EKS-RAN-00407

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00407

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.0	5.2E-97	1224	1488	265

Status

Unreviewed

Ensembl Protein

ENSRNOP00000017968

UniProt Accession

F1M778;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 1;

Gene Name

Map3k1

Gene Synonyms/Alias

Map3k1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000013177	ENSRNOP00000017968	ENSRNOT00000017968

Organism

Rattus norvegicus

Functional Description

Protein Length

1493

Protein Sequence
(FASTA)

MAAAAGDRAS SSGFPGAAAA SPEAGGGGGA LQGSGAPAAG AGLLRETGSA GRERADWRRQ 60

QLRKVRSVEL DQLPEQPLFL TASPPCPSTS PSPEPADAAA GASGFQPAAG PPPPGAASRC 120

GSHSAELAAA RDSGARSPAG AEPPSAAAPS GREMENKETL KGLHKMDDRP EERMIREKLK 180

ATCMPAWKHE WLERRNRRGP VVVKPIPIKG DGSEMSNLAA ELQGEGQAGS AAPAPKGRRS 240

PSPGSSPSGR SGKPESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS PEETSRRVNK 300

VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV FIGPQNCSCG RGTFCIHLLF VMLRVFQLEP 360

SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI KAPSRNTIQK FVSRMSNCHT LSSSSTSTSS 420

SENSIKDEEE QMCPICLLGM LDEESLTVCE DGCRNKLHHH CMSIWAEECR RNREPLICPL 480

CRSKWRSHDF YSHELSSPVD SPTSLRGVQQ PSSPQQPVAG SQRRNQESNF NLTHYGTQQI 540

PPAYKDLAEP WIQAFGMELV GCLFSRNWNV REMALRRLSH DVSGALLLAN GESTGTSGGG 600

SGGSLSAGAA SGSSQPSISG DVVEACCSVL SIVCADPVYK VYVAALKTLR AMLVYTPCHS 660

LAERIKLQRL LRPVVDTILV KCADANSRTS QLSISTLLEL CKGQAGELAV GREILKAGSI 720

GVGGVDYVLS CILGNQAESN NWQELLGRLC LIDRLLLEFP AEFYPHIVST DVSQAEPVEI 780

RYKKLLSLLA FALQSIDNSH SMVGKLSRRI YLSSARMVTT VPALFSKLVT MLSASGSSHF 840

ARMRRRLMAI ADEVEIAEVI QLGSEDTLDG QQDSSQALAP PRYPESSSLE HTAHVEKTGK 900

GLKATRLSAS SEDISDRLAG VSVGLPSSAT TEQPKPTVQT KGRPHSQCLN SSPLSPPQLM 960

FPAISAPCSS APSVPAGSVT DASKHRPQAF VPCKIPSASP QTQRKFSLQF QRTCSENRDS 1020

EKLSPVFTQS RPPPSSNIHR PKPSRPVPGS TSKLGDASKN SMTLDLNSAS QCDDSFGSGS 1080

NSGGAVIPSE ETAFTPAEDK CRLDVNPELN SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE 1140

KAESDDTYKD DVNHNQKCKE KMEAEEEEAL AIAMAMSASQ DALPIVPQLQ VENGEDIIII 1200

QQDTPETLPG HTKAKQPYRE DTEWLKGQQI GLGAFSSCYQ AQDVGTGTLM AVKQVTYVRN 1260

TSSEQEEVVE ALREEIRMMS HLNHPNIIRM LGATCEKSNY NLFIEWMAGG SVAHLLSKYG 1320

AFKESVVINY TEQLLRGLSY LHENQIIHRD VKGANLLIDS TGQRLRIADF GAAARLASKG 1380

TGAGEFQGQL LGTIAFMAPE VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA 1440

LIFKIASATT APSIPSHLSP GLRDVALRCL ELQPQDRPPS RELLKHPVFR TTW 1493

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGGCGA TCGCGCCTCG TCGTCGGGAT TCCCGGGCGC CGCGGCGGCG 60

AGCCCCGAGG CGGGCGGCGG CGGCGGAGCT CTCCAGGGAA GCGGCGCGCC CGCAGCGGGC 120

GCGGGGCTGC TGCGGGAGAC TGGCAGCGCG GGCCGCGAGC GCGCGGACTG GCGGCGGCAG 180

CAGCTGCGCA AAGTGAGGAG TGTGGAGCTG GACCAGCTGC CGGAGCAGCC GCTCTTCCTC 240

ACCGCCTCGC CGCCCTGCCC ATCTACTTCC CCGTCGCCGG AGCCCGCGGA CGCGGCTGCA 300

GGAGCGAGTG GCTTCCAGCC TGCGGCGGGA CCGCCACCCC CGGGAGCAGC GAGTCGCTGC 360

GGCTCCCACT CTGCCGAGCT GGCGGCCGCG CGGGACAGCG GCGCCCGGAG CCCCGCGGGG 420

GCCGAGCCGC CCTCTGCAGC GGCCCCCTCC GGTCGAGAGA TGGAGAATAA AGAAACCCTC 480

AAAGGATTGC ACAAGATGGA TGACCGCCCA GAGGAGCGAA TGATCAGGGA GAAGCTCAAG 540

GCGACCTGTA TGCCTGCCTG GAAGCACGAG TGGTTAGAAA GGAGGAACAG GAGAGGCCCT 600

GTGGTGGTGA AACCAATCCC TATTAAAGGA GATGGATCTG AAATGAGTAA CTTGGCAGCT 660

GAGCTCCAAG GAGAGGGCCA GGCAGGCTCT GCTGCACCAG CTCCCAAGGG CCGACGAAGC 720

CCGTCTCCTG GAAGCTCCCC ATCAGGGCGC TCAGGGAAGC CGGAATCCCC AGGAGTGAGA 780

CGGAAACGAG TGTCCCCAGT GCCTTTCCAG AGTGGCAGAA TCACACCACC TCGAAGAGCC 840

CCGTCGCCAG ATGGCTTCTC ACCGTACAGC CCAGAGGAGA CGAGCCGCCG TGTGAACAAA 900

GTGATGAGGG CCAGGCTGTA CCTCCTGCAG CAGATAGGAC CCAACTCTTT CCTGATTGGA 960

GGAGACAGTC CAGACAATAA ATACCGCGTG TTTATTGGGC CACAGAACTG CAGCTGTGGG 1020

CGTGGGACAT TCTGCATTCA CCTCTTGTTT GTCATGCTCC GGGTGTTCCA GCTAGAACCC 1080

TCCGACCCCA TGCTATGGAG AAAAACTTTA AAAAATTTTG AGGTTGAGAG TTTGTTCCAG 1140

AAATACCACA GTAGGCGTAG CTCAAGAATC AAAGCTCCAT CTCGGAACAC CATCCAGAAG 1200

TTTGTCTCAC GCATGTCAAA CTGTCACACA TTGTCATCGT CTAGCACATC CACATCTAGT 1260

TCAGAAAACA GCATCAAGGA TGAAGAGGAG CAGATGTGTC CCATCTGCTT GTTGGGCATG 1320

CTGGATGAGG AGAGCCTGAC TGTGTGTGAA GACGGCTGCA GGAACAAGCT GCACCACCAC 1380

TGCATGTCAA TCTGGGCAGA AGAATGTAGA AGAAATAGAG AACCGTTAAT ATGTCCCCTT 1440

TGTAGATCTA AGTGGAGATC CCATGACTTC TACAGCCATG AGTTATCAAG CCCTGTGGAT 1500

TCCCCTACCT CCCTGCGAGG TGTACAGCAG CCCTCCTCCC CGCAACAGCC TGTGGCCGGA 1560

TCACAGCGGA GGAATCAGGA AAGCAATTTT AACCTTACTC ATTATGGAAC CCAGCAGATT 1620

CCTCCCGCTT ACAAAGATTT AGCCGAGCCA TGGATTCAGG CATTCGGAAT GGAGCTCGTT 1680

GGCTGCTTAT TCTCTAGAAA CTGGAACGTA AGGGAGATGG CCCTTAGGCG CCTTTCCCAC 1740

GATGTTAGCG GGGCCCTGTT GTTGGCGAAC GGGGAGAGCA CTGGAACTTC TGGAGGCGGC 1800

AGCGGAGGCA GCCTAAGTGC TGGCGCCGCC AGTGGGTCTT CCCAGCCCAG CATCTCAGGG 1860

GACGTGGTGG AGGCGTGCTG CAGCGTCCTG TCTATCGTGT GCGCTGACCC TGTCTACAAA 1920

GTGTACGTTG CTGCTTTAAA AACACTGAGA GCCATGCTGG TATACACTCC TTGCCACAGC 1980

CTGGCAGAAA GAATCAAACT TCAGAGACTT CTCCGGCCAG TGGTAGACAC CATCCTAGTG 2040

AAGTGCGCAG ACGCCAATAG CCGCACGAGT CAGCTGTCCA TATCAACACT GTTGGAGCTC 2100

TGCAAGGGCC AAGCGGGGGA GTTGGCAGTT GGACGAGAAA TACTTAAAGC TGGATCCATC 2160

GGTGTTGGTG GCGTTGATTA CGTCTTAAGT TGTATTCTTG GAAACCAAGC TGAATCAAAC 2220

AACTGGCAAG AACTCCTGGG TCGCCTCTGT CTTATAGACA GATTGCTCTT GGAATTTCCT 2280

GCGGAATTTT ATCCTCATAT TGTCAGTACC GATGTCTCAC AAGCCGAGCC TGTTGAAATC 2340

AGGTATAAGA AGCTGCTGTC CCTCTTAGCC TTTGCCTTGC AATCCATTGA CAATTCCCAC 2400

TCTATGGTCG GCAAACTCTC GCGGAGGATT TATCTGAGCT CAGCACGAAT GGTGACCACA 2460

GTGCCCGCCC TGTTTTCCAA GCTGGTAACC ATGCTAAGTG CTTCTGGATC CTCCCACTTC 2520

GCCAGGATGC GCCGGCGTCT GATGGCCATT GCAGACGAGG TAGAAATTGC CGAGGTCATC 2580

CAGCTGGGTT CGGAAGACAC TTTGGATGGC CAGCAGGACA GCTCGCAGGC ATTGGCCCCT 2640

CCCCGCTATC CAGAGAGCAG CTCCCTTGAG CACACAGCCC ATGTAGAGAA AACTGGAAAA 2700

GGATTAAAAG CTACGAGACT GAGTGCCAGC TCAGAGGACA TTTCTGACAG ACTGGCTGGC 2760

GTTTCTGTAG GACTTCCTAG TTCAGCAACA ACAGAACAAC CAAAGCCAAC AGTTCAAACA 2820

AAAGGCAGAC CCCACAGTCA GTGTTTGAAC TCCTCTCCTT TGTCTCCTCC TCAGTTAATG 2880

TTTCCAGCAA TATCAGCCCC ATGTTCATCT GCCCCGTCTG TCCCAGCTGG CTCTGTAACA 2940

GATGCTTCTA AGCATAGACC TCAGGCGTTT GTTCCCTGTA AAATACCCTC TGCGTCTCCC 3000

CAAACACAGC GCAAGTTTTC CCTACAGTTC CAGAGGACCT GCTCTGAGAA CCGAGACTCA 3060

GAAAAACTCT CCCCAGTCTT TACTCAGTCG AGACCCCCAC CCTCCAGTAA CATACACAGG 3120

CCAAAGCCAT CCCGACCCGT TCCGGGTAGC ACAAGCAAAC TAGGGGATGC CTCAAAGAAC 3180

AGCATGACAC TCGACCTGAA CAGTGCTTCC CAGTGTGATG ACAGCTTTGG CAGTGGCAGC 3240

AACAGTGGCG GCGCCGTCAT ACCCAGTGAG GAGACGGCAT TCACCCCAGC AGAGGACAAG 3300

TGCAGGTTAG ATGTCAACCC CGAGCTCAAC TCCAGTATCG AGGACCTTCT TGAAGCATCT 3360

ATGCCTTCAA GTGACACAAC AGTCACTTTC AAGTCCGAAG TCGCCGTCCT CTCTCCTGAG 3420

AAGGCCGAAA GTGATGACAC CTACAAAGAT GACGTCAATC ACAATCAAAA GTGCAAAGAG 3480

AAGATGGAGG CTGAGGAAGA GGAGGCGCTC GCGATTGCCA TGGCAATGTC GGCTTCTCAG 3540

GACGCCCTCC CCATAGTCCC TCAGCTGCAG GTGGAAAATG GAGAGGATAT CATCATCATC 3600

CAGCAGGATA CACCAGAAAC CCTACCAGGG CATACCAAAG CGAAGCAGCC CTACAGAGAA 3660

GACACCGAGT GGCTGAAAGG GCAGCAGATA GGCCTCGGAG CATTTTCTTC TTGTTACCAA 3720

GCACAGGATG TGGGCACTGG AACTTTAATG GCTGTGAAAC AGGTGACCTA CGTCAGAAAC 3780

ACATCTTCTG AGCAGGAGGA AGTGGTGGAA GCCTTGAGGG AAGAGATCAG GATGATGAGC 3840

CACCTCAACC ATCCGAACAT CATCAGGATG CTGGGGGCCA CGTGCGAGAA GAGCAACTAC 3900

AACCTCTTCA TCGAGTGGAT GGCGGGAGGC TCCGTGGCTC ACCTCTTGAG TAAATATGGA 3960

GCTTTCAAGG AGTCAGTGGT CATTAACTAC ACAGAGCAGT TACTCCGTGG CCTTTCCTAT 4020

CTCCACGAGA ACCAGATCAT TCACAGAGAC GTCAAAGGGG CCAATCTGCT CATTGACAGC 4080

ACCGGTCAGC GGCTGAGAAT TGCAGACTTC GGTGCTGCCG CCAGGTTGGC ATCCAAAGGA 4140

ACTGGTGCAG GAGAGTTCCA GGGACAGTTA CTGGGGACAA TTGCATTCAT GGCGCCTGAG 4200

GTACTAAGAG GTCAGCAGTA CGGTAGGAGC TGTGACGTCT GGAGTGTTGG CTGCGCCATT 4260

ATAGAAATGG CCTGTGCAAA ACCACCCTGG AACGCAGAAA AGCACTCCAA TCATCTTGCT 4320

TTGATATTTA AGATTGCGAG TGCAACTACT GCACCATCCA TCCCGTCACA CCTGTCCCCG 4380

GGCCTGCGAG ACGTGGCTCT GCGCTGTTTA GAACTTCAAC CTCAGGACAG ACCTCCGTCA 4440

AGAGAGCTAC TGAAGCATCC TGTCTTCCGT ACAACATGGT AG 4482

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1224  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1283

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1284  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1343

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1344  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1403

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1404  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1461

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1462  LRDVALRCLELQPQDRPPSRELLKHPV  1488

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013