EKS-RAN-00465

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00465

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	490.2	1.5E-147	9	269	261

Status

Unreviewed

Ensembl Protein

ENSRNOP00000018126

UniProt Accession

Q99PS2;

Protein Name

Protein Synonyms/Alias

Casein kinase1 epsilon-2; Protein Csnk1e;

Gene Name

Csnk1e

Gene Synonyms/Alias

Csnk1e; Ck1e-2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000013076	ENSRNOP00000018126	ENSRNOT00000018126

Organism

Rattus norvegicus

Functional Description

Protein Length

416

Protein Sequence
(FASTA)

MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH IESKFYKMMQ 60

GGVGIPSIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 120

SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 180

SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 240

CKGYPSEFST YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGAARN 300

PEDVDRERRE HEREERMGQL RGSATRALPP GPPTGATANR LRSAAEPVAS TPASRIQQAG 360

NTSPRAISRA DRERKVSMRL HRGAPANVSS SDLTGRQEVS RIAASQTSVP FDHLGK 416

Nucleotide Sequence
(FASTA)

ATGGAGCTGC GTGTGGGAAA CAAGTATCGC TTGGGCCGGA AGATCGGCAG TGGGTCCTTT 60

GGCGACATCT ACCTGGGTGC CAACATTGCC TCTGGTGAGG AAGTAGCCAT CAAGCTCGAA 120

TGTGTGAAGA CGAAGCACCC ACAGCTCCAC ATCGAGAGCA AGTTCTACAA GATGATGCAG 180

GGAGGAGTGG GGATCCCATC CATCAAGTGG TGCGGGGCTG AGGGTGACTA TAACGTGATG 240

GTCATGGAGT TGCTGGGGCC CAGCCTGGAA GACCTCTTCA ACTTCTGTTC CCGAAAGTTC 300

AGCCTCAAGA CGGTGCTGCT GCTGGCCGAC CAGATGATCA GCCGCATCGA GTATATCCAC 360

TCCAAGAACT TCATCCACCG GGACGTGAAG CCTGACAACT TCCTCATGGG CCTGGGGAAG 420

AAAGGCAATC TGGTATACAT CATTGACTTC GGCCTGGCCA AGAAGTACCG GGATGCCCGT 480

ACACACCAGC ATATTCCCTA CCGGGAAAAC AAGAACCTGA CCGGCACTGC CCGCTATGCC 540

TCTATCAACA CCCACCTGGG CATTGAGCAA AGCCGTCGAG ATGACCTGGA GAGCCTGGGC 600

TATGTGCTCA TGTACTTCAA CCTGGGCTCC CTGCCCTGGC AAGGCCTCAA AGCAGCCACC 660

AAGCGTCAGA AGTACGAGCG GATCAGCGAG AAGAAGATGT CAACGCCGAT CGAGGTCCTC 720

TGCAAAGGCT ACCCCTCTGA GTTCTCAACT TACCTCAACT TCTGCCGCTC CCTGCGGTTC 780

GATGACAAAC CTGACTACTC CTACCTGCGC CAGCTCTTCC GCAATCTCTT TCACCGGCAG 840

GGTTTCTCCT ATGACTACGT CTTCGACTGG AACATGCTCA AATTCGGTGC AGCCCGGAAT 900

CCCGAGGACG TAGACCGGGA GAGACGAGAG CACGAACGGG AAGAGAGGAT GGGACAGTTG 960

CGAGGGTCCG CGACCAGAGC CCTGCCCCCT GGCCCACCAA CAGGGGCTAC CGCCAACCGA 1020

CTCCGAAGTG CAGCCGAGCC TGTGGCTTCC ACCCCGGCCT CCCGCATCCA GCAAGCTGGC 1080

AATACTTCTC CCAGAGCGAT CTCACGGGCA GACCGAGAGA GGAAGGTGAG CATGAGACTC 1140

CACAGAGGTG CGCCTGCCAA TGTCTCATCC TCAGACCTCA CTGGGCGACA AGAGGTCTCC 1200

CGAATTGCAG CCTCACAGAC AAGCGTGCCA TTTGACCATC TTGGGAAATG A 1251

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         yr+++kiGsGsfGdiylg+n+asgeevaikle++k+k+pql++es++yk++qggvgiP++

Q: 9     YRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSI  68

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         +++g+e++ynv+v++llGpsledlf++c+rkfslktvllladq+isriey+hsk++i+rd

Q: 69    KWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD  128

         ************************************************************

S: 121   ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk  180

         +kPdnfl+g+g+kg+ vy+idfGlakkyrda+t++hipyre+k+ltGtaryasinthlg+

Q: 129   VKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI  188

         ************************************************************

S: 181   eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef  240

         eqsrrddleslgyvl+yf+ gslPWqglkaatk+qkye+isekk+st+ievlc+g+P+ef

Q: 189   EQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEF  248

         ************************************************************

S: 241   atylkyvrklkfeekPdyeyl  261

         +tyl+++r+l+f++kPdy+yl

Q: 249   STYLNFCRSLRFDDKPDYSYL  269

         *******************97

Domain Sequence
(FASTA)

YRLGRKIGSG SFGDIYLGAN IASGEEVAIK LECVKTKHPQ LHIESKFYKM MQGGVGIPSI 60

KWCGAEGDYN VMVMELLGPS LEDLFNFCSR KFSLKTVLLL ADQMISRIEY IHSKNFIHRD 120

VKPDNFLMGL GKKGNLVYII DFGLAKKYRD ARTHQHIPYR ENKNLTGTAR YASINTHLGI 180

EQSRRDDLES LGYVLMYFNL GSLPWQGLKA ATKRQKYERI SEKKMSTPIE VLCKGYPSEF 240

STYLNFCRSL RFDDKPDYSY L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0034613	; P:cellular protein localization
GO:0030178	; P:negative regulation of Wnt receptor signaling pathway
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013