EKS-RAN-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	313.0	2.0E-93	5	234	230

Status

Unreviewed

Ensembl Protein

ENSRNOP00000019180

UniProt Accession

F1M4R4;

Protein Name

Protein Synonyms/Alias

Protein Map4k4;

Gene Name

Map4k4

Gene Synonyms/Alias

Map4k4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000014013	ENSRNOP00000019180	ENSRNOT00000019180

Organism

Rattus norvegicus

Functional Description

Protein Length

1178

Protein Sequence
(FASTA)

MDVTEDEEEE IKLEINMLKK YSHHRNIATY YGAFIKKSPP GHDDQLWLVM EFCGAGSITD 60

LVKNTKGNTL KEDWIAYISR EILRGLAHLH IHHVIHRDIK GQNVLLTENA EVKLVDFGVS 120

AQLDRTVGRR NTFIGTPYWM APEVIACDEN PDATYDYRSD LWSCGITAIE MAEGAPPLCD 180

MHPMRALFLI PRNPPPRLKS KKWSKKFFSF IEGCLVKNYM QRPSTEQLLK HPFIRDQPNE 240

RQVRIQLKDH IDRTRKKRGE KDETEYEYSG SEEEEEEVPE QEGEPSSIVN VPGESTLRRD 300

FLRLQQENKE RSEALRRQQL LQEQQLREQE EYKRQLLAER QKRIEQQKEQ RRRLEEQQRR 360

EREARRQQER EQRRREQEEK RRLEELERRR KEEEERRRAE DEKRRVEREQ EYIRRQLEEE 420

QRHLEILQQQ LLQEQAMLLH DHRRPHAQQP PPPQQQDRSK PSYHAPEPKP HYDPADRARE 480

VQWSHLASLK NNVSPVSRSH SFSDPSPKFA HHHLRSQDPC PPSRSEGLSQ SSDSKSEVPE 540

PTQKAWSRSD SDEVPPRVPV RTTSRSPVLS RRDSPLQGSG QQNSQAGQRN STSSIEPRLL 600

WERVEKLVPR PGSGSSSGSS NSGSQPGSHP GSQSGSGERF RVRSSSKSEG SPSQRLENAA 660

KKPEDKKEVF RPLKPAVRID LTALAKELRA VEDVRPPHKV TDYSSSSEES GTTDEEEEDV 720

EQEGADDSTS GPEDTRAASS LNLSNGETES VKTMIVHDDV ESEPAMTPSK EGTLIVRQTQ 780

SASSTLQKHK SSSSFTPFID PRLLQISPSS GTTVTSVVGF SCDGLRPEAI RQDPTRKGSV 840

VNVNPTNTRP QSDTPEIRKY KKRFNSEILC AALWGVNLLV GTESGLMLLD RSGQGKVYPL 900

ISRRRFQQMD VLEGLNVLVT ISGKKDKLRV YYLSWLRNKI LHNDPEVEKK QGWTTVGDLE 960

GCVHYKVVKY ERIKFLVIAL KSSVEVYAWA PKPYHKFMAF KSFGELVHKP LLVDLTVEEG 1020

QRLKVIYGSC AGFHAVDVDS GSVYDIYLPT HIQCTIKPHA IIILPNTDGM ELLVCYEDEG 1080

VYVNTYGRIT KDVVLQWGEM PTSVAYIRSN QTMGWGEKAI EIRSVETGHL DGVFMHKRAQ 1140

RLKFLCERND KVFFASVRSG GSSQVYFMTL GRTSLLSW 1178

Nucleotide Sequence
(FASTA)

ATGGATGTCA CCGAGGATGA AGAGGAAGAA ATCAAACTGG AGATAAATAT GCTGAAGAAA 60

TATTCTCATC ATAGAAATAT TGCAACATAC TATGGTGCTT TCATTAAGAA GAGCCCTCCA 120

GGACACGATG ACCAGCTCTG GCTCGTTATG GAGTTTTGCG GGGCTGGTTC CATCACAGAC 180

CTTGTGAAGA ACACCAAAGG GAACACGCTC AAAGAAGACT GGATTGCTTA CATCTCCCGG 240

GAAATCCTCA GGGGGTTGGC CCATCTCCAC ATTCACCATG TCATTCACCG AGACATCAAG 300

GGGCAGAACG TGCTGCTGAC TGAGAACGCG GAGGTGAAAC TTGTTGATTT TGGTGTAAGC 360

GCTCAGCTGG ACAGGACGGT TGGACGGAGA AATACATTCA TAGGCACACC ATACTGGATG 420

GCTCCGGAGG TCATCGCCTG CGACGAGAAT CCAGATGCCA CTTACGACTA CAGAAGTGAC 480

CTCTGGTCTT GTGGCATCAC GGCCATCGAG ATGGCAGAAG GAGCCCCCCC TCTCTGTGAC 540

ATGCATCCAA TGAGAGCGCT GTTTCTCATC CCCAGAAACC CTCCTCCCAG GCTGAAGTCA 600

AAAAAATGGT CAAAGAAATT TTTCAGCTTC ATAGAAGGCT GCCTGGTGAA GAATTACATG 660

CAGCGGCCCT CTACAGAGCA GCTTTTAAAA CACCCTTTCA TAAGGGATCA GCCCAATGAA 720

AGGCAGGTTC GAATCCAGCT TAAGGATCAC ATAGACCGGA CCAGGAAGAA GAGAGGCGAG 780

AAAGATGAGA CGGAGTACGA GTACAGTGGC AGTGAGGAGG AGGAGGAGGA AGTGCCTGAG 840

CAGGAGGGAG AGCCAAGTTC CATCGTCAAT GTGCCTGGAG AGTCGACTCT GCGACGTGAT 900

TTCCTGAGGC TGCAGCAAGA GAACAAGGAA CGGTCTGAGG CTCTGCGGAG ACAGCAGCTT 960

CTGCAGGAGC AGCAGCTCCG GGAGCAGGAG GAGTATAAGA GGCAGCTGCT GGCTGAGAGG 1020

CAGAAGCGGA TTGAACAGCA GAAAGAACAG AGGAGGCGGC TGGAAGAGCA ACAAAGGAGA 1080

GAGCGTGAAG CCAGGAGGCA GCAGGAACGT GAGCAGCGGC GGCGAGAACA GGAGGAGAAG 1140

AGGCGTCTGG AGGAACTGGA AAGGCGGCGT AAGGAAGAGG AAGAGAGGAG ACGGGCAGAA 1200

GACGAGAAGA GGCGAGTGGA GCGGGAGCAG GAGTACATCA GGCGGCAGCT AGAGGAAGAG 1260

CAGCGGCACC TGGAGATCCT GCAGCAGCAG CTGCTCCAGG AGCAGGCTAT GTTACTGCAC 1320

GACCACAGGA GGCCACACGC ACAACAGCCG CCACCCCCGC AGCAGCAGGA CAGGAGCAAA 1380

CCCAGCTATC ACGCTCCAGA GCCCAAGCCT CACTACGACC CTGCTGACAG AGCTCGGGAG 1440

GTACAGTGGT CCCACCTGGC ATCTCTCAAG AACAATGTCT CCCCTGTCTC GAGATCCCAT 1500

TCCTTCAGTG ACCCTTCTCC CAAATTCGCA CACCACCATC TCCGCTCTCA GGACCCATGT 1560

CCACCTTCCC GCAGTGAGGG GCTCAGTCAG AGCTCTGACT CTAAGTCGGA GGTACCTGAG 1620

CCCACCCAAA AGGCTTGGTC TAGATCAGAC AGTGACGAGG TGCCTCCAAG GGTTCCTGTG 1680

AGAACGACAT CTCGTTCCCC TGTCCTGTCC CGTCGAGATT CTCCACTGCA GGGCAGTGGG 1740

CAGCAAAATA GCCAAGCAGG ACAGAGAAAT TCCACCAGCA GTATTGAGCC CCGGCTTCTA 1800

TGGGAGAGAG TGGAAAAGCT GGTCCCCAGG CCAGGCAGTG GCAGCTCTTC AGGGTCCAGC 1860

AACTCAGGAT CCCAGCCTGG CTCCCATCCT GGGTCTCAGA GTGGCTCTGG TGAACGCTTC 1920

AGAGTGAGAT CATCATCCAA GTCTGAAGGT TCTCCATCTC AGCGCCTTGA AAATGCAGCC 1980

AAAAAACCTG AAGATAAGAA AGAAGTATTT CGACCTCTCA AACCTGCTGT AAGGATTGAC 2040

TTGACTGCGT TGGCCAAAGA GCTTCGAGCA GTGGAAGATG TGCGGCCACC TCACAAAGTG 2100

ACAGACTATT CCTCCTCCAG TGAGGAGTCT GGGACCACGG ATGAGGAGGA GGAGGATGTG 2160

GAACAGGAGG GGGCTGATGA TTCCACCTCG GGGCCAGAGG ACACCAGAGC AGCGTCGTCT 2220

CTGAATCTGA GCAACGGTGA GACAGAATCT GTGAAAACAA TGATTGTTCA TGATGACGTA 2280

GAAAGTGAAC CAGCCATGAC CCCATCCAAG GAGGGCACCC TAATCGTCCG CCAGACTCAG 2340

TCCGCTAGTA GCACACTCCA GAAACACAAA TCTTCCTCCT CCTTTACACC TTTTATAGAC 2400

CCCAGGTTAC TACAGATCTC TCCATCTAGT GGAACAACAG TTACTTCCGT TGTGGGATTT 2460

TCCTGTGATG GGCTGAGACC AGAAGCCATA AGGCAAGATC CTACTCGGAA AGGCTCAGTG 2520

GTCAATGTGA ACCCCACGAA CACTAGGCCA CAGAGTGATA CCCCCGAGAT TCGTAAATAC 2580

AAGAAGAGAT TTAACTCAGA GATCCTGTGT GCTGCCTTAT GGGGAGTGAA TTTGCTAGTT 2640

GGCACAGAGA GTGGCCTGAT GCTCTTGGAC AGAAGTGGCC AAGGGAAAGT GTACCCTCTG 2700

ATCAGCCGGA GACGGTTCCA GCAAATGGAT GTACTTGAGG GCCTGAATGT CCTGGTGACA 2760

ATATCTGGCA AAAAGGATAA GTTACGCGTC TACTATTTAT CCTGGTTAAG AAATAAAATA 2820

CTTCATAATG ATCCGGAAGT TGAGAAGAAG CAGGGGTGGA CCACCGTGGG CGACCTGGAA 2880

GGGTGCGTGC ACTATAAAGT CGTAAAATAT GAAAGAATCA AGTTTCTGGT AATCGCTTTG 2940

AAGAGTTCTG TGGAAGTCTA TGCATGGGCA CCGAAGCCAT ATCACAAATT TATGGCCTTT 3000

AAGTCATTTG GAGAACTGGT ACATAAGCCA TTACTGGTGG ATCTCACTGT CGAGGAAGGC 3060

CAGAGGTTGA AAGTGATCTA TGGATCCTGT GCTGGATTCC ATGCTGTTGA TGTGGATTCC 3120

GGCTCAGTCT ATGACATTTA TCTACCAACA CACATTCAGT GTACCATCAA ACCCCATGCA 3180

ATCATTATCC TCCCCAACAC GGATGGAATG GAGCTTCTGG TGTGCTACGA AGATGAAGGG 3240

GTTTATGTGA ACACGTACGG AAGAATCACC AAGGACGTGG TTCTGCAGTG GGGAGAGATG 3300

CCAACATCTG TAGCATACAT CCGGTCGAAT CAGACAATGG GCTGGGGAGA GAAGGCAATA 3360

GAGATACGCT CTGTGGAAAC TGGTCATTTG GACGGTGTGT TTATGCACAA AAGGGCTCAG 3420

AGACTAAAGT TCCTGTGTGA ACGTAATGAC AAGGTGTTCT TTGCTTCCGT CCGCTCTGGC 3480

GGCAGCAGCC AGGTCTACTT CATGACCTTA GGCAGGACTT CCCTTCTGAG CTGGTAG 3537

Domain Profile

S: 37    qekleelqkeisvlkklkh.pniveylesflk......eeelwlvmeylagGslsdlvke  89

         ++++ee++ ei++lkk++h +ni +y+++f+k      +++lwlvme++ +Gs++dlvk+

Q: 5     EDEEEEIKLEINMLKKYSHhRNIATYYGAFIKksppghDDQLWLVMEFCGAGSITDLVKN  64

         38999************998*****************9**********************

S: 90    elkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqle  149

         ++ ++lkE++iayi re+l++L++lH ++viHrdik++n+Llte++eVkL+dfgv+aql+

Q: 65    TKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLD  124

         ************************************************************

S: 150   ktrkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaielaegepPfkdlepl  206

         +t+ +r+t++gtpywmAPEvia++   + +Yd+++D+ws+GItaie+aeg+pP++d++p+

Q: 125   RTVGRRNTFIGTPYWMAPEVIACDenpDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPM  184

         ************************999999******************************

S: 207   kallkilkneppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257

         +al++i++n+pp+lksk k+sk+f +f+e cl kn+ +Rps+++llkh+F+

Q: 185   RALFLIPRNPPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI  234

         **************888.********************************7

Domain Sequence
(FASTA)

EDEEEEIKLE INMLKKYSHH RNIATYYGAF IKKSPPGHDD QLWLVMEFCG AGSITDLVKN 60

TKGNTLKEDW IAYISREILR GLAHLHIHHV IHRDIKGQNV LLTENAEVKL VDFGVSAQLD 120

RTVGRRNTFI GTPYWMAPEV IACDENPDAT YDYRSDLWSC GITAIEMAEG APPLCDMHPM 180

RALFLIPRNP PPRLKSKKWS KKFFSFIEGC LVKNYMQRPS TEQLLKHPFI 230

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0046328	; P:regulation of JNK cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036

; CNH; 1.

Prosites

PS50219	; CNH; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013