EKS-RAN-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.5	2.1E-167	385	661	277

Status

Unreviewed

Ensembl Protein

ENSRNOP00000043459

UniProt Accession

F1LM54;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

Fgfr1

Gene Synonyms/Alias

Fgfr1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000016050	ENSRNOP00000043459	ENSRNOT00000050980
ENSRNOG00000016050	ENSRNOP00000036885	ENSRNOT00000029284

Organism

Rattus norvegicus

Functional Description

Protein Length

729

Protein Sequence
(FASTA)

MWGWRGLLFW AVLVTATLCT ARPAPTLPEQ DALPSSEDDD DDDDSSSEEK ETDNTKPNPV 60

APYWTSPEKM EKKLHAVPAA KTVKFKCPSS GTPSPTLRWL KNGKEFKPDH RIGGYKVRYA 120

TWSIIMDSVV PSDKGNYTCI VENEYGSINH TYQLDVVERS PHRPILQAGL PANKTVALGS 180

NVEFMCKVYS DPQPHIQWLK HIEVNGSKIG PDNLPYVQIL KTAGVNTTDK EMEVLHLRNV 240

SFEDAGEYTC LAGNSIGLSH HSAWLTVLEA LEERPAVMTS PLYLEIIIYC TGAFLISCMV 300

GSVIIYKMKS GTKKSDFHSQ MAVHKLAKSI PLRRQVSADS SASMNSGVLL VRPSRLSSSG 360

TPMLAGVSEY ELPEDPRWEL PRDRLVLGKP LGEGCFGQVV LAEAIGLDKD KPNRVTKVAV 420

KMLKSDATEK DLSDLISEME MMKMIGKHKN IINLLGACTQ DGPLYVIVEY ASKGNLREYL 480

QARRPPGLEY CYNPSHNPEE QLSSKDLVSC AYQVARGMEY LASKKCIHRD LAARNVLVTE 540

DNVMKIADFG LARDIHHIDY YKKTTNGRLP VKWMAPEALF DRIYTHQSDV WSFGVLLWEI 600

FTLGGSPYPG VPVEELFKLL KEGHRMDKPS NCTNELYMMM RDCWHAVPSQ RPTFKQLVED 660

LDRIVALTSN QEYLDLSMPL DQYSPSFPDT RSSTCSSGED SVFSHEPLPE EPCLPRHPTQ 720

LANGGLKRR 729

Nucleotide Sequence
(FASTA)

ATGTGGGGCT GGAGGGGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC TCTCTGCACT 60

GCCAGACCAG CCCCAACCTT GCCCGAACAA GATGCACTGC CATCCTCGGA GGACGATGAC 120

GATGATGATG ACTCCTCCTC AGAGGAGAAA GAGACAGACA ACACCAAACC AAACCCTGTG 180

GCGCCATACT GGACATCCCC AGAGAAAATG GAGAAGAAAC TGCACGCAGT GCCAGCTGCC 240

AAGACGGTGA AATTCAAATG CCCGTCGAGT GGGACACCCA GCCCCACTTT GCGCTGGTTG 300

AAAAATGGCA AGGAATTCAA ACCTGACCAC CGGATCGGAG GCTACAAGGT TCGTTACGCC 360

ACTTGGAGCA TCATAATGGA CTCTGTGGTG CCTTCTGACA AGGGCAACTA CACCTGCATC 420

GTGGAGAACG AGTATGGGAG CATTAACCAC ACCTACCAGC TAGACGTTGT GGAGCGATCC 480

CCTCACCGGC CCATCCTTCA GGCAGGGCTA CCAGCCAACA AGACCGTGGC CCTGGGCAGC 540

AACGTGGAGT TCATGTGCAA GGTGTACAGT GACCCCCAGC CTCACATCCA GTGGCTGAAG 600

CACATCGAGG TGAATGGGAG TAAGATCGGT CCAGACAACT TGCCGTATGT CCAGATCCTG 660

AAGACTGCTG GAGTTAATAC CACCGACAAG GAAATGGAGG TGCTTCATCT ACGGAATGTC 720

TCCTTTGAGG ATGCGGGGGA GTATACGTGC TTGGCGGGTA ACTCTATCGG ACTCTCCCAT 780

CACTCTGCAT GGTTGACCGT TCTGGAAGCC CTGGAAGAGA GACCAGCCGT GATGACCTCA 840

CCTCTGTACC TGGAAATCAT TATCTACTGC ACCGGGGCCT TCCTGATCTC CTGTATGGTG 900

GGCTCCGTCA TCATCTACAA GATGAAGAGC GGCACCAAGA AGAGCGACTT CCATAGCCAG 960

ATGGCTGTGC ATAAGCTGGC TAAGAGCATC CCTCTGCGCA GACAGGTGTC AGCTGACTCC 1020

AGCGCATCCA TGAACTCCGG GGTTCTCCTG GTTCGGCCTT CGCGACTGTC CTCCAGCGGA 1080

ACCCCCATGC TAGCTGGCGT CTCTGAATAT GAGCTCCCTG AAGATCCCCG CTGGGAGCTG 1140

CCCCGGGACA GACTGGTCTT AGGAAAACCG CTTGGCGAGG GCTGCTTCGG GCAGGTGGTG 1200

TTGGCCGAAG CCATCGGTCT GGATAAGGAC AAACCCAACC GCGTGACCAA AGTGGCCGTG 1260

AAGATGTTGA AGTCTGATGC GACAGAGAAG GACCTGTCGG ACCTGATCTC GGAGATGGAG 1320

ATGATGAAAA TGATCGGGAA GCACAAGAAT ATCATCAACC TGCTGGGGGC GTGCACACAG 1380

GATGGTCCTC TCTATGTCAT TGTGGAGTAT GCCTCCAAAG GCAATCTTCG GGAGTATCTG 1440

CAGGCCCGGA GGCCTCCTGG GCTGGAGTAT TGCTACAACC CCAGCCACAA CCCTGAGGAA 1500

CAGCTGTCTT CCAAAGATCT GGTGTCCTGT GCCTATCAGG TGGCCCGGGG CATGGAGTAT 1560

CTTGCCTCGA AGAAGTGTAT ACACCGAGAC CTGGCTGCTA GGAATGTCCT GGTGACAGAG 1620

GATAATGTCA TGAAGATCGC AGACTTTGGC CTAGCTCGAG ACATTCACCA TATCGACTAC 1680

TATAAGAAAA CCACCAATGG CCGGCTGCCT GTGAAGTGGA TGGCACCTGA GGCATTGTTT 1740

GACCGGATCT ACACCCACCA GAGTGATGTG TGGTCTTTTG GGGTGCTCTT ATGGGAGATC 1800

TTCACTCTGG GTGGCTCCCC ATACCCCGGT GTGCCTGTGG AAGAACTTTT CAAGCTGCTG 1860

AAGGAGGGTC ATCGAATGGA CAAGCCCAGT AACTGTACCA ATGAGCTGTA CATGATGATG 1920

CGGGACTGCT GGCACGCAGT GCCCTCTCAG AGACCTACTT TCAAGCAGTT GGTGGAAGAC 1980

CTGGACCGCA TTGTGGCCTT GACCTCCAAC CAGGAGTATC TGGACCTGTC CATGCCACTG 2040

GACCAGTACT CGCCAAGCTT TCCGGACACA CGGAGCTCTA CCTGCTCTTC AGGGGAGGAC 2100

TCTGTCTTCT CTCATGAGCC ATTACCTGAG GAGCCCTGTC TGCCCCGACA CCCCACCCAG 2160

CTTGCAAATG GTGGACTCAA ACGGCGCTGA 2190

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 385   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  444

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 445   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  504

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 505   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  564

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 565   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  624

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 625   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  661

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0002062	; P:chondrocyte differentiation
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0007605	; P:sensory perception of sound
GO:0001657	; P:ureteric bud development
GO:0021847	; P:ventricular zone neuroblast division

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013