EKS-RAN-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	444.1	2.6E-133	234	521	288

Status

Reviewed

Ensembl Protein

ENSRNOP00000015047

UniProt Accession

Q78EA7; Q64308;

Protein Name

Bone morphogenetic protein receptor type-1A

Protein Synonyms/Alias

BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; ALK-3; Bone morphogenetic protein 4 receptor;

Gene Name

Bmpr1a

Gene Synonyms/Alias

Bmpr1a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000010814	ENSRNOP00000015047	ENSRNOT00000015047

Organism

Rattus norvegicus

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 (By similarity).

Protein Length

532

Protein Sequence
(FASTA)

MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL APEDTLPFLK 60

CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 120

TIECCRTNLC NQYLQPTLPP VVIGPFFDGS VRWLAVLISM AVCIVAMIVF SSCFCYKHYC 180

KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240

GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300

SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360

RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTRRYMAP EVLDESLSKN 420

HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 480

PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532

Nucleotide Sequence
(FASTA)

ATGACTCAGC TATACACTTA CATCAGATTA CTGGGAGCCT GTCTGTTCAT CATTTCTCAT 60

GTTCAAGGGC AGAATCTAGA TAGTATGCTC CATGGTACTG GTATGAAATC AGACGTGGAC 120

CAGAAGAAGC CGGAAAATGG AGTGACGTTA GCACCAGAGG ACACCTTACC TTTCTTAAAA 180

TGCTATTGCT CAGGACACTG CCCAGATGAC GCTATTAATA ACACATGCAT AACTAATGGC 240

CATTGCTTTG CCATTATAGA AGAAGATGAT CAGGGAGAAA CCACGTTAAC TTCTGGGTGT 300

ATGAAGTATG AAGGCTCTGA TTTTCAATGC AAGGATTCAC CAAAAGCCCA GCTACGCAGG 360

ACAATAGAAT GTTGTCGGAC CAATTTGTGC AACCAATATT TGCAGCCTAC ACTGCCCCCT 420

GTCGTTATAG GCCCATTCTT TGATGGCAGC GTCCGATGGC TGGCTGTGCT CATCTCTATG 480

GCTGTCTGTA TTGTCGCCAT GATCGTCTTC TCCAGCTGCT TCTGTTACAA ACATTACTGT 540

AAGAGTATCT CAAGCAGAGG TCGTTACAAC CGTGACTTGG AACAGGATGA AGCATTTATT 600

CCAGTAGGAG AATCACTGAA AGACCTGATT GACCAGTCAC AAAGCTCTGG TAGTGGATCT 660

GGATTACCTT TATTGGTTCA GCGAACTATT GCCAAACAGA TTCAGATGGT TCGGCAGGTT 720

GGTAAGGGCC GGTATGGAGA AGTATGGATG GGTAAATGGC GTGGTGAAAA AGTGGCTGTC 780

AAAGTGTTTT TTACCACTGA AGAAGCTAGC TGGTTTAGAG AAACAGAAAT CTACCAGACG 840

GTGTTAATGC GTCATGAAAA TATACTTGGT TTTATAGCTG CAGACATTAA AGGCACCGGT 900

TCCTGGACTC AGCTGTATTT GATTACTGAT TACCATGAGA ATGGGTCTCT CTATGACTTC 960

CTGAAATGTG CCACCCTGGA CACCAGAGCC CTACTCAAGT TAGCTTATTC TGCTGCCTGT 1020

GGTCTGTGCC ACCTCCACAC AGAAATTTAT GGCACGCAAG GCAAGCCTGC AATTGCTCAT 1080

CGAGACCTGA AGAGCAAAAA CATCCTTATT AAGAAAAATG GTAGTTGCTG TATTGCTGAC 1140

CTGGGCCTAG CTGTTAAATT CAACAGTGAC ACAAATGAAG TTGACATACC CTTGAACACC 1200

AGGGTGGGCA CCAGGCGGTA CATGGCTCCA GAAGTGCTGG ACGAGAGCCT GAGTAAAAAC 1260

CATTTCCAGC CCTACATCAT GGCTGACATC TACAGCTTTG GTTTGATCAT TTGGGAGATG 1320

GCCCGTCGCT GTATTACAGG AGGAATCGTG GAGGAATATC AATTACCATA TTACAACATG 1380

GTGCCTAGTG ACCCATCTTA TGAAGACATG CGTGAGGTCG TGTGTGTGAA ACGCTTGCGG 1440

CCAATCGTCT CTAACCGCTG GAACAGTGAT GAATGTCTTC GAGCCGTTTT GAAGCTGATG 1500

TCAGAATGCT GGGCCCATAA TCCAGCATCC AGACTCACAG CTTTGAGAAT CAAGAAGACG 1560

CTCGCAAAGA TGGTTGAATC CCAGGATGTA AAGATTTGA 1599

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++++gkGrygeVw++k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 234   IQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  293

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+d+Lk  tld++ ll+la+s+a+Gl+hLH+ei gt+

Q: 294   ADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQ  353

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNil+kk+++cciaDlGLa+k++++++e+d+  n++vGt+RYmaPE

Q: 354   G--KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDIPLNTRVGTRRYMAPE  411

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+l  ++f+ + +aD+Ys+gL++WE+a+Rc + +++veey+lp++++v+sdPs+e+m

Q: 412   VLDESLSKNHFQPYIMADIYSFGLIIWEMARRCIT-GGIVEEYQLPYYNMVPSDPSYEDM  470

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evv++k+lrP ++++w+++e+l+++ kl++ecW+++p++Rltalr+kk+l

Q: 471   REVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL  521

         *************************************************97

Domain Sequence
(FASTA)

IQMVRQVGKG RYGEVWMGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDFLKC ATLDTRALLK LAYSAACGLC HLHTEIYGTQ 120

GKPAIAHRDL KSKNILIKKN GSCCIADLGL AVKFNSDTNE VDIPLNTRVG TRRYMAPEVL 180

DESLSKNHFQ PYIMADIYSF GLIIWEMARR CITGGIVEEY QLPYYNMVPS DPSYEDMREV 240

VCVKRLRPIV SNRWNSDECL RAVLKLMSEC WAHNPASRLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0030425	; C:dendrite
GO:0016021	; C:integral to membrane
GO:0043025	; C:neuronal cell body
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0000981	; F:sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0051216	; P:cartilage development
GO:0048589	; P:developmental growth
GO:0009950	; P:dorsal/ventral axis specification
GO:0007398	; P:ectoderm development
GO:0042733	; P:embryonic digit morphogenesis
GO:0048568	; P:embryonic organ development
GO:0003272	; P:endocardial cushion formation
GO:0060914	; P:heart formation
GO:0035137	; P:hindlimb morphogenesis
GO:0006955	; P:immune response
GO:0001701	; P:in utero embryonic development
GO:0048368	; P:lateral mesoderm development
GO:0030324	; P:lung development
GO:0048382	; P:mesendoderm development
GO:0001707	; P:mesoderm formation
GO:0001880	; P:Mullerian duct regression
GO:0050768	; P:negative regulation of neurogenesis
GO:0014032	; P:neural crest cell development
GO:0021998	; P:neural plate mediolateral regionalization
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0060021	; P:palate development
GO:0048352	; P:paraxial mesoderm structural organization
GO:0021983	; P:pituitary gland development
GO:0030501	; P:positive regulation of bone mineralization
GO:0050679	; P:positive regulation of epithelial cell proliferation
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0001756	; P:somitogenesis
GO:0019827	; P:stem cell maintenance

KEGG

rno:81507

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013