EKS-RAN-00109
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00109
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec442.16.5E-133404654251
StatusUnreviewed
Ensembl ProteinENSRNOP00000047924
UniProt AccessionD3ZSK8;
Protein Name
Protein Synonyms/Alias Protein Btk;
Gene NameBtk
Gene Synonyms/Alias Btk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000011331ENSRNOP00000047924ENSRNOT00000043770
OrganismRattus norvegicus
Functional Description
Protein Length661
Protein Sequence
(FASTA)
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGGSK GWRRYSHARE 60
KNYCVENILP PKIPPTRDQV LQRRGEESSE MEQISIIERF PYPFQVVYDE GPLYVFSPTE 120
ELRKRWIHQL KNVIRYNSDL VQKYHPCFWI DGQYLCCSQT AKNAMGCQIL ENRNGSLKPG 180
SSHRKTKKPL PPTPEEDQIL KKPLPPEPTA APISTSELKK VVALYDYMPM NANDLQLRKG 240
EEYFILEESN LPWWRARDKN GQEGYIPSNY VTEAEDSIEM YEWYSKHMTR SQAEQLLKQE 300
GKEGGFIVRD SSKAGKYTVS VFAKSTGEPQ GVIRHYVVCS TPQSQYYLAE KHLFSTIPEL 360
INYHQHNSAG LISRLKYPVS KQNKNAPSTA GLGYGSWEID PKDLTFLKEL GTGQFGVVKY 420
GKWRGQYDVA IKMIREGSMS EDEFIEEAKV MMNLSHEKLV QLYGVCTKQR PIFIITEYMA 480
NGCLLNYLRE MRHRFQTQQL LEMCKDVCEA MEYLESKQFL HRDLASQEAQ TVPRGKVKAS 540
LETLRKYVLD DEYTSSVGSK FPVRWSPPEV LMYSKFSSKS DIWAFGVLMW EIYSLGKIPY 600
ERFTNSETAE HIAQGLRLYR PHLASDRVYT IMYSCWHEKA DERPSFKILL SNILDVMDEE 660
S 661
Nucleotide Sequence
(FASTA)
ATGGCTGCTG TGATACTGGA GAGCATCTTT CTGAAGCGCT CCCAGCAGAA AAAGAAAACA 60
TCACCTTTAA ATTTTAAGAA GCGCCTATTT CTCCTGACTG TGCACAAACT TTCATACTAT 120
GAATATGACT TTGAACGTGG GGGTAGCAAG GGTTGGAGGA GGTACAGTCA TGCCAGGGAA 180
AAAAATTATT GTGTTGAAAA TATTCTTCCA CCAAAGATTC CACCAACTAG GGACCAAGTA 240
TTACAGAGGA GGGGTGAGGA GTCCAGTGAA ATGGAACAGA TTTCAATCAT TGAAAGGTTC 300
CCGTACCCAT TTCAGGTCGT ATATGATGAA GGACCTCTCT ATGTTTTCTC CCCAACCGAA 360
GAGCTGAGAA AACGCTGGAT TCACCAGCTC AAAAATGTAA TCCGGTACAA TAGTGACCTG 420
GTGCAGAAAT ATCATCCTTG CTTCTGGATT GATGGACAGT ATCTCTGCTG CTCTCAGACA 480
GCCAAGAATG CTATGGGCTG CCAAATTTTG GAGAACAGGA ATGGAAGCTT AAAACCTGGA 540
AGTTCTCATC GAAAAACAAA AAAGCCTCTT CCCCCTACCC CAGAGGAAGA TCAGATCTTG 600
AAAAAGCCAC TCCCCCCTGA GCCAACAGCA GCACCAATCT CCACAAGTGA GCTGAAAAAG 660
GTCGTGGCCC TTTATGATTA TATGCCAATG AATGCAAATG ACTTACAATT GCGAAAGGGC 720
GAGGAGTATT TTATCCTGGA GGAGAGCAAC CTACCATGGT GGCGAGCACG AGATAAAAAT 780
GGGCAGGAAG GCTATATCCC CAGTAACTAT GTCACCGAAG CAGAGGACTC CATAGAGATG 840
TATGAGTGGT ATTCCAAGCA CATGACTCGA AGTCAAGCTG AGCAACTTCT AAAGCAAGAG 900
GGGAAAGAAG GAGGTTTCAT TGTCAGAGAC TCCAGCAAAG CTGGAAAATA CACTGTGTCT 960
GTGTTTGCTA AATCTACAGG GGAGCCTCAA GGGGTGATAC GCCATTATGT TGTGTGCTCC 1020
ACACCTCAGA GCCAGTATTA CCTGGCTGAG AAGCACCTTT TCAGCACCAT TCCTGAGCTC 1080
ATCAACTACC ATCAACATAA CTCTGCAGGC CTCATATCCA GGCTGAAATA TCCTGTATCG 1140
AAACAAAACA AAAACGCGCC TTCTACGGCA GGCCTGGGCT ATGGATCATG GGAAATTGAT 1200
CCAAAGGACT TGACCTTCTT GAAGGAGCTT GGGACTGGAC AATTTGGTGT CGTCAAATAT 1260
GGGAAGTGGA GGGGCCAATA TGATGTGGCC ATCAAGATGA TCAGAGAAGG TTCCATGTCT 1320
GAGGATGAAT TCATTGAAGA AGCCAAAGTC ATGATGAATC TTTCCCATGA GAAGCTAGTG 1380
CAGTTGTATG GAGTCTGCAC CAAACAGCGC CCCATCTTCA TCATCACTGA ATACATGGCT 1440
AATGGCTGCC TCTTGAACTA CCTGAGGGAG ATGCGGCACC GCTTCCAGAC ACAGCAGCTG 1500
CTTGAGATGT GCAAAGATGT CTGTGAAGCA ATGGAATACT TGGAGTCAAA GCAGTTCCTT 1560
CATAGAGACC TGGCTAGTCA AGAGGCTCAA ACAGTACCAA GAGGAAAAGT CAAGGCCAGC 1620
CTAGAGACTT TGAGAAAGTA TGTTCTTGAT GATGAATACA CCAGCTCGGT AGGCTCCAAA 1680
TTTCCAGTCC GGTGGTCTCC ACCAGAAGTG CTCATGTATA GCAAATTCAG CAGCAAATCT 1740
GACATCTGGG CTTTTGGGGT TCTAATGTGG GAAATTTACT CCCTGGGGAA AATACCATAT 1800
GAGAGATTTA CTAACAGTGA GACAGCAGAA CACATTGCTC AAGGCTTACG TCTCTACAGG 1860
CCTCATTTGG CATCAGACAG GGTATATACC ATCATGTACA GCTGCTGGCA TGAGAAAGCA 1920
GATGAACGTC CTAGTTTCAA AATTCTCTTG AGTAACATTC TAGATGTCAT GGATGAAGAA 1980
TCTTGA 1986
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr+++dvaik+i+eg+mse++fieeakvmm+lsh+klvqly
Q: 404   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLY  463
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd
Q: 464   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  523
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         la+++        vk s   l +yvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w
Q: 524   LASQEAQTVPRGKVKASLETLRKYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  583
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy++m+scw+ek++er
Q: 584   AFGVLMWEIYSLGKIPYERFTNSETAEHIAQGLRLYRPHLASDRVYTIMYSCWHEKADER  643
         ************************************************************
S: 241   ptfkellsale  251
         p+fk lls++ 
Q: 644   PSFKILLSNIL  654
         ********996
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IREGSMSEDE FIEEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120
LASQEAQTVP RGKVKASLET LRKYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180
AFGVLMWEIY SLGKIPYERF TNSETAEHIA QGLRLYRPHL ASDRVYTIMY SCWHEKADER 240
PSFKILLSNI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-POA-00100
EKS-PTV-00097
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0031410; C:cytoplasmic vesicle
GO:0005829; C:cytosol
GO:0045121; C:membrane raft
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713; F:protein tyrosine kinase activity
GO:0048469; P:cell maturation
GO:0007249; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108; P:peptidyl-tyrosine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013