EKS-RAN-00248

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00248

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	320.2	1.1E-95	11	263	253

Status

Unreviewed

Ensembl Protein

ENSRNOP00000059313

UniProt Accession

D3ZIC0;

Protein Name

Protein Synonyms/Alias

Protein Melk;

Gene Name

Melk

Gene Synonyms/Alias

Melk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000013598	ENSRNOP00000059313	ENSRNOT00000066277

Organism

Rattus norvegicus

Functional Description

Protein Length

362

Protein Sequence
(FASTA)

MKDYDELLKY YELYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRVKTEIDA 60

LKNLRHQHIC QLYHVLETKN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VIFRQILSAV 120

AYVHSQGYAH RDLKPENLLF DENHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI 180

QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYEVPK WLSPSSILLL 240

QQMLQVDPKR RISMKNLLNH PWILQDYSCP IEWQSKASLT HLDEDCITEL SVHHRNSRQT 300

MEDLISSWQY DHLTATYLLL LAKKARGKPA RLQLLSFSGG TTSTTPKAIK EPEPGRYVHK 360

WR 362

Nucleotide Sequence
(FASTA)

ATGAAAGATT ATGACGAGCT CCTTAAATAC TATGAATTAT ATGAAACTAT TGGGACAGGT 60

GGCTTTGCAA AGGTCAAACT TGCCTGTCAT ATCCTCACTG GAGAAATGGT AGCTATAAAA 120

ATCATGGATA AGAATGCACT AGGGAGCGAT TTGCCCCGAG TCAAAACTGA AATTGATGCC 180

CTGAAGAATC TGAGACATCA GCATATATGT CAGCTCTACC ATGTGCTAGA GACAAAGAAC 240

AAAATATTCA TGGTGCTTGA GTACTGTCCA GGAGGAGAGC TGTTTGACTA CATCATCTCC 300

CAGGATCGCC TGTCGGAAGA GGAGACCCGA GTCATCTTCC GCCAGATCCT GTCTGCAGTT 360

GCATATGTGC ACAGCCAGGG CTATGCCCAC AGGGACCTCA AGCCAGAAAA TTTATTGTTT 420

GACGAAAATC ATAAGCTAAA GCTGATTGAC TTTGGTCTCT GTGCAAAACC CAAGGGCAAC 480

AAGGACTACC ATCTACAGAC ATGCTGTGGG AGTCTGGCGT ATGCAGCACC TGAACTAATA 540

CAAGGGAAAT CGTATCTTGG ATCAGAGGCA GATGTTTGGA GCATGGGCAT CCTCCTATAT 600

GTGCTTATGT GTGGATTCCT CCCGTTTGAT GATGATAATG TCATGGCTTT GTACAAGAAG 660

ATAATGAGAG GGAAGTATGA AGTTCCCAAG TGGCTGTCTC CCAGCAGCAT CCTGCTTCTC 720

CAGCAGATGC TTCAGGTGGA CCCAAAGAGA CGGATTTCTA TGAAAAATCT CTTGAACCAT 780

CCCTGGATCC TGCAAGATTA CAGCTGTCCC ATTGAGTGGC AAAGCAAGGC TTCTTTGACT 840

CACCTTGATG AGGATTGCAT AACAGAGCTT TCTGTACATC ACCGCAACAG CAGGCAAACA 900

ATGGAGGATT TAATTTCGTC GTGGCAGTAT GATCACCTCA CAGCCACCTA CCTTCTGCTT 960

CTAGCCAAGA AGGCTCGAGG GAAGCCAGCT CGTCTGCAGC TTCTGTCCTT CTCTGGTGGG 1020

ACCACCAGCA CCACTCCAAA GGCAATCAAA GAACCTGAGC CTGGAAGATA TGTCCACAAG 1080

TGGCGATAG 1089

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l +t+G+g f+kVkla+h +t+e+va+Ki++k++l +  l ++k+Ei++lk+l+h++i

Q: 11    YELYETIGTGGFAKVKLACHILTGEMVAIKIMDKNALGS-DLPRVKTEIDALKNLRHQHI  69

         999*******************************88875.589*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++v+etk+k+++vley+ ggeLfdyi ++ rl+e+e+r +f+q++sav Y+hs+g +

Q: 70    CQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVIFRQILSAVAYVHSQGYA  129

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+++++k++DFGl+++ k +   +l+t+cGs++YaaPel++gk+Y g++

Q: 130   HRDLKPENLLFDENHKLKLIDFGLCAKPKGNkdYHLQTCCGSLAYAAPELIQGKSYLGSE  189

         *************************9665443389*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +DvWs+G++Ly+l++g lPfd++n+ +l++ki++gk+e+pk+ls++ + Ll+++L+vdp+

Q: 190   ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPK  249

         ************************************************************

S: 239   kRatieeilkhewl  252

         +R++++++l+h+w+

Q: 250   RRISMKNLLNHPWI  263

         *************7

Domain Sequence
(FASTA)

YELYETIGTG GFAKVKLACH ILTGEMVAIK IMDKNALGSD LPRVKTEIDA LKNLRHQHIC 60

QLYHVLETKN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VIFRQILSAV AYVHSQGYAH 120

RDLKPENLLF DENHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI QGKSYLGSEA 180

DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYEVPK WLSPSSILLL QQMLQVDPKR 240

RISMKNLLNH PWI 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0061351	; P:neural precursor cell proliferation
GO:0043065	; P:positive regulation of apoptotic process
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013