EKS-RAN-00146

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00146

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	557.0	7.4E-168	466	742	277

Status

Unreviewed

Ensembl Protein

ENSRNOP00000023144

UniProt Accession

F1LQA0;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

Fgfr3

Gene Synonyms/Alias

Fgfr3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000016818	ENSRNOP00000023144	ENSRNOT00000023144

Organism

Rattus norvegicus

Functional Description

Protein Length

800

Protein Sequence
(FASTA)

MVVPACVLVF CVAVVAGVTS EPPGPEQRVG RRAAEVPGPE PSQQEQVAFG SGDTVELSCH 60

PPGGAPTGPT LWAKDGVGLV ASHRILVGPQ RLQVLNATHE DAGVYSCQQR LTRRVLCHFS 120

VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP ERMDKKLLAV PAANTVRFRC PAAGNPTPSI 180

SWLKNGKEFR GEHRIGGIKL RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL 240

ERSPHRPILQ AGLPANQTAV LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYV 300

TVLKTAGANT TDRELEVLSL HNVTFEDAGE YTCLAGNSIG FSHHSAWLVV LPAEEELMEV 360

DEAGSVYAGV LSYGVGFFLF ILVVAAVTLC RLRSPPKKGL GSPTVHKVSR FPLKRQVSLE 420

SNSSMNSNTP LVRIARLSSG EGPVLANVSE LELPADPKWE LSRTRLTLGK PLGEGCFGQV 480

VMAEAIGIDK DRTAKPVTVA VKMLKDDATD KDLSDLVSEM EMMKMIGKHK NIINLLGACT 540

QGGPLYVLVE YAAKGNLREF LRARRPPGMD YSFDACRLPE EQLTCKDLVS CAYQVARGME 600

YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNLD YYKKTTNGRL PVKWMAPEAL 660

FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL LKEGHRMDKP ANCTHDLYMI 720

MRECWHAVPS QRPTFKQLVE DLDRILTVTS TDEYLDLSVP FEQYSPGGQD TPSSSSSGDD 780

SVFTHDLLPP GPPSNGGPRT 800

Nucleotide Sequence
(FASTA)

ATGGTAGTCC CGGCCTGCGT GCTAGTGTTC TGCGTGGCGG TCGTGGCTGG AGTTACTTCC 60

GAGCCTCCCG GTCCAGAGCA GCGAGTTGGT CGGAGAGCGG CAGAGGTTCC AGGGCCTGAA 120

CCTAGCCAGC AGGAGCAGGT GGCCTTCGGC AGTGGGGACA CTGTGGAGCT GAGCTGCCAT 180

CCGCCTGGAG GTGCCCCCAC AGGCCCCACT CTCTGGGCTA AGGACGGTGT GGGGCTGGTG 240

GCCTCCCACC GTATCCTGGT GGGGCCTCAG AGGCTTCAAG TGCTAAACGC CACCCATGAG 300

GATGCTGGGG TCTACAGCTG CCAGCAGCGG CTAACCCGGC GTGTGCTGTG CCACTTTAGT 360

GTGCGTGTGA CAGATGCTCC GTCCTCAGGA GATGACGAAG ATGGGGAGGA CGTGGCTGAA 420

GACACAGGGG CTCCTTACTG GACTCGACCG GAGCGTATGG ATAAGAAACT GCTGGCTGTG 480

CCAGCTGCAA ACACTGTACG CTTCCGCTGC CCAGCTGCTG GCAACCCCAC CCCCTCCATC 540

TCCTGGCTGA AGAACGGCAA AGAATTCCGA GGGGAGCACC GCATTGGGGG CATTAAGCTC 600

CGGCACCAGC AGTGGAGCTT GGTCATGGAA AGTGTGGTGC CCTCTGACCG CGGCAATTAC 660

ACCTGCGTGG TTGAGAACAA GTTTGGCAGC ATCCGGCAGA CGTACACCCT GGATGTGCTG 720

GAGCGCTCCC CACACCGGCC CATCCTGCAG GCTGGGCTGC CAGCCAACCA GACAGCCGTT 780

CTGGGCAGTG ACGTGGAGTT CCACTGCAAG GTGTACAGCG ACGCACAGCC ACACATCCAG 840

TGGCTGAAGC ACGTGGAGGT GAATGGGAGC AAGGTGGGCC CTGACGGCAC GCCCTACGTC 900

ACTGTACTCA AGACTGCAGG AGCTAACACC ACCGACAGGG AGCTAGAGGT TCTGTCCTTG 960

CACAATGTCA CCTTTGAGGA TGCGGGGGAG TACACCTGCC TGGCGGGCAA TTCTATCGGG 1020

TTTTCCCATC ACTCTGCGTG GCTGGTGGTG CTGCCAGCCG AGGAGGAGCT GATGGAAGTT 1080

GACGAGGCTG GCAGCGTGTA CGCGGGTGTC CTCAGCTACG GGGTGGGCTT CTTCCTCTTC 1140

ATCCTGGTGG TGGCGGCAGT GACGCTCTGC CGTCTGCGCA GTCCCCCAAA GAAGGGCCTG 1200

GGCTCGCCCA CCGTGCACAA GGTCTCTCGC TTCCCGCTTA AGCGACAGGT GTCCTTGGAG 1260

TCTAATTCCT CTATGAACTC CAACACACCT CTCGTCCGGA TTGCCCGGCT GTCCTCAGGA 1320

GAAGGTCCTG TCCTGGCCAA TGTTTCTGAA CTTGAGCTGC CTGCTGACCC CAAGTGGGAG 1380

CTATCCAGGA CCCGGCTGAC ACTCGGTAAG CCTCTTGGAG AAGGCTGCTT TGGACAGGTT 1440

GTCATGGCAG AAGCTATTGG CATCGACAAG GACCGCACTG CCAAGCCTGT CACCGTGGCC 1500

GTGAAGATGC TGAAAGATGA TGCCACTGAC AAGGACCTGT CGGACCTGGT GTCTGAGATG 1560

GAGATGATGA AAATGATTGG CAAGCACAAG AACATCATTA ACCTGTTGGG GGCCTGCACC 1620

CAGGGTGGGC CCCTGTATGT GCTGGTGGAG TATGCAGCCA AGGGCAACCT GCGAGAGTTC 1680

CTCCGGGCAC GGCGGCCTCC AGGCATGGAT TACTCCTTTG ATGCCTGCAG GCTGCCAGAG 1740

GAACAGCTCA CCTGCAAGGA TCTGGTGTCC TGTGCCTACC AGGTGGCACG GGGCATGGAG 1800

TACTTGGCTT CCCAGAAGTG TATTCACAGA GACCTGGCTG CCAGAAACGT GCTGGTGACT 1860

GAGGACAATG TGATGAAGAT TGCAGACTTT GGCCTGGCCC GAGATGTGCA CAACCTGGAT 1920

TACTACAAGA AGACCACAAA TGGCCGGCTA CCTGTGAAGT GGATGGCACC AGAGGCCCTT 1980

TTTGACCGAG TCTACACCCA TCAGAGTGAT GTCTGGTCCT TTGGTGTCCT CCTCTGGGAG 2040

ATCTTTACAC TGGGTGGGTC ACCATATCCT GGCATCCCAG TGGAAGAGCT TTTCAAGCTG 2100

TTGAAAGAGG GCCACCGCAT GGACAAGCCA GCCAACTGCA CACATGACCT GTACATGATC 2160

ATGCGGGAAT GTTGGCATGC AGTGCCTTCA CAGAGGCCCA CCTTCAAGCA GTTGGTAGAG 2220

GATTTAGACC GCATCCTCAC GGTGACATCA ACTGACGAGT ACTTGGACCT CTCGGTGCCA 2280

TTTGAACAGT ACTCGCCAGG TGGCCAAGAT ACTCCTAGCT CCAGCTCGTC CGGGGACGAC 2340

TCTGTGTTCA CCCATGACCT GCTACCCCCA GGCCCACCCA GCAATGGGGG ACCTCGGACG 2400

TGA 2403

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aeaig+dkd+++k vtvavkmlk+datdkdl+dlvseme++k+

Q: 466   LTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  525

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyv+veyaakGnlreflrarrp+g+++s d+++ +eeqlt+

Q: 526   IGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTC  585

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyykkt

Q: 586   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT  645

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh

Q: 646   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  705

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl

Q: 706   RMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVEDL  742

         ***********************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA IGIDKDRTAK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQGGPL YVLVEYAAKG NLREFLRARR PPGMDYSFDA CRLPEEQLTC 120

KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT 180

TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240

RMDKPANCTH DLYMIMRECW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0009898	; C:internal side of plasma membrane
GO:0005764	; C:lysosome
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0061144	; P:alveolar secondary septum development
GO:0060385	; P:axonogenesis involved in innervation
GO:0060349	; P:bone morphogenesis
GO:0051216	; P:cartilage development
GO:0022010	; P:central nervous system myelination
GO:0090102	; P:cochlea development
GO:0048546	; P:digestive tract morphogenesis
GO:0072148	; P:epithelial cell fate commitment
GO:0060113	; P:inner ear receptor cell differentiation
GO:0070307	; P:lens fiber cell development
GO:0002089	; P:lens morphogenesis in camera-type eye
GO:0000165	; P:MAPK cascade
GO:0002009	; P:morphogenesis of an epithelium
GO:0043066	; P:negative regulation of apoptotic process
GO:0048712	; P:negative regulation of astrocyte differentiation
GO:0050680	; P:negative regulation of epithelial cell proliferation
GO:0045839	; P:negative regulation of mitosis
GO:0045879	; P:negative regulation of smoothened signaling pathway
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0045597	; P:positive regulation of cell differentiation
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010518	; P:positive regulation of phospholipase activity
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0042511	; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0046777	; P:protein autophosphorylation
GO:0048678	; P:response to axon injury
GO:0035019	; P:somatic stem cell maintenance
GO:0021762	; P:substantia nigra development

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013