EKS-RAN-00389
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00389
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src386.18.6E-116192441250
StatusUnreviewed
Ensembl ProteinENSRNOP00000017337
UniProt AccessionD3ZDS3;
Protein Name
Protein Synonyms/Alias PTK6 protein tyrosine kinase 6 (Predicted); Protein Ptk6;
Gene NamePtk6
Gene Synonyms/Alias Ptk6; Ptk6_predicted; rCG_38544;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000012987ENSRNOP00000017337ENSRNOT00000017337
OrganismRattus norvegicus
Functional Description
Protein Length451
Protein Sequence
(FASTA)
MVSLDKAHLG PKYVGLWDFK ARTDEELSFQ AGDLLHVTRK EEQWWWATLL DAEGKALAEG 60
YVPHNYLAEK ETVESEPWFF GCISRSEAMH RLQSEDYPKG TFLIRVSQKP GADYVLSVWD 120
AEAVRHYRIW RNSAGRLHLN EVVSFSSLSE LVNYHKTHNL SPGLQLSMAC WKLKTEPLPH 180
WDDWERPREE FTLCKKLGSG YFGEVFEGLW KGLVRVAVKV ISRDNLLHQH TFQAEIQAMK 240
KLRHKHILSL YAVATAGDPV YIITELMPKG SLLQLLRDSD EKDLPILELV DFASQVAEGM 300
CYLESQNYIH RDLAARNVLV TENNLCKVGD FGLARLVKED IYLSRDHNVP YKWTAPEALS 360
RGHYSIKSDV WSFGVLLHEI FSRGQMPYPG MSNHETFLRV DAGYRMPCPL ECPPNIHKLM 420
LSCWSRDPKQ RPCFKDLCEK LSGITRYENL V 451
Nucleotide Sequence
(FASTA)
ATGGTGTCTT TGGACAAGGC TCACCTGGGT CCTAAGTATG TGGGCCTCTG GGACTTCAAA 60
GCACGAACGG ACGAGGAGCT GAGCTTTCAG GCAGGAGACC TCCTCCATGT TACCAGGAAG 120
GAGGAACAGT GGTGGTGGGC CACCCTGCTG GATGCGGAAG GCAAGGCCTT GGCTGAGGGC 180
TACGTGCCCC ACAACTACCT GGCTGAGAAG GAAACTGTGG AGTCTGAACC GTGGTTCTTT 240
GGTTGCATCT CCCGCTCAGA GGCCATGCAC AGGCTGCAGT CTGAGGACTA CCCGAAGGGT 300
ACCTTCCTGA TCAGAGTCAG CCAGAAGCCA GGAGCAGACT ATGTCCTCTC CGTGTGGGAT 360
GCTGAGGCTG TTCGACATTA CAGGATCTGG AGGAACAGTG CGGGCAGGCT GCACCTGAAT 420
GAGGTGGTAT CCTTCTCCAG TCTGTCTGAG CTTGTGAACT ACCACAAGAC CCACAACCTG 480
TCCCCTGGCC TACAGCTCTC CATGGCCTGC TGGAAGCTCA AAACTGAGCC CTTGCCCCAC 540
TGGGATGACT GGGAGAGGCC GAGGGAGGAG TTCACGCTCT GTAAGAAGCT GGGGTCTGGC 600
TACTTTGGGG AGGTCTTTGA AGGGCTCTGG AAAGGCCTGG TCCGTGTGGC TGTGAAGGTG 660
ATCTCTAGAG ACAATCTCCT GCACCAGCAC ACCTTCCAGG CTGAGATTCA AGCCATGAAG 720
AAGCTGCGAC ACAAGCACAT CCTGTCGCTG TACGCTGTGG CAACTGCAGG GGACCCAGTC 780
TATATCATCA CGGAGCTCAT GCCCAAGGGG AGCCTGCTGC AGCTATTGCG GGACTCGGAT 840
GAGAAAGACC TGCCTATTTT GGAACTGGTG GACTTTGCAT CACAGGTTGC CGAGGGCATG 900
TGCTACCTGG AATCTCAGAA TTACATTCAC CGTGACCTGG CTGCAAGGAA CGTTCTCGTT 960
ACTGAGAACA ATCTCTGCAA AGTGGGGGAC TTTGGGCTGG CCAGGCTCGT CAAGGAGGAC 1020
ATCTACCTTT CCCGTGACCA CAACGTCCCC TACAAATGGA CAGCACCTGA GGCACTTTCC 1080
CGAGGGCATT ACTCCATCAA ATCGGATGTC TGGTCTTTTG GTGTTCTCCT TCATGAAATT 1140
TTCAGCAGGG GGCAGATGCC CTACCCAGGC ATGTCCAATC ACGAAACCTT CCTGAGGGTG 1200
GATGCCGGCT ACCGCATGCC CTGCCCCTTG GAGTGCCCAC CCAACATACA CAAGCTGATG 1260
CTTAGCTGTT GGAGCAGAGA CCCTAAGCAG AGACCCTGCT TCAAAGACCT GTGTGAGAAA 1320
CTCTCAGGTA TCACTAGGTA TGAGAACCTG GTCTGA 1356
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegt.lspeafleeaqilkklrheklvkly  60
         +l+kklG+G+fGev++g+wkg v+vavk++++++ l++++f++e+q++kklrh+++++ly
Q: 192   TLCKKLGSGYFGEVFEGLWKGLVRVAVKVISRDNlLHQHTFQAEIQAMKKLRHKHILSLY  251
         799******************************98999**********************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         av+++++P+yi+telm kGsll++l+++++k l++ +lvd+a+qvaeGm+yle++n+ihr
Q: 252   AVATAGDPVYIITELMPKGSLLQLLRDSDEKDLPILELVDFASQVAEGMCYLESQNYIHR  311
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dlaarnvlv+e++++kv+dfGlarl+++d+y +++ +++P+kWtaPea++ g+++iksdv
Q: 312   DLAARNVLVTENNLCKVGDFGLARLVKEDIYLSRD-HNVPYKWTAPEALSRGHYSIKSDV  370
         ********************************997.99**********************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfG+ll+ei+++G++PypGm+n+e++ +v++gyr+p+p ecp ++++l+l+cw++dp++
Q: 371   WSFGVLLHEIFSRGQMPYPGMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQ  430
         ************************************************************
S: 241   rPtfetlqevl  251
         rP+f+ l+e+l
Q: 431   RPCFKDLCEKL  441
         ******99875
Domain Sequence
(FASTA)
TLCKKLGSGY FGEVFEGLWK GLVRVAVKVI SRDNLLHQHT FQAEIQAMKK LRHKHILSLY 60
AVATAGDPVY IITELMPKGS LLQLLRDSDE KDLPILELVD FASQVAEGMC YLESQNYIHR 120
DLAARNVLVT ENNLCKVGDF GLARLVKEDI YLSRDHNVPY KWTAPEALSR GHYSIKSDVW 180
SFGVLLHEIF SRGQMPYPGM SNHETFLRVD AGYRMPCPLE CPPNIHKLML SCWSRDPKQR 240
PCFKDLCEKL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00349
EKS-ANC-00363
EKS-BOT-00375
EKS-CAJ-00379
EKS-CAP-00407
EKS-DAR-00754
EKS-EQC-00366
EKS-ERE-00055
EKS-FEC-00362
EKS-GAA-00458
EKS-GOG-00364
EKS-HOS-00381
EKS-ICT-00355
EKS-LOA-00382
EKS-MAM-00374
EKS-MAE-00042
EKS-MOD-00364
EKS-MUM-00407
EKS-MUP-00369
EKS-MYL-00371
EKS-NOL-00342
EKS-ORA-00325
EKS-ORL-00444
EKS-PES-00332
EKS-POA-00364
EKS-PRC-00072
EKS-PTV-00096
EKS-SAH-00345
EKS-TEN-00473
EKS-XET-00506
EKS-XIM-00472
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0001726; C:ruffle
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0016477; P:cell migration
GO:0071300; P:cellular response to retinoic acid
GO:0060575; P:intestinal epithelial cell differentiation
GO:0045926; P:negative regulation of growth
GO:0061099; P:negative regulation of protein tyrosine kinase activity
GO:0010976; P:positive regulation of neuron projection development
GO:0046777; P:protein autophosphorylation
GO:0042503; P:tyrosine phosphorylation of Stat3 protein
GO:0042506; P:tyrosine phosphorylation of Stat5 protein
KEGG
rno:366275;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013