EPS-RAN-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	190.3	6.4E-56	820	1066	247

Status

Unreviewed

Ensembl Protein

ENSRNOP00000021745

UniProt Accession

D4A254;

Protein Name

Protein Synonyms/Alias

Protein Phlpp2;

Gene Name

Phlpp2

Gene Synonyms/Alias

Phlpp2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000016108	ENSRNOP00000021745	ENSRNOT00000021744

Organism

Rattus norvegicus

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

MGEVEPVPAG SLEPPEPPEA AAPRRPGGIR VLKRNMKHNG SRNCLNRRSR FGSRERDWLR 60

EDVKRGCVYL YGADTTTATT TTTSSSSSSS SSSSSDLHLV LCTVETPASE ICAGEGRESL 120

YLQLHGDLVR RLEPTERPLQ IVYDYLSRLG FEDPVRIQEE ATNPDLSCMI RFYGEKPCQM 180

DHLDRILLSG IYNVRKGKTQ LHKWAERLVV LCGTCLIVSS VKDCQTGKMH ILPLVGGKIE 240

EVKRRQHSLA FSSAGAQAQT YHVSFETLAE YQRWQRQASK VVSQRISTVD LSCYSLEEVP 300

EHLFYSQDIT YLNLRHNFMQ LERPGGLDTL YKFSQLKGLN LSHNKLGLFP VLLCEISTLT 360

ELNLSCNGFH DLPSQIGNLL NLQTLCLDGN VLTALPDELG NLQQLTSLGI SFNNFSQIPE 420

VLEKLTMLDK VVMAGNRLEI LNLGVLTRMN HVKHVDLRMN HLKTVIIENL EGNKHITHMD 480

LRDNQLTDLD LSSLCSLEQL HCERNQLREL TLSGFSLRNL YANWNKLTAV NVYPVPSLLT 540

SLELSRNLLE CIPDWACEAK KLEILDISYN LLTEVPMRIL SSLSLRKLMV GHNHIHVLPA 600

LVEHIPLEVL DVQHNTLSRL PDTLFSKALN LRYLNASANS LESLPSACAG EESLSVLQLL 660

YLTNNLLTDQ CIPVLVGHPH LRVLHLANNQ LQTFPASKLN KLEQLEELNL SGNKLKAIPT 720

TIANCKRLHT LVAHANNISI FPEILQLPQI QFVDLSCNDL TEILIPETLP ATLQDLDLTG 780

NTNLVLEHKT LDMFSHITTL KIDQKPLPTT DSTVTSTFWS HGLAEMAGQR NKLCVSALAM 840

DNFAEGVGAV YGMFDGDRNE ELPRLLQCTM ADVLLEEVQH STSDTVFMAN TFLVSHRKLG 900

MAGQKLGSSA LLCYIRPDTA DPTSSFSLTV ANVGTCQAVL CRGGKPVPLS KVFSLEHDPE 960

EAQRVKDQKA IITEDNKVNG VTCCTRMLGC TYLYPWILPK PHISSTPLTI QDELLILGNK 1020

ALWEHLSYLE AVSAVRHVQD PLAAAKKLCT LAQSYGCQDN VGAMVVYLNI GEEGCTCEMH 1080

GLALPGPVGF ASTATIKDAP KPTTPSSSSG IASELSSEVS TSEVSSEVGS TASDEHNTVG 1140

LETSLLPRPE RRCSLHPVPS AGTFQRQPSC ATFSSNQSDN GLDSDDDQPV EGVITNGSRV 1200

EVEVDIHCCR GRESENSPTL PKNSSYPCSE EHARGLGFGI RRQNSVNSGI LLPVNKDKME 1260

LQKSPSTSCL YGKKLSNGSI VPLEDSLNLI EVATEAPKRK TGYFAAPTQL EPEDQFVVPR 1320

DLEDEVKEQM KQHQESRPEP EPREEDRTEP LQEFDTAL 1358

Nucleotide Sequence
(FASTA)

ATGGGGGAGG TGGAGCCCGT GCCCGCGGGC TCGCTGGAGC CCCCGGAGCC ACCTGAAGCG 60

GCGGCGCCTC GCCGGCCCGG AGGTATTCGG GTCCTAAAGA GGAATATGAA ACACAATGGG 120

AGCAGAAATT GTTTGAATAG AAGAAGTAGG TTTGGCTCTC GAGAAAGAGA CTGGCTAAGA 180

GAAGATGTGA AGAGAGGCTG TGTTTACCTT TATGGAGCGG ACACGACCAC TGCCACTACA 240

ACCACCACCT CCTCCTCCTC CTCCTCCTCC TCCTCCTCCT CCTCTGATTT ACATCTTGTC 300

CTTTGCACAG TGGAGACACC AGCGTCAGAA ATATGTGCTG GAGAGGGAAG AGAAAGTCTC 360

TATCTACAGC TTCATGGAGA TCTGGTCAGG AGACTGGAGC CCACTGAACG GCCTCTCCAG 420

ATTGTTTACG ACTACTTATC CAGGCTGGGG TTTGAAGATC CCGTGCGCAT ACAGGAGGAG 480

GCTACGAACC CTGATCTCAG CTGTATGATT CGATTTTATG GTGAAAAGCC ATGCCAGATG 540

GATCATCTGG ACCGAATCCT GCTGTCTGGC ATCTATAACG TCCGCAAAGG GAAGACCCAG 600

CTGCACAAAT GGGCTGAGCG CCTCGTTGTT CTCTGTGGCA CCTGCCTTAT TGTCTCCTCA 660

GTGAAGGATT GCCAAACTGG AAAGATGCAC ATCTTGCCAC TGGTTGGGGG AAAGATAGAA 720

GAAGTGAAGC GCCGGCAACA CTCCCTTGCT TTCAGCTCAG CTGGAGCCCA AGCTCAGACC 780

TATCATGTCA GCTTCGAGAC TTTGGCTGAG TACCAGAGAT GGCAGCGGCA GGCGTCTAAG 840

GTGGTGTCCC AGAGGATCAG CACCGTGGAC CTCTCGTGTT ACAGCCTTGA GGAGGTTCCT 900

GAGCATCTCT TCTACAGTCA AGACATCACC TACCTCAACC TGCGACACAA CTTCATGCAG 960

TTAGAAAGAC CAGGGGGCCT TGACACACTC TACAAATTTT CTCAACTGAA GGGCCTGAAC 1020

TTGTCCCATA ATAAGCTTGG ACTGTTTCCT GTGTTGCTGT GTGAGATTTC TACCCTGACT 1080

GAACTCAACC TTTCTTGTAA TGGATTTCAT GACTTGCCAA GTCAGATTGG TAATCTGTTA 1140

AATCTTCAGA CCCTCTGCCT TGATGGCAAT GTTCTCACAG CTCTACCAGA TGAATTGGGA 1200

AACCTGCAGC AGCTTACTTC TCTGGGAATT TCCTTCAACA ATTTTAGTCA AATTCCTGAA 1260

GTTTTGGAGA AACTCACCAT GTTAGATAAA GTGGTTATGG CAGGAAACCG TTTGGAAATC 1320

CTGAACCTAG GGGTGCTGAC CAGGATGAAC CATGTTAAGC ATGTGGATCT AAGGATGAAC 1380

CACTTGAAAA CGGTGATTAT TGAAAATCTG GAGGGAAATA AACACATCAC TCACATGGAT 1440

TTGCGGGACA ATCAGTTGAC TGATTTGGAC CTTAGCTCCT TATGTAGCTT GGAGCAGCTG 1500

CATTGTGAGC GGAACCAGTT GAGAGAGCTG ACACTCAGTG GCTTCTCCCT TCGAAACCTC 1560

TACGCCAATT GGAACAAGCT GACAGCAGTG AATGTCTATC CAGTACCAAG CCTGCTCACT 1620

TCTTTGGAAC TCTCCCGAAA CTTGCTAGAA TGTATCCCTG ACTGGGCCTG TGAAGCAAAA 1680

AAGCTAGAAA TACTAGATAT AAGCTACAAT CTGCTTACAG AGGTTCCCAT GAGAATTCTG 1740

AGTAGTCTGA GTCTTCGGAA ACTGATGGTA GGACACAACC ACATCCATGT CCTTCCGGCA 1800

CTGGTGGAGC ACATTCCCCT CGAGGTACTG GATGTCCAGC ATAACACTCT GTCCAGGCTG 1860

CCGGACACAC TGTTCTCCAA GGCCTTAAAT CTCAGGTACT TGAATGCATC CGCAAATAGT 1920

CTGGAGTCTT TGCCTTCTGC GTGTGCTGGA GAGGAGAGTC TGAGTGTGCT GCAGCTGCTG 1980

TACCTGACCA ACAACCTTCT GACAGACCAG TGCATACCTG TTTTGGTCGG GCACCCACAC 2040

CTGCGTGTTC TGCACCTTGC AAACAACCAG CTACAGACCT TTCCTGCAAG CAAACTAAAC 2100

AAATTGGAGC AACTGGAAGA ACTGAATCTA AGTGGGAACA AGCTTAAAGC TATTCCCACA 2160

ACCATAGCAA ACTGCAAAAG ACTGCACACC CTTGTCGCAC ATGCCAACAA CATCAGCATT 2220

TTCCCAGAGA TCCTGCAGCT GCCTCAGATT CAGTTTGTTG ACCTGAGTTG CAATGATTTG 2280

ACAGAAATAC TAATTCCAGA GACTCTGCCT GCCACTTTAC AAGACCTTGA TCTTACAGGA 2340

AATACAAATC TGGTTCTGGA ACACAAGACT TTGGACATGT TTAGCCATAT CACAACACTG 2400

AAAATTGATC AGAAACCTTT ACCGACCACA GATTCTACAG TTACATCAAC CTTCTGGAGC 2460

CATGGACTGG CCGAGATGGC TGGGCAGAGG AATAAACTCT GTGTGTCTGC TCTGGCTATG 2520

GATAACTTTG CAGAGGGCGT GGGGGCTGTG TACGGCATGT TTGATGGGGA CAGGAATGAG 2580

GAACTCCCCC GTCTGCTGCA GTGTACAATG GCAGACGTGC TTTTGGAAGA GGTACAGCAC 2640

TCAACAAGTG ACACCGTTTT CATGGCCAAT ACCTTCCTGG TGTCTCACAG GAAATTAGGA 2700

ATGGCTGGCC AGAAGCTAGG TTCCTCTGCT CTCCTGTGCT ATATTCGACC TGACACTGCC 2760

GACCCAACAA GTAGTTTTAG CTTGACTGTA GCCAATGTTG GCACGTGCCA AGCTGTCCTG 2820

TGCCGAGGTG GAAAGCCAGT ACCTCTTTCT AAAGTCTTCA GCTTGGAGCA TGACCCAGAG 2880

GAGGCACAGA GGGTGAAGGA CCAGAAAGCT ATCATAACAG AGGACAACAA GGTGAATGGG 2940

GTTACCTGCT GCACCCGGAT GCTGGGATGT ACATACCTCT ACCCCTGGAT CCTCCCCAAG 3000

CCTCACATAT CCTCCACTCC GCTTACCATT CAAGATGAAT TGCTGATTTT GGGAAACAAA 3060

GCACTGTGGG AACACTTGTC CTATCTAGAA GCTGTCAGTG CAGTCCGTCA TGTGCAAGAC 3120

CCATTAGCTG CTGCTAAGAA GCTGTGCACA TTAGCACAGA GCTATGGTTG TCAGGACAAT 3180

GTGGGGGCAA TGGTGGTTTA TTTGAACATT GGTGAAGAAG GCTGTACCTG TGAAATGCAT 3240

GGGCTTGCCC TTCCAGGCCC TGTGGGATTT GCTTCAACAG CAACCATCAA GGATGCCCCC 3300

AAGCCAACCA CTCCCTCCTC TAGCAGTGGG ATTGCCTCAG AGCTGAGCAG TGAGGTGTCG 3360

ACCTCAGAGG TGAGCAGTGA GGTGGGTTCC ACAGCGTCTG ACGAACACAA CACTGTGGGC 3420

CTGGAGACGA GCTTGCTTCC CAGGCCTGAG AGGCGCTGTA GTCTGCACCC TGTGCCCTCT 3480

GCAGGCACTT TCCAGCGCCA GCCTTCTTGT GCTACCTTTT CCAGCAATCA GTCTGACAAT 3540

GGACTGGACA GTGACGATGA CCAGCCTGTT GAAGGCGTCA TAACCAATGG CAGCAGGGTT 3600

GAGGTAGAGG TAGACATTCA TTGCTGCCGA GGCAGAGAGT CTGAGAACTC CCCTACTCTC 3660

CCGAAGAATT CTTCCTACCC CTGTTCAGAG GAACATGCTA GGGGGTTGGG TTTTGGGATC 3720

CGAAGACAGA ACAGTGTGAA TAGTGGTATA CTTCTGCCAG TGAACAAAGA CAAGATGGAG 3780

TTACAGAAGT CTCCCTCCAC TTCTTGTTTG TATGGAAAGA AACTCTCCAA TGGCTCCATT 3840

GTGCCCCTAG AAGACAGCCT GAACCTCATT GAGGTGGCCA CAGAAGCACC CAAGAGGAAA 3900

ACTGGCTATT TTGCTGCCCC CACTCAGCTG GAACCAGAGG ATCAATTTGT TGTCCCCCGT 3960

GACCTGGAAG ACGAAGTGAA GGAGCAAATG AAGCAGCACC AGGAGAGCAG GCCTGAGCCT 4020

GAACCCAGGG AAGAGGACCG GACAGAGCCC CTGCAGGAGT TTGATACAGC ACTGTGA 4077

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++++ g+rn+++ ++ +++nf++  +     a++g++DG++++e  + +++++ ++l

Q: 820   SHGLAEMAGQRNKLCVSALAMDNFAEGVG-----AVYGMFDGDRNEELPRLLQCTMADVL  874

         6899*********************9877.....59************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++    +++  + ++a++Fl  +++l       ++ +k Gs+a++++i+++

Q: 875   LEEVQ----HSTSDTVFMANTFLVSHRKL------GMAGQKLGSSALLCYIRPDtadpts  924

         ***99....67777789************......89***************999999**

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsre.dEleRieeaggsvilkdgaRvlGvL  172

           +l+vanvG ++avLcr+gk+v+ls+ ++ +++ +E +R++++++ +++++  +v+Gv+

Q: 925   sfSLTVANVGTCQAVLCRGGKPVPLSKVFSLEHDpEEAQRVKDQKAIITEDN--KVNGVT  982

         *******************************9876**********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R+lG++yl+p++ p+P+++s++lt +de liL+ + lw+++s  eavs+vr+v +

Q: 983   CCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYLEAVSAVRHVQD--  1040

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           + +aakkL++la+++g++dnv a+vv

Q: 1041  --PLAAAKKLCTLAQSYGCQDNVGAMVV  1066

         ..************************97

Domain Sequence
(FASTA)

SHGLAEMAGQ RNKLCVSALA MDNFAEGVGA VYGMFDGDRN EELPRLLQCT MADVLLEEVQ 60

HSTSDTVFMA NTFLVSHRKL GMAGQKLGSS ALLCYIRPDT ADPTSSFSLT VANVGTCQAV 120

LCRGGKPVPL SKVFSLEHDP EEAQRVKDQK AIITEDNKVN GVTCCTRMLG CTYLYPWILP 180

KPHISSTPLT IQDELLILGN KALWEHLSYL EAVSAVRHVQ DPLAAAKKLC TLAQSYGCQD 240

NVGAMVV 247

Keyword

Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0001917	; C:photoreceptor inner segment
GO:0042622	; C:photoreceptor outer segment membrane
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR011993	; PH_like_dom.
IPR001932	; PP2C-like.

Pfam

PF00560	; LRR_1; 1.
PF12799	; LRR_4; 1.
PF00481	; PP2C; 1.

SMARTs

SM00369	; LRR_TYP; 1.
SM00332	; PP2Cc; 1.

Prosites

PS51450

; LRR; 17.

Prints

Created Date

20-Feb-2013