EKS-RAN-00388

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00388

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	391.3	2.2E-117	247	495	249

Status

Unreviewed

Ensembl Protein

ENSRNOP00000017668

UniProt Accession

Q5FVG7;

Protein Name

Protein Synonyms/Alias

Protein Srms; RCG38599; Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites;

Gene Name

Srms

Gene Synonyms/Alias

Srms; rCG_38599;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000013003	ENSRNOP00000017668	ENSRNOT00000017668

Organism

Rattus norvegicus

Functional Description

Protein Length

507

Protein Sequence
(FASTA)

MRLRPQPGPL GMEPFLRKRL TFLSFFWDKI WPAGESEEDI PRIQGQDDNP VPEQPAAVEP 60

CSFPAPRARL FRALYDFTAR CAEELSVSRG DRLYALKEEG EYIFAQRLSG PPSTGLVPVT 120

YLAKATPETP SDQPWYFNGI SRTQAQQLLL SPANAPGAFL IRPSESSIGG YSLSVRAQAK 180

VCHYRICMAP SGGLYLQEGR LFPSLDALLA YYKTNWKLIQ NPLLQPCVPQ MPLAQDEWER 240

PRSEFVLRRK LGEGFFGEVW EGLWLGSTPV AVKVIKSADM KLADLTKEIE ALKSLRHERL 300

IRLHAICSLG EPVYIVTELM GKGNLQVYLG SPEGKALSLP HLLGFACQVA EGMSYLEERR 360

VVHRDLAARN VLVGDDLTCK VADFGLARLL KDDVYSPSSG SKIPVKWTAP EAANYRVFSQ 420

KSDVWSFGIL LYEVFTYGQC PYEGMTNHET LQQISRGYRL PRPAVCPAEV YMLMVECWKG 480

SPEERPTFAT LREKLNAINR RLHLGLT 507

Nucleotide Sequence
(FASTA)

ATGCGCCTTC GTCCGCAACC AGGCCCCCTA GGCATGGAGC CCTTCCTCCG GAAGCGGCTC 60

ACTTTCTTGT CCTTTTTCTG GGATAAGATA TGGCCAGCGG GTGAGTCGGA GGAAGACATC 120

CCCAGGATCC AGGGACAGGA CGACAACCCA GTGCCGGAGC AACCAGCTGC CGTTGAACCT 180

TGTAGCTTCC CAGCCCCACG CGCCCGACTC TTCCGCGCGC TCTACGACTT CACTGCTCGA 240

TGTGCAGAGG AACTGAGCGT CAGCCGCGGG GACAGACTCT ACGCCCTCAA GGAGGAGGGG 300

GAGTACATTT TTGCCCAAAG GCTCTCTGGG CCACCCAGCA CCGGACTAGT TCCAGTCACC 360

TACCTTGCCA AGGCTACCCC GGAGACGCCC TCAGACCAAC CTTGGTACTT CAATGGGATC 420

AGCAGGACTC AGGCCCAGCA GTTGCTCTTG TCTCCTGCCA ACGCACCAGG GGCCTTCCTC 480

ATCCGGCCCA GCGAAAGCAG CATCGGGGGA TATTCTCTGT CAGTCAGGGC TCAGGCCAAA 540

GTCTGCCACT ATCGAATCTG CATGGCACCT AGCGGCGGCC TCTACCTGCA GGAGGGTCGA 600

CTCTTCCCCA GCCTGGATGC ATTGCTAGCT TACTACAAGA CCAACTGGAA GCTGATCCAG 660

AACCCTCTGT TGCAGCCCTG TGTACCCCAG ATGCCCTTGG CTCAGGACGA GTGGGAACGG 720

CCACGTTCAG AATTTGTCCT TCGGAGAAAA CTGGGTGAAG GCTTCTTCGG GGAGGTGTGG 780

GAAGGCCTGT GGCTGGGCTC TACACCTGTG GCGGTGAAGG TAATCAAATC AGCTGACATG 840

AAGCTGGCAG ACCTCACCAA GGAGATTGAG GCACTGAAGA GCCTGAGGCA TGAGCGGCTA 900

ATCCGACTGC ACGCTATATG CTCCCTGGGT GAACCCGTGT ACATCGTTAC TGAACTCATG 960

GGCAAGGGCA ACTTGCAGGT CTACCTGGGC AGCCCTGAGG GAAAGGCCCT GAGCCTGCCT 1020

CATCTACTGG GATTTGCCTG CCAGGTAGCT GAGGGCATGA GCTACCTGGA GGAGCGGCGT 1080

GTTGTCCACC GCGACTTGGC TGCCAGGAAC GTGCTGGTGG GGGATGACCT CACCTGCAAG 1140

GTAGCTGATT TTGGCCTGGC CAGACTGCTC AAGGACGACG TCTACTCCCC AAGCAGTGGC 1200

TCCAAGATCC CCGTCAAGTG GACGGCACCT GAGGCTGCTA ATTACCGTGT CTTTTCCCAA 1260

AAGTCAGATG TTTGGTCCTT TGGCATCCTG CTGTATGAGG TCTTCACTTA TGGCCAGTGT 1320

CCCTATGAGG GAATGACCAA CCACGAGACG CTACAGCAGA TTAGTCGTGG ATACCGGCTG 1380

CCACGCCCAG CTGTCTGCCC AGCAGAGGTC TACATGCTCA TGGTGGAGTG CTGGAAGGGC 1440

AGCCCTGAGG AGCGTCCCAC CTTTGCCACA CTGAGGGAGA AGCTGAATGC TATAAACAGA 1500

CGCCTCCACC TGGGCCTCAC GTGA 1524

Domain Profile

S: 3     lvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklyav  62

         l +klGeG fGevw+g+w gs++vavk++k+++++ +++++e+++lk+lrhe+l++l+a+

Q: 247   LRRKLGEGFFGEVWEGLWLGSTPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAI  306

         789*********************************************************

S: 63    vseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrdl  122

         +s +eP+yivtelm kG+l+ +l + egk+l+lp+l+ +a+qvaeGm+ylee++++hrdl

Q: 307   CSLGEPVYIVTELMGKGNLQVYLGSPEGKALSLPHLLGFACQVAEGMSYLEERRVVHRDL  366

         ************************************************************

S: 123   aarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvWs  182

         aarnvlvg++l++kvadfGlarl++dd y++++g+k+P+kWtaPea+++++f++ksdvWs

Q: 367   AARNVLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWS  426

         ************************************************************

S: 183   fGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeerP  242

         fGill+e++t+G++Py+Gmtn+e+l+q++rgyrlprp+ cp+e+y l++ecwk +peerP

Q: 427   FGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRPAVCPAEVYMLMVECWKGSPEERP  486

         ************************************************************

S: 243   tfetlqevl  251

         tf tl+e+l

Q: 487   TFATLREKL  495

         *****9876

Domain Sequence
(FASTA)

LRRKLGEGFF GEVWEGLWLG STPVAVKVIK SADMKLADLT KEIEALKSLR HERLIRLHAI 60

CSLGEPVYIV TELMGKGNLQ VYLGSPEGKA LSLPHLLGFA CQVAEGMSYL EERRVVHRDL 120

AARNVLVGDD LTCKVADFGL ARLLKDDVYS PSSGSKIPVK WTAPEAANYR VFSQKSDVWS 180

FGILLYEVFT YGQCPYEGMT NHETLQQISR GYRLPRPAVC PAEVYMLMVE CWKGSPEERP 240

TFATLREKL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

rno:296472

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013