EKS-RAN-00145
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00145
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR558.32.8E-168386662277
StatusUnreviewed
Ensembl ProteinENSRNOP00000022331
UniProt AccessionF1LSG7;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFgfr2
Gene Synonyms/Alias Fgfr2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000016374ENSRNOP00000059005ENSRNOT00000068183
ENSRNOG00000016374ENSRNOP00000022331ENSRNOT00000022331
ENSRNOG00000016374ENSRNOP00000061479ENSRNOT00000065448
ENSRNOG00000016374ENSRNOP00000022253ENSRNOT00000022253
OrganismRattus norvegicus
Functional Description
Protein Length726
Protein Sequence
(FASTA)
MGLPSTWRYG TGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT TLEPEGAPYW 60
TNTEKMEKRL HAVPAANTVK FRCPAGGNPT PTMRWLKNGK EFKQEHRIGG YKVRNQHWSL 120
IMESVVPSDK GNYTCLVENE YGSINHTYHL DVVERSPHRP ILQAGLPANA STVVGGDVEF 180
VCKVYSDAQP HIQWIKHVEK NGSKYGPDGL PYLKVLKHSG INSSNAEVLA LFNVTEMDAG 240
EYICKVSNYI GQANQSAWLT VLPKQQAPVR EKEITASPDY LEIAIYCIGV FLIACMVVTV 300
IFCRMKTTTK KPDFSSQPAV HKLTKRIPLR RQVTVSAESS SSMNSNTPLV RITTRLSSTA 360
DTPMLAGVSE YELPEDPKWE FPRDKLTLGK PLGEGCFGQV VMAEAVGIDK DRPKEAVTVA 420
VKMLKDDATE KDLSDLVSEM EMMKMIGKHK NIINLLGACT QDGPLYVIVE YASKGNLREY 480
LRARRPPGME YSYDINRVPE EQMTFKDLVS CTYQLARGME YLASQKCIHR DLAARNVLVT 540
ENNVMKIADF GLARDINNID YYKKTTNGRL PVKWMAPEAL FDRVYTHQSD VWSFGVLMWE 600
IFTLGGSPYP GIPVEELFKL LKEGHRMDKP TNCTNELYMM MRDCWHAVPS QRPTFKQLVE 660
DLDRILTLTT NEEYLDLTQP LEQYSPSYPD TRSSCSSGDD SVFSPDPMPY DPCLPQYPHI 720
NGSVKT 726
Nucleotide Sequence
(FASTA)
ATGGGATTAC CGTCCACATG GAGATATGGA ACAGGACCAG GGATTGGCAC CGTGACCATG 60
GTCAGCTGGG GGCGCTTCAT CTGCCTGGTC TTGGTCACCA TGGCAACCTT GTCCCTGGCC 120
CGGCCCTCCT TCAGTTTAGT TGAAGATACC ACTTTAGAAC CAGAAGGAGC ACCGTACTGG 180
ACCAACACCG AAAAGATGGA GAAGCGGCTC CATGCTGTCC CTGCCGCCAA CACTGTGAAG 240
TTCCGCTGTC CAGCCGGGGG GAATCCAACA CCCACAATGA GGTGGCTAAA AAACGGGAAG 300
GAGTTTAAGC AGGAGCATCG CATCGGAGGC TATAAGGTAC GAAACCAGCA CTGGAGCCTT 360
ATTATGGAAA GTGTGGTCCC ATCAGACAAA GGCAATTACA CCTGCCTGGT GGAGAATGAA 420
TACGGGTCCA TCAACCACAC CTACCACCTT GATGTTGTTG AGCGATCACC ACACCGGCCC 480
ATCCTCCAAG CTGGACTGCC TGCAAATGCC TCCACGGTGG TCGGAGGGGA CGTAGAATTT 540
GTCTGCAAGG TTTATAGTGA TGCCCAGCCC CATATCCAGT GGATCAAACA TGTGGAAAAG 600
AACGGCAGTA AATATGGACC TGATGGGCTG CCCTACCTCA AGGTCCTGAA GCACTCGGGG 660
ATAAATAGCT CCAATGCAGA AGTGCTGGCT CTGTTCAATG TGACGGAGAT GGATGCTGGG 720
GAATATATAT GTAAGGTCTC CAATTATATA GGGCAGGCCA ACCAGTCTGC CTGGCTCACT 780
GTCCTGCCCA AACAGCAAGC ACCTGTGAGA GAGAAGGAGA TCACAGCTTC CCCAGATTAC 840
CTGGAGATAG CTATTTACTG CATAGGGGTC TTCTTAATCG CCTGCATGGT GGTGACAGTC 900
ATCTTTTGCC GAATGAAGAC CACGACCAAG AAGCCAGACT TCAGCAGCCA GCCAGCTGTG 960
CACAAGCTGA CCAAGCGCAT CCCCCTGCGG AGACAGGTAA CAGTTTCGGC CGAGTCCAGC 1020
TCGTCCATGA ACTCCAACAC CCCACTGGTG AGGATAACGA CACGTCTGTC CTCAACGGCG 1080
GACACCCCGA TGCTAGCAGG GGTCTCTGAG TACGAGTTGC CAGAGGATCC AAAGTGGGAA 1140
TTCCCCAGAG ATAAGCTGAC GCTGGGCAAA CCCCTGGGGG AAGGCTGCTT CGGGCAAGTA 1200
GTCATGGCTG AAGCGGTGGG AATCGATAAG GACAGACCCA AGGAGGCAGT CACCGTGGCG 1260
GTGAAGATGT TGAAAGATGA CGCCACAGAG AAGGACCTGT CTGACCTGGT GTCAGAGATG 1320
GAGATGATGA AGATGATTGG TAAACATAAG AACATCATCA ACCTCCTGGG GGCCTGCACC 1380
CAGGATGGAC CCCTCTATGT CATAGTCGAA TACGCATCGA AAGGCAACCT CCGGGAATAC 1440
CTCCGGGCCC GGAGGCCACC TGGCATGGAG TACTCCTATG ACATTAACCG AGTTCCCGAG 1500
GAGCAGATGA CCTTCAAGGA CTTGGTGTCC TGCACCTACC AGCTGGCGAG AGGCATGGAG 1560
TACTTGGCTT CCCAAAAATG TATCCATCGA GACTTGGCAG CCAGAAATGT GCTGGTAACA 1620
GAAAACAACG TGATGAAGAT AGCAGACTTT GGCCTGGCCA GGGATATCAA CAACATAGAC 1680
TATTACAAAA AGACCACGAA TGGGCGACTT CCAGTCAAGT GGATGGCTCC TGAAGCCCTT 1740
TTTGATAGAG TTTACACTCA TCAGAGTGAT GTCTGGTCCT TCGGGGTGTT AATGTGGGAG 1800
ATCTTCACTT TAGGGGGTTC ACCCTACCCA GGGATTCCCG TGGAGGAACT TTTTAAGCTG 1860
CTCAAAGAGG GCCACAGGAT GGACAAGCCC ACCAACTGCA CCAATGAACT GTACATGATG 1920
ATGAGGGACT GCTGGCATGC TGTACCCTCA CAGAGGCCCA CGTTTAAGCA GTTGGTGGAA 1980
GACTTGGATC GAATTCTGAC TCTCACAACC AATGAGGAAT ACTTGGACCT CACCCAGCCT 2040
CTCGAACAGT ATTCTCCTAG TTACCCCGAC ACAAGGAGCT CTTGTTCTTC AGGGGACGAT 2100
TCTGTGTTTT CTCCAGACCC CATGCCTTAT GACCCCTGCC TGCCTCAGTA TCCACACATA 2160
AACGGCAGTG TTAAAACATG A 2181
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkd++k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 386   LTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  445
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+
Q: 446   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  505
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 506   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  565
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 566   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  625
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl
Q: 626   RMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  662
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDRPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPTNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAJ-00155
EKS-CAF-00154
EKS-CAP-00147
EKS-DAR-00432
EKS-DRM-00071
EKS-EQC-00145
EKS-FEC-00140
EKS-GAM-00078
EKS-GAG-00125
EKS-GAA-00175
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LAC-00158
EKS-LOA-00149
EKS-MAM-00147
EKS-MOD-00147
EKS-MUM-00151
EKS-MUP-00151
EKS-NOL-00141
EKS-ORN-00182
EKS-ORC-00138
EKS-ORL-00170
EKS-OTG-00152
EKS-PAT-00137
EKS-PES-00132
EKS-POA-00143
EKS-PTV-00139
EKS-SAH-00142
EKS-TAG-00176
EKS-TAR-00191
EKS-TEN-00183
EKS-XET-00137
EKS-XIM-00176
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0001525; P:angiogenesis
GO:0007409; P:axonogenesis
GO:0030282; P:bone mineralization
GO:0060349; P:bone morphogenesis
GO:0060667; P:branch elongation involved in salivary gland morphogenesis
GO:0060670; P:branching involved in labyrinthine layer morphogenesis
GO:0048755; P:branching morphogenesis of a nerve
GO:0060449; P:bud elongation involved in lung branching
GO:0045165; P:cell fate commitment
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0061031; P:endodermal digestive tract morphogenesis
GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069; P:hair follicle morphogenesis
GO:0032808; P:lacrimal gland development
GO:0060601; P:lateral sprouting from an epithelium
GO:0070307; P:lens fiber cell development
GO:0060174; P:limb bud formation
GO:0048286; P:lung alveolus development
GO:0060463; P:lung lobe morphogenesis
GO:0060484; P:lung-associated mesenchyme development
GO:0060615; P:mammary gland bud formation
GO:0003149; P:membranous septum morphogenesis
GO:0060915; P:mesenchymal cell differentiation involved in lung development
GO:0060916; P:mesenchymal cell proliferation involved in lung development
GO:0030901; P:midbrain development
GO:0035264; P:multicellular organism growth
GO:0008285; P:negative regulation of cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528; P:neuromuscular junction development
GO:0042476; P:odontogenesis
GO:0035265; P:organ growth
GO:0030916; P:otic vesicle formation
GO:0003148; P:outflow tract septum morphogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0051781; P:positive regulation of cell division
GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010518; P:positive regulation of phospholipase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009791; P:post-embryonic development
GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523; P:prostate epithelial cord elongation
GO:0046777; P:protein autophosphorylation
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453; P:regulation of cell fate commitment
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014; P:regulation of multicellular organism growth
GO:0051150; P:regulation of smooth muscle cell differentiation
GO:0008589; P:regulation of smoothened signaling pathway
GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489; P:synaptic vesicle transport
GO:0001657; P:ureteric bud development
GO:0055010; P:ventricular cardiac muscle tissue morphogenesis
KEGG
rno:25022;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013