EKS-RAN-00361

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00361

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	396.9	4.6E-119	116	377	262

Status

Unreviewed

Ensembl Protein

ENSRNOP00000053702

UniProt Accession

D3ZID5;

Protein Name

Protein Synonyms/Alias

Protein Tnk1;

Gene Name

Tnk1

Gene Synonyms/Alias

Tnk1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000015578	ENSRNOP00000053702	ENSRNOT00000056860

Organism

Rattus norvegicus

Functional Description

Protein Length

667

Protein Sequence
(FASTA)

MLPEASSLWL LRLLRDVQLA QFYRPILEEL NVTRPEHFDF VRPEDLDNLG MGRPAQRRLT 60

EALKRYRSGV KSKNWVYKIL GGFAPEQKEI PPYSDSLPHL HEPEGGLKCL IPEGAVCRGE 120

LLGSGCFGVV HQGLWTLPGG QSIPVAVKSL RVGPEGPMGT ELGDFLREVS VMMKLEHPHV 180

LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPMPPLPVT LLCLFLRQLA GAMAYLGSCG 240

LVHRDLATRN LLLASPRKIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRQGAF 300

SAASDVWMFG VTLWEMFSGG EEPWAGVPPY LILQRLEKDR ARLPKPALCS RALYSLALRC 360

WAPHPADRPT FSNLEGLLQE AWLSEGRCVR EVTEPGALRM EPGDPITIIE GSPDTTTWKG 420

QNGRTLKVGN FPASAVTLAD LGGSPVTHPV HRGSPARGEK YRGGTDGDRE KAVLQDLPPA 480

RNQRRKVPLQ RMKGISKSLE SVLSLGPRPA GGGSSPPELR RGCTRAWPQG LADLPPRPPD 540

LPPRPPIICS SQPIQPHRVR PKREPLHNHC TGAPGSSKVT IPPGGPLSDS EWQRKIVEVE 600

LSVHGVTYQE CQMALRTMGG DVASAIRNLK VDQLFHLSNR SRADCRRILE HHHWDLSAAS 660

RYVLARS 667

Nucleotide Sequence
(FASTA)

ATGCTCCCCG AAGCCAGTTC CCTGTGGCTC CTTCGGCTGC TCCGGGACGT CCAGCTGGCC 60

CAGTTCTACC GGCCCATCCT TGAGGAACTC AACGTCACTC GGCCAGAACA TTTTGACTTT 120

GTAAGGCCTG AGGACCTGGA CAACCTTGGC ATGGGCAGGC CTGCCCAACG AAGACTTACT 180

GAAGCCCTGA AGAGGTACCG TTCGGGGGTC AAGTCTAAGA ACTGGGTGTA CAAGATACTT 240

GGGGGTTTTG CTCCTGAACA GAAGGAGATC CCTCCATACT CAGACAGTCT TCCACACCTC 300

CATGAGCCAG AGGGGGGACT CAAGTGTCTG ATTCCAGAGG GTGCTGTGTG CAGAGGGGAA 360

CTGCTGGGTT CAGGCTGCTT TGGTGTTGTA CATCAAGGGC TATGGACACT ACCCGGTGGT 420

CAAAGTATCC CAGTGGCTGT CAAGTCCCTC CGTGTGGGTC CCGAGGGTCC GATGGGCACA 480

GAACTGGGAG ACTTCCTGCG GGAAGTGTCT GTCATGATGA AACTGGAGCA CCCACATGTG 540

CTGCGCCTGC ATGGCCTCGT ACTGGGCCAG CCTCTACAGA TGGTGATGGA ACTTGCGCCA 600

CTGGGTTCCC TGCATGCGCG CCTGACTGCC CCAGCACCGA TGCCCCCACT GCCTGTAACC 660

CTACTGTGCC TTTTTCTGCG TCAGTTGGCA GGAGCCATGG CGTACTTGGG GTCCTGTGGG 720

TTAGTGCACA GGGATCTTGC TACCCGTAAC CTCCTGCTAG CCTCACCTCG GAAGATCAAG 780

GTGGCTGATT TTGGACTGGT GCGGCCACTG GGCGGCGCCC GAGGTCGCTA CGTTATGGGT 840

GGGCCCCGTC CCATCCCCTA TGCCTGGTGC GCTCCTGAGA GCCTACGCCA GGGAGCCTTC 900

TCGGCTGCCT CCGACGTGTG GATGTTTGGC GTGACACTCT GGGAAATGTT TTCTGGAGGC 960

GAGGAACCCT GGGCAGGTGT TCCACCATAT CTCATCCTAC AGCGGCTGGA GAAGGACCGA 1020

GCCAGGCTGC CAAAGCCTGC CCTCTGTTCC AGGGCCCTCT ACTCCCTTGC CTTGCGTTGC 1080

TGGGCCCCTC ATCCTGCAGA CCGGCCTACC TTTTCCAATC TGGAAGGACT GCTTCAAGAG 1140

GCTTGGCTCT CTGAGGGGCG CTGTGTGAGG GAGGTCACAG AGCCAGGTGC TTTGCGGATG 1200

GAGCCCGGTG ACCCCATCAC TATCATTGAG GGCAGCCCAG ACACCACAAC CTGGAAGGGA 1260

CAGAATGGTC GCACCCTCAA AGTGGGCAAC TTTCCGGCTT CAGCAGTGAC ACTAGCAGAC 1320

TTGGGGGGAT CCCCAGTCAC CCATCCAGTC CACAGAGGTT CCCCTGCCCG TGGAGAGAAA 1380

TACAGAGGGG GCACAGATGG GGACAGGGAG AAGGCAGTGT TACAAGACCT ACCCCCGGCA 1440

CGGAACCAGA GAAGGAAGGT GCCCCTGCAG AGGATGAAAG GCATTTCCAA GAGTCTGGAG 1500

TCAGTTCTGT CCCTGGGCCC TAGACCCGCA GGAGGTGGTT CAAGCCCTCC AGAACTTCGA 1560

CGAGGATGTA CTAGAGCTTG GCCTCAAGGA CTCGCAGACC TCCCTCCACG CCCACCAGAC 1620

CTGCCTCCAC GCCCACCCAT CATCTGCTCC TCTCAGCCCA TCCAGCCCCA CAGAGTCCGG 1680

CCCAAAAGAG AACCCTTACA TAATCACTGC ACTGGAGCGC CTGGGTCCAG CAAAGTCACT 1740

ATCCCCCCTG GAGGTCCCTT ATCAGACTCG GAGTGGCAGA GGAAGATTGT AGAGGTAGAG 1800

CTGAGTGTGC ATGGCGTCAC CTACCAGGAG TGCCAAATGG CACTCAGAAC CATGGGGGGA 1860

GATGTGGCTT CTGCTATCCG GAACCTCAAG GTAGACCAGC TCTTCCACCT CAGTAACCGG 1920

TCCAGAGCAG ATTGTCGTCG CATTCTGGAG CATCACCACT GGGACCTGTC AGCAGCCAGT 1980

CGCTACGTCC TGGCCCGGTC CTGA 2004

Domain Profile

S: 1     iklleklGeGsfgvvkrgeWsapsgksvqvavkvlk..sdkllstelddflrevsvllkl  58

         ++++e+lG+G+fgvv++g W+ p+g+s++vavk+l+  ++  ++tel+dflrevsv++kl

Q: 116   VCRGELLGSGCFGVVHQGLWTLPGGQSIPVAVKSLRvgPEGPMGTELGDFLREVSVMMKL  175

         56889******************************9999*********************

S: 59    ehenlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglay  118

         eh++++rl+G+vl+qpl++v+ela+lgsl++rl+++a  ++l+v+ll+ +++q+a ++ay

Q: 176   EHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPMPPLPVTLLCLFLRQLAGAMAY  235

         ************************************************************

S: 119   leskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPesl  178

         l+s+ lvhrdla+rnlllas++++k++dfGlvr+lg ++++yv+  ++++P+aWcaPesl

Q: 236   LGSCGLVHRDLATRNLLLASPRKIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESL  295

         ************************************************************

S: 179   rtrkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediys  238

         r+ +fs asdvW+fGvtlWemfs GeePW+g++++ il++++k+++rl+kP +c++++ys

Q: 296   RQGAFSAASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKDRARLPKPALCSRALYS  355

         ************************************************************

S: 239   lllkcWakkpadrpkfsalkek  260

         l+l+cWa +padrp+fs+l++

Q: 356   LALRCWAPHPADRPTFSNLEGL  377

         *******************976

Domain Sequence
(FASTA)

VCRGELLGSG CFGVVHQGLW TLPGGQSIPV AVKSLRVGPE GPMGTELGDF LREVSVMMKL 60

EHPHVLRLHG LVLGQPLQMV MELAPLGSLH ARLTAPAPMP PLPVTLLCLF LRQLAGAMAY 120

LGSCGLVHRD LATRNLLLAS PRKIKVADFG LVRPLGGARG RYVMGGPRPI PYAWCAPESL 180

RQGAFSAASD VWMFGVTLWE MFSGGEEPWA GVPPYLILQR LEKDRARLPK PALCSRALYS 240

LALRCWAPHP ADRPTFSNLE GL 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013