EKS-RAN-00302
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00302
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR330.88.7E-99202503302
StatusReviewed
Ensembl ProteinENSRNOP00000020103
UniProt AccessionQ62893; Q63045; Q9R0A7;
Protein NameAnti-Muellerian hormone type-2 receptor
Protein Synonyms/Alias Anti-Muellerian hormone type II receptor; AMH type II receptor; C14; MIS type II receptor; MISRII; MRII;
Gene NameAmhr2
Gene Synonyms/Alias Amhr2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000014850ENSRNOP00000020103ENSRNOT00000020103
OrganismRattus norvegicus
Functional DescriptionOn ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Protein Length557
Protein Sequence
(FASTA)
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EVVDAGPGPP KGIRCLYSHC 60
CFGIWNLTHG RAQVEMQGCL DSDEPGCESL HCDPVPRAHP SPSSTLFTCS CGTDFCNANY 120
SHLPPSGNRG APGPQEPQAT PGGPIWMAQL LLGVFLVLLL SIIILALLQR KACRVQGGSD 180
PEPEPGSGGD CSEELPELAE LRFSQVIQEG GHAVVWAGRL QGEMVAIKAF PPRAVAQFRA 240
ERAVYQLLGL QHNHIVRFIT AGQGGPGPLP SGPLLVLELY PKGSLCHYLT QYTSDWGSSL 300
RMALSLAEGL AFLHGERWQD GQYKPGIAHR DLSSQNVLIR EDRSCAIGDL GLALVLPGLA 360
QPPALAPTQP RGPAAILEAG TQRYMAPELL DKTLDLQDWG TALQRADVYS LALLLWEILS 420
RCSDLRPDHR PPPFQLAYEA ELGSNPSACE LWALAVAERK RPNIPSSWSC SATDPRGLRE 480
LLEDCWDADP EARLTAECVQ QRLAALAYPQ VASSFPESCP QGCPENCPAA PASAAFPCRP 540
QQSSCLLSVQ QGSGSKS 557
Nucleotide Sequence
(FASTA)
ATGCTGGGGA CACTGGGGCT TTGGACACTG CTTCCTGCAG CTGCACAAGT ATCCCCAAAC 60
AGGAGGACCT GTGTGTTCTT TGAGGCTCCT GGAGTTCGGG GAAGCACAAA AACACTGGGG 120
GAAGTGGTAG ATGCAGGACC AGGCCCCCCG AAGGGTATCC GCTGCCTCTA CAGCCATTGC 180
TGCTTTGGGA TCTGGAATCT GACCCATGGC CGGGCACAAG TGGAGATGCA AGGATGCCTA 240
GACAGTGATG AACCCGGCTG TGAGTCCCTC CACTGTGACC CCGTCCCCCG AGCGCACCCC 300
AGCCCCAGCT CCACACTCTT CACATGCTCC TGCGGTACCG ACTTCTGCAA TGCCAACTAC 360
AGCCATCTGC CTCCTTCAGG AAACCGAGGG GCTCCCGGCC CCCAGGAGCC TCAGGCTACC 420
CCAGGTGGGC CCATCTGGAT GGCGCAGCTG CTGCTGGGAG TGTTCCTTGT GCTGCTGCTG 480
AGTATCATCA TCTTGGCCCT GTTACAACGA AAAGCCTGTA GAGTGCAAGG TGGGTCAGAC 540
CCGGAGCCGG AGCCAGGCTC AGGAGGAGAC TGCAGTGAGG AACTGCCCGA GTTGGCTGAG 600
CTGCGCTTCT CCCAGGTAAT CCAGGAAGGA GGTCATGCAG TCGTCTGGGC TGGGAGGCTC 660
CAGGGTGAGA TGGTAGCCAT CAAGGCCTTC CCCCCAAGGG CTGTGGCCCA GTTCCGAGCT 720
GAGCGAGCTG TGTACCAGCT GCTAGGCCTA CAGCATAACC ACATTGTTCG CTTTATCACT 780
GCTGGCCAGG GAGGCCCTGG CCCCTTGCCC TCTGGGCCTT TGCTGGTACT GGAACTGTAC 840
CCTAAGGGCT CCTTATGCCA CTACTTGACT CAGTACACGA GCGACTGGGG CAGTTCCTTG 900
AGGATGGCTC TGTCCCTGGC CGAGGGCCTG GCGTTTCTCC ACGGGGAGCG TTGGCAGGAT 960
GGCCAGTACA AACCAGGTAT CGCTCACCGA GACCTGAGCA GCCAGAATGT GCTCATTCGG 1020
GAAGATAGGT CATGTGCCAT CGGAGACCTG GGCCTTGCCT TGGTACTCCC TGGCCTTGCT 1080
CAGCCCCCTG CCTTGGCCCC TACTCAACCC CGAGGCCCAG CTGCCATTTT GGAGGCTGGC 1140
ACCCAGAGGT ACATGGCTCC GGAGCTCTTG GACAAGACTC TAGACCTGCA GGACTGGGGC 1200
ACAGCTCTCC AGAGAGCGGA TGTTTACTCT CTGGCTCTAC TACTGTGGGA GATCCTGAGC 1260
CGCTGTTCCG ATTTGAGGCC TGACCACAGA CCACCACCTT TTCAATTGGC TTATGAGGCA 1320
GAACTGGGCA GCAATCCCAG TGCCTGTGAG CTCTGGGCCC TGGCGGTCGC GGAGAGGAAG 1380
CGCCCCAACA TCCCTTCCTC TTGGAGCTGC TCTGCCACAG ACCCTAGGGG GCTGAGGGAG 1440
CTCCTGGAAG ATTGCTGGGA CGCAGACCCA GAAGCAAGGC TGACAGCTGA GTGTGTGCAG 1500
CAGCGCCTGG CAGCCCTGGC TTATCCTCAG GTGGCTTCCT CCTTCCCAGA GAGCTGTCCA 1560
CAGGGCTGCC CAGAGAACTG CCCTGCAGCG CCTGCCTCTG CGGCTTTCCC CTGCAGGCCT 1620
CAGCAGAGTT CTTGTCTCCT CAGTGTTCAG CAAGGCTCTG GCTCTAAGTC CTGA 1674
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
         +++++i++G ++ Vw+++l+ge+vA+K+f+ +  a++++E+++yq+  l+h++i++fi+a
Q: 202   RFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHNHIVRFITA  261
         6889********************************************************
S: 62    dk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120
          +     + +  llv+e+++kgsL++yL+++t+d+ ++lr+alsla+Gla+LH e ++++
Q: 262   GQgGPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHGE-RWQD  320
         **88999************************************************.8999
S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee........ldlaansqvG  172
         g++Kp iaHRDl+s+N+l+++d++c+i+DlGLal l   ++         +  aa+ ++G
Q: 321   GQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLAQPpalaptqpRGPAAILEAG  380
         **********************************776665555888888888899*****
S: 173   tkRYmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfee  229
         t+RYmaPE+l+++l+l+d+  a++raDvYsl+L+lWE++sRc++  +d++ ++++l++e+
Q: 381   TQRYMAPELLDKTLDLQDWGtALQRADVYSLALLLWEILSRCSDlrPDHRPPPFQLAYEA  440
         *******************99***********************999*************
S: 230   vvgsdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvk  288
         ++gs+Ps+ e++++ v +++rP+ip++w++++ + + l++lle+cWdadpeaRlta++v+
Q: 441   ELGSNPSACELWALAVAERKRPNIPSSWSCSAtDPRGLRELLEDCWDADPEARLTAECVQ  500
         *****************************998799*************************
S: 289   krl  291
         +rl
Q: 501   QRL  503
         986
Domain Sequence
(FASTA)
RFSQVIQEGG HAVVWAGRLQ GEMVAIKAFP PRAVAQFRAE RAVYQLLGLQ HNHIVRFITA 60
GQGGPGPLPS GPLLVLELYP KGSLCHYLTQ YTSDWGSSLR MALSLAEGLA FLHGERWQDG 120
QYKPGIAHRD LSSQNVLIRE DRSCAIGDLG LALVLPGLAQ PPALAPTQPR GPAAILEAGT 180
QRYMAPELLD KTLDLQDWGT ALQRADVYSL ALLLWEILSR CSDLRPDHRP PPFQLAYEAE 240
LGSNPSACEL WALAVAERKR PNIPSSWSCS ATDPRGLREL LEDCWDADPE ARLTAECVQQ 300
RL 302
KeywordATP-binding; Complete proteome; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00268
EKS-ANC-00275
EKS-BOT-00286
EKS-CAJ-00292
EKS-CAF-00292
EKS-CAP-00321
EKS-EQC-00278
EKS-FEC-00272
EKS-GOG-00285
EKS-HOS-00292
EKS-ICT-00271
EKS-LOA-00296
EKS-MAM-00288
EKS-MAE-00019
EKS-MIM-00022
EKS-MUM-00317
EKS-MUP-00282
EKS-MYL-00288
EKS-NOL-00264
EKS-ORC-00268
EKS-OTG-00292
EKS-PAT-00271
EKS-POA-00278
EKS-PTV-00042
EKS-SAH-00268
EKS-SUS-00251
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0042562; F:hormone binding
GO:0046872; F:metal ion binding
GO:0005026; F:transforming growth factor beta receptor activity, type II
GO:0007548; P:sex differentiation
GO:0007179; P:transforming growth factor beta receptor signaling pathway
KEGG
rno:29530;
InterPros
IPR000472; Activin_rcpt.
IPR015771; Anti-muellerian_hrmn_rcpt_II.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
Prints
Created Date20-Feb-2013