EKS-RAN-00018
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00018
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR509.52.1E-1539791245267
StatusReviewed
Ensembl ProteinENSRNOP00000018638
UniProt AccessionQ64716; Q63146;
Protein NameInsulin receptor-related protein
Protein Synonyms/Alias IRR; IR-related receptor;
Gene NameInsrr
Gene Synonyms/Alias Insrr;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000013344ENSRNOP00000018638ENSRNOT00000018638
OrganismRattus norvegicus
Functional DescriptionReceptor with tyrosine-protein kinase activity.Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Protein Length1299
Protein Sequence
(FASTA)
MAVPALWPWG VYLLMSLLSL GSCLDTLEVC PSLDIRSEVT ELRRLENCSV VEGHLQILLM 60
FAATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGARLF LGYALIIFEM 120
PHLRDIGLPS LGAVLRGAVR VEKNQELCHL STIDWGLLQP APGANHIVGN KLGEECADVC 180
PGVLGAAGEP CVRTTFGGHT DYRCWTSSHC QRVCPCPRGL ACTVGGECCH SECLGGCSQP 240
EDPRACVACR HLYFQGVCLP TCPPGTYQYE SWRCVTAELC GHLREVPGHA TAFGIYEGSC 300
LAQCPPGFTR NGSSIFCHKC EGLCPKECKV GTKTIDSVQA TQDLVGCTHV EGSLILNLRQ 360
GYNLEPELQR NLGLVETITG FLKIKHSFAL VTLGFFKNLK LIRGDSMVDG NYTLYVLDNQ 420
NLQQLGSWVA AGLTIPVGKI YFAFNPRLCL EHIYQLEEVT GTRGRQSKAE INPRTNGDRA 480
ACQTRTLRFV FNLTEEDRIL LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGT 540
QSWNLLDVEL PLSRTQEPGV TLAPLKPWTQ YAVFVRAITL TTAEDSPHQG AQSPIVYLRT 600
LPAAPTVPQD VISTSNSSSH LLVRWKPPVQ RNGNITYYLV LWQRLAEDGD LYINDYCHRG 660
LRLPTSSHDT RFDREDPALE AEPEQGCCPC QHSPPGQALP ALEAQEVTFQ KKFENFLHHA 720
ITIPKAPWKV TSINKNPQRD SERHRRETGL LRLGKNNSDF EIHEDKVPRE RAVLSGLRHF 780
TEYRIDIHAC NHAAHTVGCS AATFVFARTM PHREADGIPG KVVWKAVGKS SVILHWLEPP 840
DPNGLILKYE IKYRRLGEEA TVLCVSRLRY AKVGGVHLAL LPPGNYSAKV RATSLAGNGS 900
WTDGVAFYIT GPEEEDTGGL RILLTVTPVG FMLLVMLAAL GFFYSKKRNS TLYTSVNPEY 960
FSASHMYVPD EWEVPREQIA IIRELGQGSF GMVYEGLARG LEAGEESTPV ALKTVNELAS 1020
ARERVEFLKE ASVMKAFKCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSH LRSLRPEAEN 1080
NPGLPQPALS DMIQMAGEIA DGMAYLAAKK FVHRDLAARN CMVSQDFTVK IGDFGMTRDV 1140
YETDYYRKGG KGLLPVRWMA PESLKDGIFT THSDVWSFGV VLWEIVTLAE QPYQGLSNEQ 1200
VLKFVMDGGV LEEQEDPIQL QELMRRCWQH TPRLRPTFVH ILDRIQDELR PSFRLCSFYY 1260
SPECQRGQAS LLPTEAEPDS PPTLNGASDY GPPNGDPGH 1299
Nucleotide Sequence
(FASTA)
ATGGCAGTGC CTGCTCTGTG GCCCTGGGGA GTATACTTGC TTATGAGCCT GCTGTCCTTG 60
GGATCTTGCC TGGACACACT GGAGGTGTGC CCCAGTCTTG ACATCCGCTC GGAGGTGACA 120
GAGCTCCGTC GGCTGGAGAA CTGCAGTGTG GTGGAGGGTC ACCTACAGAT CCTCCTCATG 180
TTTGCCGCCA CGGGAGAGGA CTTCCGAGGC CTCAGCTTTC CTCGCCTCAC CCAGGTGACT 240
GACTACCTGC TGCTGTTCCG AGTCTATGGC CTAGAGAGCC TTCGAGACCT CTTCCCCAAC 300
CTTGCTGTGA TCCGAGGTGC GCGCCTCTTC CTGGGCTATG CACTTATAAT CTTCGAGATG 360
CCCCACTTGA GGGACATTGG GCTGCCGTCG CTTGGGGCCG TGCTGCGTGG GGCCGTTCGT 420
GTGGAGAAGA ACCAGGAACT TTGCCATCTC TCCACCATTG ACTGGGGCCT GCTGCAGCCT 480
GCACCTGGTG CCAACCACAT TGTTGGGAAC AAGCTGGGTG AGGAGTGTGC TGACGTGTGC 540
CCTGGTGTGC TGGGGGCTGC TGGTGAGCCC TGTGTGAGAA CCACCTTCGG TGGGCACACC 600
GACTACAGGT GTTGGACCTC CAGCCACTGT CAGAGAGTGT GTCCCTGCCC CCGTGGGCTG 660
GCCTGCACAG TAGGTGGCGA GTGCTGCCAC AGTGAATGTC TCGGGGGCTG CAGTCAGCCT 720
GAAGACCCTC GAGCCTGCGT AGCTTGCCGC CACCTCTACT TCCAAGGAGT CTGCCTCCCC 780
ACCTGCCCTC CGGGCACCTA CCAGTATGAG TCTTGGCGGT GTGTCACTGC GGAGCTCTGT 840
GGCCATCTGC GAGAGGTTCC TGGACATGCC ACCGCCTTTG GCATCTACGA GGGCAGCTGC 900
CTAGCTCAGT GCCCTCCAGG CTTCACCCGT AATGGCAGCA GCATTTTCTG CCATAAGTGT 960
GAGGGCCTGT GCCCCAAAGA GTGCAAGGTT GGGACAAAGA CCATCGACTC TGTCCAAGCC 1020
ACACAGGACC TAGTGGGCTG CACCCATGTG GAGGGGAGCC TCATCCTCAA CCTTCGACAA 1080
GGCTACAATC TGGAGCCAGA GCTTCAACGC AACCTGGGGC TGGTGGAGAC CATCACCGGC 1140
TTCCTCAAAA TCAAGCACTC TTTTGCACTC GTGACCCTGG GATTTTTCAA GAACCTCAAA 1200
CTAATCCGGG GAGATTCCAT GGTGGATGGG AACTACACTC TGTACGTGTT AGACAACCAG 1260
AACCTGCAAC AGTTGGGGTC TTGGGTGGCC GCAGGGCTCA CCATTCCCGT GGGCAAAATA 1320
TACTTCGCCT TCAACCCACG CCTCTGCCTG GAGCACATAT ACCAACTGGA AGAGGTGACC 1380
GGAACCAGAG GCCGGCAAAG CAAGGCTGAA ATCAACCCCC GGACCAATGG AGATCGTGCT 1440
GCCTGCCAGA CTCGCACTCT GCGCTTTGTG TTCAACCTGA CCGAGGAGGA CCGCATCCTC 1500
CTGCGCTGGG AGCGCTATGA GCCACTGGAG GCCCGTGACC TGCTCAGCTT CATCGTCTAT 1560
TACAAGGAGT CCCCATTCCA GAATGCCACA GAACACGTGG GTCCAGACGC CTGTGGAACT 1620
CAGAGCTGGA ATCTGTTGGA TGTGGAACTA CCCCTCAGCC GCACCCAGGA GCCCGGGGTG 1680
ACCCTAGCCC CCCTAAAGCC CTGGACGCAG TATGCTGTGT TTGTGCGAGC CATCACACTG 1740
ACCACGGCTG AGGACAGCCC CCATCAGGGA GCCCAGAGCC CCATTGTCTA CCTGCGAACA 1800
TTACCTGCAG CACCCACAGT ACCCCAGGAC GTCATCTCCA CCTCCAATTC CTCTTCACAC 1860
CTCCTGGTGC GCTGGAAGCC GCCGGTCCAG CGCAATGGAA ACATCACCTA TTACCTGGTG 1920
TTGTGGCAGC GGCTAGCAGA GGACGGTGAC CTCTACATCA ATGACTACTG CCACCGCGGT 1980
CTGCGGCTGC CCACCAGCAG CCACGACACA CGCTTCGACC GTGAAGACCC GGCGCTGGAG 2040
GCTGAGCCGG AGCAAGGCTG CTGTCCTTGC CAACACTCGC CTCCTGGTCA GGCCCTGCCT 2100
GCACTGGAGG CACAAGAGGT CACCTTCCAG AAAAAGTTTG AAAACTTCCT ACACCATGCC 2160
ATCACCATCC CCAAGGCCCC GTGGAAAGTG ACATCCATCA ACAAGAACCC CCAAAGGGAT 2220
TCGGAGAGGC ACCGCCGGGA AACTGGGCTT CTCAGACTAG GGAAAAACAA CTCGGATTTT 2280
GAGATTCATG AGGACAAGGT TCCCCGGGAG CGAGCAGTAT TGAGCGGCTT GCGACACTTC 2340
ACAGAATACA GGATTGACAT CCATGCCTGC AACCACGCGG CACACACTGT GGGCTGCAGC 2400
GCTGCCACCT TCGTCTTTGC ACGCACCATG CCACATAGAG AGGCCGATGG CATCCCAGGG 2460
AAAGTGGTCT GGAAGGCGGT TGGCAAGAGC AGTGTCATCT TGCATTGGCT TGAGCCACCT 2520
GACCCCAATG GGCTCATCCT CAAGTATGAA ATCAAGTACC GCCGCCTTGG AGAGGAGGCC 2580
ACAGTGCTTT GTGTGTCCCG TCTTCGATAT GCCAAAGTTG GTGGGGTCCA CCTGGCTCTG 2640
CTGCCTCCTG GAAACTACTC TGCTAAAGTT CGGGCCACCT CATTGGCTGG CAATGGCTCC 2700
TGGACTGACG GTGTTGCCTT CTACATCACC GGTCCAGAGG AAGAGGATAC TGGGGGACTG 2760
CGCATCCTCC TCACTGTCAC CCCTGTCGGC TTCATGCTGC TCGTGATGCT TGCTGCCCTT 2820
GGTTTCTTCT ACAGCAAAAA GAGAAACAGC ACGCTGTACA CATCCGTGAA CCCGGAGTAT 2880
TTTAGTGCAT CCCACATGTA TGTCCCCGAC GAGTGGGAGG TCCCTCGGGA GCAGATAGCC 2940
ATCATCCGCG AGCTGGGCCA GGGCTCTTTT GGGATGGTAT ATGAGGGACT GGCACGAGGA 3000
CTTGAGGCTG GAGAGGAGTC TACACCTGTA GCCCTGAAGA CAGTTAATGA GCTGGCCAGC 3060
GCTCGGGAAC GCGTTGAATT CCTCAAGGAA GCATCTGTCA TGAAGGCCTT CAAGTGTCAC 3120
CATGTGGTCC GTCTCCTGGG TGTGGTGTCT CAGGGCCAGC CAACTTTGGT CATCATGGAG 3180
TTAATGACCC GTGGAGACCT CAAGAGCCAT CTCCGATCTC TGAGACCTGA GGCAGAGAAC 3240
AACCCTGGCC TCCCACAGCC AGCACTCAGT GACATGATTC AGATGGCTGG TGAGATTGCA 3300
GATGGCATGG CCTATCTTGC TGCCAAGAAG TTTGTGCACC GGGACCTGGC AGCCCGCAAC 3360
TGCATGGTGT CTCAGGATTT TACCGTCAAA ATTGGTGACT TCGGAATGAC TCGGGATGTG 3420
TACGAGACAG ACTATTACCG CAAGGGTGGA AAGGGGCTAC TGCCTGTGCG CTGGATGGCC 3480
CCTGAGTCCC TCAAAGACGG AATCTTCACC ACTCACTCAG ACGTCTGGTC CTTTGGTGTG 3540
GTGCTCTGGG AGATTGTGAC CCTAGCTGAA CAACCGTACC AGGGCCTATC AAACGAGCAG 3600
GTGCTGAAGT TTGTCATGGA CGGTGGAGTT CTAGAGGAGC AAGAGGATCC AATTCAGCTA 3660
CAGGAGCTGA TGAGACGCTG CTGGCAGCAT ACTCCACGCC TGCGCCCGAC TTTCGTCCAC 3720
ATCCTGGATC GCATACAGGA TGAACTTCGT CCCTCTTTCC GGCTCTGCTC CTTCTACTAC 3780
AGCCCCGAGT GTCAGCGGGG CCAGGCCTCC TTGCTGCCTA CTGAGGCAGA GCCTGACTCC 3840
CCACCAACCT TAAATGGAGC TTCAGACTAT GGTCCCCCAA ATGGGGACCC AGGACACTGA 3900
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+++relGqGsfGmvyeG+a+++++gee+t+va+ktvne as+rer+eflkeasvmk+fk
Q: 979   IAIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFK  1038
         6899********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal+++iqma+e
Q: 1039  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALSDMIQMAGE  1098
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+akkfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw
Q: 1099  IADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1158
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         m+peslkdG+ft++sdvwsfGvvlweivtlaeqpyqGlsneqvlkfv+dggvle+ e  p
Q: 1159  MAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEEQED-P  1217
         ******************************************************9986.8
S: 241   elltelmrlcwqynpklrpsfleivell  268
          +l+elmr+cwq++p+lrp+f++i++++
Q: 1218  IQLQELMRRCWQHTPRLRPTFVHILDRI  1245
         99**********************9975
Domain Sequence
(FASTA)
IAIIRELGQG SFGMVYEGLA RGLEAGEEST PVALKTVNEL ASARERVEFL KEASVMKAFK 60
CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPEA ENNPGLPQPA LSDMIQMAGE 120
IADGMAYLAA KKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180
MAPESLKDGI FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLKFVMDG GVLEEQEDPI 240
QLQELMRRCW QHTPRLRPTF VHILDRI 267
KeywordATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00014
EKS-BOT-00016
EKS-CAJ-00018
EKS-CAF-00018
EKS-CAP-00017
EKS-EQC-00019
EKS-FEC-00017
EKS-GOG-00020
EKS-HOS-00019
EKS-ICT-00018
EKS-LOA-00016
EKS-MAM-00017
EKS-MEG-00015
EKS-MOD-00016
EKS-MUM-00016
EKS-MUP-00019
EKS-MYL-00019
EKS-NOL-00017
EKS-ORC-00016
EKS-OTG-00017
EKS-PAT-00018
EKS-PES-00018
EKS-POA-00017
EKS-SAH-00015
EKS-SUS-00014
EKS-XET-00017
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
rno:60663;
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013