EKS-RAN-00336

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00336

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	335.1	3.6E-100	34	292	259

Status

Unreviewed

Ensembl Protein

ENSRNOP00000015496

UniProt Accession

D3ZJG0;

Protein Name

Protein Synonyms/Alias

RCG57812, isoform CRA_a; STE20-like serine/threonine-protein kinase;

Gene Name

Slk

Gene Synonyms/Alias

Slk; rCG_57812;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000011339	ENSRNOP00000015496	ENSRNOT00000015495

Organism

Rattus norvegicus

Functional Description

Protein Length

1203

Protein Sequence
(FASTA)

MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EEFWEIIGEL GDGAFGKVYK AQNKETNVLA 60

AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120

LELERPLTES QIQVVCKQTL EALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180

TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240

MRVLLKIAKS EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPV 300

RELIAEAKAE VTEEVEDGKE EDDDDETESA LPIPANKRAS SDLSIASSEE DKLSQNACIL 360

ESVSERTEHN TSGDKFSNKV LSEKPTPEGP EKAVDVDGPA NDVNLETVAE PNDQAVGFHE 420

NGREKKRPKL ESQPDTEDQQ TVDVNLVGEG NDSNIVILET NTDCLKPEED RNEENQEIIE 480

NKLTQSEEIK DIHIQTMDLV SQETGEKEAD FQAIDNEVGF TKEETQEKLG KDDKTQKVVI 540

SDISSEVGTD EAPGDTQKAA EQSQDAEGGA GEEAPEPAQT LTEKATEGPE AHGAEEEPRS 600

GERVEDKQLE QQSAVCEGEG QVTSTSESTR ATTEEPETDE VDQVSESNSI EELERLGVTG 660

AEEQALGSKG EAATEVDLER EENAQELPIK AEPQAPAASQ PSEPPPVLIP SINIHSENTE 720

NKGEMGALPK PETILPPEPE NGKGNDTDSG TGSTVENSSS DLNLSISSFL SKTKDSGSVS 780

LQETRRQKKT LKKTRKFIVD GVEVSVTTSK IVTDSDSKTE ELRFLRRQEL RELRLLQKEE 840

QKAQQQLNGK LQQQREQIFR RFEQEMLSKK RQYDQEIENL EKQQKQTIER LEQEHTNRLR 900

DEAKRIKGEQ EKELSKFQNM LRNRKKEEQE FVQKQQQELD GALKKIIQQQ KAELANIERE 960

CLNNKQQLLR AREAAIWELE ERHLQEKHQL LKQQLKDQYF IQRHQLLKRH EKETEQMQRY 1020

NQRLIEELKN RQTQERARLP KIQRSEAKTR MAMFKKSLRI NSTATPDQDR EKIKQFAAQE 1080

EKRQKNERMA QHQKHESQMR DLQLQCEANV RELHQLQNEK CHLLVEHETQ KLKELDEEHS 1140

QELKEWREKL RPRKKTLEEE FARKLQEQEV FFKMTGESEC LNPSAQSRIS KFYPIPTLHS 1200

TGS 1203

Nucleotide Sequence
(FASTA)

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAACAG 60

TACGAACACG TGAAGAGAGA CCTGAACCCC GAGGAGTTTT GGGAGATTAT CGGAGAGCTG 120

GGCGACGGAG CCTTTGGGAA AGTGTATAAG GCCCAGAATA AGGAGACCAA TGTTTTAGCT 180

GCTGCAAAGG TGATTGACAC CAAATCTGAA GAAGAACTTG AAGATTATAT GGTTGAGATT 240

GACATATTAG CATCTTGTGA TCACCCAAAC ATAGTCAAGC TTCTAGATGC CTTCTATTAT 300

GAGAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGGG GAGCAGTAGA TGCCGTGATG 360

CTTGAACTTG AGAGACCATT AACTGAGTCC CAAATTCAAG TAGTTTGCAA GCAGACATTA 420

GAGGCGTTGA ATTACCTACA TGACAATAAA ATCATCCACA GAGATCTAAA AGCTGGCAAT 480

ATTCTCTTTA CCTTAGATGG AGACATTAAA TTAGCGGATT TTGGAGTGTC AGCTAAGAAT 540

ACCAGGACAA TTCAAAGGAG GGATTCATTT ATTGGCACAC CGTATTGGAT GGCTCCTGAA 600

GTCGTCATGT GTGAGACATC GAAGGACAGA CCCTATGACT ACAAAGCGGA CGTTTGGTCC 660

CTGGGAATCA CTTTAATAGA AATGGCTGAG ATAGAGCCGC CTCATCATGA GCTAAACCCA 720

ATGCGAGTGC TGCTGAAAAT AGCAAAGTCG GAGCCCCCCA CACTAGCACA GCCATCCAGA 780

TGGTCTTCAA ATTTTAAGGA CTTTCTAAAG AAATGCTTGG AAAAGAATGT GGATGCGCGG 840

TGGACCACAT CCCAGCTGTT ACAGCATCCC TTTGTTACCG TTGATTCCAA CAAACCAGTC 900

CGAGAATTGA TTGCTGAGGC GAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAG 960

GAAGATGACG ATGATGAGAC AGAGAGTGCT CTGCCAATAC CTGCGAATAA ACGCGCCTCC 1020

TCTGACCTCA GCATTGCCAG CTCTGAGGAA GATAAGCTTT CACAAAATGC TTGTATTTTG 1080

GAATCTGTGT CAGAAAGAAC AGAACACAAT ACTTCTGGGG ATAAATTTAG CAACAAAGTT 1140

CTTAGTGAGA AGCCTACTCC TGAGGGACCT GAGAAGGCTG TGGATGTGGA TGGGCCTGCA 1200

AATGATGTTA ACTTAGAAAC TGTGGCTGAA CCAAATGACC AAGCGGTAGG ATTCCATGAG 1260

AATGGGAGAG AGAAGAAAAG ACCCAAACTG GAAAGTCAAC CAGATACAGA AGACCAACAA 1320

ACTGTGGATG TTAATTTAGT CGGTGAAGGA AATGACAGCA ATATAGTAAT TTTAGAAACA 1380

AACACTGATT GTCTGAAACC AGAGGAAGAC AGAAATGAAG AAAACCAAGA GATAATTGAG 1440

AATAAACTTA CACAATCTGA AGAAATTAAA GATATACATA TTCAAACAAT GGACTTAGTT 1500

TCTCAAGAAA CTGGAGAAAA AGAGGCAGAT TTTCAGGCAA TTGACAATGA AGTTGGGTTT 1560

ACAAAGGAAG AAACCCAAGA GAAATTGGGA AAAGATGATA AAACTCAAAA AGTTGTGATC 1620

AGTGATATAA GCAGTGAGGT GGGAACAGAC GAGGCTCCAG GTGATACCCA GAAGGCTGCT 1680

GAGCAGAGCC AGGATGCAGA GGGTGGGGCT GGGGAAGAAG CCCCGGAGCC TGCCCAGACA 1740

CTAACAGAGA AGGCCACTGA GGGCCCTGAG GCTCATGGTG CTGAGGAAGA GCCTCGTAGT 1800

GGAGAGAGAG TAGAGGATAA GCAGCTAGAG CAGCAGTCTG CAGTGTGTGA AGGTGAGGGA 1860

CAGGTAACCA GCACTTCAGA GAGCACACGG GCAACCACGG AGGAACCAGA GACTGACGAA 1920

GTTGACCAAG TCAGCGAGTC AAATAGCATT GAGGAACTAG AGAGACTTGG AGTTACTGGT 1980

GCTGAGGAAC AGGCTCTAGG GAGCAAAGGG GAGGCTGCTA CGGAGGTAGA TTTGGAGAGA 2040

GAAGAAAATG CACAGGAACT GCCAATTAAA GCAGAGCCCC AAGCTCCTGC AGCATCGCAG 2100

CCCAGTGAAC CTCCCCCTGT CTTAATACCC AGTATTAATA TTCATTCGGA AAACACAGAA 2160

AATAAAGGAG AAATGGGTGC TTTGCCAAAA CCTGAAACCA TACTGCCACC AGAGCCTGAA 2220

AATGGAAAGG GAAATGACAC GGACTCAGGG ACTGGGTCCA CTGTGGAGAA CAGCAGCAGT 2280

GACCTGAACT TGTCCATCTC TAGCTTCCTG AGCAAAACCA AGGACAGTGG CTCGGTGTCT 2340

CTGCAGGAGA CAAGAAGACA GAAGAAAACA TTGAAGAAAA CACGTAAATT TATTGTTGAT 2400

GGAGTAGAAG TGAGTGTGAC AACATCAAAG ATAGTTACAG ACAGCGACTC TAAAACCGAG 2460

GAATTGCGGT TTCTCAGGCG TCAGGAACTT CGAGAGCTAA GGCTTCTCCA GAAGGAAGAG 2520

CAGAAAGCCC AGCAGCAGCT CAACGGGAAA TTGCAGCAGC AGCGCGAGCA GATCTTCAGG 2580

CGCTTTGAGC AGGAGATGCT GAGTAAGAAG CGACAATATG ACCAAGAAAT TGAGAATCTA 2640

GAGAAGCAGC AGAAACAGAC AATTGAACGA CTAGAACAAG AACACACAAA CCGCCTGAGA 2700

GACGAAGCTA AGCGCATCAA AGGAGAGCAG GAGAAGGAGC TGTCCAAGTT CCAGAATATG 2760

CTAAGAAACC GAAAGAAGGA GGAACAAGAA TTTGTTCAGA AGCAACAGCA AGAGTTAGAC 2820

GGCGCTCTGA AAAAGATCAT CCAGCAGCAG AAGGCAGAGT TGGCCAATAT TGAGAGAGAG 2880

TGCTTGAATA ACAAGCAGCA GCTCCTGAGA GCCCGAGAAG CTGCAATTTG GGAGCTTGAA 2940

GAACGACATT TACAAGAAAA GCACCAGCTG CTTAAACAGC AACTTAAAGA TCAGTATTTC 3000

ATACAGAGAC ATCAGCTGCT TAAACGCCAC GAGAAGGAAA CAGAACAAAT GCAGCGTTAC 3060

AATCAACGAC TTATTGAAGA ATTGAAGAAC AGACAGACTC AGGAACGAGC TAGACTGCCC 3120

AAGATTCAGA GAAGTGAAGC CAAGACACGA ATGGCCATGT TTAAAAAAAG TTTGAGGATT 3180

AACTCAACAG CTACACCAGA CCAGGACCGT GAAAAAATTA AACAGTTTGC TGCACAGGAA 3240

GAAAAGAGAC AGAAAAATGA GAGAATGGCT CAGCATCAAA AACACGAGAG TCAGATGCGG 3300

GACCTTCAGT TGCAGTGTGA AGCCAACGTC CGAGAGCTGC ACCAGCTGCA GAATGAAAAA 3360

TGCCACCTGT TGGTTGAACA TGAGACTCAG AAACTGAAGG AGTTAGATGA GGAGCACAGC 3420

CAAGAGCTCA AGGAGTGGAG AGAGAAGCTG AGGCCCAGGA AGAAGACACT GGAGGAAGAG 3480

TTTGCCAGGA AACTTCAGGA ACAGGAAGTG TTCTTTAAAA TGACCGGGGA GTCCGAATGC 3540

CTCAACCCCT CAGCGCAGAG CCGGATCTCC AAATTCTACC CTATTCCCAC CTTACATTCC 3600

ACTGGGTCAT AG 3612

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkvy+a++k+t+ l+a k+i+++++e+le+++ ei +l +++hpniv+

Q: 34    WEIIGELGDGAFGKVYKAQNKETNVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f++e++lw+++e++agG+++ ++  el+++l+E+qi+++++++l+aL+ylH++k+i

Q: 94    LLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLEALNYLHDNKII  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niL+t +g++kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaD+wslGIt+ie+ae epP+++l+p+++llki+k+epp+l +++++s++fk+f++kc

Q: 213   DYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKC  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+++s+ll+h+F+

Q: 273   LEKNVDARWTTSQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIIGELGDG AFGKVYKAQN KETNVLAAAK VIDTKSEEEL EDYMVEIDIL ASCDHPNIVK 60

LLDAFYYENN LWILIEFCAG GAVDAVMLEL ERPLTESQIQ VVCKQTLEAL NYLHDNKIIH 120

RDLKAGNILF TLDGDIKLAD FGVSAKNTRT IQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADVWSLGI TLIEMAEIEP PHHELNPMRV LLKIAKSEPP TLAQPSRWSS NFKDFLKKCL 240

EKNVDARWTT SQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013