EKS-RAN-00165
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00165
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC471.21.2E-141407667261
StatusUnreviewed
Ensembl ProteinENSRNOP00000020959
UniProt AccessionF1LMV8;
Protein Name
Protein Synonyms/Alias Protein kinase C epsilon type;
Gene NamePrkce
Gene Synonyms/Alias Prkce;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000015603ENSRNOP00000020959ENSRNOT00000020959
OrganismRattus norvegicus
Functional Description
Protein Length736
Protein Sequence
(FASTA)
MVVFNGLLKI KICEAVSLKP TAWSLRHAVG PRPQTFLLDP YIALNVDDSR IGQTATKQKT 60
NSPAWHDEFV TDVCNGRKIE LAVFHDAPIG YDDFVANCTI QFEELLQNGS RHFEDWIDLE 120
PEGKVYVIID LSGSSGEEPQ DCLEEVYRSL DPSFRQENDG HPVHQTKGHC LCARHCRKPC 180
ACSKVRDLLE GVIGKQGYQC QVCTCVVHKR CHELIITKCA GLKKQETPDE VGSQRFSVNM 240
PHKFGIHNYK VPTFCDHCGS LLWGLLRQGL QCKVCKMNVH RRCETNVAPN CGVDARGIAK 300
VLADLGVTPD KITNSGQRRK KLAAGAESPQ PASGNSPSED DRSKSAPTSP CDQELKELEN 360
NIRKALSFDN RGEEHRASSS TDGQLASPGE NGEVRQGQAK RLGLDEFNFI KVLGKGSFGK 420
VMLAELKGKD EVYAVKVLKK DVILQDDDVD CTMTEKRILA LARKHPYLTQ LYCCFQTKDR 480
LFFVMEYVNG GDLMFQIQRS RKFDEPRSRF YAAEVTSALM FLHQHGVIYR DLKLDNILLD 540
AEGHCKLADF GMCKEGILNG VTTTTFCGTP DYIAPEILQE LEYGPSVDWW ALGVLMYEMM 600
AGQPPFEADN EDDLFESILH DDVLYPVWLS KEAVSILKAF MTKNPHKRLG CVAAQNGEDA 660
IKQHPFFKEI DWVLLEQKKI KPPFKPRIKT KRDVNNFDQD FTREEPILTL VDEAIVKQIN 720
QEEFKGFSYF GEDLMP 736
Nucleotide Sequence
(FASTA)
ATGGTAGTGT TCAATGGCCT TCTTAAGATC AAAATCTGCG AGGCCGTGAG CTTGAAGCCC 60
ACAGCCTGGT CGCTGCGCCA TGCGGTGGGA CCCCGGCCCC AGACGTTCCT TCTGGACCCC 120
TACATTGCCC TTAACGTGGA CGACTCGCGC ATCGGCCAAA CAGCCACCAA GCAGAAGACC 180
AACAGTCCGG CCTGGCACGA TGAGTTCGTC ACTGATGTGT GCAATGGGCG CAAGATCGAG 240
CTGGCTGTCT TTCACGATGC TCCTATCGGC TACGACGACT TCGTGGCCAA CTGCACCATC 300
CAGTTCGAGG AGCTGCTGCA GAATGGGAGC CGTCACTTCG AGGACTGGAT TGATCTGGAG 360
CCAGAAGGAA AAGTCTACGT GATCATCGAT CTCTCGGGAT CATCGGGCGA AGAACCACAA 420
GATTGTCTAG AGGAGGTGTA TAGGTCACTG GATCCTTCCT TTAGGCAGGA AAATGACGGC 480
CACCCAGTGC ACCAGACGAA GGGGCATTGT CTATGTGCCA GGCACTGCAG GAAGCCCTGT 540
GCCTGCTCCA AAGTGAGGGA CCTTCTGGAG GGTGTCATAG GAAAACAGGG ATATCAATGT 600
CAAGTTTGTA CCTGCGTCGT CCACAAACGA TGCCATGAGC TCATTATTAC GAAGTGCGCT 660
GGGCTAAAGA AACAGGAAAC CCCTGACGAG GTGGGCTCCC AACGCTTCAG CGTCAACATG 720
CCCCACAAGT TCGGGATCCA CAACTACAAG GTCCCCACGT TCTGTGACCA CTGTGGCTCC 780
CTGCTCTGGG GCCTCTTGCG GCAGGGCCTG CAGTGTAAAG TCTGCAAAAT GAATGTTCAC 840
CGTCGATGCG AGACCAACGT GGCTCCCAAT TGTGGGGTGG ACGCCAGAGG AATTGCCAAG 900
GTGCTGGCCG ATCTTGGCGT TACTCCAGAC AAAATCACCA ACAGTGGCCA GAGAAGGAAA 960
AAGCTCGCTG CTGGTGCTGA GTCCCCACAG CCGGCTTCTG GAAACTCCCC ATCAGAAGAC 1020
GACCGATCCA AGTCAGCGCC CACCTCCCCT TGTGACCAGG AACTAAAAGA ACTTGAAAAC 1080
AACATCCGGA AGGCCTTGTC ATTTGACAAC CGAGGAGAGG AGCACCGAGC CTCGTCGTCT 1140
ACTGATGGCC AGCTGGCAAG CCCTGGCGAG AACGGTGAAG TCCGGCAAGG CCAGGCCAAG 1200
CGCTTGGGCC TGGATGAGTT CAACTTCATC AAGGTGTTAG GCAAAGGCAG CTTTGGCAAG 1260
GTCATGCTGG CCGAGCTCAA GGGTAAGGAT GAAGTCTATG CTGTGAAGGT CTTAAAGAAG 1320
GACGTCATCC TGCAGGATGA CGACGTGGAC TGCACGATGA CAGAGAAGAG GATTTTGGCT 1380
CTGGCGCGGA AACACCCTTA TCTAACCCAA CTCTATTGCT GCTTCCAGAC CAAGGACCGC 1440
CTCTTCTTCG TCATGGAATA TGTAAACGGT GGAGACCTCA TGTTCCAGAT TCAGCGGTCC 1500
CGAAAATTCG ATGAGCCTCG TTCCCGGTTC TATGCTGCCG AGGTCACATC TGCTCTCATG 1560
TTTCTCCACC AACATGGAGT GATCTACAGG GATTTGAAAC TGGACAACAT CCTTCTAGAT 1620
GCAGAAGGTC ACTGCAAGCT GGCTGACTTT GGGATGTGCA AGGAAGGGAT TCTGAATGGC 1680
GTGACAACTA CCACCTTCTG TGGGACTCCT GACTACATAG CTCCAGAGAT CCTGCAGGAG 1740
TTGGAGTACG GCCCCTCAGT GGACTGGTGG GCCCTGGGCG TGCTGATGTA CGAGATGATG 1800
GCCGGGCAGC CCCCCTTTGA AGCTGACAAC GAGGACGACT TGTTTGAATC CATCCTTCAC 1860
GATGACGTTC TCTACCCTGT CTGGCTTAGC AAGGAGGCTG TCAGCATCCT GAAAGCTTTC 1920
ATGACCAAGA ACCCGCACAA GCGCCTGGGC TGCGTGGCAG CACAGAACGG GGAAGATGCC 1980
ATCAAGCAAC ATCCATTCTT CAAGGAGATT GACTGGGTAC TGCTGGAGCA GAAGAAAATC 2040
AAGCCCCCCT TCAAGCCGAG AATTAAAACC AAGAGAGATG TCAATAACTT TGACCAAGAC 2100
TTTACCCGGG AAGAGCCAAT ACTTACACTT GTGGATGAAG CAATCGTGAA GCAGATCAAC 2160
CAGGAAGAAT TCAAAGGCTT CTCCTACTTT GGTGAAGACC TGATGCCCTG A 2211
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+++kvlGkGsfgkv+laelk++de+ya+kvlkkdv+lqdddv++t++ekr+lala+k+p
Q: 407   FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP  466
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g
Q: 467   YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHG  526
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         +iyrdlkldn+lldaeGh+kladfG+cke+il+g tt+tfcGtPdyiaPeil+e eyg s
Q: 527   VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPS  586
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+ilk+++tk+p+
Q: 587   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPH  646
         ************************************************************
S: 241   krlGv..keegeedikehaff  259
         krlG+  +++ge++ik+h+ff
Q: 647   KRLGCvaAQNGEDAIKQHPFF  667
         *****6449***********9
Domain Sequence
(FASTA)
FNFIKVLGKG SFGKVMLAEL KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP 60
YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG 120
VIYRDLKLDN ILLDAEGHCK LADFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS 180
VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPH 240
KRLGCVAAQN GEDAIKQHPF F 261
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00162
EKS-ANC-00164
EKS-BOT-00170
EKS-CAE-00130
EKS-CAJ-00174
EKS-CAF-00177
EKS-CAP-00170
EKS-DAR-00463
EKS-DRM-00083
EKS-FEC-00160
EKS-GAG-00146
EKS-GAA-00205
EKS-GOG-00168
EKS-HOS-00176
EKS-ICT-00165
EKS-LAC-00185
EKS-LOA-00169
EKS-MAM-00168
EKS-MEG-00135
EKS-MIM-00077
EKS-MUM-00175
EKS-MUP-00174
EKS-MYL-00179
EKS-NOL-00163
EKS-ORN-00215
EKS-ORC-00157
EKS-ORL-00201
EKS-OTG-00176
EKS-PAT-00161
EKS-PES-00150
EKS-POA-00166
EKS-SUS-00146
EKS-TAG-00198
EKS-TAR-00222
EKS-TAS-00059
EKS-TEN-00214
EKS-XET-00158
EKS-XIM-00208
EKS-SAC-00081
Gene Ontology
GO:0005829; C:cytosol
GO:0005783; C:endoplasmic reticulum
GO:0005794; C:Golgi apparatus
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004699; F:calcium-independent protein kinase C activity
GO:0008047; F:enzyme activator activity
GO:0035276; F:ethanol binding
GO:0046872; F:metal ion binding
GO:0030546; F:receptor activator activity
GO:0071361; P:cellular response to ethanol
GO:0071456; P:cellular response to hypoxia
GO:0035556; P:intracellular signal transduction
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0035641; P:locomotory exploration behavior
GO:0002281; P:macrophage activation involved in immune response
GO:0030838; P:positive regulation of actin filament polymerization
GO:0071777; P:positive regulation of cell cycle cytokinesis
GO:0010811; P:positive regulation of cell-substrate adhesion
GO:2001031; P:positive regulation of cellular glucuronidation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0010763; P:positive regulation of fibroblast migration
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032024; P:positive regulation of insulin secretion
GO:0050996; P:positive regulation of lipid catabolic process
GO:0043410; P:positive regulation of MAPK cascade
GO:0070257; P:positive regulation of mucus secretion
GO:0032230; P:positive regulation of synaptic transmission, GABAergic
GO:0090303; P:positive regulation of wound healing
GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0051209; P:release of sequestered calcium ion into cytosol
GO:0043278; P:response to morphine
GO:0035669; P:TRAM-dependent toll-like receptor 4 signaling pathway
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013