EPS-RAN-00035

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00035

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	93.1	2.9E-26	52	334	283

Status

Unreviewed

Ensembl Protein

ENSRNOP00000059322

UniProt Accession

D4A6C6;

Protein Name

Protein Synonyms/Alias

Protein Map3k7ip1; RCG59826;

Gene Name

Map3k7ip1

Gene Synonyms/Alias

Map3k7ip1; rCG_59826;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000017285	ENSRNOP00000059322	ENSRNOT00000067904

Organism

Rattus norvegicus

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MAAQRRSLLQ SEQQPSWTDD LPLCHFSGVG SASNRSYSAD GKGTESHPPE DNWLKFRSEN 60

NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNTEHTDA DVRRVLLQAF DVVERSFLES 120

IDDALAEKAS LQSQLPEGVP QHQLLPQYQK ILERLKALEK EISGGAMAVV AVLLNNKLYV 180

ANVGTNRALL CRSTVDGLQV TQLNVDHTAE NEDELFRLSQ LGLDAGKIKQ VGVICGQEST 240

RRIGDYKVKY GYTDIDLLST AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 300

GPGQANQEVA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAK FCPRHEDMTL 360

LVRNFGYPLG EMSQPTPTPA PGGRVYPVSV PYSSAQSTSK TSVTLSLVMP SQGQMVNGSH 420

SASTLDEATP TLTNQSPTLT LQSTNTHTQS SSSSSDGGLF RSRPAHSLPP GEDGRVEPYV 480

DFAEFYRLWS VDHGEQSVMT AP 502

Nucleotide Sequence
(FASTA)

ATGGCGGCGC AGAGGAGGAG CCTGCTCCAG AGTGAGCAGC AGCCAAGCTG GACAGATGAC 60

CTGCCACTCT GTCACTTCTC CGGCGTTGGT TCAGCTTCCA ACCGTAGCTA CTCTGCTGAT 120

GGCAAGGGCA CTGAGAGTCA CCCTCCGGAG GACAACTGGC TCAAGTTCAG AAGTGAAAAC 180

AACTGCTTCC TGTATGGGGT CTTCAATGGC TATGATGGCA ACCGCGTGAC CAACTTTGTG 240

GCGCAGAGAC TCTCTGCAGA GCTCCTGCTG GGCCAGCTCA ACACCGAACA CACAGATGCT 300

GATGTGCGAC GGGTCCTGCT GCAGGCCTTC GATGTGGTGG AGAGGAGCTT CCTGGAGTCT 360

ATCGATGATG CCTTGGCTGA GAAAGCAAGC CTCCAGTCCC AGCTGCCGGA GGGTGTGCCC 420

CAACACCAGC TGCTACCTCA GTATCAGAAG ATCCTGGAGA GACTCAAGGC ACTGGAGAAG 480

GAGATCTCGG GAGGGGCCAT GGCTGTTGTG GCGGTCCTTC TCAACAACAA GCTCTACGTT 540

GCCAATGTTG GTACGAACAG GGCCCTTCTG TGCAGATCCA CCGTGGACGG GCTACAGGTC 600

ACACAGCTGA ACGTGGACCA CACCGCCGAG AATGAGGACG AGCTCTTCCG TCTCTCACAA 660

CTGGGTTTAG ACGCAGGGAA GATCAAGCAG GTGGGCGTCA TCTGTGGACA GGAGAGCACC 720

AGGCGAATTG GGGATTACAA GGTCAAATAT GGCTACACTG ACATTGACCT GCTCAGCACT 780

GCCAAATCCA AACCCATCAT CGCAGAGCCC GAAATCCACG GCGCACAGCC TCTGGATGGC 840

GTGACGGGCT TCCTGGTACT GATGTCGGAG GGGCTGTACA AGGCCCTGGA GGCAGCCCAT 900

GGGCCTGGGC AGGCCAACCA GGAGGTTGCC GCAATGATTG ACACCGAATT TGCCAAGCAG 960

ACCTCCCTCG ATGCAGTTGC CCAGGCTGTG GTAGACCGTG TAAAGCGTAT CCACAGTGAC 1020

ACCTTTGCCA GCGGTGGGGA GCGGGCCAAG TTCTGCCCAC GGCATGAAGA CATGACCCTG 1080

CTGGTGAGGA ACTTTGGCTA TCCATTAGGT GAAATGAGCC AGCCGACACC CACCCCGGCC 1140

CCAGGGGGCC GTGTGTACCC TGTTTCTGTG CCCTACTCAA GTGCCCAGAG CACCAGCAAG 1200

ACCAGTGTGA CTCTGTCCCT CGTCATGCCT TCTCAGGGCC AGATGGTCAA CGGCTCTCAC 1260

AGTGCCTCCA CCTTGGATGA AGCCACTCCT ACTCTCACTA ACCAGAGCCC CACTCTGACC 1320

CTGCAGTCTA CCAACACCCA CACCCAGAGC AGCAGCTCCA GCTCGGACGG GGGCCTCTTC 1380

CGCTCCAGAC CGGCTCACTC ACTTCCACCT GGAGAGGATG GCAGGGTCGA GCCCTATGTG 1440

GACTTTGCTG AGTTTTACCG ACTCTGGAGC GTGGACCATG GCGAGCAGAG TGTGATGACG 1500

GCACCTTAG 1509

Domain Profile

S: 24    nflkspekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaF  83

         n lk +++++   ++gv++G  g++v++f++++l+  l     ++e ++++v+++l +aF

Q: 52    NWLKFRSENN-CFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNTEHTDADVRRVLLQAF  110

         4555555555.589********************97666555569***************

S: 84    lstdeel................................kvleeksldidk..sGstavv  109

           +++ +                                k+le+ +  +++   G+ avv

Q: 111   DVVERSFlesiddalaekaslqsqlpegvpqhqllpqyqKILERLKALEKEisGGAMAVV  170

         ***********************************999855555544444466999****

S: 110   alikdsklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvil  162

         a++ ++klyvanvG  ra+Lcr+  +   + +l +dH++++edEl R+++ g   g++ +

Q: 171   AVLLNNKLYVANVGTNRALLCRSTvDglqVTQLNVDHTAENEDELFRLSQLGldaGKIKQ  230

         **********************763467799*********************87777776

S: 163   kdgaRvlGvLavsRalGdlylk..............pyvtpePevtshrl.tsedefliL  207

              ++G  + +R +Gd+++k              + +++ePe++  +  +  + fl+L

Q: 231   VG--VICG-QESTRRIGDYKVKygytdidllstaksKPIIAEPEIHGAQPlDGVTGFLVL  287

         64..4555.69************************999*******98765155555****

S: 208   asDGlwdvvs........neeavslvrdvlekkeaeqeaakkLvkla  246

          s Gl++ ++        n+e+ +++     k+++++++a+ +v++

Q: 288   MSEGLYKALEaahgpgqaNQEVAAMIDTEFAKQTSLDAVAQAVVDRV  334

         *******9953334333377888888777778888888888888776

Domain Sequence
(FASTA)

NWLKFRSENN CFLYGVFNGY DGNRVTNFVA QRLSAELLLG QLNTEHTDAD VRRVLLQAFD 60

VVERSFLESI DDALAEKASL QSQLPEGVPQ HQLLPQYQKI LERLKALEKE ISGGAMAVVA 120

VLLNNKLYVA NVGTNRALLC RSTVDGLQVT QLNVDHTAEN EDELFRLSQL GLDAGKIKQV 180

GVICGQESTR RIGDYKVKYG YTDIDLLSTA KSKPIIAEPE IHGAQPLDGV TGFLVLMSEG 240

LYKALEAAHG PGQANQEVAA MIDTEFAKQT SLDAVAQAVV DRV 283

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0003824	; F:catalytic activity
GO:0019209	; F:kinase activator activity
GO:0000185	; P:activation of MAPKKK activity
GO:0003007	; P:heart morphogenesis
GO:0001701	; P:in utero embryonic development
GO:0030324	; P:lung development
GO:0008152	; P:metabolic process
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

rno:315139

;

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013