EKS-RAN-00403

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00403

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	363.4	1.0E-108	356	616	261

Status

Unreviewed

Ensembl Protein

ENSRNOP00000057715

UniProt Accession

F1M9D0;

Protein Name

Protein Synonyms/Alias

Protein Map3k2;

Gene Name

Map3k2

Gene Synonyms/Alias

Map3k2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000014089	ENSRNOP00000057715	ENSRNOT00000060996

Organism

Rattus norvegicus

Functional Description

Protein Length

619

Protein Sequence
(FASTA)

MDDQQALNSI MQDLAVLHKA SRPALSLQET RKAKPSSPKK QNDVRVKFEH RGEKRILQVT 60

RPVKLEDLRS KSKIAFGQSM DLHYTNNELV IPLTTQDDLD KAVELLDRSI HMKSLKILLV 120

LNGSTQATNL EPSPSPDDLN NTPLGAERKK RLSVVGPPNR DRSSPPPGYI PDELHQIARN 180

GSFTSINSEG EFIPESMDQM LDPLSLSSPE NSGSGSCPSL DSPLDGESYP KSRMPRAQSY 240

PDNHQEFSDY DNPIFEKFGK GGTYPRRYHV SYHHQEYNDG RKTFPRARRT QGTSFRSPVS 300

FSPTDHSLST SSGSSIFTPE YEDSRIRRRG SDIDNPTLTV TDISPPSRSP RAPTNWRLGK 360

LLGQGAFGRV YLCYDVDTGR ELAVKQVQFN PDSPETSKEV NALECEIQLL KNLLHERIVQ 420

YYGCLRDPQE KTLSIFMEYM PGGSIKDQLK AYGALTENVT RKYTRQILEG VHYLHSNMIV 480

HRDIKGANIL RDSTGNIKLG DFGASKRLQT ICLSGTGMKS VTGTPYWMSP EVISGEGYGR 540

KADIWSVACT VVEMLTEKPP WAEFEAMAAI FKIATQPTNP KLPPHVSDYT RDFLKRIFVE 600

AKLRPSAEEL LRHLFVHCH 619

Nucleotide Sequence
(FASTA)

ATGGATGATC AGCAAGCTTT GAATTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 60

AGTCGGCCAG CATTATCTTT ACAAGAAACC AGAAAAGCAA AACCCTCTTC ACCAAAAAAA 120

CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCTT GCAGGTTACT 180

AGACCAGTTA AACTAGAAGA TCTGAGGTCT AAGTCTAAAA TTGCCTTTGG ACAGTCTATG 240

GATCTACACT ATACCAACAA CGAGTTGGTA ATTCCGTTAA CTACCCAAGA TGACTTGGAC 300

AAAGCTGTGG AACTGCTGGA TCGCAGTATC CACATGAAGA GTCTCAAGAT ATTACTTGTT 360

CTAAATGGGA GTACACAGGC TACTAATTTA GAGCCGTCAC CATCACCAGA CGATCTGAAT 420

AATACACCAC TCGGTGCGGA GAGGAAAAAG CGGCTATCTG TAGTAGGTCC CCCTAATAGG 480

GATAGAAGTT CTCCACCCCC AGGATACATT CCAGATGAAC TGCACCAGAT TGCCCGGAAC 540

GGGTCTTTCA CCAGCATCAA CAGTGAAGGA GAGTTCATCC CAGAGAGCAT GGACCAAATG 600

CTGGATCCAC TGTCTTTAAG CAGCCCTGAA AACTCTGGCT CAGGAAGCTG CCCGTCACTG 660

GATAGTCCTT TGGATGGAGA AAGCTACCCA AAATCACGGA TGCCTAGGGC ACAGAGCTAC 720

CCAGATAATC ATCAGGAGTT TTCAGACTAT GATAACCCCA TTTTTGAGAA ATTTGGAAAA 780

GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATACCATC ATCAAGAGTA TAATGATGGT 840

CGGAAGACTT TTCCAAGAGC CAGAAGGACC CAGGGCACCA GTTTCCGGTC TCCTGTGAGT 900

TTCAGTCCTA CTGATCACTC CTTAAGCACT AGTAGTGGGA GCAGCATCTT TACCCCAGAG 960

TATGAAGACA GTCGGATAAG AAGACGGGGG AGTGACATAG ACAATCCTAC TTTGACTGTC 1020

ACAGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCAA CCAACTGGAG ATTGGGCAAA 1080

CTGCTTGGCC AAGGAGCTTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACCGGACGA 1140

GAACTGGCTG TTAAACAAGT TCAGTTTAAC CCTGACAGCC CCGAGACCAG CAAGGAAGTA 1200

AATGCACTTG AGTGTGAAAT TCAGTTGTTG AAAAACTTGT TGCATGAGCG AATTGTTCAG 1260

TATTATGGCT GTCTGAGGGA TCCTCAGGAG AAAACACTTT CCATCTTTAT GGAGTACATG 1320

CCAGGGGGCT CAATTAAGGA CCAACTCAAA GCATATGGAG CCCTTACTGA GAATGTGACG 1380

AGGAAATACA CCCGTCAGAT TCTGGAGGGG GTCCATTACC TGCATAGTAA TATGATTGTC 1440

CATAGAGACA TCAAAGGAGC GAATATCTTA AGGGATTCCA CGGGCAATAT CAAGCTAGGA 1500

GACTTTGGAG CTAGCAAACG ACTTCAGACC ATCTGTCTCT CAGGCACAGG GATGAAGTCT 1560

GTCACAGGCA CGCCATATTG GATGAGTCCT GAGGTCATTA GTGGAGAAGG CTATGGCAGA 1620

AAAGCAGATA TCTGGAGCGT AGCATGTACG GTGGTGGAGA TGCTAACTGA AAAGCCACCT 1680

TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAGATCG CCACTCAGCC AACAAACCCA 1740

AAGCTGCCAC CTCATGTCTC AGACTATACT CGGGACTTTC TCAAACGGAT TTTTGTAGAG 1800

GCCAAACTCC GACCTTCAGC CGAGGAGCTC CTGCGGCACC TGTTCGTGCA TTGCCACTAG 1860

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         w+ ++++g+G+fg+vy+++dvdtg+ lavK+v+++p++ +++kev+al++Ei+llk+l H

Q: 356   WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPDSPETSKEVNALECEIQLLKNLLH  415

         78899*******************************************************

S: 61    enivkyyGv..eveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLH  118

         e+iv+yyG+  + +e++l+if+Ey++gGs++++l++yg+l+e+v++kyt+qileg++yLH

Q: 416   ERIVQYYGClrDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH  475

         *********777899*********************************************

S: 119   ekkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         +++ivHRDiKgaNil ds+g++kl+DFGaskrl++++ + + ++s+tGt+++m+PEvi++

Q: 476   SNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISG  535

         **********************************************************99

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         +  gygrkaDiWs++c+v+emlt+k+P+ae+ e++a++fk++++ t+P++p ++s+ ++d

Q: 536   E--GYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD  592

         8..****************************.9***************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++++ +++k rpsaeeLL+h f+

Q: 593   FLKRIF-VEAKLRPSAEELLRHLFV  616

         ******.899************996

Domain Sequence
(FASTA)

WRLGKLLGQG AFGRVYLCYD VDTGRELAVK QVQFNPDSPE TSKEVNALEC EIQLLKNLLH 60

ERIVQYYGCL RDPQEKTLSI FMEYMPGGSI KDQLKAYGAL TENVTRKYTR QILEGVHYLH 120

SNMIVHRDIK GANILRDSTG NIKLGDFGAS KRLQTICLSG TGMKSVTGTP YWMSPEVISG 180

EGYGRKADIW SVACTVVEML TEKPPWAEFE AMAAIFKIAT QPTNPKLPPH VSDYTRDFLK 240

RIFVEAKLRP SAEELLRHLF V 261

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0071260	; P:cellular response to mechanical stimulus
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013