EPS-RAN-00132

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00132

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PDP	402.1	7.3E-121	229	439	211

Status

Unreviewed

Ensembl Protein

ENSRNOP00000062054

UniProt Accession

F1LP63;

Protein Name

Protein Synonyms/Alias

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial;

Gene Name

Pdp1

Gene Synonyms/Alias

Pdp1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000016180	ENSRNOP00000062054	ENSRNOT00000067823

Organism

Rattus norvegicus

Functional Description

Protein Length

538

Protein Sequence
(FASTA)

MPAPTQLFFP LVRNCELSRI YGTACYCHHK HLCCSPPYIP QNRLRYTPHP AYATFCRPRE 60

NWWQYTQGRR YASTPQKFYL TPPQVNSILK ANEYSFKVPE FDGKNVSSIL GFDSNQLPAN 120

APIEDRRSAA TCLQTRGMLL GVFDGHAGCA CSQAVSERLF YYIAVSLLPH ETLLEIENAV 180

ESGRALLPIL QWHKHPNDYF SKEASKLYFN SLRTYWQELI DLNTGESADI DVKEALINAF 240

KRLDNDISLE AQVGDPNSFL NYLVLRVAFS GATACVAHVD GVDLHVANTG DSRAMLGVQE 300

EDGSWSAVTL SNDHNAQNER ELERLKLEHP KNEAKSVVKQ DRLLGLLMPF RAFGDVKFKW 360

SIDLQKRVIE SGPDQLNDNE YTKFIPPNYH TPPYLTAEPE VTYHRLRPQD KFLVLATDGL 420

WETMHRQDVV RIVGEYLTGM HHQQPIAVGG YKVTLGQMHG LLTERRAKMS SVFEDQNAAT 480

HLIRHAVGNN EFGAVDHERL SKMLSLPEEL ARMYRDDITI IVVQFNSHVV GAYQNQEQ 538

Nucleotide Sequence
(FASTA)

ATGCCAGCAC CAACTCAACT GTTTTTTCCT CTCGTCCGTA ACTGTGAACT GAGCAGAATC 60

TATGGCACTG CATGTTACTG CCACCACAAA CATCTCTGCT GTTCACCACC GTACATTCCT 120

CAGAATCGTC TGAGATACAC ACCCCATCCA GCATATGCTA CCTTTTGTAG GCCAAGGGAG 180

AACTGGTGGC AGTATACTCA AGGAAGGAGA TATGCTTCTA CGCCTCAGAA ATTTTACCTC 240

ACACCTCCAC AAGTCAACAG CATCCTTAAA GCTAATGAAT ACAGCTTCAA AGTACCAGAA 300

TTTGATGGCA AAAATGTCAG TTCCATTCTT GGATTTGACA GCAATCAGCT GCCTGCAAAT 360

GCACCCATAG AAGACCGGAG AAGTGCAGCA ACCTGCTTGC AGACCAGAGG GATGCTTTTG 420

GGCGTTTTTG ATGGTCATGC AGGCTGTGCT TGCTCCCAGG CAGTCAGTGA AAGACTCTTC 480

TATTATATTG CTGTTTCCTT GTTACCCCAT GAGACTTTGC TAGAGATTGA AAATGCAGTG 540

GAGAGTGGTC GGGCACTGCT ACCTATCCTT CAGTGGCACA AGCACCCCAA TGATTACTTC 600

AGTAAGGAGG CATCCAAATT GTATTTCAAC AGCTTGAGGA CTTACTGGCA AGAGCTTATA 660

GACCTCAATA CTGGAGAATC AGCTGATATT GATGTTAAGG AGGCTTTAAT TAATGCTTTC 720

AAGAGACTTG ATAATGACAT TTCATTGGAG GCTCAAGTCG GTGATCCTAA TTCTTTTCTC 780

AATTACCTGG TGCTTCGGGT AGCATTTTCT GGGGCTACTG CTTGTGTGGC CCATGTAGAT 840

GGTGTTGACC TCCATGTGGC TAACACTGGC GATAGTAGAG CCATGCTAGG TGTGCAAGAA 900

GAAGATGGCT CCTGGTCAGC AGTCACGCTC TCTAATGACC ACAATGCTCA GAATGAAAGA 960

GAACTAGAAC GTCTAAAACT GGAACACCCA AAAAATGAGG CCAAGAGCGT GGTAAAGCAG 1020

GATCGGCTGC TTGGCTTGCT GATGCCCTTT AGGGCTTTTG GGGATGTAAA GTTCAAATGG 1080

AGCATTGACC TTCAAAAGAG AGTGATAGAG TCTGGCCCAG ACCAGTTGAA TGACAATGAA 1140

TACACCAAGT TTATCCCTCC TAACTATCAT ACACCTCCTT ATCTCACTGC TGAGCCAGAG 1200

GTAACTTATC ACCGATTAAG GCCACAGGAT AAATTCCTAG TGTTAGCAAC TGATGGATTG 1260

TGGGAGACTA TGCATAGACA GGATGTGGTT AGGATTGTGG GTGAGTACTT AACTGGTATG 1320

CATCACCAAC AGCCAATAGC TGTTGGTGGG TACAAGGTGA CTCTGGGACA GATGCATGGC 1380

CTTTTAACAG AAAGGAGAGC AAAGATGTCA TCAGTCTTTG AGGATCAGAA TGCAGCAACC 1440

CATCTCATTC GCCATGCTGT AGGCAATAAT GAATTTGGAG CTGTTGATCA TGAACGACTC 1500

TCTAAAATGC TTAGCCTTCC TGAAGAGCTT GCTCGGATGT ATAGAGATGA CATTACAATC 1560

ATTGTAGTTC AGTTCAATTC TCATGTTGTA GGAGCATATC AAAACCAGGA ACAGTAA 1617

Domain Profile

S: 2     didvkealvnafkrldedisleaqvsdedevlrylvlrvalsGataclahvdGvdlhvan  61

         didvkeal+nafkrld+disleaqv+d++++l+ylvlrva+sGatac+ahvdGvdlhvan

Q: 229   DIDVKEALINAFKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVAN  288

         89**********************************************************

S: 62    tGdsravlGvqeedgswsavklsrdhnaqneselerlkaehpkseaktvikedrllglli  121

         tGdsra+lGvqeedgswsav+ls+dhnaqne+elerlk+ehpk+eak+v+k+drllgll+

Q: 289   TGDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELERLKLEHPKNEAKSVVKQDRLLGLLM  348

         ************************************************************

S: 122   plrafGdvkfkwskelqkrvvesgfdvladney.kfiapnyytppyltaepevtyhrlrp  180

         p+rafGdvkfkws++lqkrv+esg+d+l+dney kfi+pny+tppyltaepevtyhrlrp

Q: 349   PFRAFGDVKFKWSIDLQKRVIESGPDQLNDNEYtKFIPPNYHTPPYLTAEPEVTYHRLRP  408

         ************************************************************

S: 181   qdkflvlasdGlwdllsredvvrlvgeylae  211

         qdkflvla+dGlw++++r+dvvr+vgeyl+

Q: 409   QDKFLVLATDGLWETMHRQDVVRIVGEYLTG  439

         ****************************875

Domain Sequence
(FASTA)

DIDVKEALIN AFKRLDNDIS LEAQVGDPNS FLNYLVLRVA FSGATACVAH VDGVDLHVAN 60

TGDSRAMLGV QEEDGSWSAV TLSNDHNAQN ERELERLKLE HPKNEAKSVV KQDRLLGLLM 120

PFRAFGDVKF KWSIDLQKRV IESGPDQLND NEYTKFIPPN YHTPPYLTAE PEVTYHRLRP 180

QDKFLVLATD GLWETMHRQD VVRIVGEYLT G 211

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013