EKS-RAN-00386

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00386

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	424.6	1.5E-127	235	484	250

Status

Unreviewed

Ensembl Protein

ENSRNOP00000015021

UniProt Accession

Q4KM97;

Protein Name

Protein Synonyms/Alias

B lymphoid kinase; B lymphoid tyrosine kinase; Protein Blk;

Gene Name

Blk

Gene Synonyms/Alias

Blk; rCG_52180;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000010798	ENSRNOP00000015021	ENSRNOT00000015021

Organism

Rattus norvegicus

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

MGLLSSKRQI SEKSKSWSPV KARAQGKVPP PLPPLVVFNH LPPPSPNQHP DEEERFVVAL 60

FDYAAVNDRD LQVLKGEKLQ VLKSTGDWWL ARSLVTGREG YVPSNFVAPV ETLEVEKWFF 120

RTISRKDAER QLLAPMNKAG SFLIRESESN KGAFSLSVKD VTSQGEMVKH YKIRSLDNGG 180

YYISPRITFP TLQALVQHYS EKGDGLCQKL TLPCVNPAPK NPWAQDEWEI PRQSLKLVRK 240

LGSGQFGEVW MGYYKNNMKV AIKTLKEGTM SPEAFLGEAN VMKTLQHERL VRLYAVVTRE 300

PIYIVTEYMA RGCLLDFLKT DEGSRLSLPR LIDMSAQVAE GMAYIERMNS IHRDLRAANI 360

LVSETLCCKI ADFGLARIID SEYTAQEGAK FPIKWTAPEA IHFGVFTIKA DVWSFGVLLM 420

EIVTYGRVPY PGMSNPEVIR SLEHGYRMPC PETCPPELYH DVITECWRGR PEERPTFEFL 480

QSVLEDFYTA TEGQYELQP 499

Nucleotide Sequence
(FASTA)

ATGGGGCTAC TGAGCAGCAA GAGGCAGATC AGCGAGAAGA GCAAGAGCTG GAGCCCTGTG 60

AAGGCCCGCG CCCAGGGCAA GGTACCCCCG CCCCTGCCAC CCCTGGTTGT CTTCAACCAC 120

CTCCCTCCTC CATCTCCTAA CCAGCACCCA GATGAAGAGG AGCGTTTTGT GGTGGCCCTG 180

TTTGACTATG CCGCTGTGAA TGACAGGGAC CTGCAAGTGC TAAAGGGAGA GAAGCTCCAA 240

GTCTTGAAGA GCACTGGAGA CTGGTGGTTG GCCAGGTCAC TCGTCACAGG AAGAGAAGGC 300

TATGTGCCCA GCAACTTTGT GGCCCCAGTA GAGACCCTGG AAGTAGAAAA ATGGTTCTTC 360

AGGACCATTA GCCGGAAGGA TGCTGAGAGG CAGTTGCTGG CTCCAATGAA CAAAGCCGGC 420

TCCTTTCTCA TCAGAGAGAG TGAGAGCAAT AAAGGTGCCT TTTCCCTATC TGTGAAAGAC 480

GTCACCAGCC AGGGGGAGAT GGTCAAGCAC TATAAGATCC GCTCACTGGA CAATGGAGGC 540

TATTACATCT CGCCCCGGAT CACCTTCCCC ACCCTCCAGG CCCTGGTGCA GCACTATTCT 600

GAGAAAGGGG ACGGTTTGTG TCAGAAGTTG ACCCTGCCCT GTGTGAACCC AGCCCCGAAG 660

AATCCCTGGG CCCAAGACGA ATGGGAAATC CCCAGGCAGT CCCTCAAGTT GGTCCGGAAA 720

CTTGGGTCTG GGCAGTTTGG TGAAGTCTGG ATGGGTTATT ACAAAAATAA CATGAAGGTG 780

GCAATCAAGA CCCTGAAGGA GGGAACCATG TCTCCGGAAG CTTTCCTGGG TGAGGCCAAC 840

GTGATGAAAA CCCTGCAGCA TGAGAGGCTG GTCCGTCTCT ACGCCGTGGT CACCAGAGAG 900

CCCATCTACA TTGTCACGGA ATACATGGCC AGAGGATGCT TGCTGGATTT TCTGAAGACC 960

GATGAAGGTA GCAGATTGTC CCTTCCAAGG CTGATTGACA TGTCAGCCCA GGTTGCAGAA 1020

GGGATGGCTT ACATAGAGCG CATGAATTCC ATCCACCGTG ACCTGCGGGC AGCCAACATC 1080

CTGGTGTCTG AGACCTTGTG CTGCAAAATC GCTGACTTCG GCTTGGCCAG GATCATCGAC 1140

AGTGAATATA CTGCCCAAGA GGGGGCCAAG TTCCCCATCA AGTGGACTGC CCCAGAAGCC 1200

ATCCACTTCG GGGTGTTTAC CATCAAGGCT GATGTGTGGT CCTTTGGAGT CTTGCTGATG 1260

GAGATTGTCA CATATGGGCG TGTTCCCTAC CCAGGAATGA GCAACCCTGA GGTCATCCGT 1320

AGCCTGGAGC ATGGCTACCG AATGCCATGC CCAGAGACAT GTCCGCCTGA GTTGTACCAT 1380

GACGTCATCA CTGAGTGCTG GCGAGGCCGA CCTGAGGAGC GGCCTACCTT TGAGTTCCTG 1440

CAGTCAGTGC TGGAGGACTT CTACACAGCC ACGGAGGGCC AATATGAGCT GCAGCCTTAG 1500

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lklv+klG+GqfGevw+g++k+++kva+ktlkegt+speafl ea+++k+l+he+lv+ly

Q: 235   LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLY  294

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++ ePiyivte+ma+G+lldflk++eg++l+lp+l+d++aqvaeGmay+e++n ihr

Q: 295   AVVTR-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHR  353

         *****.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv+e+l++k+adfGlar+i d+eyta+egak+PikWtaPeai++g+ftik+dv

Q: 354   DLRAANILVSETLCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADV  412

         **************************.899******************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelye.lllecwkkdpe  239

         WsfG+ll+eivt+G+vPypGm+n ev++++e+gyr+p+pe+cp ely+ +++ecw+ +pe

Q: 413   WSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYHdVITECWRGRPE  472

         **********************************************998***********

S: 240   erPtfetlqevl  251

         erPtfe+lq+vl

Q: 473   ERPTFEFLQSVL  484

         ********9986

Domain Sequence
(FASTA)

LKLVRKLGSG QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKT LQHERLVRLY 60

AVVTREPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQVAEGMAY IERMNSIHRD 120

LRAANILVSE TLCCKIADFG LARIIDSEYT AQEGAKFPIK WTAPEAIHFG VFTIKADVWS 180

FGVLLMEIVT YGRVPYPGMS NPEVIRSLEH GYRMPCPETC PPELYHDVIT ECWRGRPEER 240

PTFEFLQSVL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0050853	; P:B cell receptor signaling pathway
GO:0032024	; P:positive regulation of insulin secretion

KEGG

rno:364403

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013