EKS-RAN-00329
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00329
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20349.41.5E-10430281252
StatusUnreviewed
Ensembl ProteinENSRNOP00000061873
UniProt AccessionD4A648;
Protein Name
Protein Synonyms/Alias Protein Stk4; Serine/threonine kinase 4 (Predicted);
Gene NameStk4
Gene Synonyms/Alias Stk4; Stk4_predicted; rCG_32066;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000013529ENSRNOP00000061873ENSRNOT00000066657
OrganismRattus norvegicus
Functional Description
Protein Length487
Protein Sequence
(FASTA)
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ 60
VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT 120
LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK 180
RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RAIFMIPTNP 240
PPTFRKPEVW SDNFMDFVKQ CLVKSPEQRA TATQLLQHPF VKSAKGAAIL RDLINEAMDV 300
KLKRQEAQQR AVDQDDDENS EEDEMDSGTM VRAAGDDMGT VRVASTMSGG ANTMIEHGDT 360
LPSQLGTMVI NTEDEEEEGT MKRRDETMQP AKPSFLEYFE QKEKENQINS FGKNVSGSLK 420
NSSDWKIPQD GDYEFLKSWT VEDLQKRLSA LDPMMEQEME EIRQKYRSKR QPILDAIEAK 480
KRRQQNF 487
Nucleotide Sequence
(FASTA)
ATGGAGACCG TGCAACTGAG GAACCCACCG CGCAGGCAGC TGAAAAAGTT GGATGAAGAT 60
AGTTTAACTA AACAGCCAGA AGAAGTGTTT GATGTCTTAG AGAAACTTGG AGAAGGGTCT 120
TATGGCAGCG TGTACAAGGC GATTCACAAA GAGACCGGCC AGATTGTCGC CATCAAGCAG 180
GTGCCCGTGG AGTCGGACCT GCAGGAGATA ATCAAGGAAA TCTCGATAAT GCAGCAGTGT 240
GACAGCCCAC ATGTCGTCAA ATACTATGGC AGCTACTTTA AGAACACGGA CCTGTGGATT 300
GTTATGGAGT ACTGTGGGGC TGGTTCTGTA TCCGATATTA TTCGGCTCCG AAACAAGACG 360
TTAACAGAAG ATGAAATAGC TACAATATTA CAATCAACTC TTAAAGGATT AGAATACCTT 420
CATTTTATGA GAAAAATACA CCGAGATATC AAGGCGGGAA ATATTTTGCT AAACACAGAA 480
GGCCATGCAA AGCTTGCAGA CTTTGGAGTC GCAGGCCAAC TTACAGATAC CATGGCAAAG 540
AGGAATACAG TGATAGGGAC ACCGTTTTGG ATGGCTCCTG AAGTTATTCA GGAAATCGGG 600
TACAACTGTG TGGCAGACAT CTGGTCTCTG GGAATCACGG CCATAGAAAT GGCTGAAGGA 660
AAGCCCCCAT ACGCTGACAT CCATCCAATG AGGGCAATAT TCATGATTCC TACAAACCCT 720
CCTCCCACAT TCCGTAAGCC CGAGGTGTGG TCGGACAACT TCATGGATTT CGTGAAGCAG 780
TGTCTGGTAA AAAGCCCGGA GCAGAGAGCC ACAGCCACTC AGCTCCTCCA GCACCCGTTT 840
GTTAAGAGCG CCAAGGGAGC GGCCATACTG CGAGACTTAA TTAACGAGGC CATGGACGTG 900
AAACTGAAGC GCCAGGAAGC CCAGCAGCGG GCAGTGGACC AGGACGACGA TGAGAACTCA 960
GAGGAGGATG AAATGGACTC TGGCACGATG GTTCGAGCTG CGGGTGATGA CATGGGCACT 1020
GTCCGAGTAG CCAGCACGAT GAGCGGCGGA GCCAATACTA TGATTGAGCA CGGTGACACA 1080
TTGCCATCCC AGCTGGGTAC CATGGTGATC AACACGGAGG ATGAGGAAGA GGAAGGAACC 1140
ATGAAAAGGA GAGATGAGAC CATGCAGCCT GCAAAACCGT CTTTTCTTGA ATACTTTGAA 1200
CAAAAAGAAA AGGAAAATCA GATCAACAGC TTTGGCAAGA ATGTATCTGG CTCTCTGAAG 1260
AATTCTTCAG ATTGGAAAAT ACCTCAGGAT GGAGACTACG AGTTTCTGAA GAGCTGGACT 1320
GTGGAGGACC TTCAGAAGCG GCTCTCTGCC CTCGACCCCA TGATGGAGCA GGAAATGGAA 1380
GAGATCCGGC AGAAATACCG CTCCAAGCGG CAGCCAATCC TGGATGCCAT CGAAGCCAAG 1440
AAGAGGAGGC AACAGAACTT CTGA 1464
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +++le++g+G++g+vy+a +k+tg++vaik++ +e+  +l+e++keis+++++++p++v+
Q: 30    FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVK  87
         7899*******************************7..9*********************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s++k+++lw+vmey+ +Gs+sd+++  ++++l+E++ia+il+++lk+LeylH +++i
Q: 88    YYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEDEIATILQSTLKGLEYLHFMRKI  146
         ****************************.99*****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180
         Hrdika+niLl++eg+ kL+dfgva ql++t++kr+tv+gtp+wmAPEvi+  e gY++ 
Q: 147   HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ--EIGYNCV  204
         ***************************************************..9******
S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240
         aDiwslGItaie+aeg+pP++d++p++a+++i++n+pp++++++ +s++f +fv++cl k
Q: 205   ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEVWSDNFMDFVKQCLVK  264
         ************************************************************
S: 241   npekRpsasellkhkFl  257
         +pe+R++a++ll+h+F+
Q: 265   SPEQRATATQLLQHPFV  281
         ****************7
Domain Sequence
(FASTA)
FDVLEKLGEG SYGSVYKAIH KETGQIVAIK QVPVESDLQE IIKEISIMQQ CDSPHVVKYY 60
GSYFKNTDLW IVMEYCGAGS VSDIIRLRNK TLTEDEIATI LQSTLKGLEY LHFMRKIHRD 120
IKAGNILLNT EGHAKLADFG VAGQLTDTMA KRNTVIGTPF WMAPEVIQEI GYNCVADIWS 180
LGITAIEMAE GKPPYADIHP MRAIFMIPTN PPPTFRKPEV WSDNFMDFVK QCLVKSPEQR 240
ATATQLLQHP FV 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00294
EKS-ANC-00306
EKS-BOT-00313
EKS-CAE-00261
EKS-CAJ-00321
EKS-CAF-00316
EKS-CAP-00348
EKS-EQC-00306
EKS-FEC-00300
EKS-GAG-00267
EKS-GAA-00393
EKS-GOG-00309
EKS-HOS-00321
EKS-ICT-00294
EKS-LAC-00325
EKS-LOA-00325
EKS-MAM-00328
EKS-MEG-00256
EKS-MOD-00310
EKS-MUM-00346
EKS-MUP-00308
EKS-MYL-00313
EKS-NOL-00288
EKS-ORN-00415
EKS-ORA-00276
EKS-ORC-00297
EKS-ORL-00377
EKS-OTG-00323
EKS-PAT-00297
EKS-PES-00280
EKS-POA-00303
EKS-SAH-00293
EKS-SOA-00034
EKS-TAG-00330
EKS-TUT-00072
EKS-XET-00388
EKS-XIM-00408
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0043539; F:protein serine/threonine kinase activator activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0060706; P:cell differentiation involved in embryonic placenta development
GO:0000902; P:cell morphogenesis
GO:0007417; P:central nervous system development
GO:0003157; P:endocardium development
GO:0035329; P:hippo signaling cascade
GO:0006917; P:induction of apoptosis
GO:0007243; P:intracellular protein kinase cascade
GO:0030216; P:keratinocyte differentiation
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0046621; P:negative regulation of organ growth
GO:0001841; P:neural tube formation
GO:0001569; P:patterning of blood vessels
GO:0018105; P:peptidyl-serine phosphorylation
GO:0060215; P:primitive hemopoiesis
GO:0046777; P:protein autophosphorylation
KEGG
rno:311622;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR011524; SARAH.
IPR024205; SARAH_domain.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF11629; Mst1_SARAH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50951; SARAH; 1.
Prints
Created Date20-Feb-2013