EKS-RAN-00412

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00412

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	548.7	2.5E-165	582	846	265

Status

Reviewed

Ensembl Protein

ENSRNOP00000023419

UniProt Accession

P57097;

Protein Name

Tyrosine-protein kinase Mer

Protein Synonyms/Alias

Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK;

Gene Name

Mertk

Gene Synonyms/Alias

Mertk; Mer;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000017319	ENSRNOP00000023419	ENSRNOT00000023419

Organism

Rattus norvegicus

Functional Description

Receptor tyrosine kinase that transduces signals fromthe extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity).

Protein Length

994

Protein Sequence
(FASTA)

MVLAPLLLGL LLLSALWNGG TAEKEEEIKP DQPFSGPLPG SLPADHRPFF APHSSGDQLS 60

PSQTGRSHPA HTATPQMTSA ASNLLPPVAF KNTIGRIVLS EHKSVKFNCS INIPNVYQET 120

AGISWWKDGK ELLGAHHSIT QFYPDEEGVS IIALFSITSV QRSDNGSYIC KMKVNDREVV 180

SDPIYVEVQG LPYFTKQPES VNVTRNTAFN LTCQAVGPPE PVNIFWVQNS SRVNENPERS 240

PSVLTVAGLT ETAVFSCEAH NDKGLTVSKG VQINIKVIPS PPTEVHILNS TAHSILVSWV 300

PGFDGYSPLQ NCSIQVKEAD QLSNGSVMVF NTSASPHLYE VQQLQALANY SVTVSCRNEI 360

GWSAVSPWIL ASTTEGAPAV APLNITVFLN ESSNNLEIRW TKPPIKRQDG ELVGYRISHV 420

WESAGTSKEL SEEVSQNGSW AQVPVQMHNA TCTVRIAVIT KGGIGPFSEP VDVAIPEHSR 480

VDYAPSSTPA PGNTESMLII LGCFCGFVLM GLILYLSLAI KRRVQETKFG GAFSEEDSQL 540

VVNYRAKKSF CRRAIELTLQ SLGVSEELQN KLEDVVVDRN LLILGKVLGE GEFGSVMEGN 600

LKQEDGTSQK VAVKTMKLDN FSLREIEEFL SEAACMKDFN HPNVIRLLGV CIELSSQGIP 660

KPMVILPFMK YGDLHTFLLY SRIESVPKSI PLQTLLKFMV DIAQGMEYLS SRNFLHRDLA 720

ARNCMLRDDM TVCVADFGLS KKIYSGDYYR QGRIAKMPVK WIAIESLADR VYTSKSDVWA 780

FGVTMWEIAT RGMTPYPGVQ NHEMYDYLLH GHRLKQPEDC LDDLYEIMYS CWSADPLDRP 840

TFSVLRLQLE KLSESLPDAQ DKESIIYINT QLLESCEGLA NRSSLAGLDM NIDPDSIIAS 900

CTAGAAVSVV MAEVHENNLH EERYILNGGN EEWEDVASTP FATVTAGKDG VLPEDRLTKN 960

GISWSHHSTL PLGSPSPDEL LFADDSSGDS EVLM 994

Nucleotide Sequence
(FASTA)

ATGGTTCTGG CCCCACTACT GCTGGGGCTG CTGCTGCTAT CCGCACTCTG GAATGGAGGC 60

ACTGCTGAAA AGGAGGAAGA AATCAAGCCA GATCAGCCAT TTTCAGGGCC TTTACCAGGG 120

AGCCTACCAG CTGACCACAG GCCATTCTTC GCCCCTCACT CCAGTGGGGA CCAGCTGTCA 180

CCATCCCAGA CTGGAAGATC ACATCCAGCA CACACAGCCA CTCCCCAGAT GACCTCTGCA 240

GCATCAAACC TCCTGCCTCC TGTTGCATTT AAAAACACAA TTGGACGCAT AGTACTTTCG 300

GAACATAAAA GTGTCAAATT TAATTGCTCG ATCAACATTC CTAACGTGTA TCAAGAAACA 360

GCTGGCATTT CGTGGTGGAA AGATGGAAAG GAACTGCTTG GGGCACATCA TTCAATCACA 420

CAGTTTTATC CTGATGAGGA AGGGGTATCA ATAATTGCAT TGTTCAGCAT AACCAGTGTG 480

CAGCGCTCAG ACAATGGGTC GTACATCTGT AAGATGAAGG TGAACGATAG AGAGGTTGTG 540

TCTGATCCCA TATACGTGGA AGTCCAAGGA CTCCCTTACT TTACTAAGCA GCCTGAGAGC 600

GTGAATGTCA CCAGAAACAC AGCCTTCAAC CTCACCTGCC AGGCTGTGGG ACCCCCTGAG 660

CCCGTCAACA TCTTCTGGGT TCAAAATAGC AGCCGTGTTA ATGAAAATCC AGAAAGGTCC 720

CCGTCTGTCC TAACTGTCGC TGGTCTGACA GAGACCGCAG TCTTCAGCTG TGAGGCCCAC 780

AACGACAAAG GACTGACGGT GTCCAAGGGT GTACAGATCA ACATCAAAGT CATCCCTTCC 840

CCACCCACTG AAGTCCATAT CCTCAACAGC ACAGCGCACA GCATCCTGGT CTCCTGGGTC 900

CCAGGGTTTG ATGGCTACTC CCCACTTCAG AACTGCAGCA TTCAGGTCAA GGAAGCTGAC 960

CAGCTGAGTA ATGGCTCAGT CATGGTTTTT AATACCTCTG CTTCGCCACA TCTGTATGAA 1020

GTCCAGCAGC TGCAAGCCCT GGCTAATTAC AGCGTCACTG TGTCCTGTCG GAATGAGATT 1080

GGCTGGTCTG CAGTGAGCCC TTGGATCCTG GCCAGCACTA CAGAAGGAGC TCCAGCAGTG 1140

GCGCCTCTAA ACATCACTGT GTTTCTGAAC GAATCCAGCA ACAACCTGGA AATCAGATGG 1200

ACGAAGCCTC CAATTAAGCG GCAGGATGGG GAACTGGTGG GCTACCGGAT ATCTCACGTG 1260

TGGGAGAGTG CGGGGACTTC CAAAGAGCTT TCTGAAGAAG TCAGCCAGAA TGGCAGCTGG 1320

GCTCAGGTTC CTGTCCAAAT GCACAATGCC ACCTGCACAG TGAGAATCGC CGTCATCACT 1380

AAAGGGGGCA TTGGGCCCTT CAGTGAGCCA GTGGATGTAG CCATTCCGGA GCACAGTAGG 1440

GTAGATTACG CACCCTCATC AACCCCAGCC CCTGGCAACA CCGAGTCTAT GCTCATCATC 1500

CTGGGCTGCT TCTGCGGGTT TGTTCTCATG GGGTTGATTC TGTATCTTTC TCTGGCCATC 1560

AAAAGGAGAG TCCAGGAAAC AAAGTTTGGG GGTGCATTCT CCGAGGAGGA CTCCCAATTA 1620

GTTGTAAATT ACAGAGCAAA GAAGTCCTTC TGTCGGCGAG CCATCGAGCT TACCTTGCAA 1680

AGCCTGGGGG TGAGCGAGGA GCTGCAAAAC AAGCTAGAAG ATGTTGTGGT TGACAGAAAT 1740

CTTCTAATTC TTGGGAAAGT TCTGGGCGAA GGAGAGTTTG GGTCTGTAAT GGAAGGAAAT 1800

CTGAAGCAGG AAGATGGGAC TTCTCAGAAG GTGGCAGTGA AGACCATGAA GTTGGACAAC 1860

TTTTCTCTAC GGGAGATCGA GGAGTTTCTC AGCGAAGCAG CGTGCATGAA AGACTTCAAT 1920

CACCCAAACG TCATCCGGCT TCTAGGCGTG TGTATAGAAC TGAGCTCTCA AGGCATCCCG 1980

AAGCCCATGG TGATTTTACC CTTCATGAAA TACGGAGACC TCCACACCTT CCTGCTATAT 2040

TCCCGGATAG AATCAGTACC GAAGTCCATC CCCCTGCAGA CACTGCTGAA GTTCATGGTG 2100

GACATTGCCC AGGGAATGGA GTACCTGAGC AGCAGGAATT TTCTCCACAG GGATTTAGCT 2160

GCTCGGAATT GCATGTTGCG GGATGACATG ACTGTCTGCG TGGCAGACTT TGGCCTCTCT 2220

AAGAAGATTT ACAGTGGTGA TTATTACCGC CAAGGCCGCA TTGCCAAAAT GCCTGTGAAG 2280

TGGATCGCCA TAGAGAGCCT GGCGGACCGA GTCTACACAA GCAAGAGTGA CGTGTGGGCT 2340

TTTGGCGTGA CCATGTGGGA AATAGCAACA CGGGGAATGA CTCCCTATCC TGGAGTCCAG 2400

AACCATGAGA TGTACGATTA CCTTCTCCAC GGCCACAGGC TGAAGCAGCC CGAGGACTGC 2460

CTGGATGATC TGTATGAAAT CATGTACTCT TGCTGGAGTG CTGATCCCCT GGACCGACCC 2520

ACCTTCTCAG TGCTGAGGCT GCAGCTGGAA AAGCTCTCCG AGAGTTTGCC TGATGCCCAG 2580

GACAAAGAAT CCATCATCTA CATCAATACA CAGTTACTAG AGAGCTGCGA GGGCCTAGCC 2640

AACAGGTCCT CCCTCGCAGG GCTAGACATG AACATTGATC CTGACTCCAT CATTGCCTCT 2700

TGCACAGCAG GTGCTGCTGT CAGCGTGGTC ATGGCGGAAG TTCACGAGAA CAACCTTCAT 2760

GAGGAAAGAT ACATCTTAAA TGGGGGCAAC GAGGAATGGG AAGATGTGGC CTCCACTCCA 2820

TTTGCTACAG TCACAGCTGG AAAAGATGGT GTGTTACCAG AGGACAGACT CACCAAAAAT 2880

GGCATCTCCT GGTCTCACCA TAGTACGCTA CCCTTGGGGA GCCCATCACC AGATGAACTT 2940

CTGTTTGCAG ACGACTCCTC GGGAGACTCT GAAGTTCTGA TGTGA 2985

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l+lgkvlgegefgsvmeg+lkqedg+++kvavkt+kld+++ +eieeflseaacmk+f+h

Q: 582   LILGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSLREIEEFLSEAACMKDFNH  641

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         pnvirl+gv++e s++g +pkp+vilpfmkygdlh+fllysr+++ p+ +plqtl+kfmv

Q: 642   PNVIRLLGVCIELSSQG-IPKPMVILPFMKYGDLHTFLLYSRIESVPKSIPLQTLLKFMV  700

         ****************9.******************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia+gmeylssrnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk

Q: 701   DIAQGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  760

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc

Q: 761   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC  820

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ld+ly++my+cw+adp drp+fsvlr

Q: 821   LDDLYEIMYSCWSADPLDRPTFSVLR  846

         *************************9

Domain Sequence
(FASTA)

LILGKVLGEG EFGSVMEGNL KQEDGTSQKV AVKTMKLDNF SLREIEEFLS EAACMKDFNH 60

PNVIRLLGVC IELSSQGIPK PMVILPFMKY GDLHTFLLYS RIESVPKSIP LQTLLKFMVD 120

IAQGMEYLSS RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180

IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL 240

DDLYEIMYSC WSADPLDRPT FSVLR 265

Keyword

ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005615	; C:extracellular space
GO:0016021	; C:integral to membrane
GO:0001750	; C:photoreceptor outer segment
GO:0016028	; C:rhabdomere
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0043277	; P:apoptotic cell clearance
GO:0001779	; P:natural killer cell differentiation
GO:0051250	; P:negative regulation of lymphocyte activation
GO:0006909	; P:phagocytosis
GO:0030168	; P:platelet activation
GO:0050766	; P:positive regulation of phagocytosis
GO:0043491	; P:protein kinase B signaling cascade
GO:0060041	; P:retina development in camera-type eye
GO:0032940	; P:secretion by cell
GO:0007283	; P:spermatogenesis
GO:0034446	; P:substrate adhesion-dependent cell spreading
GO:0060068	; P:vagina development

KEGG

rno:65037

;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013