EKS-RAN-00396
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00396
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK316.12.2E-94161396236
StatusUnreviewed
Ensembl ProteinENSRNOP00000020437
UniProt AccessionF1LQ89;
Protein Name
Protein Synonyms/Alias Mitogen-activated protein kinase kinase kinase 12;
Gene NameMap3k12
Gene Synonyms/Alias Map3k12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000015134ENSRNOP00000020437ENSRNOT00000020437
OrganismRattus norvegicus
Functional Description
Protein Length888
Protein Sequence
(FASTA)
MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGG 60
GGPSPSPGGE PPPEPFANSV LQLHEQDTGG PGGATGSPES RASRVRADEV RLQCQSGSGF 120
LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180
EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240
VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300
MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360
HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420
EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480
LQLELKEREL LRREQALERR CPGLLKSHTS RSLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540
ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRSRRGKTRH RKASAKGSCG DLPGLRAALP 600
PHEPGGLGSP GGLGVGPTAW DACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGATG 660
GARDPGSPPP PQGDTPPSEG SAPGSTSPDS PGGAKGEPPP PVGPGEGVGL LGTGREGTTG 720
RGGSRAGYQH LTPAALLYRA AVTRSQKRGI SSEEEEGEVD SEVELPPSQR WPQGPNMRQS 780
LSTFSSENPS DVEEGTASEP SPSGTPEVGS TNTDERPDER SDDMCSQGSE IPLDLPTSEV 840
VPERETSSLP MQHQDDQGPN PEDSDCDSTE LDNSNSIDAL RPPASLPP 888
Nucleotide Sequence
(FASTA)
ATGGCCTGCC TCCATGAAAC CCGAACACCC TCCCCTTCCT TTGGAGGCTT TGTGTCTACT 60
CTAAGTGAGG CCTCCATGCG AAAGCTGGAT CCAGACACTT CAGACTGCAC CCCTGAGAAG 120
GACCTGACAC CTACCCAATG TGTACTTCGA GATGTTGTGC CTCTCGGTGG GCAGGGTGGA 180
GGAGGGCCCA GCCCCTCCCC AGGTGGAGAG CCTCCTCCAG AGCCTTTTGC CAATAGTGTC 240
CTGCAGCTAC ATGAGCAGGA TACAGGTGGG CCAGGGGGAG CCACCGGGTC ACCTGAGAGT 300
CGAGCATCTA GGGTTCGAGC TGATGAGGTA CGTCTGCAGT GCCAGAGTGG CAGTGGCTTC 360
CTTGAAGGTC TTTTTGGCTG CCTGCGCCCT GTCTGGACAA TGATTGGCAA AGCCTACTCC 420
ACAGAGCACA AGCAACAGCA GGAAGACCTT TGGGAAGTCC CCTTTGAGGA AATCCTGGAC 480
CTGCAGTGGG TAGGCTCAGG GGCTCAGGGT GCCGTTTTCC TGGGACGCTT TCATGGGGAG 540
GAGGTAGCTG TGAAGAAGGT TCGAGACCTC AAGGAGACCG ACATCAAGCA TCTTCGAAAA 600
CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTTTGCA CACAGGCCCC GTGCTACTGC 660
ATCCTCATGG AGTTCTGTGC CCAAGGACAG CTGTATGAGG TGCTCAGGGC GGGCCGCCCC 720
GTTACCCCCT CCTTGCTGGT TGACTGGTCC ATGGGCATCG CTGGAGGCAT GAATTACCTA 780
CACCTGCACA AAATCATCCA TAGAGACCTG AAGTCACCCA ACATGCTAAT CACATACGAC 840
GATGTGGTGA AGATCTCAGA CTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 900
ATGTCCTTTG CAGGGACAGT AGCCTGGATG GCTCCTGAAG TGATCAGAAA TGAACCTGTG 960
TCTGAGAAGG TTGACATCTG GTCCTTTGGG GTGGTGCTTT GGGAATTACT GACTGGAGAG 1020
ATTCCCTACA AAGATGTAGA CTCCTCAGCC ATCATCTGGG GTGTGGGAAG CAACAGTCTT 1080
CACCTGCCTG TACCCTCTAG CTGCCCAGAC GGCTTTAAAA TTCTGCTTCG CCAGTGCTGG 1140
AACAGCAAAC CTCGGAACCG CCCATCATTC CGACAGATCT TGCTGCACCT GGACATCGCC 1200
TCGGCTGATG TGCTCTCTAC ACCCCAGGAG ACTTACTTTA AATCCCAGGC AGAGTGGCGG 1260
GAAGAAGTAA AACTGCACTT TGAAAAGATT AAGTCAGAAG GGACCTGTCT GCACCGCCTA 1320
GAAGAGGAAC TGGTGATGCG GAGAAGGGAG GAGCTCAGAC ATGCCCTGGA CATCAGGGAG 1380
CACTATGAGC GCAAGTTGGA GAGAGCTAAC AACTTGTACA TGGAACTGAA TGCCCTCATG 1440
TTGCAACTAG AACTCAAAGA GAGGGAATTG CTCAGGCGAG AGCAAGCTTT AGAAAGGAGG 1500
TGTCCTGGTC TACTGAAGTC ACACACGTCC CGAAGCCTCC TACATGGAAA CACGATGGAG 1560
AAGCTCATCA AGAAAAGGAA TGTGCCACAG AAACTGTCAC CCCATAGCAA AAGGCCAGAT 1620
ATTCTCAAGA CAGAGTCTTT GCTACCTAAA CTAGATGCAG CCCTAAGTGG GGTGGGGCTT 1680
CCTGGGTGTC CTAAGGGCCC CCCTTCACCT GGGAGGAGTC GTCGTGGCAA GACCCGTCAC 1740
CGAAAGGCCA GCGCCAAGGG CAGCTGTGGA GACCTGCCTG GGCTTCGTGC AGCTTTGCCA 1800
CCCCATGAGC CTGGAGGACT AGGAAGCCCA GGAGGCCTAG GAGTGGGCCC TACAGCTTGG 1860
GATGCCTGCC CCCCTGCTCT CCGTGGACTC CACCATGACC TTCTACTTCG GAAGATGTCT 1920
TCATCATCCC CAGACCTGTT ATCAGCAGCA CTGGGAGCCC GAGGCCGAGG GGCAACAGGG 1980
GGAGCTCGGG ATCCTGGCTC ACCACCTCCA CCCCAGGGTG ATACTCCTCC AAGTGAGGGA 2040
TCAGCTCCTG GTTCCACCAG CCCAGATTCA CCTGGGGGAG CTAAAGGGGA ACCACCTCCA 2100
CCAGTAGGGC CTGGAGAAGG TGTGGGGCTG CTGGGAACTG GAAGGGAAGG GACTACAGGC 2160
CGGGGAGGAA GCCGGGCTGG GTACCAGCAC TTGACCCCCG CTGCGCTGCT GTACAGGGCT 2220
GCTGTGACTC GTAGTCAGAA ACGTGGTATC TCATCTGAAG AGGAAGAAGG AGAGGTCGAC 2280
AGTGAAGTAG AGCTACCCCC AAGTCAAAGG TGGCCTCAGG GCCCGAACAT GCGTCAGTCA 2340
CTATCTACGT TCAGCTCAGA GAACCCATCA GATGTGGAGG AAGGTACAGC TAGTGAGCCT 2400
TCCCCAAGTG GCACACCGGA AGTTGGCAGC ACCAACACTG ATGAGCGACC AGATGAACGG 2460
TCTGATGACA TGTGCTCACA GGGTTCAGAA ATCCCACTGG ACCTACCTAC TTCAGAGGTG 2520
GTCCCTGAAC GTGAAACCAG CTCCTTGCCC ATGCAACACC AGGATGACCA GGGCCCCAAT 2580
CCTGAGGACT CAGACTGTGA CAGCACTGAA TTGGACAACT CCAACAGCAT TGATGCCTTG 2640
CGGCCCCCAG CCTCCCTTCC TCCATGA 2667
Domain Profile
S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63
          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G
Q: 161   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  211
         689**************************9999.........******************
S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123
         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii
Q: 212   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  266
         **************************..99************************...9**
S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182
         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D
Q: 267   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  325
         ***********.99****************99****************************
S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242
         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+
Q: 326   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  385
         ************************************************************
S: 243   kRpsfseivks  253
         +Rpsf++i+ +
Q: 386   NRPSFRQILLH  396
         ********876
Domain Sequence
(FASTA)
LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60
ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120
DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180
IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00355
EKS-BOT-00381
EKS-CAE-00303
EKS-CAJ-00386
EKS-CAF-00381
EKS-CAP-00413
EKS-DAR-00760
EKS-DIO-00060
EKS-DRM-00177
EKS-EQC-00370
EKS-FEC-00368
EKS-GAA-00464
EKS-GOG-00371
EKS-HOS-00388
EKS-ICT-00359
EKS-LAC-00398
EKS-LOA-00389
EKS-MAM-00380
EKS-MUM-00414
EKS-MUP-00373
EKS-MYL-00378
EKS-NOL-00348
EKS-OCP-00078
EKS-ORN-00489
EKS-ORC-00358
EKS-ORL-00451
EKS-OTG-00383
EKS-PAT-00361
EKS-PEM-00201
EKS-POA-00371
EKS-PRC-00080
EKS-PTV-00100
EKS-SAH-00348
EKS-SUS-00332
EKS-TAR-00485
EKS-TEN-00482
EKS-XET-00494
EKS-XIM-00478
Gene Ontology
GO:0033267; C:axon part
GO:0005829; C:cytosol
GO:0030426; C:growth cone
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0016572; P:histone phosphorylation
GO:0000165; P:MAPK cascade
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR017419; MAP3K12_MAP3K13.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013