| Tag | Content |
|---|
| EKPD ID | EPS-RAN-00134 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PPP/PP6 | 417.6 | 7.7E-126 | 47 | 239 | 193 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000021176 |
| UniProt Accession | Q64620; Q6AZ47; |
| Protein Name | Serine/threonine-protein phosphatase 6 catalytic subunit |
| Protein Synonyms/Alias | PP6C; Protein phosphatase V; PP-V; |
| Gene Name | Ppp6c |
| Gene Synonyms/Alias | Ppp6c; Ppv; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Catalytic subunit of protein phosphatase 6 (PP6). PP6 isa component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (By similarity). |
| Protein Length | 305 |
Protein Sequence
(FASTA) | | MAPLDLDKYV EIARQCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD 60 | | LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT 120 | | QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE 180 | | RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV 240 | | HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT 300 | | TPYFL 305 |
|
Nucleotide Sequence
(FASTA) | | ATGGCGCCAC TGGATCTGGA CAAGTATGTG GAGATAGCGC GGCAGTGCAA GTACCTTCCC 60 | | GAAAACGACC TGAAGCGGCT ATGTGACTAT GTTTGTGATC TGCTCTTGGA AGAGTCGAAT 120 | | GTTCAGCCTG TATCAACGCC AGTAACAGTG TGCGGGGACA TACATGGACA GTTTTATGAT 180 | | CTTTGCGAAC TGTTCAGAAC TGGAGGTCAG GTTCCTGACA CAAACTACAT ATTTATGGGT 240 | | GATTTTGTAG ACAGAGGTTA CTATAGTTTG GAGACCTTCA CTTATCTTCT TGCACTAAAG 300 | | GCTAAGTGGC CTGACCGTAT TACACTTTTA AGAGGAAATC ATGAGAGTAG ACAGATAACG 360 | | CAGGTGTACG GATTTTATGA TGAGTGCCAA ACCAAATATG GAAATGCTAA TGCCTGGAGA 420 | | TACTGTACCA AAGTTTTTGA CATGCTCACA GTAGCAGCTT TAATAGATGA GCAGATTTTG 480 | | TGTGTTCATG GTGGTTTATC TCCTGATATC AAAACACTGG ATCAAATTCG AACTATTGAG 540 | | CGAAATCAGG AAATTCCTCA CAAAGGAGCA TTTTGTGACC TGGTATGGTC AGATCCTGAA 600 | | GATGTGGACA CTTGGGCAAT CAGTCCCAGA GGAGCAGGTT GGCTTTTTGG AGCAAAAGTC 660 | | ACAAATGAGT TTGTTCATAT CAACAACTTA AAACTCATCT GCAGAGCACA TCAGCTTGTG 720 | | CACGAAGGCT ATAAGTTTAT GTTTGACGAG AAGCTGGTCA CAGTGTGGTC TGCTCCTAAC 780 | | TACTGCTATC GCTGTGGAAA CATTGCTTCC ATCATGGTCT TCAAAGACGT CAACACGAGA 840 | | GAACCAAAGT TATTCCGAGC AGTTCCAGAT TCAGAACGTG TTATTCCTCC CAGAACCACG 900 | | ACGCCGTATT TCCTTTGA 918 |
|
| Domain Profile | S: 1 pvtvcgdihgqfydllklfrtggqvpdtnyiflgdfvdrgyyslevftlllllkakypak 60 | pvtvcgdihgqfydl++lfrtggqvpdtnyif+gdfvdrgyysle+ft+ll+lkak+p++ | Q: 47 PVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDR 106 | 9*********************************************************** |
| S: 61 itllrgnhesrqitqvygfydeclrkygnanawkyctkvfdlltlaaiidekvlcvhggl 120 | itllrgnhesrqitqvygfydec++kygnanaw+yctkvfd+lt+aa+ide++lcvhggl | Q: 107 ITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGL 166 | ************************************************************ |
| S: 121 spdirtldqirliernqeiphegafcdllwsdpedvetwavsprgagwlfgskvtkefnh 180 | spdi+tldqir+iernqeiph+gafcdl+wsdpedv+twa+sprgagwlfg+kvt+ef+h | Q: 167 SPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVH 226 | ************************************************************ |
| S: 181 innldlicrahql 193 | innl+licrahql | Q: 227 INNLKLICRAHQL 239 | ************7 |
|
Domain Sequence
(FASTA) | | PVTVCGDIHG QFYDLCELFR TGGQVPDTNY IFMGDFVDRG YYSLETFTYL LALKAKWPDR 60 | | ITLLRGNHES RQITQVYGFY DECQTKYGNA NAWRYCTKVF DMLTVAALID EQILCVHGGL 120 | | SPDIKTLDQI RTIERNQEIP HKGAFCDLVW SDPEDVDTWA ISPRGAGWLF GAKVTNEFVH 180 | | INNLKLICRA HQL 193 |
|
| Keyword | Cell cycle; Complete proteome; Cytoplasm; Hydrolase; Iron; Manganese; Metal-binding; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |