EKS-RAN-00485
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00485
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK335.92.2E-10021312292
StatusUnreviewed
Ensembl ProteinENSRNOP00000020851
UniProt AccessionG3V9J9;
Protein Name
Protein Synonyms/Alias Mitogen-activated protein kinase 4;
Gene NameMapk4
Gene Synonyms/Alias Mapk4; rCG_41713;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000015401ENSRNOP00000020851ENSRNOT00000020851
ENSRNOG00000015401ENSRNOP00000050164ENSRNOT00000047271
OrganismRattus norvegicus
Functional Description
Protein Length477
Protein Sequence
(FASTA)
MAEKGDCIAS VYGYDLGGRF TDFQPLGFGV NGLVLSATDS RACRKVAVKK IVLSDARSMK 60
HALREIKIIR RLDHDNIVKV YEVLGPKGSD LQGELFKFSV AYIVQEYMET DLACLLEQGT 120
LTEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIADQHYS 180
HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGKMLFA GAHELEQMQL 240
ILDTIPVVRE EDKEELLRVM PSFVSSTWEV KRPLRKLLPD VNREAIDFLE KILTFNPMDR 300
LTAEMGLQHP YMSPYSCPED EPTSQHPFRI EDEIDDLVLM AASQSQLSNW DRYPVSLSSD 360
LEWRPDRCQD ASEVQRDPRA GSTPLAEDVQ VDPRKDSQSS SERFLEQSHS SMERAFEADY 420
GRSCDYKVGS PSYLDKLLWR DNKPHHYSEP KLILDLSHWK QAASAPPGCS SSRPSVT 477
Nucleotide Sequence
(FASTA)
ATGGCAGAGA AAGGTGACTG CATCGCCAGT GTCTACGGGT ACGACCTTGG TGGGCGCTTC 60
ACTGACTTCC AACCCCTCGG CTTCGGGGTC AACGGGCTGG TGCTGTCGGC TACGGACAGC 120
AGGGCTTGCC GGAAGGTAGC CGTGAAGAAG ATTGTGCTGA GTGACGCACG AAGCATGAAG 180
CACGCGCTCC GAGAGATCAA AATCATCCGG CGCCTGGACC ACGACAACAT CGTCAAAGTG 240
TACGAGGTAC TGGGACCCAA GGGTAGCGAT CTGCAGGGCG AGCTCTTTAA GTTCAGCGTG 300
GCTTATATTG TCCAAGAGTA CATGGAGACT GACCTGGCAT GCCTGCTAGA GCAGGGCACG 360
CTGACCGAGG AGCACGCTAA GCTATTCATG TACCAGCTGC TGCGTGGGCT CAAGTACATC 420
CACTCTGCCA ACGTGTTGCA CAGGGACCTG AAGCCCGCCA ACATTTTCAT CAGCACGGAG 480
GACCTCGTGC TGAAGATCGG GGATTTCGGG CTGGCCAGAA TCGCGGACCA GCATTACTCC 540
CACAAGGGTT ATCTGTCGGA AGGGTTGGTG ACAAAGTGGT ACCGCTCTCC ACGACTGCTC 600
CTGTCCCCGA ACAACTACAC GAAAGCCATC GATATGTGGG CAGCTGGCTG CATCCTAGCG 660
GAGATGCTCA CGGGGAAAAT GCTCTTTGCT GGGGCTCACG AGCTTGAGCA GATGCAGCTC 720
ATCCTAGACA CCATCCCTGT AGTGCGGGAG GAAGACAAGG AGGAGCTGCT CAGGGTGATG 780
CCGTCCTTTG TCAGCAGCAC TTGGGAGGTG AAGAGGCCAC TGCGTAAGCT ACTCCCGGAT 840
GTCAACCGTG AAGCCATTGA CTTTCTGGAG AAGATCCTGA CCTTTAACCC CATGGACCGC 900
CTAACAGCTG AGATGGGGCT ACAGCATCCT TACATGAGCC CGTATTCGTG CCCCGAGGAT 960
GAGCCCACCT CACAACACCC CTTCCGCATT GAAGACGAGA TCGACGACCT CGTACTGATG 1020
GCTGCCAGTC AGAGCCAGCT CTCCAACTGG GACAGGTATC CCGTGAGCCT GTCGTCAGAT 1080
CTGGAATGGC GGCCTGACCG CTGTCAGGAC GCGAGCGAGG TGCAGCGCGA CCCACGTGCT 1140
GGCTCTACTC CGCTGGCGGA GGATGTTCAG GTGGACCCAC GCAAGGACTC ACAGAGCAGC 1200
TCCGAGCGCT TCCTGGAGCA GTCGCACTCG TCCATGGAGC GCGCCTTTGA GGCCGACTAT 1260
GGACGGTCCT GCGACTACAA AGTGGGGTCT CCGTCCTACC TGGACAAGCT GCTGTGGCGC 1320
GACAACAAGC CCCACCACTA CTCGGAACCC AAGCTCATCC TGGACCTGTC GCACTGGAAG 1380
CAGGCGGCCA GCGCACCCCC CGGCTGCAGT AGCAGCAGAC CCAGTGTCAC GTGA 1434
Domain Profile
S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNii  61
         ++ +plg G +g+v+sa+d+r+ ++va+kk++  ++++ s+k++lRE+k++++l+h+Ni+
Q: 21    TDFQPLGFGVNGLVLSATDSRACRKVAVKKIV--LSDARSMKHALREIKIIRRLDHDNIV  78
         6789***************************9..9*************************
S: 62    klldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglk  116
         k+++v+ p+      el +++  Y+v+e+metdL+ ++++ +l++eh+kl++yq+lrglk
Q: 79    KVYEVLGPKGsdlqgELFKFSVAYIVQEYMETDLACLLEQGTLTEEHAKLFMYQLLRGLK  138
         ********99888888999*****************************************
S: 117   ylHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPe  173
         y+Hsanv+HrDlKP+N++++++   lki dFGlar+ad+++++k  l+e ++t+wYr+P+
Q: 139   YIHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIADQHYSHKgyLSEGLVTKWYRSPR  198
         *******************8765169***************9999***************
S: 174   illslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkies  233
         +lls ++ytka+D+W++GCIlaE+ltgk+lf+g++e++q+++il++++ ++ee+ +++ +
Q: 199   LLLSPNNYTKAIDMWAAGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEELLR  258
         ***********************************************************9
S: 234   eearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
           + ++++s+++ k+ ++++l+p+ ++ea+d+lek+L+++p++R+++e+ L+hpY+
Q: 259   V-MPSFVSSTWEVKR-PLRKLLPDVNREAIDFLEKILTFNPMDRLTAEMGLQHPYM  312
         5.9*******99988.9**************************************7
Domain Sequence
(FASTA)
TDFQPLGFGV NGLVLSATDS RACRKVAVKK IVLSDARSMK HALREIKIIR RLDHDNIVKV 60
YEVLGPKGSD LQGELFKFSV AYIVQEYMET DLACLLEQGT LTEEHAKLFM YQLLRGLKYI 120
HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIADQHYS HKGYLSEGLV TKWYRSPRLL 180
LSPNNYTKAI DMWAAGCILA EMLTGKMLFA GAHELEQMQL ILDTIPVVRE EDKEELLRVM 240
PSFVSSTWEV KRPLRKLLPD VNREAIDFLE KILTFNPMDR LTAEMGLQHP YM 292
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00440
EKS-ANC-00458
EKS-BOT-00472
EKS-CAJ-00477
EKS-CAF-00471
EKS-CAP-00503
EKS-DAR-00882
EKS-EQC-00459
EKS-FEC-00449
EKS-GAM-00277
EKS-GAA-00574
EKS-GOG-00460
EKS-HOS-00479
EKS-ICT-00446
EKS-LAC-00480
EKS-LOA-00476
EKS-MAM-00468
EKS-MIM-00087
EKS-MOD-00464
EKS-MUM-00503
EKS-MUP-00463
EKS-MYL-00464
EKS-NOL-00429
EKS-OCP-00123
EKS-ORN-00596
EKS-ORA-00404
EKS-ORC-00446
EKS-ORL-00543
EKS-OTG-00479
EKS-PAT-00442
EKS-PES-00414
EKS-POA-00457
EKS-SAH-00441
EKS-SUS-00412
EKS-TAR-00587
EKS-TEN-00586
EKS-XET-00620
EKS-XIM-00588
Gene Ontology
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0000165; P:MAPK cascade
KEGG
rno:54268;
InterPros
IPR011009; Kinase-like_dom.
IPR008350; MAPK_ERK3/4.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01771; ERK3ERK4MAPK.
Created Date20-Feb-2013