EKS-RAN-00150
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00150
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/NDR507.31.6E-1527051010306
StatusUnreviewed
Ensembl ProteinENSRNOP00000020098
UniProt AccessionF1M2K4;
Protein Name
Protein Synonyms/Alias
Gene NameLats1
Gene Synonyms/Alias Lats1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000014916ENSRNOP00000020098ENSRNOT00000020098
OrganismRattus norvegicus
Functional Description
Protein Length1130
Protein Sequence
(FASTA)
MKRGEKPEGY RQMRPKTFPA SNYSGSSRQM LQEIRESLRN LSKPSDAAKA EHNLNKMSTE 60
DPRQVRNPPK FGTHHKALQE IRNSLLPFAN ETSSSRIPSE VNPQMFQDLQ AAGFDEDMVI 120
QALQKTNNRS IEAAVEFISK MSYQDPRREQ MAAAAARPIN ATMKPGNVQH SISRKQSWKG 180
SKESLVPQRH GPSLGENVVY RSESPNSQAD VGRPLSGSGI TAFAQAHPSN GQRVNPPPPP 240
QVRSVTPPPP PRGQTPPPRG TTPPPPSWEP NSQTKRYSGN MEYVISRISP VPPGAWQEGY 300
PPPPLNTSPM NPPNQGQRGI SSVPVGRQPI IMQSTSKFNF TPGRPGVQNG GGQTDFIMHQ 360
NVVPTGAVNR QPPPPYPLTP ANGQSPSALQ AGGPAAPPSF SNGNVPPTMM VPNRNSHNME 420
LYNINVPGLQ TTWPQSSSAP VQSSPSSGHE IPTWQPNIPV RSNSFNNPLG SRASHSANSQ 480
PSATTVTAIT PAPIQQPVKS MRVLKPELQT ALAPTHPSWM PQPVQTVQPS PFSEGAASNV 540
PVIPPVAEAP SYQGPPPPYP KHLLHQTPSV PPYESASKPC KDDQPSSAKE EDSEKSLDSV 600
DSGDKEKKQI TTSPITVRKN KKDEERRESR IQSYSPQAFK FFMEQHVENV LKSHQQRLHR 660
KKQLENEMMR VGLSQDAQDQ MRKMLCQKES NYIRLKRAKM DKSMFVKIKT LGIGAFGEVC 720
LARKVDTKAL YATKTLRKKD VLLRNQVAHV KAERDILAEA DNEWVVRLYY SFQDKDNLYF 780
VMDYIPGGDM MSLLIRMGIF PENLARFYIA ELTCAVESVH KMGFIHRDIK PDNILIDRDG 840
HIKLTDFGLC TGFRWTHDSK YYQSGDHPRQ DSMDFSSEWG DPSNCRCGDR LKPLERRAAR 900
QHQRCLAHSL VGTPNYIAPE VLLRTGYTQL CDWWSVGVIL FEMLVGQPPF LAQTPLETQM 960
KVINWQTSLH IPPQAKLSPE ASDLIIKLCR GPEDRLGKNG ADEIKAHPFF KTIDFSSDLR 1020
QQSASYIPKI THPTDTSNFD PVDPDKLWSD GNEEENINDT LNGWYKNGKH PEHAFYEFTF 1080
RRFFDDNGYP YNYPKPIEYE YVSSQGSEQQ SDEDDQHTGS DVNNRDLVYV 1130
Nucleotide Sequence
(FASTA)
ATGAAGAGGG GTGAAAAGCC AGAAGGGTAC AGACAGATGA GGCCTAAGAC CTTTCCTGCC 60
AGCAACTACT CTGGCAGCAG CCGACAAATG CTGCAGGAGA TCCGAGAATC CCTTAGGAAT 120
TTATCAAAGC CATCTGATGC CGCAAAGGCC GAGCATAACC TGAACAAGAT GTCGACCGAA 180
GATCCCAGGC AGGTGAGAAA TCCGCCCAAA TTTGGCACAC ATCATAAAGC CTTGCAAGAA 240
ATTCGAAACT CTCTACTACC TTTCGCAAAC GAGACGAGTT CTTCCCGGAT CCCTTCAGAA 300
GTTAATCCAC AGATGTTTCA GGATTTGCAG GCTGCTGGCT TTGATGAGGA TATGGTTATT 360
CAAGCTCTTC AGAAAACCAA TAACAGAAGC ATAGAAGCAG CTGTTGAATT CATTAGTAAA 420
ATGAGTTATC AGGATCCTCG TCGAGAGCAG ATGGCTGCAG CAGCTGCCAG ACCTATCAAT 480
GCCACCATGA AACCAGGAAA TGTGCAACAT TCAATTAGCC GAAAACAAAG CTGGAAAGGT 540
TCTAAAGAGT CTTTAGTTCC TCAGAGACAC GGTCCATCTC TAGGAGAAAA TGTGGTTTAT 600
CGATCTGAAA GTCCCAACTC ACAGGCGGAT GTAGGAAGAC CTCTGTCTGG ATCCGGCATT 660
ACGGCATTTG CTCAAGCTCA CCCAAGCAAT GGACAGAGAG TGAACCCACC ACCACCACCT 720
CAAGTTAGGA GTGTTACTCC TCCACCACCT CCACGAGGGC AGACCCCACC TCCACGAGGC 780
ACAACTCCCC CTCCCCCCTC GTGGGAGCCT AACTCTCAGA CAAAGCGCTA CTCTGGGAAC 840
ATGGAATATG TAATCTCCCG AATCTCTCCT GTTCCACCTG GGGCGTGGCA GGAGGGCTAC 900
CCTCCACCAC CTCTTAACAC TTCCCCCATG AATCCCCCCA ACCAGGGACA GAGAGGCATC 960
AGTTCTGTTC CAGTTGGCAG GCAACCAATC ATCATGCAAA GTACTAGCAA ATTTAACTTT 1020
ACACCAGGGA GACCTGGAGT TCAGAATGGT GGTGGTCAGA CTGATTTTAT CATGCACCAA 1080
AATGTTGTCC CCACTGGTGC TGTGAATCGG CAACCACCAC CACCATATCC TCTGACCCCA 1140
GCTAATGGAC AAAGCCCTTC TGCTTTGCAA GCAGGCGGTC CTGCTGCTCC ACCATCATTC 1200
TCCAATGGAA ATGTTCCTCC AACGATGATG GTGCCGAACA GGAACAGTCA TAACATGGAG 1260
CTGTATAATA TCAATGTCCC TGGACTGCAA ACAACTTGGC CCCAGTCGTC TTCTGCCCCT 1320
GTGCAATCAT CTCCAAGCAG TGGGCATGAA ATTCCTACGT GGCAACCTAA CATACCAGTG 1380
AGGTCAAATT CTTTTAATAA CCCACTAGGA AGTAGAGCAA GTCACTCTGC TAATTCTCAG 1440
CCTTCCGCCA CGACAGTTAC TGCCATCACA CCAGCTCCTA TTCAGCAGCC CGTGAAAAGC 1500
ATGCGCGTTC TGAAACCAGA GCTGCAGACT GCCTTAGCCC CAACCCATCC TTCTTGGATG 1560
CCACAGCCAG TTCAGACCGT TCAGCCTAGC CCTTTTTCTG AGGGTGCAGC TTCAAACGTG 1620
CCAGTCATCC CACCTGTGGC GGAAGCTCCA AGCTATCAGG GCCCACCACC ACCTTATCCA 1680
AAACATCTGC TACACCAAAC CCCATCTGTT CCTCCATATG AGTCAGCGAG TAAACCCTGC 1740
AAAGACGATC AGCCTAGCTC AGCCAAGGAA GAGGATAGTG AAAAGAGTTT GGACAGTGTT 1800
GACTCTGGGG ATAAAGAGAA GAAACAGATT ACAACTTCAC CTATCACTGT TCGGAAAAAC 1860
AAGAAAGACG AAGAGCGAAG AGAGTCTCGC ATTCAGAGTT ACTCCCCGCA GGCCTTTAAA 1920
TTCTTCATGG AGCAACACGT AGAGAACGTC CTGAAGTCTC ATCAGCAGCG TCTGCATCGC 1980
AAGAAGCAAC TAGAGAATGA AATGATGCGG GTTGGATTAT CTCAAGATGC CCAGGATCAA 2040
ATGAGAAAGA TGCTTTGCCA GAAAGAGTCT AACTATATTC GTCTTAAAAG GGCTAAAATG 2100
GACAAGTCTA TGTTTGTAAA GATAAAGACA TTAGGAATAG GAGCATTTGG TGAAGTCTGT 2160
CTAGCAAGAA AAGTCGATAC GAAAGCTTTG TATGCAACAA AAACTCTACG AAAGAAAGAC 2220
GTTCTGCTCC GAAATCAGGT GGCTCATGTG AAAGCTGAGC GAGATATCCT AGCAGAAGCT 2280
GACAACGAGT GGGTGGTCCG CTTGTACTAC TCATTCCAGG ACAAGGACAA CTTGTACTTT 2340
GTGATGGACT ACATTCCTGG GGGTGATATG ATGAGCCTGT TAATTAGAAT GGGCATCTTT 2400
CCCGAAAACC TGGCACGATT CTACATAGCA GAACTTACCT GTGCAGTTGA AAGTGTTCAT 2460
AAAATGGGTT TTATTCATAG AGACATTAAA CCTGATAACA TTTTGATTGA CCGAGATGGA 2520
CATATTAAAT TGACTGACTT TGGCTTGTGC ACTGGCTTCA GATGGACACA TGACTCCAAG 2580
TACTACCAGA GTGGGGATCA CCCACGGCAA GATAGCATGG ATTTCAGTAG CGAATGGGGA 2640
GATCCTTCCA ACTGTCGGTG TGGGGACAGA CTGAAGCCAC TAGAGCGGAG AGCTGCTCGC 2700
CAGCACCAGC GATGTCTAGC TCACTCTCTG GTTGGGACTC CCAACTATAT AGCACCTGAA 2760
GTGCTACTAC GGACAGGATA TACACAGCTG TGTGATTGGT GGAGTGTTGG TGTTATTCTT 2820
TTTGAAATGT TGGTGGGACA ACCTCCTTTC TTGGCACAAA CACCATTAGA AACCCAAATG 2880
AAGGTTATCA ACTGGCAAAC TTCTCTTCAC ATCCCACCTC AAGCCAAGCT CAGTCCTGAA 2940
GCCTCTGACC TCATTATCAA ACTTTGCCGA GGACCAGAAG ACCGTCTAGG CAAGAACGGT 3000
GCTGATGAAA TAAAGGCTCA TCCATTTTTT AAGACCATTG ATTTCTCTAG TGATCTGAGA 3060
CAGCAGTCTG CTTCATACAT CCCCAAAATC ACGCACCCAA CAGACACGTC CAATTTTGAC 3120
CCTGTTGACC CTGATAAGTT GTGGAGCGAT GGTAACGAGG AAGAAAATAT CAACGACACT 3180
CTGAACGGAT GGTATAAAAA CGGAAAGCAC CCTGAGCATG CTTTCTATGA GTTTACCTTT 3240
CGGAGGTTCT TTGATGACAA TGGCTACCCA TATAATTATC CAAAGCCCAT CGAATATGAA 3300
TACGTTAGTT CCCAGGGCTC AGAGCAGCAG TCCGATGAAG ACGATCAACA CACAGGCTCA 3360
GATGTAAACA ACCGTGATCT AGTGTATGTT TAA 3393
Domain Profile
S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60
         f k+k++g+GafGev+l+rk dtk++ya+k+lrkkd+l +nqvahvkaerdilaead+ew
Q: 705   FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW  764
         889*********************************************************
S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120
         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+++i++e+larfyiael++avesvhk+Gf
Q: 765   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF  824
         ************************************************************
S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173
         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ ++ ++d++++s+       
Q: 825   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSSewgdpsn  884
         **************************************************9999******
S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228
              +lk+lerr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvil+eml
Q: 885   crcgdRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML  944
         ************************************************************
S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288
         vG+pPfla+tp et++kvinw+++l++p++++ls+ea+dli +l+  +e+rlgk+G+dei
Q: 945   VGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEI  1004
         ************************************************************
S: 289   kkhpff  294
         k+hpff
Q: 1005  KAHPFF  1010
         *****9
Domain Sequence
(FASTA)
FVKIKTLGIG AFGEVCLARK VDTKALYATK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60
VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMGIFPENL ARFYIAELTC AVESVHKMGF 120
IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHPRQDSMD FSSEWGDPSN 180
CRCGDRLKPL ERRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILFEML 240
VGQPPFLAQT PLETQMKVIN WQTSLHIPPQ AKLSPEASDL IIKLCRGPED RLGKNGADEI 300
KAHPFF 306
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00146
EKS-ANC-00146
EKS-BOT-00153
EKS-CAE-00122
EKS-CAJ-00158
EKS-CAF-00161
EKS-CAP-00153
EKS-CII-00092
EKS-DAR-00439
EKS-DIO-00082
EKS-DRM-00073
EKS-EQC-00151
EKS-ERE-00024
EKS-FEC-00144
EKS-GAG-00131
EKS-GAA-00180
EKS-GOG-00152
EKS-HOS-00159
EKS-ICT-00147
EKS-LAC-00162
EKS-LOA-00153
EKS-MAM-00150
EKS-MEG-00121
EKS-MOD-00153
EKS-MUM-00158
EKS-MUP-00158
EKS-MYL-00161
EKS-NOL-00146
EKS-OCP-00100
EKS-ORN-00188
EKS-ORA-00131
EKS-ORC-00144
EKS-ORL-00175
EKS-OTG-00159
EKS-PAT-00144
EKS-PES-00136
EKS-POA-00150
EKS-PTV-00143
EKS-SAH-00148
EKS-SOA-00027
EKS-SUS-00134
EKS-TAG-00181
EKS-TAR-00197
EKS-TAS-00057
EKS-TEN-00188
EKS-TUT-00146
EKS-VIP-00072
EKS-XET-00142
EKS-XIM-00182
Gene Ontology
GO:0005737; C:cytoplasm
GO:0000922; C:spindle pole
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0051220; P:cytoplasmic sequestering of protein
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0035329; P:hippo signaling cascade
GO:0009755; P:hormone-mediated signaling pathway
GO:0030216; P:keratinocyte differentiation
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0030833; P:regulation of actin filament polymerization
GO:0000819; P:sister chromatid segregation
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013