EKS-RAN-00188
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00188
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK411.22.1E-12361309249
StatusReviewed
Ensembl ProteinENSRNOP00000023416
UniProt AccessionQ924U5; A1A5M5;
Protein NameDual specificity testis-specific protein kinase 2
Protein Synonyms/Alias Testicular protein kinase 2;
Gene NameTesk2
Gene Synonyms/Alias Tesk2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000017282ENSRNOP00000023416ENSRNOT00000023416
OrganismRattus norvegicus
Functional DescriptionDual specificity protein kinase activity catalyzingautophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis (By similarity).
Protein Length570
Protein Sequence
(FASTA)
MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NTVQVGRVSS SSYRAIISAF SRLTSLDDFT 60
REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK EMQLMNRLSH PNILRFMGVC 120
VHQGQLHALT EYINSGNLEQ LLDSNLYLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 180
NCLIKRDENG YSAVVADFGL AEKIPDASIG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 240
SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PSDFLQLTFN CCNMDPKLRP 300
SFEEIGKTLE EIMSRLQEEE LERDRKLQPT AKGLLEKVPG GKRLSSLDDK IPHKSPRPRR 360
TIWLSRSQSD IFSRKPPRTV NVLDPYYQPR DGATHTPKVN PFSARQDLKG GKVKFFDLPS 420
KSVISLVFDL DAPGPGTVSL ADCQEPLAPS SRRWRSLPGS PEFLHQACPF VGCEESLSDG 480
PPPRLSSLKY RVREIPPFRT SALSATSAHE AMDCSNPQEE NGFVPRPKGT SPCSGAASEE 540
MEVEEERPRR APVHFSISGI SLQTQGEQDG 570
Nucleotide Sequence
(FASTA)
ATGGATCGGA GCAAACGGAA CTCGATCGCA GGGTTTCCCC CGCGTGTGGA GCGTCTGGAA 60
GAATTTGAAG GAGGCGGTGG AGGGGATGGG AACACTGTGC AGGTGGGAAG AGTTTCGTCA 120
TCTTCATATC GTGCGATTAT CAGTGCCTTT TCCAGACTGA CGAGTTTGGA TGACTTCACC 180
CGTGAAAAAA TAGGATCTGG GTTCTTCTCC GAGGTTTTCA AGGTTCGGCA CAGAGCTTCA 240
GGGCAGGTGA TGGCTCTCAA GATGAACACG CTGAGCAGTA ACCGAGCAAA CCTGCTGAAG 300
GAGATGCAGC TCATGAACAG ACTGTCCCAT CCCAACATCC TCAGGTTCAT GGGTGTGTGT 360
GTACATCAAG GACAGTTGCA TGCACTTACA GAGTACATCA ACTCTGGGAA CCTGGAGCAG 420
CTGCTAGACA GTAACCTGTA TTTGCCTTGG ACTGTGAGAG TGAAACTGGC CTATGACATA 480
GCAGTGGGGC TCAGCTACCT TCACTTCAAA GGCATTTTCC ACCGGGACCT CACGTCGAAG 540
AACTGCCTTA TAAAGAGAGA TGAAAACGGT TACTCTGCGG TGGTAGCTGA TTTCGGCCTG 600
GCTGAGAAGA TTCCTGATGC TAGTATAGGG AGTGAGAAGC TAGCTGTGGT GGGCTCACCT 660
TTCTGGATGG CACCTGAGGT TCTCCGAGAT GAACCTTACA ATGAGAAGGC AGACGTGTTC 720
TCTTACGGTA TCATCCTCTG CGAGATCATC GCCCGCATCC AGGCTGATCC GGACTATCTT 780
CCCCGCACAG AGAATTTCGG GCTGGATTAT GATGCTTTCC AGCACATGGT GGGAGACTGC 840
CCCTCAGACT TCCTGCAACT CACCTTCAAC TGCTGTAATA TGGACCCCAA ACTGCGCCCA 900
TCCTTTGAGG AGATTGGGAA GACCCTAGAG GAAATTATGA GCCGCTTACA GGAAGAAGAG 960
TTGGAGAGAG ACAGGAAGCT GCAGCCCACA GCTAAAGGAC TATTGGAGAA AGTGCCCGGA 1020
GGGAAGCGAC TGAGTTCACT GGATGACAAG ATTCCCCACA AGTCTCCACG TCCAAGACGT 1080
ACTATCTGGT TGTCTCGAAG CCAGTCAGAC ATTTTCTCTC GTAAGCCCCC ACGTACAGTC 1140
AATGTCTTGG ACCCCTATTA CCAGCCACGA GATGGTGCTA CACATACCCC AAAAGTCAAC 1200
CCTTTCAGTG CACGCCAAGA CCTCAAGGGT GGGAAGGTCA AATTCTTTGA CCTACCCAGC 1260
AAATCTGTTA TTTCCCTTGT ATTTGACCTG GATGCACCAG GGCCTGGAAC TGTATCTCTA 1320
GCTGACTGTC AGGAGCCTTT GGCCCCATCT TCCAGACGGT GGCGGTCTTT GCCTGGTTCA 1380
CCCGAGTTCT TGCATCAGGC TTGTCCATTT GTGGGGTGTG AAGAATCACT GTCTGATGGG 1440
CCTCCACCAC GACTCAGTAG TCTCAAGTAC AGAGTAAGAG AGATCCCACC ATTCCGGACA 1500
TCTGCCCTAT CAGCTACTTC AGCCCATGAG GCCATGGATT GCTCTAACCC CCAAGAAGAA 1560
AACGGTTTTG TTCCCAGGCC TAAGGGGACC AGCCCATGCA GTGGGGCTGC CTCTGAGGAG 1620
ATGGAGGTGG AGGAAGAAAG GCCACGAAGA GCTCCTGTCC ACTTCTCTAT CTCTGGAATA 1680
AGCTTGCAAA CCCAGGGAGA GCAGGACGGG TGA 1713
Domain Profile
S: 4     geklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlkfiG  63
          ek+G+Gffsevfkv+hrasG+vm+lk  ++++++nr+nllke++l+++l+hpn+l+f+G
Q: 61    REKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANLLKEMQLMNRLSHPNILRFMG  118
         69*************************..*******************************
S: 64    vlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihrdln  123
         v+v++++lh+lteyi++G+l++ll+s+  lpwt+rv+la+dia+Glsylh+kgi+hrdl+
Q: 119   VCVHQGQLHALTEYINSGNLEQLLDSNLYLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLT  178
         ************************************************************
S: 124   sknclvre...dksvvvadfGlarlvveerkkseklrslkkkdrkkrltvvGsPywmaPe  180
         skncl+++   ++s+vvadfGla          ek+++++ +  +++l+vvGsP+wmaPe
Q: 179   SKNCLIKRdenGYSAVVADFGLA----------EKIPDASIG--SEKLAVVGSPFWMAPE  226
         *******9887899*********..........999999888..899*************
S: 181   vlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaedcPeaf  240
         vl+++ y+ek+dvfs+Gi+lceiiar++adPdylPrte+fgld++af++ +v+ dcP++f
Q: 227   VLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAFQH-MVG-DCPSDF  284
         *************************************************.999.******
S: 241   lklavvccdldpesrpsfeelekkl  265
         l+l+++cc++dp+ rpsfee+ k+l
Q: 285   LQLTFNCCNMDPKLRPSFEEIGKTL  309
         *********************9876
Domain Sequence
(FASTA)
REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK EMQLMNRLSH PNILRFMGVC 60
VHQGQLHALT EYINSGNLEQ LLDSNLYLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 120
NCLIKRDENG YSAVVADFGL AEKIPDASIG SEKLAVVGSP FWMAPEVLRD EPYNEKADVF 180
SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQHMVGDC PSDFLQLTFN CCNMDPKLRP 240
SFEEIGKTL 249
KeywordATP-binding; Complete proteome; Kinase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00182
EKS-ANC-00186
EKS-BOT-00194
EKS-CAJ-00200
EKS-CAF-00199
EKS-CAP-00219
EKS-CIS-00230
EKS-DAR-00495
EKS-ECT-00070
EKS-EQC-00188
EKS-FEC-00181
EKS-GAG-00166
EKS-GOG-00188
EKS-HOS-00200
EKS-ICT-00185
EKS-LAC-00205
EKS-LOA-00191
EKS-MAM-00194
EKS-MEG-00149
EKS-MOD-00192
EKS-MUM-00197
EKS-MUP-00194
EKS-MYL-00198
EKS-NOL-00181
EKS-OCP-00126
EKS-ORN-00247
EKS-ORA-00171
EKS-ORC-00177
EKS-ORL-00230
EKS-OTG-00199
EKS-PAT-00185
EKS-PES-00168
EKS-POA-00185
EKS-SAH-00186
EKS-SUS-00168
EKS-TAG-00218
EKS-TAR-00250
EKS-TEN-00246
EKS-TUT-00180
EKS-XIM-00241
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004712; F:protein serine/threonine/tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0006915; P:apoptotic process
GO:0048041; P:focal adhesion assembly
GO:0035556; P:intracellular signal transduction
GO:0007283; P:spermatogenesis
KEGG
rno:170908;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013