EKS-RAN-00405

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00405

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	347.7	6.2E-104	1122	1380	259

Status

Unreviewed

Ensembl Protein

ENSRNOP00000062453

UniProt Accession

F1M5K9;

Protein Name

Protein Synonyms/Alias

Protein Map3k4;

Gene Name

Map3k4

Gene Synonyms/Alias

Map3k4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000017419	ENSRNOP00000062453	ENSRNOT00000064018

Organism

Rattus norvegicus

Functional Description

Protein Length

1387

Protein Sequence
(FASTA)

MNTPSQSPHK DLGKGVEAVE EYSYKQGKKT RATLRTTERD HKKNAQCSFM LDSVAGSLPK 60

KSIPDVDLNK PYLSLGCSNA KLPVSMPMPI ARTARQTSRT DCPADRLKFF ETLRLLLKLT 120

SVSKKKDREQ RGQENTAAFW FNRSNELIWL ELQAWHAGRT INDQDLFLYT ARQAIPDIIN 180

EILTFKVNYG SAAFSRNGAG FNGTSLEGQC RTLHGTNSLG CSTYHEHLQR QRVSFEQVKR 240

IMELLEYMEA LYPSLQALQK DYERYAAKDF EDRVQALCLW LNITKDLNQK LRIMGTVLGI 300

KNLSDIGWPV FEIPSPRPSK GYEPEEEGED TEGELRELES GTEESDEERS PNPRVPELRL 360

SADTILDSHS QGCASRKLER LESEEDSVGW GIADCGPEAS RHCLTSIYRP FVDKALKQMG 420

LRKLILRLHK LMNGSLQRAR VALVKDDRPV EFSDFPGPMW GSDYVQLSGT PPSSEQKCSA 480

VSWEELRAMD LPSFEPAFLV LCRVLLNVIH ECLKLRLEQR PAGEPSLLSI KQVYFDYMRS 540

WIQMLQQLPQ ASHSLKNLLE EEWNFTKEIT HYIRGGEAQA GKLFCDIAGM LLKSTGSFLD 600

SGLQESCAEL WISADDNGAA DELRRSVIEI SRALKELFHE ARERASKALG FAKMLRKDLE 660

IAAEFVLSAS ARELLDVLRA KQYVKVQIPG LENLHVFVPD SLAEEKKIIL QLLNAATGKD 720

CSKDPDDVFV DAFLLLTKHG DRARDSEDGW STWEARAIKI VPQVETVDTL RSMQVDNLLL 780

VVMESAHLVL QRKAFQQSIE GLMTVHHEQT SSQPVIAKAL QQLKNDALEL CNRISDAIDR 840

VDHMFTLELD AEVEESESAT LQQYYREAMI QGYNFGFEYH KEVVRLMSGE FRQKIGDKYI 900

SFAQKWMNYV LTKCESGRGT RPRWATQGFD FLQAIEPAFI SALPEDDFLS LQALMNECIG 960

HVIGKPHSPV TAIHRNSPRP VKVPRCHSDP PNPHLIIPTP EGFRGSSVPE NDRLASIAAE 1020

LQFRSLSRHS SPTEERDEPA YPRSDSSGST RRSWELRTLI SQTKDSASKQ GPIEAIQKSV 1080

RLFEERRYRE MRRKNIIGQV CDTPKSYDNI MHVGLRKVTF KWQRGNKIGE GQYGKVYTCI 1140

SVDTGELMAM KEIRFQPNDH KTIKETADEL KIFEGIKHPN LVRYFGVELH REEMYIFMEY 1200

CDEGTLEEVS RLGLQEHVIR LYSKQITVAI NVLHEHGIVH RDIKGANIFL TSSGLIKLGD 1260

FGCSVKLKNN AQTMPGEVNS TLGTAAYMAP EVITRAKGEG HGRAADIWSL GCVVIEMVTG 1320

KRPWHEFEHN FQIMYKVGMG HKPPIPERLS PEGKDFLSHC LESDPKIRWT ASQLLDHAFV 1380

KVCTDEE 1387

Nucleotide Sequence
(FASTA)

ATGAACACAC CGAGTCAGTC TCCACATAAA GACTTGGGGA AGGGAGTGGA GGCCGTGGAG 60

GAGTACAGCT ACAAGCAGGG GAAGAAGACG CGAGCGACTC TGAGGACAAC AGAGCGAGAC 120

CATAAGAAAA ATGCACAGTG CTCGTTCATG TTGGACTCAG TGGCCGGGTC TTTGCCAAAA 180

AAATCTATTC CAGATGTGGA TCTCAATAAG CCTTACCTCA GCCTCGGCTG TAGCAACGCC 240

AAGCTGCCAG TCTCTATGCC CATGCCTATA GCCAGAACTG CGCGGCAGAC TTCCCGGACG 300

GACTGCCCAG CGGATCGGTT AAAGTTCTTT GAAACACTGC GCCTTTTGCT AAAGCTTACC 360

TCAGTCTCGA AGAAGAAGGA CAGGGAACAG AGGGGACAGG AAAACACGGC TGCTTTCTGG 420

TTCAACCGGT CAAATGAACT GATCTGGTTA GAGCTCCAGG CCTGGCACGC AGGCCGCACC 480

ATCAATGACC AGGACCTCTT TTTATACACA GCCCGCCAAG CCATCCCAGA TATTATCAAT 540

GAAATCCTCA CATTCAAAGT TAATTATGGA AGCGCTGCCT TCTCTAGAAA TGGAGCTGGT 600

TTCAACGGTA CCTCGCTAGA AGGTCAGTGC AGAACCCTTC ATGGGACGAA CAGTCTAGGC 660

TGTTCAACCT ACCACGAGCA CCTCCAGCGC CAGAGGGTCT CATTTGAGCA GGTGAAACGG 720

ATAATGGAGC TGCTAGAGTA CATGGAAGCA CTTTATCCGT CCTTGCAGGC TCTGCAGAAG 780

GACTACGAGA GATACGCCGC AAAGGACTTT GAGGACAGAG TGCAGGCACT CTGCCTGTGG 840

CTAAACATCA CGAAAGATTT AAATCAGAAG TTGAGGATTA TGGGCACTGT TCTGGGCATC 900

AAGAACTTAT CAGACATTGG CTGGCCAGTG TTTGAAATCC CTTCCCCTCG GCCATCCAAA 960

GGCTACGAGC CTGAGGAGGA GGGCGAGGAC ACAGAGGGAG AGCTGAGGGA GCTGGAGAGT 1020

GGGACGGAGG AGAGTGATGA GGAGCGAAGT CCCAATCCGA GGGTGCCAGA GCTCAGGCTG 1080

TCTGCCGACA CCATCTTGGA CAGTCACTCC CAGGGCTGCG CGTCCAGGAA ACTTGAGAGG 1140

CTCGAGTCCG AGGAGGACTC TGTAGGCTGG GGGATAGCAG ACTGTGGTCC CGAAGCCAGT 1200

AGGCATTGTT TGACTTCTAT CTATAGACCG TTCGTGGACA AAGCACTGAA GCAAATGGGG 1260

CTGAGGAAGT TAATTTTACG ACTTCATAAG CTAATGAATG GCTCCTTGCA AAGGGCTCGT 1320

GTAGCTCTGG TAAAGGATGA CCGTCCTGTG GAGTTCTCTG ACTTTCCAGG TCCCATGTGG 1380

GGCTCGGATT ATGTGCAGTT GTCGGGGACG CCTCCTTCCT CGGAGCAGAA GTGCAGTGCT 1440

GTGTCCTGGG AAGAGCTGAG GGCCATGGAC CTGCCCTCCT TTGAGCCCGC CTTCCTGGTG 1500

CTCTGCCGGG TCCTGCTGAA CGTGATCCAT GAGTGCCTGA AGCTGCGGCT GGAACAGAGG 1560

CCGGCCGGGG AGCCTTCCCT CTTGAGTATC AAGCAGGTGT ATTTTGACTA CATGAGAAGC 1620

TGGATCCAAA TGCTACAGCA GTTACCTCAG GCTTCCCATA GCTTAAAAAA CCTGCTAGAA 1680

GAAGAATGGA ATTTCACCAA AGAAATAACC CATTACATCC GGGGAGGAGA AGCACAGGCT 1740

GGAAAGCTTT TCTGTGACAT TGCAGGGATG CTGCTGAAAT CCACGGGGAG CTTTCTGGAC 1800

TCTGGCCTAC AGGAGAGCTG TGCTGAACTG TGGATCAGCG CCGACGACAA CGGTGCTGCC 1860

GACGAGCTAA GGAGGTCTGT CATCGAGATC AGCCGAGCAC TCAAGGAGCT CTTCCATGAG 1920

GCCCGGGAAA GAGCCTCCAA GGCCCTGGGC TTTGCTAAAA TGCTGAGGAA GGACCTAGAA 1980

ATAGCAGCAG AGTTTGTTCT GTCTGCGTCT GCCCGAGAGC TCCTAGACGT TCTGAGAGCA 2040

AAGCAGTATG TTAAGGTACA GATTCCTGGG CTAGAGAATT TGCACGTGTT TGTCCCCGAC 2100

AGCCTCGCTG AGGAGAAGAA AATTATTTTG CAGCTACTCA ATGCTGCCAC AGGAAAGGAC 2160

TGCTCAAAGG ATCCGGACGA CGTCTTTGTG GATGCCTTCC TGCTCCTGAC CAAGCATGGG 2220

GACCGAGCCC GTGACTCAGA AGATGGCTGG AGCACATGGG AAGCACGAGC TATCAAAATT 2280

GTGCCTCAGG TGGAGACCGT GGACACCCTG AGAAGCATGC AGGTGGACAA CCTTCTGCTG 2340

GTTGTCATGG AGTCTGCTCA CCTCGTACTT CAGAGAAAGG CCTTCCAGCA GTCCATTGAG 2400

GGGCTGATGA CTGTACACCA TGAGCAGACA TCCAGCCAGC CAGTCATTGC CAAAGCTTTA 2460

CAGCAGCTAA AGAACGATGC GCTCGAGCTG TGCAACAGAA TAAGCGATGC CATCGACCGC 2520

GTGGACCACA TGTTCACGCT GGAGTTGGAT GCCGAGGTCG AGGAGTCCGA GTCGGCCACG 2580

CTGCAGCAGT ACTACCGAGA GGCCATGATT CAGGGCTACA ACTTCGGGTT TGAGTATCAT 2640

AAAGAAGTTG TTCGTTTGAT GTCTGGAGAA TTCAGACAGA AGATAGGAGA CAAATATATA 2700

AGCTTTGCCC AGAAGTGGAT GAATTATGTG CTGACCAAAT GTGAGAGCGG CAGAGGCACA 2760

AGACCCAGAT GGGCCACCCA AGGTTTTGAT TTCCTACAAG CCATTGAACC TGCCTTTATT 2820

TCAGCTTTAC CAGAAGATGA CTTCTTGAGT TTGCAAGCCC TGATGAATGA GTGCATTGGG 2880

CACGTCATAG GAAAGCCACA CAGCCCTGTC ACAGCTATCC ATCGGAACAG CCCCCGCCCT 2940

GTGAAGGTGC CCCGATGCCA CAGTGACCCT CCTAACCCTC ACCTCATCAT CCCAACTCCA 3000

GAGGGATTCA GGGGTTCCAG CGTCCCTGAA AATGACCGCT TGGCCTCCAT AGCTGCAGAA 3060

CTGCAGTTCA GGTCTCTGAG TCGGCACTCG AGCCCCACGG AAGAGCGAGA CGAGCCAGCA 3120

TATCCTCGGA GCGACTCAAG TGGATCAACA CGGAGAAGCT GGGAACTTCG AACACTCATC 3180

AGCCAGACCA AAGACTCGGC CTCTAAGCAG GGGCCCATAG AGGCCATCCA GAAGTCAGTC 3240

CGACTGTTTG AAGAGAGGAG GTATCGAGAG ATGAGGAGGA AGAATATCAT CGGTCAAGTG 3300

TGCGATACCC CTAAGTCCTA TGATAACATC ATGCATGTTG GACTGAGGAA GGTGACGTTT 3360

AAGTGGCAAA GAGGAAACAA AATCGGAGAA GGGCAGTATG GAAAAGTGTA CACCTGCATC 3420

AGCGTCGACA CAGGGGAGCT GATGGCCATG AAGGAGATTC GATTTCAGCC TAACGACCAT 3480

AAGACTATCA AGGAAACTGC AGACGAGTTG AAAATATTTG AAGGCATCAA GCACCCCAAC 3540

CTGGTCCGGT ACTTTGGTGT GGAGCTTCAC AGGGAAGAGA TGTACATCTT CATGGAGTAC 3600

TGTGATGAAG GCACACTAGA GGAGGTGTCA AGGCTGGGCC TTCAGGAGCA CGTCATCCGG 3660

TTGTATTCCA AGCAGATCAC TGTCGCCATC AACGTCCTCC ATGAGCATGG CATCGTTCAC 3720

CGAGACATCA AAGGTGCCAA TATCTTCCTT ACATCGTCTG GACTAATCAA ACTGGGAGAT 3780

TTTGGATGCT CAGTGAAACT TAAAAACAAT GCTCAGACCA TGCCTGGCGA GGTGAACAGC 3840

ACCCTAGGGA CAGCAGCTTA CATGGCCCCT GAAGTTATTA CCCGAGCTAA AGGAGAAGGC 3900

CACGGACGTG CGGCAGACAT CTGGAGTCTG GGGTGCGTCG TCATAGAGAT GGTGACTGGC 3960

AAGCGGCCTT GGCATGAGTT TGAACACAAC TTTCAGATTA TGTACAAGGT GGGAATGGGA 4020

CACAAGCCAC CAATCCCCGA AAGGTTAAGC CCTGAAGGAA AGGACTTTCT CTCGCACTGC 4080

CTGGAAAGTG ACCCGAAGAT AAGGTGGACA GCCAGCCAGC TCCTTGACCA CGCTTTTGTC 4140

AAGGTTTGCA CAGATGAAGA GTGA 4164

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1122  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1178

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1179  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITVAINVLHEH  1236

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1237  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1296

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe+ls+egkd

Q: 1297  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEFEHNFQIMYKVGMGH-KPPIPERLSPEGKD  1355

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle+dpk r++a++LL+h f+

Q: 1356  FLSHCLESDPKIRWTASQLLDHAFV  1380

         **********************996

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITVAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEFEHNF QIMYKVGMGH KPPIPERLSP EGKDFLSHCL 240

ESDPKIRWTA SQLLDHAFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0019100	; P:male germ-line sex determination
GO:0043507	; P:positive regulation of JUN kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013