EKS-RAN-00313
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00313
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR501.45.9E-151691948258
StatusUnreviewed
Ensembl ProteinENSRNOP00000054686
UniProt AccessionF1M7X4;
Protein Name
Protein Synonyms/Alias Receptor tyrosine-protein kinase erbB-4;
Gene NameErbb4
Gene Synonyms/Alias Erbb4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000014248ENSRNOP00000019283ENSRNOT00000019283
ENSRNOG00000014248ENSRNOP00000054686ENSRNOT00000057877
OrganismRattus norvegicus
Functional Description
Protein Length1265
Protein Sequence
(FASTA)
SVCAGTENKL SSLSDLEQQY RALRKYYENC EVVMGNLEIT SIEHNRDLSF LRSIREVTGY 60
VLVALNQFRY LPLENLRIIR GTKLYEDRYA LAIFLNYRKD GNFGLQELGL KNLTEILNGG 120
VYVDQNKFLC YADTIHWQDI VRNPWPSNMT LVSTIGSSGC GRCHKSCTGR CWGPTENHCQ 180
TLTRTVCAEQ CDGRCYGPYV SDCCHRECAG GCSGPKDTDC FACMNFNDSG ACVTQCPQTF 240
VYNPTTFQLE HNFNAKYTYG AFCVKKCPHN FVVDSSSCVR ACPSSKMEVE ENGIKMCKPC 300
TDICPKACDG IGTGSLMSAQ TVDSNIDKFI NCTKINGNLI FLVTGIHGDP YNAIDAIDPE 360
KLNVFRTVRE ITGFLNIQSW PPNMTDFSVF SNLVTIGGRV LYSGLSLLIL KQQGITSLQF 420
QSLKEISAGN IYITDNSNLC YYHTINWTTL FSTVNQRIVI RDNRRAENCT AEGMVCNHLC 480
SNDGCWGPGP DQCLSCRRFS RGKICIESCN LYDGEFREFE NGSICVECDS QCEKMEDGLL 540
TCHGPGPDNC TKCSHFKDGP NCVEKCPDGL QGANSFIFKY ADQDRECHPC HPNCTQGCNG 600
PTSHDCIYYP WTGHSTLPQH ARTPLIAAGV IGGLFILVIM ALTFAVYVRR KSIKKKRALR 660
RFLETELVEP LTPSGTAPNQ AQLRILKETE LKRVKVLGSG AFGTVYKGIW VPEGETVKIP 720
VAIKILNETT GPKANVEFMD EALIMASVDH PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY 780
VHEHKDNIGS QLLLNWCVQI AKGMMYLEER RLVHRDLAAR NVLVKSPNHV KITDFGLARL 840
LEGDEKEYNA DGGKMPIKWM ALECIHYRKF THQSDVWSYG VTIWELMTFG GKPYDGIPTR 900
EIPDLLEKGE RLPQPPICTI DVYMVMVKCW MIDADSRPKF KELAAEFSRM ARDPQRYLVI 960
QGDDRMKLPS PNDSKFFQNL LDEEDLEDMM DAEEYLVPQA FNIPPPIYTS RTRIDSNRNQ 1020
FVYQDGGFAT QQGMPMPYRA TTSTIPEAPV AQGATAEMFD DSCCNGTLRK PVVPHVQEDS 1080
STQRYSADPT VFAPERNPRA ELDEEGYMTP MHDKPKQEYL NPVEENPFVS RRKNGDLQAL 1140
DNPEYHSASS GPPKAEDEYV NEPLYLNTFT NALGNAEYMK NSLLSVPEKA KKAFDNPDYW 1200
NHSLPPRSTL QHPDYLQEYS TKYFYKQNGR IRPIVAENPE YLSEFSLKPG TMLPPPPYRH 1260
RNTVV 1265
Nucleotide Sequence
(FASTA)
TCAGTGTGTG CCGGAACAGA GAACAAACTG AGCTCTCTCT CTGATCTGGA GCAGCAGTAC 60
CGAGCCTTGC GCAAATACTA TGAAAACTGC GAGGTAGTCA TGGGCAACCT GGAGATCACC 120
AGCATAGAGC ACAACCGGGA CCTCTCCTTC CTGCGGTCTA TCCGAGAAGT CACAGGCTAT 180
GTACTTGTGG CCCTCAACCA GTTTCGTTAC CTGCCTCTGG AGAATTTACG CATTATTCGT 240
GGGACAAAAC TGTATGAAGA TCGCTATGCC TTAGCAATAT TCTTAAACTA CAGGAAAGAT 300
GGCAACTTTG GACTTCAAGA ACTGGGATTA AAGAACCTGA CCGAAATACT AAATGGTGGA 360
GTCTATGTAG ACCAGAACAA ATTCCTATGT TATGCTGATA CTATACACTG GCAAGATATT 420
GTTCGGAATC CATGGCCTTC CAACATGACT CTGGTGTCAA CAATTGGAAG TTCTGGATGC 480
GGAAGATGCC ATAAGTCTTG CACTGGTCGA TGCTGGGGAC CCACAGAAAA TCACTGCCAG 540
ACCTTGACCA GGACTGTGTG TGCTGAACAA TGTGATGGCA GGTGCTATGG ACCCTACGTC 600
AGTGACTGCT GCCATCGAGA ATGTGCCGGA GGCTGCTCAG GACCAAAAGA CACTGACTGC 660
TTTGCCTGCA TGAACTTCAA TGACAGTGGA GCCTGTGTTA CTCAGTGTCC CCAAACGTTC 720
GTCTACAATC CAACCACCTT TCAACTGGAA CACAACTTCA ATGCAAAGTA CACATATGGA 780
GCATTCTGTG TTAAGAAATG TCCACATAAC TTCGTGGTAG ATTCCAGTTC TTGTGTACGA 840
GCCTGCCCTA GTTCCAAGAT GGAAGTCGAA GAAAATGGAA TTAAAATGTG TAAGCCTTGC 900
ACTGATATTT GCCCCAAAGC ATGTGATGGA ATCGGCACCG GATCCTTGAT GTCTGCTCAG 960
ACTGTGGATA GTAACATTGA CAAATTCATA AACTGCACCA AGATCAACGG GAATCTCATC 1020
TTTCTTGTCA CTGGCATTCA TGGTGACCCT TACAATGCTA TTGACGCCAT AGACCCAGAG 1080
AAACTGAATG TCTTTCGGAC AGTCAGAGAA ATAACAGGTT TCCTGAACAT ACAATCTTGG 1140
CCCCCAAATA TGACAGATTT CAGTGTTTTC TCCAACCTTG TAACCATTGG AGGAAGAGTC 1200
CTCTACAGTG GTCTCTCATT GCTTATCCTC AAACAACAAG GTATCACTTC ACTACAGTTC 1260
CAGTCTCTGA AGGAAATCAG TGCGGGCAAT ATCTACATCA CGGACAACAG CAACCTGTGT 1320
TATTACCACA CCATCAACTG GACAACACTG TTCAGCACCG TTAACCAGAG GATAGTGATC 1380
CGAGACAACA GGAGGGCTGA GAACTGTACT GCTGAAGGGA TGGTGTGTAA CCACCTGTGT 1440
TCAAATGATG GTTGTTGGGG ACCTGGGCCA GACCAGTGTC TGTCATGTCG GCGCTTCAGC 1500
AGGGGAAAGA TCTGTATAGA GTCCTGCAAC CTTTATGATG GGGAGTTTCG AGAGTTTGAA 1560
AACGGCTCCA TCTGTGTTGA GTGTGACTCC CAGTGTGAGA AAATGGAAGA CGGACTCCTC 1620
ACATGCCATG GACCGGGACC TGACAACTGT ACAAAGTGTT CTCATTTTAA AGATGGTCCT 1680
AACTGTGTAG AGAAATGTCC AGATGGCCTA CAGGGAGCAA ACAGTTTCAT ATTTAAGTAC 1740
GCAGATCAGG ATCGGGAGTG CCACCCTTGC CATCCAAACT GCACCCAGGG GTGTAACGGT 1800
CCCACTAGTC ATGACTGCAT TTACTACCCA TGGACGGGCC ATTCCACTTT ACCACAACAT 1860
GCTAGAACTC CACTGATTGC AGCCGGAGTC ATTGGAGGGC TCTTCATCCT GGTCATCATG 1920
GCTCTGACAT TTGCCGTTTA TGTCAGAAGG AAGAGCATCA AAAAGAAACG CGCTTTGAGA 1980
AGATTCCTGG AGACAGAGCT AGTCGAGCCC TTAACCCCTA GTGGCACAGC ACCCAATCAA 2040
GCTCAACTTC GAATTTTGAA GGAAACAGAG CTAAAGAGGG TAAAAGTCCT TGGCTCGGGA 2100
GCATTTGGAA CCGTTTATAA AGGAATCTGG GTGCCTGAAG GTGAAACTGT GAAAATCCCT 2160
GTGGCTATTA AGATCCTCAA TGAGACAACT GGCCCCAAAG CCAATGTGGA GTTCATGGAT 2220
GAGGCACTGA TTATGGCAAG TGTGGATCAC CCACACCTAG TGCGTTTACT GGGTGTGTGT 2280
CTGAGCCCCA CTATCCAGTT GGTTACTCAG TTGATGCCAC ATGGCTGCCT ACTGGAATAT 2340
GTCCACGAAC ACAAGGATAA CATCGGATCA CAGCTGCTGT TGAACTGGTG TGTCCAGATT 2400
GCTAAGGGAA TGATGTATCT GGAGGAAAGG CGGCTTGTTC ATCGGGATCT GGCAGCCCGC 2460
AATGTGTTGG TGAAATCTCC AAATCATGTT AAAATCACAG ACTTTGGACT GGCCCGGCTC 2520
TTGGAAGGAG ATGAAAAAGA ATACAATGCT GACGGTGGCA AGATGCCAAT TAAATGGATG 2580
GCTCTGGAAT GTATACATTA TAGGAAATTC ACACATCAAA GCGATGTTTG GAGCTACGGT 2640
GTCACTATAT GGGAACTGAT GACCTTTGGA GGAAAGCCCT ATGATGGAAT TCCAACGCGA 2700
GAAATCCCTG ACTTATTAGA GAAGGGAGAG CGTTTGCCTC AACCTCCCAT CTGCACTATT 2760
GACGTTTACA TGGTCATGGT CAAATGTTGG ATGATCGATG CTGACAGCAG ACCTAAATTC 2820
AAAGAACTGG CTGCTGAGTT TTCAAGGATG GCTAGAGACC CTCAAAGATA CCTAGTAATT 2880
CAGGGGGATG ATCGCATGAA GCTTCCCAGT CCAAACGACA GCAAATTCTT CCAGAATCTC 2940
TTGGATGAAG AGGATTTGGA AGATATGATG GACGCTGAGG AATATTTGGT CCCCCAGGCT 3000
TTCAATATCC CACCTCCTAT CTACACATCC AGAACAAGAA TTGACTCCAA TAGGAATCAG 3060
TTTGTGTACC AGGATGGGGG TTTCGCTACA CAACAAGGAA TGCCCATGCC CTACCGAGCC 3120
ACAACCAGCA CCATACCAGA GGCTCCAGTC GCCCAGGGTG CAACGGCTGA GATGTTTGAT 3180
GACTCCTGCT GTAATGGTAC CCTGCGAAAG CCAGTGGTAC CCCACGTCCA AGAGGACAGT 3240
AGCACTCAGA GGTATAGTGC CGACCCCACA GTGTTCGCCC CAGAACGGAA CCCTCGAGCA 3300
GAACTGGATG AAGAAGGCTA CATGACTCCC ATGCATGACA AGCCAAAACA AGAATATCTG 3360
AATCCTGTGG AAGAGAACCC TTTTGTGTCC CGGAGGAAGA ATGGAGACCT TCAAGCTTTA 3420
GATAATCCAG AGTATCACAG CGCTTCCAGC GGTCCCCCCA AGGCAGAGGA TGAGTACGTG 3480
AATGAGCCCC TTTATCTCAA CACCTTCACC AACGCCTTGG GAAATGCAGA GTACATGAAA 3540
AACAGCTTAC TGTCTGTGCC AGAGAAAGCC AAGAAAGCAT TTGACAACCC CGACTACTGG 3600
AACCACAGCC TGCCACCCCG GAGCACTCTT CAGCACCCAG ACTACCTGCA GGAATACAGC 3660
ACAAAATATT TTTATAAACA GAATGGACGG ATCCGCCCTA TTGTGGCAGA GAATCCTGAG 3720
TACCTCTCAG AGTTCTCGCT GAAGCCAGGC ACTATGCTGC CCCCTCCGCC CTACAGACAC 3780
CGGAATACTG TGGTGTGA 3798
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 691   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASVDH  750
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gcll+yv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 751   PHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  810
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 811   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  870
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 871   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  930
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela+efs
Q: 931   MIDADSRPKFKELAAEFS  948
         ****************96
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASVDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-CII-00175
EKS-CIS-00072
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MAM-00300
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0061026; P:cardiac muscle tissue regeneration
GO:0045165; P:cell fate commitment
GO:0021551; P:central nervous system morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0007507; P:heart development
GO:0007595; P:lactation
GO:0060749; P:mammary gland alveolus development
GO:0060644; P:mammary gland epithelial cell differentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0001755; P:neural crest cell migration
GO:0021889; P:olfactory bulb interneuron differentiation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013