EKS-RAN-00193

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00193

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	512.9	2.7E-154	4	284	281

Status

Reviewed

Ensembl Protein

ENSRNOP00000050970

UniProt Accession

P20793; G3V7Y4; Q6AYW0;

Protein Name

Serine/threonine-protein kinase MAK

Protein Synonyms/Alias

Male germ cell-associated kinase;

Gene Name

Mak

Gene Synonyms/Alias

Mak;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000015101	ENSRNOP00000050970	ENSRNOT00000040707
ENSRNOG00000015101	ENSRNOP00000020672	ENSRNOT00000020672

Organism

Rattus norvegicus

Functional Description

Essential for the regulation of ciliary length andrequired for the long-term survival of photoreceptors (By similarity). Could play an important function in spermatogenesis. Phosphorylates FZR1 in a cell cycle-dependent manner (By similarity). Plays a role in the transcriptional coactivation of AR (By similarity).

Protein Length

581

Protein Sequence
(FASTA)

MNRYTTMRQL GDGTYGSVLM GKSNESGELV AIKRMKRKFY SWDECMNLRE VKSLKKLNHA 60

NVIKLKEVIR ENDHLYFIFE YMKENLYQLM KDRNKLFPES VIRNIMYQIL QGLAFIHKHG 120

FFHRDMKPEN LLCMGPELVK IADFGLAREL RSQPPYTDYV STRWYRAPEV LLRSSVYSSP 180

IDVWAVGSIM AELYTFRPLF PGTSEVDEIF KICQVLGTPK KSDWPEGYQL ASSMNFRFPQ 240

CIPINLKTLI PNASSEAIQL MTEMLNWDPK KRPTASQALK HPYFQVGQVL GPSAHHLDAK 300

QTLHKQLQPP EPKPSSSERD PKPLPNILDQ PAGQPQPKQG HQPLQAIQPP QNTVVQPPPK 360

QQGHHKQPQT MFPSIVKTIP TNPVSTVGHK GARRRWGQTV FKSGDSCDNI EDCDLGASHS 420

KKPSMDAFKE KKKKESPFRF PEAGLPVSNH LKGENRNLHA SLKSDTNLST ASTAKQYYLK 480

QSRYLPGVNP KNVSLVAGGK DINSHSWNNQ LFPKSLGSMG ADLAFKRSNA DYTWSTKTGQ 540

GQFSGRTYNP TAKNLNIVNR TQPVPSVHGR TDWVAKYGGH R 581

Nucleotide Sequence
(FASTA)

ATGAACCGAT ATACAACCAT GAGGCAGCTG GGGGACGGCA CGTACGGGAG TGTGCTTATG 60

GGCAAGAGCA ATGAGTCTGG GGAGCTGGTG GCAATCAAGA GGATGAAGAG AAAGTTCTAT 120

TCTTGGGATG AGTGTATGAA CTTGCGAGAA GTTAAGTCCC TGAAGAAACT CAATCATGCC 180

AATGTGATTA AACTAAAAGA AGTTATCAGA GAAAATGACC ATCTTTATTT TATATTTGAA 240

TATATGAAAG AAAACCTCTA TCAGCTAATG AAAGACAGAA ACAAACTGTT CCCTGAGTCA 300

GTCATCAGAA ATATTATGTA TCAAATACTA CAGGGGCTGG CATTTATCCA CAAACATGGC 360

TTTTTTCACA GGGACATGAA ACCTGAGAAT TTGCTTTGCA TGGGTCCAGA GCTGGTGAAG 420

ATTGCTGATT TTGGACTTGC GAGAGAATTA AGATCACAGC CACCATATAC TGACTATGTG 480

TCTACCAGAT GGTACCGTGC TCCTGAAGTT TTGCTAAGGT CTTCAGTGTA CAGCTCTCCC 540

ATTGACGTGT GGGCCGTGGG AAGTATAATG GCCGAGCTAT ATACGTTTAG ACCGCTTTTC 600

CCAGGGACCA GTGAAGTTGA TGAGATCTTT AAAATTTGCC AAGTGTTAGG GACTCCCAAG 660

AAAAGTGACT GGCCGGAGGG GTACCAGCTG GCATCCTCCA TGAACTTCCG CTTTCCCCAG 720

TGCATTCCTA TAAACCTGAA AACTCTCATT CCCAATGCCA GTAGTGAGGC TATTCAGCTT 780

ATGACAGAAA TGCTTAACTG GGATCCAAAG AAACGGCCAA CTGCAAGCCA GGCACTGAAG 840

CACCCATATT TTCAAGTCGG TCAGGTATTG GGCCCTTCTG CACACCATCT GGATGCAAAA 900

CAGACTTTGC ACAAGCAGCT GCAGCCTCCA GAGCCAAAGC CATCTTCCTC TGAACGGGAT 960

CCTAAGCCTT TGCCAAACAT CCTTGATCAG CCTGCCGGGC AGCCCCAGCC AAAACAGGGC 1020

CACCAACCAC TGCAGGCCAT TCAGCCACCA CAGAACACAG TGGTTCAGCC ACCTCCAAAG 1080

CAGCAGGGTC ACCATAAGCA ACCACAAACG ATGTTTCCAA GTATCGTCAA AACCATACCA 1140

ACGAATCCAG TCAGCACAGT AGGCCATAAG GGGGCCCGGA GACGGTGGGG TCAGACAGTC 1200

TTCAAGTCTG GAGACAGCTG TGACAACATC GAGGACTGCG ACTTGGGAGC CTCCCACTCC 1260

AAGAAGCCGA GCATGGATGC CTTCAAGGAA AAAAAGAAGA AGGAGTCTCC ATTTCGGTTT 1320

CCAGAAGCAG GACTCCCAGT CTCCAACCAC TTGAAGGGGG AAAATAGAAA TTTACATGCA 1380

TCCTTAAAAT CTGACACAAA CTTGTCAACT GCTTCAACCG CTAAGCAGTA CTATTTGAAA 1440

CAATCAAGAT ACCTTCCGGG TGTGAACCCC AAGAACGTGT CTTTGGTAGC TGGCGGCAAG 1500

GATATAAATT CACACTCTTG GAATAATCAG CTATTTCCTA AGTCTCTGGG ATCCATGGGG 1560

GCGGACCTCG CTTTCAAGAG GAGTAACGCA GACTATACCT GGAGCACAAA AACTGGCCAA 1620

GGCCAGTTTT CAGGACGAAC TTACAATCCC ACAGCCAAAA ATCTCAATAT TGTGAACCGC 1680

ACACAGCCAG TTCCCTCGGT GCACGGGAGG ACAGACTGGG TGGCTAAGTA CGGAGGCCAC 1740

CGGTAG 1746

Domain Profile

S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60

         y+++++lGdGt+g+vl++ks+++gelvaik+mkrkf+s++e++nlrevkslkkln h+n+

Q: 4     YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HANV  62

         99*****************************************************.****

S: 61    iklkeviidrendslylvlelmeenlyqlikdrrkllsesklksilyqilkglafihkhg  120

         iklkevi  rend+ly+++e+m+enlyql+kdr+kl++es++++i+yqil+glafihkhg

Q: 63    IKLKEVI--RENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHG  120

         *******..***************************************************

S: 121   ffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvyssp  180

         ffhrd+kPen+l++g+elvk+adfGlare+rs++PytdyvstrwyraPevllrs+vyssp

Q: 121   FFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSP  180

         ************************************************************

S: 181   ldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkfpq  240

         +d+wavG+++ae++++rplfPG+se+d+ifki++vlGtPkk++w+e+y+las++n++fpq

Q: 181   IDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQ  240

         ************************************************************

S: 241   vegsslktlvsnaskealellkdllaydPderataqqalkypyf  284

         +++++lktl++nas+ea++l++++l++dP++r+ta+qalk+pyf

Q: 241   CIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYF  284

         *******************************************9

Domain Sequence
(FASTA)

YTTMRQLGDG TYGSVLMGKS NESGELVAIK RMKRKFYSWD ECMNLREVKS LKKLNHANVI 60

KLKEVIREND HLYFIFEYMK ENLYQLMKDR NKLFPESVIR NIMYQILQGL AFIHKHGFFH 120

RDMKPENLLC MGPELVKIAD FGLARELRSQ PPYTDYVSTR WYRAPEVLLR SSVYSSPIDV 180

WAVGSIMAEL YTFRPLFPGT SEVDEIFKIC QVLGTPKKSD WPEGYQLASS MNFRFPQCIP 240

INLKTLIPNA SSEAIQLMTE MLNWDPKKRP TASQALKHPY F 281

Keyword

Alternative splicing; ATP-binding; Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Spermatogenesis; Transcription; Transcription regulation; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0030496	; C:midbody
GO:0072686	; C:mitotic spindle
GO:0005634	; C:nucleus
GO:0001917	; C:photoreceptor inner segment
GO:0001750	; C:photoreceptor outer segment
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0003713	; F:transcription coactivator activity
GO:0007049	; P:cell cycle
GO:0030154	; P:cell differentiation
GO:0007275	; P:multicellular organismal development
GO:0045494	; P:photoreceptor cell maintenance
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0007283	; P:spermatogenesis
GO:0006351	; P:transcription, DNA-dependent

KEGG

rno:25677

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013