKPENILM CVDGAYVRRM AAEATEWQKA 240
GAPPPSGSAV STAPQQKPIG KISKNKKKKL KKKQKRQAEL LEKRLQEIEE LEREAERKIL 300
EENTTSAEAS SEQDGECQPE VKLKEAELED TTEEETAKDN GEVEDQEEKE DTEKENTEKD 360
EDDVEQELEN IDPTWMESPK ANGHIENGLF LLEQQLEDEE DEEDDCANPE EYNLDEPNAE 420
SDYTYSSSYE QFNGELPNGQ PKSPEFPTPL FSGPLEPVAS DSVLSEGSPL TEPEESSPSR 480
DRSRTVSASS TGDLPKTKTR AADLLVNPLD PQNADKIRVK IADLGNACWV HKHFTEDIQT 540
RQYRSIEVLI GAGYSTPADI WSTACMAFEL ATGDYLFEPH SGEDYSRDED HIAHIIELLG 600
SIPRHFALSG KYSREFFNRR GELRHITKLK PWSLFDVLVE KYGWPHEDAA QFTDFLIPML 660
EMVPEKRASA GECLRHPWLN S 681
Nucleotide Sequence
(FASTA)
ATGTCAGTTA ACTCTGAGAA GTCGTCCTCT TCAGAAAGGC CGGAGCCTCA ACAGAAAGCT 60
CCTTTAGTTC CTCCTCCTCC ACCACCGCCA CCGCCACCAC CACTGCCAGA CCCCGTGCCT 120
CCAGAGCCAG AGGAGGAGAT TCTGGGGTCA GATGATGAGG AGCAGGAGGA CCCCGCGGAT 180
TACTGCAAAG GTGGCTATCA TCCAGTGAAA ATCGGAGACC TCTTCAATGG TCGCTATCAT 240
GTCATTAGGA AGCTAGGATG GGGGCACTTT TCCACCGTCT GGCTATGCTG GGATATGCAA 300
GGGAAGAGGT TTGTCGCCAT GAAAGTTGTA AAAAGTGCAC AGCATTATAC AGAGACAGCC 360
TTGGATGAAA TTAAATTGCT CAAATGTGTT CGAGAAAGTG ACCCCAGTGA CCCAAACAAA 420
GACATGGTAG TCCAGCTAAT CGATGACTTC AAGATCTCAG GCATGAATGG GATACATGTC 480
TGCATGGTCT TCGAAGTACT TGGTCACCAT CTCCTCAAAT GGATCATCAA GTCCAACTAT 540
CAAGGCCTCC CAGTCCGCTG TGTGAAGAGT ATCATTCGAC AGGTCCTTCA GGGCTTAGAC 600
TATCTACACA GCAAGTGCAA GATAATCCAC ACTGATATCA AGCCGGAGAA CATCCTGATG 660
TGTGTGGACG GCGCGTACGT GCGGAGAATG GCGGCCGAGG CTACGGAGTG GCAGAAAGCA 720
GGTGCTCCTC CTCCTTCTGG GTCTGCAGTG AGTACGGCTC CACAGCAGAA ACCTATAGGA 780
AAAATATCTA AAAACAAAAA GAAAAAGCTA AAAAAGAAAC AGAAGAGGCA GGCTGAGTTG 840
CTGGAGAAGC GCCTGCAGGA GATTGAGGAA TTGGAGAGAG AAGCCGAAAG GAAAATCCTA 900
GAAGAGAACA CCACCTCTGC AGAAGCTTCC AGTGAGCAAG ATGGAGAATG CCAGCCTGAG 960
GTGAAACTGA AAGAGGCCGA GTTAGAGGAC ACAACTGAGG AAGAGACAGC AAAGGACAAT 1020
GGTGAAGTTG AAGACCAGGA AGAGAAAGAA GACACAGAGA AGGAAAACAC TGAGAAGGAT 1080
GAAGATGATG TTGAACAGGA ACTTGAGAAC ATAGACCCTA CGTGGATGGA GTCCCCTAAG 1140
GCCAACGGCC ATATTGAAAA TGGCCTGTTT TTACTGGAGC AGCAGCTGGA GGATGAAGAG 1200
GATGAGGAAG ATGACTGTGC AAACCCCGAG GAGTATAACC TGGATGAACC AAATGCGGAG 1260
AGTGATTATA CGTATAGCAG CTCCTATGAA CAATTCAATG GTGAATTGCC AAACGGACAG 1320
CCTAAGAGTC CAGAGTTTCC CACACCGCTG TTTTCTGGGC CCTTAGAACC TGTGGCCTCT 1380
GACTCTGTGC TGTCAGAGGG ATCACCACTC ACCGAGCCAG AGGAAAGCAG TCCATCCCGT 1440
GACAGAAGCA GGACAGTTTC AGCCTCCAGT ACTGGAGACT TGCCAAAAAC AAAAACCCGG 1500
GCAGCTGACC TGTTGGTGAA CCCTCTGGAT CCACAGAATG CAGATAAAAT TAGAGTAAAA 1560
ATTGCTGACC TGGGAAATGC TTGTTGGGTG CATAAACATT TCACAGAGGA TATCCAAACA 1620
CGTCAGTATA GGTCCATAGA GGTTTTGATA GGAGCAGGCT ACAGTACACC TGCAGACATT 1680
TGGAGTACAG CATGCATGGC ATTTGAGCTG GCAACAGGAG ACTATTTGTT CGAACCGCAT 1740
TCTGGGGAAG ACTATTCCAG AGATGAAGAC CACATAGCCC ACATCATAGA GCTGCTAGGC 1800
AGTATCCCAA GGCACTTTGC TCTGTCTGGA AAATACTCCC GGGAGTTCTT CAACCGCAGA 1860
GGAGAACTGC GGCACATCAC CAAGCTGAAG CCCTGGAGCC TCTTTGATGT TCTTGTGGAA 1920
AAGTATGGCT GGCCCCATGA AGATGCTGCA CAGTTTACAG ATTTCCTGAT CCCAATGTTA 1980
GAGATGGTTC CAGAAAAACG AGCCTCAGCT GGCGAATGCC TTCGGCATCC TTGGTTGAAT 2040
TCTTAG 2046
Domain Profile
S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60
         yhvirkLGWGhfstvWL+wd+q+krfva+kvvksa+hytetaldeikllk+vresdpsdp
Q: 79    YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDP  138
         9***********************************************************
S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120
         ++++vvql+ddfkisG+nG+hvc+vfevLG++Llk+iiksny+Glp+++vk+iirqvL+g
Q: 139   NKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQG  198
         ************************************************************
S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180
         Ldylh+kCkiihtdikPen+L++vd +y+rr+aaeatewqkaga+ppsgsavstapq+k+
Q: 199   LDYLHSKCKIIHTDIKPENILMCVDGAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKP  258
         ************************************************************
S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214
         i+k+sknkkkklkkkqkrqaellekrlqe+eele                          
Q: 259   IGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEreaerkileenttsaeasseqdgecq  318
         ************************************************************
S: 215   .................aaeanseaedqelkedaekgeleeieadveeevanedea....  253
                          +a++n+e+edqe+ked+ek+++e++e+dve+e+ n+d++    
Q: 319   pevklkeaeledtteeeTAKDNGEVEDQEEKEDTEKENTEKDEDDVEQELENIDPTwmes  378
         ********************************************************8888
S: 254   ....................seeee...................essltsssdaesksge  274
                             +   e                   es++t+ss++e+++ge
Q: 379   pkanghienglflleqqledE---EdeeddcanpeeynldepnaESDYTYSSSYEQFNGE  435
         888888777777777766541...04557788888888888999****************
S: 275   l.......seastellsesleqlacgsvls..............................  297
         l       +e++t+l+s++le++a++svls                              
Q: 436   LpngqpksPEFPTPLFSGPLEPVASDSVLSegspltepeesspsrdrsrtvsasstgdlp  495
         *999999999**************************************************
S: 298   ..........vnplepknadkikvkiadLGnaCwvhkhftediqtrqyrslevliGagyg  347
                   vnpl+p+nadki+vkiadLGnaCwvhkhftediqtrqyrs+evliGagy+
Q: 496   ktktraadllVNPLDPQNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYS  555
         ************************************************************
S: 348   tpadiWstaClafeLatGdyLfephsgedysrdedhiakiiellGkiPrklilkGkysre  407
         tpadiWstaC+afeLatGdyLfephsgedysrdedhia+iiellG+iPr+++l+Gkysre
Q: 556   TPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSRE  615
         ************************************************************
S: 408   ffnkkgeLrhitkLkpwsLlevLvekyewskeeaaefsdfLlPmleldpekrasaaeclk  467
         ffn++geLrhitkLkpwsL++vLveky+w++e+aa+f+dfL+Pmle++pekrasa+ecl+
Q: 616   FFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLR  675
         ************************************************************
S: 468   hpwL  471
         hpwL
Q: 676   HPWL  679
         ***8
Domain Sequence
(FASTA)
YHVIRKLGWG HFSTVWLCWD MQGKRFVAMK VVKSAQHYTE TALDEIKLLK CVRESDPSDP 60
NKDMVVQLID DFKISGMNGI HVCMVFEVLG HHLLKWIIKS NYQGLPVRCV KSIIRQVLQG 120
LDYLHSKCKI IHTDIKPENI LMCVDGAYVR RMAAEATEWQ KAGAPPPSGS AVSTAPQQKP 180
IGKISKNKKK KLKKKQKRQA ELLEKRLQEI EELEREAERK ILEENTTSAE ASSEQDGECQ 240
PEVKLKEAEL EDTTEEETAK DNGEVEDQEE KEDTEKENTE KDEDDVEQEL ENIDPTWMES 300
PKANGHIENG LFLLEQQLED EEDEEDDCAN PEEYNLDEPN AESDYTYSSS YEQFNGELPN 360
GQPKSPEFPT PLFSGPLEPV ASDSVLSEGS PLTEPEESSP SRDRSRTVSA SSTGDLPKTK 420
TRAADLLVNP LDPQNADKIR VKIADLGNAC WVHKHFTEDI QTRQYRSIEV LIGAGYSTPA 480
DIWSTACMAF ELATGDYLFE PHSGEDYSRD EDHIAHIIEL LGSIPRHFAL SGKYSREFFN 540
RRGELRHITK LKPWSLFDVL VEKYGWPHED AAQFTDFLIP MLEMVPEKRA SAGECLRHPW 600
L 601
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00169
EKS-ANC-00170
EKS-BOT-00177
EKS-CAJ-00181
EKS-CAF-00184
EKS-CAP-00204
EKS-CII-00116
EKS-DRM-00090
EKS-EQC-00175
EKS-FEC-00167
EKS-GAM-00096
EKS-GAG-00153
EKS-GAA-00219
EKS-GOG-00176
EKS-HOS-00183
EKS-ICT-00173
EKS-LAC-00189
EKS-LOA-00176
EKS-MAM-00176
EKS-MEG-00139
EKS-MOD-00177
EKS-MUM-00182
EKS-MUP-00180
EKS-MYL-00185
EKS-NOL-00170
EKS-ORN-00224
EKS-ORA-00156
EKS-ORC-00164
EKS-ORL-00209
EKS-OTG-00183
EKS-PAT-00167
EKS-PEM-00094
EKS-POA-00173
EKS-SAH-00169
EKS-SUS-00156
EKS-TAG-00207
EKS-TAR-00230
EKS-TEN-00228
EKS-XET-00210
EKS-XIM-00219
EKS-SAC-00082
EKS-SCP-00104
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005730; C:nucleolus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0001525; P:angiogenesis
GO:0007243; P:intracellular protein kinase cascade
GO:0045071; P:negative regulation of viral genome replication
GO:0035063; P:nuclear speck organization
GO:0045787; P:positive regulation of cell cycle
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043525; P:positive regulation of neuron apoptotic process
GO:0045070; P:positive regulation of viral genome replication
GO:0000245; P:spliceosomal complex assembly
KEGG
rno:296753;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013