EKS-RAN-00300

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00300

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	395.0	2.4E-118	244	537	294

Status

Reviewed

Ensembl Protein

ENSRNOP00000035501

UniProt Accession

P38438;

Protein Name

TGF-beta receptor type-2

Protein Synonyms/Alias

TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II;

Gene Name

Tgfbr2

Gene Synonyms/Alias

Tgfbr2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000013265	ENSRNOP00000035501	ENSRNOT00000037883

Organism

Rattus norvegicus

Functional Description

Transmembrane serine/threonine kinase forming with theTGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways (By similarity).

Protein Length

567

Protein Sequence
(FASTA)

MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SVNSDLMAGD NSGAVKLPQL CKFCDVTLST 60

CDNQKSCMSN CSVTSICEKP QEVCVAVWRK NDKNITLETV CHDPKFTYHG FTLEDATSPT 120

CVMKEKKRAG ETFFMCSCNT EECNDYIIFN EEYTTSSPDL LLVIIQVTGV SLLPPLGIAI 180

AVIAIFYCYR VHRQQKLSPS WESSKPRKLM DFSDNCAIIL EDDRSDISST CANNINHNTE 240

LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYSSWKTE KDIFSDINLK 300

HENILQFLTA EERKTEMGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH 360

LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 420

TARYMAPEVL ESRMNLENME SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE 480

HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QIVCETLTEC WDHDPEARLT AQCVAERFSE 540

LEHPDRLSGR SCSQEKIPED GSLNTTK 567

Nucleotide Sequence
(FASTA)

ATGGGTCGGG GGCTGCTCCG GGGCCTGTGG CCGCTGCACA TCGTCCTGTG GACGCGCATC 60

GCCAGCACGA TCCCGCCGCA CGTTCCCAAG TCGGTTAACA GCGATCTGAT GGCGGGTGAC 120

AACAGCGGTG CGGTCAAGCT TCCACAGCTG TGCAAGTTTT GCGACGTGAC ACTGTCCACT 180

TGTGACAACC AGAAGTCTTG CATGAGCAAC TGCAGCGTCA CCTCCATCTG TGAGAAGCCG 240

CAGGAAGTCT GCGTGGCCGT GTGGAGGAAG AACGACAAGA ACATTACTCT GGAGACCGTT 300

TGCCACGACC CCAAGTTCAC CTACCACGGC TTCACTCTGG AAGATGCCAC TTCTCCCACG 360

TGCGTCATGA AGGAAAAGAA AAGGGCAGGC GAGACCTTCT TCATGTGCTC CTGTAACACA 420

GAGGAGTGTA ACGATTACAT CATCTTTAAT GAAGAATACA CCACCAGCAG TCCTGACCTG 480

TTGCTGGTCA TTATCCAAGT GACGGGCGTC AGCCTCCTGC CTCCGCTGGG GATTGCCATA 540

GCTGTCATTG CCATCTTCTA CTGTTACCGT GTCCACCGGC AGCAGAAGTT GAGCCCCTCC 600

TGGGAGAGCA GCAAGCCCCG GAAGCTCATG GATTTCAGCG ACAACTGCGC CATCATCCTG 660

GAGGACGACC GCTCTGACAT CAGCTCTACG TGCGCCAACA ACATCAATCA CAATACGGAA 720

CTGCTGCCCA TCGAGCTGGA CACGCTGGTG GGGAAGGGCC GCTTCGCCGA GGTCTACAAG 780

GCCAAGCTGA AGCAGAACAC TTCAGAGCAG TTTGAGACCG TGGCTGTCAA GATCTTCCCC 840

TACGAGGAAT ACTCCTCGTG GAAAACGGAG AAGGACATCT TCTCTGACAT CAACCTGAAA 900

CACGAGAACA TCCTGCAGTT CCTGACGGCC GAGGAGCGGA AGACGGAGAT GGGCAAGCAG 960

TACTGGCTGA TCACGGCGTT TCATGCTAAG GGCAACCTGC AGGAGTACCT CACTAGGCAC 1020

GTCATCAGCT GGGAGGACCT GCGGAAGCTG GGCAGCTCCC TGGCCCGGGG CATCGCCCAT 1080

CTGCACAGTG ACCACACTCC TTGTGGGAGG CCCAAGATGC CCATTGTTCA CAGGGACCTC 1140

AAGAGCTCTA ACATCCTAGT GAAGAACGAT TTGACCTGTT GCCTGTGTGA CTTCGGGCTG 1200

TCCTTGCGCC TGGACCCTAC TCTGTCTGTG GATGACCTGG CCAACAGCGG GCAGGTGGGA 1260

ACAGCGAGAT ACATGGCCCC GGAAGTTCTA GAATCCAGGA TGAATTTGGA GAACATGGAG 1320

TCCTTCAAGC AGACGGATGT CTACTCCATG GCTCTGGTAC TCTGGGAAAT GACGTCTCGC 1380

TGCAACGCTG TGGGAGAAGT GAAAGATTAT GAGCCCCCAT TTGGTTCCAA GGTGCGGGAG 1440

CACCCCTGTG TGGAGAGCAT GAAAGACAAC GTGCTGAGAG ACCGAGGACG GCCTGAAATC 1500

CCCAGCTTCT GGCTCAACCA CCAGGGCATC CAGATCGTGT GTGAGACACT GACCGAGTGC 1560

TGGGACCACG ACCCCGAGGC CCGTCTCACA GCCCAGTGTG TGGCAGAGCG CTTCAGTGAA 1620

CTGGAGCACC CAGATAGACT CTCCGGGAGG AGCTGCTCCC AGGAGAAGAT TCCAGAAGAC 1680

GGCTCCCTGA ACACTACCAA ATAG 1704

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ +swk+Ek+i++ ++l+hen

Q: 244   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYSSWKTEKDIFSDINLKHEN  303

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 304   ILQFLTAEERKTEMGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  363

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 364   D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  422

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 423   RYMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  481

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip+ w +++ ++ ++++l+ecWd+dpeaRlta++v++r

Q: 482   PCVESMKDNVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAER  537

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YSSWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTEMGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120

DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENMESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSF WLNHQGIQIV CETLTECWDH DPEARLTAQC VAER 294

Keyword

Apoptosis; ATP-binding; Cell membrane; Complete proteome; Differentiation; Disulfide bond; Glycoprotein; Growth regulation; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009986	; C:cell surface
GO:0005829	; C:cytosol
GO:0070022	; C:transforming growth factor beta receptor homodimeric complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0046982	; F:protein heterodimerization activity
GO:0042803	; F:protein homodimerization activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0007568	; P:aging
GO:0006915	; P:apoptotic process
GO:0007182	; P:common-partner SMAD protein phosphorylation
GO:0048565	; P:digestive tract development
GO:0009790	; P:embryo development
GO:0007566	; P:embryo implantation
GO:0030324	; P:lung development
GO:0060044	; P:negative regulation of cardiac muscle cell proliferation
GO:0031100	; P:organ regeneration
GO:0043415	; P:positive regulation of skeletal muscle tissue regeneration
GO:0048661	; P:positive regulation of smooth muscle cell proliferation
GO:0006898	; P:receptor-mediated endocytosis
GO:0043627	; P:response to estrogen stimulus
GO:0009749	; P:response to glucose stimulus
GO:0001666	; P:response to hypoxia
GO:0009612	; P:response to mechanical stimulus
GO:0007584	; P:response to nutrient
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001570	; P:vasculogenesis
GO:0042060	; P:wound healing

KEGG

rno:81810

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013