EKS-RAN-00063

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00063

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	368.5	2.6E-110	39	323	285

Status

Reviewed

Ensembl Protein

ENSRNOP00000021607

UniProt Accession

Q4KM47;

Protein Name

Cyclin-dependent kinase 10

Protein Synonyms/Alias

Cell division protein kinase 10;

Gene Name

Cdk10

Gene Synonyms/Alias

Cdk10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000016088	ENSRNOP00000059465	ENSRNOT00000066552
ENSRNOG00000016088	ENSRNOP00000021607	ENSRNOT00000021607

Organism

Rattus norvegicus

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MAEVDLESDQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ 60

TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 120

EQDLASLLEN MPTPFSEAQV KCILLQVLRG LQYLHRSFII HRDLKVSNLL MTDKGCVKTA 180

DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHKPLLP 240

GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LAGQYSLRKQ PYNNLKHKFP WLSEAGLRLL 300

NFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAA TEGQSKRCRP 360

Nucleotide Sequence
(FASTA)

ATGGCGGAGG TGGACCTGGA GTCGGATCAG ATCCGACTGA AGTGTATCCG TAAGGAAGGT 60

TTCTTCACCG TGCCTCCAGA ACACAGGCTC GGAAGATGCC GAAGCGTTAA GGAGTTCGAG 120

AAGCTGAACC GGATTGGCGA GGGCACCTAT GGCATTGTGT ATCGAGCCCG GGATACGCAG 180

ACGGATGAAA TTGTTGCCCT GAAGAAGGTG CGGATGGACA AAGAGAAAGA TGGCATCCCC 240

ATCAGCAGCC TGCGTGAAAT CACACTGCTC CTGCGTCTCC GCCATCCCAA CATTGTGGAG 300

CTGAAGGAGG TGGTTGTTGG CAACCACCTG GAGAGCATCT TCCTGGTCAT GGGTTACTGT 360

GAACAAGATC TGGCCAGCCT ATTGGAAAAT ATGCCAACGC CCTTCTCGGA GGCCCAGGTT 420

AAGTGCATCC TGCTGCAAGT GCTTCGAGGC CTTCAGTACC TGCACCGGAG CTTCATCATC 480

CACAGGGACC TGAAGGTGTC CAACTTGCTC ATGACAGATA AGGGCTGTGT GAAGACAGCC 540

GATTTCGGCC TGGCTCGGGC CTATGGTGTT CCAGTAAAGC CAATGACTCC CAAGGTTGTT 600

ACCCTCTGGT ACCGAGCCCC AGAGCTGCTG CTTGGAACTA CTACCCAGAC TACCAGCATC 660

GACATGTGGG CTGTTGGCTG CATCCTGGCA GAGCTGCTGG CCCATAAGCC CCTTCTCCCT 720

GGCACTTCCG AGATCCACCA GATCGACTTG ATCGTACAGC TGTTGGGGAC ACCGAGTGAG 780

AATATCTGGC CTGGTTTCTC CAAGCTGCCC CTGGCCGGCC AGTACAGCCT GAGGAAACAG 840

CCCTACAACA ACCTCAAGCA CAAGTTCCCA TGGCTCTCAG AGGCCGGACT GCGCCTGCTC 900

AACTTCCTCT TCATGTATGA CCCTAAGAAA AGGGCAACAG CAGGAGACTG CCTGGAGAGT 960

TCCTACTTCA AGGAGAAGCC CCTACCCTGC GAGCCGGAGC TCATGCCTAC CTTCCCCCAC 1020

CACCGTAACA AGCGTGCTGC CCCAGCTGCC ACTGAGGGGC AGAGCAAACG ATGCCGGCCC 1080

TGA 1083

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d++t+e+vAlKk+r++kek+g+pi++lrEi+ll +l+h+ni

Q: 39    FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNI  98

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk +llq+l+gl+ylH++

Q: 99    VELKEVVVGNHlESIFLVMGYCEQDLASLLENMPT-PFSEAQVKCILLQVLRGLQYLHRS  157

         ********5555***********************.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k aDfGlara+++p+k +t++vvTlwYraPelLlg+++ +

Q: 158   FIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQT  217

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W+vgcilaell++kpl++g+sei+q++ i++llgtpse++wp++sklp +  +s+

Q: 218   TSIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLAGqYSL  277

         ******************************************************99889*

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+ll+ l+++dpkkR +a ++l+++yf

Q: 278   RKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATAGDCLESSYF  323

         *********************************************8

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TQTDEIVALK KVRMDKEKDG IPISSLREIT LLLRLRHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMPTPFSEA QVKCILLQVL RGLQYLHRSF 120

IIHRDLKVSN LLMTDKGCVK TADFGLARAY GVPVKPMTPK VVTLWYRAPE LLLGTTTQTT 180

SIDMWAVGCI LAELLAHKPL LPGTSEIHQI DLIVQLLGTP SENIWPGFSK LPLAGQYSLR 240

KQPYNNLKHK FPWLSEAGLR LLNFLFMYDP KKRATAGDCL ESSYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle

KEGG

rno:361434

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013