EKS-RAN-00502

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00502

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	425.6	6.3E-128	18	273	256

Status

Unreviewed

Ensembl Protein

ENSRNOP00000036851

UniProt Accession

D3ZA89;

Protein Name

Protein Synonyms/Alias

Protein Tbck; Similar to RIKEN cDNA A630047E20 (Predicted);

Gene Name

Tbck

Gene Synonyms/Alias

Tbck; RGD1307816_predicted; rCG_28549;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000011454	ENSRNOP00000036851	ENSRNOT00000038827

Organism

Rattus norvegicus

Functional Description

Protein Length

860

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQVLKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERRPASH SAVLCIAYEV LEGLQYLNKH GIVHRALSPH 120

NILLDRKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKST DHVPSEKPLP 180

SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLG CVDDTLIVLA EEHGCLDIIK 240

ELPENALSIL KKCLTFHPPK RPTPDELMKD QVFSEVSPLY TPFIKPASLF SSSLRCADLT 300

LPEDISDVCK DIDDDYLAER SIEEVYYLWC LAGGDLEKEL INKEIIRSKP PICTLPKLKD 360

VGGEAFYPLL EDDQSSLPHS NSNNELSAAA SLPLIIRERD TEYQLNRIIL FDRLLKAYPY 420

KKNQIWKEAR VDIPPLMRGL TWAALLGVEG AIHAKYDAID KDTPIPTDRQ IEVDIPRCHQ 480

YDELLSSPEG HAKFRRVLKA WVVSHPDLVY WQGLDSLCAP FLYLNFNNEA LAYACMSAFI 540

PKYLYNFFLK DNSHVIQEYL TVFSQMISFH DPELSNHLNE IGFIPDLYAI PWFLTMFTHV 600

FPLHKIFHLW DTLLLGNSSF PFCIGVAILQ QLRDRLLANG FNECILLFSD LPEIDIERCV 660

RESVNLFCWT PKSATYRQHA QPPRPASESS AVRSSSAPYF SAECTDPPKT DLSRESIPLS 720

DLKSEVSPRI SAEDLIDLCE LTVTGHFKTP TKKTKSSKPK LLVVDIRNSE DFLRGHIAGS 780

INIPFSAAFT AEGELSQGPY TTMLHSFKGK VIVIVGHVAK QTSEFAAHLV KMKYPRVCIL 840

DGGINKIKPT GLLTVPSPQI 860

Nucleotide Sequence
(FASTA)

ATGTTTCCTT TGAAGGATGC TGAAATGGGC GCCTTTACTT TCTTTGCCTC AGCTCTTCCA 60

CATGATGTTT GTGGAAGCAA CGGCCTTCCC CTCACACCAA ACTCCATCAA AATCTTAGGT 120

CGCTTTCAAG TCCTTAAGAC CATCACCCAT CCCAGACTGT GTCAATATGT GGATATTTCT 180

AGAGGAAAGC ATGAGAGACT GGTGGTGGTA GCAGAGCACT GTGAGCGGAG TTTGGAAGAC 240

CTTCTACGGG AAAGGAGACC TGCAAGTCAC TCAGCAGTTC TGTGCATAGC ATATGAGGTA 300

CTTGAGGGCT TGCAGTACTT GAACAAGCAT GGCATAGTAC ACCGGGCCTT GTCTCCTCAT 360

AATATCCTGT TGGATCGGAA GGGTCACATT AAACTGGCTA AATTTGGACT TTATCACATG 420

ACAGCCCATG GCGATGATGT CGATTTCCCA ATAGGGTACC CCTCATATCT GGCTCCTGAG 480

GTGATTGCAC AAGGAATTTT CAAAAGCACT GATCATGTGC CCAGTGAAAA GCCATTGCCC 540

TCCGGCCCCA AATCAGATGT ATGGTCTCTT GGGATAATTT TATTTGAGCT TTGTGTGGGA 600

AGAAAATTGT TTCAGAGCTT GGATATTTCT GAAAGACTAA AATTTTTGCT TACTTTGGGC 660

TGTGTGGATG ATACTCTAAT CGTTCTGGCT GAGGAGCACG GGTGTCTGGA CATTATCAAG 720

GAGCTTCCTG AAAATGCGCT CAGTATTTTG AAGAAGTGCC TCACCTTCCA TCCGCCTAAG 780

AGGCCAACCC CAGATGAGCT AATGAAGGAC CAGGTGTTCA GTGAGGTGTC ACCTTTGTAC 840

ACCCCCTTTA TCAAGCCTGC CAGCCTGTTT TCATCTTCTC TGAGATGCGC TGATTTAACT 900

CTGCCCGAGG ATATCAGTGA CGTGTGCAAA GATATAGATG ATGATTACCT GGCGGAGAGA 960

TCTATTGAGG AAGTTTACTA CCTTTGGTGT TTGGCTGGGG GAGACCTGGA GAAGGAGCTG 1020

ATAAACAAGG AAATTATTCG ATCCAAACCA CCTATCTGCA CACTTCCGAA ATTAAAAGAT 1080

GTTGGCGGGG AAGCATTTTA CCCATTGCTT GAAGACGACC AGTCAAGTTT ACCGCACTCG 1140

AACAGCAATA ACGAGTTGTC TGCAGCTGCT TCCCTGCCTT TAATCATCAG AGAGAGGGAC 1200

ACAGAGTACC AACTAAACAG GATTATTCTC TTTGACAGGC TGTTGAAGGC TTACCCATAC 1260

AAAAAAAATC AAATCTGGAA AGAAGCAAGA GTTGACATCC CTCCACTTAT GCGGGGTTTA 1320

ACCTGGGCTG CTCTTCTGGG AGTTGAGGGA GCTATTCACG CCAAGTACGA TGCCATTGAT 1380

AAAGACACTC CGATTCCCAC AGACAGACAA ATTGAAGTGG ATATCCCCCG CTGTCATCAG 1440

TATGACGAAC TCTTGTCATC ACCAGAAGGC CATGCAAAGT TCCGGCGTGT GCTGAAAGCT 1500

TGGGTAGTTT CTCATCCTGA TCTTGTGTAC TGGCAAGGTC TTGACTCACT CTGTGCTCCA 1560

TTCCTGTATC TAAATTTCAA CAATGAAGCT TTGGCGTATG CATGCATGTC TGCTTTTATT 1620

CCCAAATATC TGTATAACTT CTTCTTGAAA GACAACTCAC ATGTAATACA AGAGTACCTG 1680

ACTGTGTTCT CCCAGATGAT CTCCTTCCAT GATCCAGAGC TGAGTAATCA CCTCAACGAG 1740

ATTGGCTTCA TCCCTGATCT CTACGCCATC CCGTGGTTTC TCACCATGTT CACTCATGTA 1800

TTTCCACTGC ACAAAATTTT CCACCTCTGG GATACGTTAT TGCTTGGAAA TTCCTCTTTC 1860

CCATTCTGCA TTGGGGTGGC TATCCTCCAG CAGCTCCGGG ATCGTCTTTT GGCTAATGGC 1920

TTCAATGAAT GCATCCTTCT CTTCTCCGAC TTACCAGAAA TTGACATTGA ACGCTGCGTG 1980

CGAGAGTCGG TCAATCTGTT TTGCTGGACT CCTAAAAGTG CTACATACAG GCAGCATGCT 2040

CAGCCTCCAA GGCCGGCCTC TGAGAGCAGT GCCGTCAGAA GCTCATCAGC GCCTTACTTC 2100

TCTGCCGAGT GTACTGACCC TCCAAAAACA GACCTGTCAA GAGAATCCAT CCCTTTAAGT 2160

GACCTGAAAT CGGAAGTGTC ACCGCGGATT TCAGCAGAGG ACCTGATTGA TCTGTGTGAG 2220

CTCACGGTCA CAGGCCACTT CAAAACCCCC ACCAAGAAAA CCAAGTCCAG TAAACCCAAG 2280

CTCCTGGTGG TTGACATCCG AAACAGTGAG GACTTTCTTC GAGGTCACAT TGCAGGCAGC 2340

ATCAACATCC CTTTCAGCGC AGCGTTCACA GCGGAAGGAG AGCTCAGCCA GGGCCCTTAC 2400

ACCACCATGC TGCACAGCTT CAAGGGGAAG GTCATTGTGA TTGTGGGGCA CGTGGCTAAG 2460

CAAACATCCG AGTTTGCAGC TCACCTTGTG AAGATGAAAT ATCCAAGAGT CTGCATTCTA 2520

GATGGCGGCA TTAACAAGAT CAAGCCAACG GGCCTCCTCA CGGTCCCCTC TCCTCAGATA 2580

TGA 2583

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfq+Lk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQVLKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+er+p s+s vl+iayevl+gl+ylnkh+ivhral+p++illdrkg+ +kLak+G

Q: 78    LEDLLRERRPASHSAVLCIAYEVLEGLQYLNKHGIVHRALSPHNILLDRKGH-IKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         ++k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGifkstdhvpSEKPLPSGPKSDVWSLGIILFE  196

         ************************************************************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+tli+laee++cldiik+l+e+  ++lkkCLt+

Q: 197   LCVGRKLFQSLDISERLKFLLTLGCVDDTLIVLAEEHGCLDIIKELPENALSILKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +p kRp+pdel+k++vf

Q: 257   HPPKRPTPDELMKDQVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQVLKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERRP ASHSAVLCIA YEVLEGLQYL NKHGIVHRAL SPHNILLDRK GHIKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIF KSTDHVPSEK PLPSGPKSDV WSLGIILFEL 180

CVGRKLFQSL DISERLKFLL TLGCVDDTLI VLAEEHGCLD IIKELPENAL SILKKCLTFH 240

PPKRPTPDEL MKDQVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

rno:295446

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013