EPS-RAN-00128

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00128

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	620.0	8.1E-187	185	496	312

Status

Reviewed

Ensembl Protein

ENSRNOP00000023078

UniProt Accession

P53042;

Protein Name

Serine/threonine-protein phosphatase 5

Protein Synonyms/Alias

PP5; Protein phosphatase T; PPT;

Gene Name

Ppp5c

Gene Synonyms/Alias

Ppp5c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000016907	ENSRNOP00000023078	ENSRNOT00000023078

Organism

Rattus norvegicus

Functional Description

May play a role in the regulation of RNA biogenesisand/or mitosis.

Protein Length

499

Protein Sequence
(FASTA)

MAMAEGERTE CAEPPRDEPP AEGTLKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 60

NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 120

TVVKVKPNDK DAKMKYQECS KIVKQKAFER AIAGDEHRRS VVDSLDIESM TIEDEYSGPK 180

LEDGKVTITF MKDLMQWYKD QKKLHRKCAY QILVQVKEVL CKLSTLVETT LKETEKITVC 240

GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 300

RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 360

VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSVSKR GVSCQFGPDV TKAFLEENQL 420

DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP 480

HPNVKPMAYA NTLLQLGMM 499

Nucleotide Sequence
(FASTA)

ATGGCGATGG CGGAGGGCGA GCGGACTGAG TGTGCTGAGC CCCCCCGGGA CGAACCCCCG 60

GCCGAAGGCA CTCTGAAGCG GGCAGAGGAG CTCAAGACAC AGGCCAACGA CTACTTCAAA 120

GCCAAGGACT ACGAGAACGC TATCAAGTTC TACAGTCAGG CCATCGAGTT GAACCCCAGC 180

AATGCCATCT ACTATGGCAA CCGCAGCCTG GCCTACCTGC GCACCGAGTG CTATGGCTAT 240

GCACTGGGCG ATGCCACACG GGCTATCGAG CTTGACAAGA AGTACATCAA AGGTTACTAC 300

CGCCGGGCGG CTAGCAACAT GGCACTGGGC AAGTTCCGGG CTGCCCTGCG TGACTACGAG 360

ACGGTGGTGA AGGTGAAGCC TAATGACAAG GATGCCAAGA TGAAGTACCA GGAGTGCAGC 420

AAGATTGTGA AGCAGAAGGC CTTTGAGAGG GCCATTGCAG GCGACGAGCA CAGACGCTCT 480

GTCGTGGACT CTCTGGACAT CGAAAGCATG ACCATTGAAG ATGAATACAG TGGGCCCAAG 540

CTTGAGGATG GCAAAGTGAC AATCACCTTC ATGAAAGACC TCATGCAGTG GTACAAGGAT 600

CAGAAGAAAC TGCACCGGAA GTGCGCCTAC CAGATCCTAG TGCAGGTGAA GGAAGTCCTC 660

TGCAAGCTGA GCACGCTGGT GGAGACAACG CTGAAAGAGA CAGAGAAGAT TACAGTGTGT 720

GGGGACACCC ATGGCCAGTT TTATGACCTC CTCAACATAT TTGAGCTCAA CGGTTTACCC 780

TCAGAGACCA ACCCCTATAT ATTTAACGGC GACTTTGTGG ACCGTGGTTC CTTCTCCGTT 840

GAAGTGATCC TCACCCTCTT TGGCTTCAAG CTCCTGTATC CAGATCATTT TCATCTACTT 900

CGAGGCAACC ACGAGACGGA CAACATGAAC CAGATCTATG GCTTCGAGGG CGAGGTGAAG 960

GCCAAGTACA CAGCCCAAAT GTATGAGCTC TTCAGCGAGG TGTTCGAGTG GCTTCCGCTG 1020

GCACAGTGTA TCAATGGCAA AGTGCTGATC ATGCATGGAG GCCTATTCAG CGAAGATGGT 1080

GTCACTCTGG ATGACATCCG GAAGATTGAG CGGAATCGGC AGCCCCCAGA CTCAGGTCCC 1140

ATGTGTGACC TGCTGTGGTC AGATCCCCAG CCACAGAATG GGCGCTCCGT CAGCAAGCGT 1200

GGTGTGAGTT GTCAGTTTGG GCCCGATGTC ACCAAGGCCT TCCTGGAGGA GAATCAACTG 1260

GACTACATCA TCCGCAGCCA TGAAGTCAAA GCTGAGGGCT ACGAGGTGGC CCATGGTGGC 1320

CGCTGTGTCA CCGTCTTCTC TGCCCCCAAT TATTGTGACC AGATGGGAAA CAAAGCCTCC 1380

TACATCCACC TCCAGGGCTC CGACCTGCGG CCCCAGTTCC ACCAATTCAC AGCAGTGCCT 1440

CACCCCAACG TCAAGCCCAT GGCATACGCC AACACGCTGC TGCAGCTAGG AATGATGTGA 1500

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+i f+k+l++++k++kkl+rk+a++ilv+v++vl kl++++e+++ke++kitvcGdth

Q: 185   KVTITFMKDLMQWYKDQKKLHRKCAYQILVQVKEVLCKLSTLVETTLKETEKITVCGDTH  244

         799*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         GqfydllnifelnGlpse+npy+fnGdfvdrGsfsveviltlfg+kllyPdhf+llrGnh

Q: 245   GQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLLRGNH  304

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn+iyGfegevkakyta++yelf+evfewlPlaq+ingkvl+mhGGlfsedgvtld

Q: 305   ETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLD  364

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirkiern+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvtk+fleen+ldyii

Q: 365   DIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTKAFLEENQLDYII  424

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++g++vtvfsapnycd++gn+as+ih++++dlr+++++f+av+hp+v

Q: 425   RSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVPHPNV  484

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+ll+l

Q: 485   KPMAYANTLLQL  496

         *********997

Domain Sequence
(FASTA)

KVTITFMKDL MQWYKDQKKL HRKCAYQILV QVKEVLCKLS TLVETTLKET EKITVCGDTH 60

GQFYDLLNIF ELNGLPSETN PYIFNGDFVD RGSFSVEVIL TLFGFKLLYP DHFHLLRGNH 120

ETDNMNQIYG FEGEVKAKYT AQMYELFSEV FEWLPLAQCI NGKVLIMHGG LFSEDGVTLD 180

DIRKIERNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTKAF LEENQLDYII 240

RSHEVKAEGY EVAHGGRCVT VFSAPNYCDQ MGNKASYIHL QGSDLRPQFH QFTAVPHPNV 300

KPMAYANTLL QL 312

Keyword

Acetylation; Complete proteome; Hydrolase; Iron; Manganese; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005829	; C:cytosol
GO:0005794	; C:Golgi apparatus
GO:0043005	; C:neuron projection
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0004871	; F:signal transducer activity
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0006470	; P:protein dephosphorylation
GO:0051291	; P:protein heterooligomerization
GO:0043278	; P:response to morphine

KEGG

rno:65179

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 2.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013