EKS-RAN-00011
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00011
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph429.24.9E-129626880255
StatusUnreviewed
Ensembl ProteinENSRNOP00000024037
UniProt AccessionD3ZDH4;
Protein Name
Protein Synonyms/Alias Eph receptor A1 (Predicted); Protein Epha1;
Gene NameEpha1
Gene Synonyms/Alias Epha1; Epha1_predicted; rCG_28177;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000017525ENSRNOP00000024037ENSRNOT00000024037
OrganismRattus norvegicus
Functional Description
Protein Length977
Protein Sequence
(FASTA)
MERRWPLGLA LLLLLLCAPL PPGARAEEVT LMDTSTAQGE LGWLLDPPET GWSEVQQMLN 60
GTPLYMYQDC PIQEGGDTDH WLRSNWIYRG EEASRVHVEL QFTVRDCKSF PGGAGPLGCK 120
ETFNLFYMES DQDVGIQLRR PLFQKVTTVA ADQSFTIRDL ASGSVKLNVE HCSLGHLTRR 180
GLYLAFHNPG SCVALVSVRV FYQRCAETVH GLAHFPHTLP GPTGLVEVAG TCLSHAQISL 240
GSSGTPRMHC SPDGEWLVPV GQCQCEPGYE ESGGSVGCTA CPTGFYRMDM NTLHCLKCPQ 300
HSVAESEGST ICTCENGHYR APGEGPQVAC TRPPSAPQNL SFSASGTQLS LRWEPPRDTG 360
GRQDIRYSVE CLQCRGIAQD GGPCQPCGKG VHFSPAASGL TASTVQVEGL EPYANYTFTI 420
KSQNRVSGLD SSSPSSASLS INMGQAESLS GLSLKLVKKE PRQLELTWAG SRLQNPGGNL 480
SYELHVLNQD EEWHQMVLEP RVLLTKLQPD TTYIVRVRTL TPLGPGPFSP DHEFRTSPPV 540
SRSLTGGEIV AIIFGLLLGI ALLIGIYVFR SRRGQRQRQQ RQRERTTNVD REDKLWLKPY 600
VDLQAYEDPA QGALDFAQEL DPAWLIVDTV IGEGEFGEVY RGALRIPSQD CKTVAIKTLK 660
DTSPDGYWWN FLREATIMGQ FNHPHILRLE GVITKRKPIM IITEFMENGA LDAFLKERED 720
QLVPGQLVAM LLGIASGMNY LSGHNYVHRD LAARNILVNQ NLCCKVSDFG LTRLLDDFDG 780
TYETQGGKIP IRWTAPEAIA HRIFTTASDV WSFGIVMWEV LSFGDKPYGE MSNQEVMKSI 840
EDGYRLPPPV DCPAPLYELM KNCWAYDRAR RPHFLQLQAH LEQLLTDPHS LRTIANFDPR 900
VTLRLPSLSG SDGIPYRSVS EWLESIRMKR YILHFRSAGL DTMECVLELT AEDLTQMGIT 960
LPGHQKRILC SIQGFKD 977
Nucleotide Sequence
(FASTA)
ATGGAGCGGC GCTGGCCCCT GGGGCTCGCA CTGCTGCTGC TGCTGCTCTG CGCCCCGCTG 60
CCCCCGGGGG CGCGCGCCGA GGAAGTCACT TTAATGGACA CGAGCACAGC ACAAGGAGAG 120
TTGGGCTGGC TTCTGGATCC CCCAGAGACT GGGTGGAGTG AGGTGCAACA AATGCTGAAC 180
GGGACACCCC TGTACATGTA CCAAGACTGC CCAATACAGG AAGGTGGAGA TACTGACCAC 240
TGGCTTCGCT CCAACTGGAT CTACCGAGGA GAGGAAGCCT CACGTGTCCA CGTAGAGCTG 300
CAGTTCACTG TGCGGGACTG TAAAAGTTTC CCAGGGGGAG CTGGGCCTCT GGGATGCAAA 360
GAGACCTTCA ACCTTTTCTA CATGGAGAGT GACCAGGATG TGGGCATTCA ACTCCGACGG 420
CCTTTGTTCC AAAAGGTAAC AACTGTGGCA GCAGACCAGA GCTTCACCAT CAGAGACCTG 480
GCCTCTGGCT CTGTAAAGCT GAACGTAGAG CACTGCTCCT TGGGTCACCT CACCCGCCGT 540
GGTCTCTACC TAGCTTTCCA CAACCCGGGA TCCTGTGTGG CGCTCGTATC TGTAAGGGTG 600
TTCTACCAGC GCTGCGCAGA GACTGTGCAT GGCTTGGCCC ACTTCCCTCA CACTCTCCCT 660
GGACCTACAG GGTTGGTAGA AGTAGCTGGA ACCTGCCTCT CCCATGCACA GATCAGCCTG 720
GGGTCCTCAG GTACACCACG CATGCATTGC AGCCCTGATG GCGAGTGGTT GGTGCCTGTG 780
GGTCAGTGCC AGTGCGAGCC TGGCTATGAG GAAAGCGGTG GAAGTGTGGG ATGCACTGCC 840
TGTCCTACTG GTTTCTATCG AATGGACATG AATACTCTCC ACTGTCTCAA GTGCCCCCAA 900
CATAGCGTAG CAGAGTCTGA GGGGTCTACC ATCTGTACCT GTGAGAATGG ACATTATCGA 960
GCCCCTGGGG AGGGCCCCCA GGTAGCATGC ACGCGTCCCC CATCAGCTCC CCAAAATCTG 1020
AGCTTCTCTG CATCAGGCAC TCAGCTCTCC CTACGCTGGG AGCCCCCAAG AGATACAGGG 1080
GGACGCCAAG ATATCAGATA CAGTGTGGAA TGCTTGCAGT GTCGGGGCAT TGCACAGGAT 1140
GGGGGTCCCT GCCAACCCTG TGGAAAAGGT GTGCACTTTT CCCCGGCAGC TTCCGGGCTC 1200
ACCGCATCTA CTGTGCAAGT TGAAGGCCTC GAGCCTTATG CCAACTACAC GTTTACCATC 1260
AAATCCCAGA ACAGAGTGTC GGGACTGGAC AGTTCCAGCC CTAGCAGCGC TTCTCTCAGT 1320
ATCAACATGG GGCAAGCAGA GTCACTCTCT GGCCTGTCAC TGAAGCTGGT GAAGAAAGAG 1380
CCGAGGCAGC TGGAGCTGAC TTGGGCAGGG TCCCGACTCC AAAACCCTGG GGGGAATCTG 1440
AGCTATGAGC TGCACGTGCT GAACCAGGAT GAAGAATGGC ACCAAATGGT GCTGGAACCC 1500
AGGGTCTTGC TGACAAAACT TCAGCCAGAT ACCACATACA TTGTCAGAGT ACGAACACTG 1560
ACCCCACTGG GGCCTGGCCC TTTCTCCCCT GACCATGAGT TCCGGACAAG CCCACCAGTT 1620
TCCAGAAGCC TGACTGGAGG AGAGATTGTG GCCATCATCT TTGGATTGCT GCTTGGAATA 1680
GCTCTGCTGA TCGGGATTTA TGTCTTCCGT TCAAGGAGAG GCCAGCGACA GAGACAGCAG 1740
AGGCAGCGTG AACGCACCAC CAATGTCGAT CGAGAGGACA AGCTGTGGCT AAAACCCTAT 1800
GTGGACCTCC AGGCCTATGA GGACCCTGCA CAGGGAGCCT TAGACTTTGC CCAGGAACTG 1860
GACCCTGCCT GGCTGATTGT GGACACTGTC ATAGGAGAAG GGGAGTTTGG GGAAGTGTAT 1920
CGGGGAGCCC TGAGAATCCC CAGCCAAGAC TGCAAGACCG TGGCCATTAA GACCTTGAAA 1980
GACACATCCC CAGATGGCTA CTGGTGGAAT TTCCTTCGAG AAGCAACTAT CATGGGCCAG 2040
TTCAACCACC CACACATTCT ACGCCTAGAA GGTGTCATCA CGAAAAGAAA GCCGATCATG 2100
ATCATCACAG AATTTATGGA AAATGGAGCC CTTGATGCCT TTCTGAAGGA ACGGGAGGAC 2160
CAGCTAGTTC CTGGTCAGCT AGTGGCTATG CTTCTGGGCA TAGCATCAGG CATGAACTAC 2220
CTCAGTGGCC ACAATTATGT CCATAGAGAC CTGGCTGCCA GGAACATCTT GGTGAATCAG 2280
AACTTGTGCT GCAAGGTATC TGACTTTGGC CTGACCCGCC TCCTGGATGA CTTCGATGGC 2340
ACCTATGAAA CCCAGGGAGG AAAGATCCCT ATCCGTTGGA CAGCCCCAGA AGCTATTGCC 2400
CATCGGATCT TCACCACAGC CAGTGATGTT TGGAGCTTTG GGATTGTAAT GTGGGAGGTG 2460
TTGAGTTTTG GCGACAAACC CTATGGGGAG ATGAGCAATC AAGAGGTAAT GAAAAGCATT 2520
GAGGATGGGT ACCGGCTGCC CCCTCCTGTG GATTGTCCTG CCCCCCTGTA TGAACTCATG 2580
AAGAACTGCT GGGCTTACGA CCGTGCCCGT CGGCCCCACT TCCTCCAGCT GCAGGCACAT 2640
CTGGAACAGC TGCTCACGGA CCCCCATTCC CTAAGGACAA TTGCCAACTT TGACCCTAGG 2700
GTGACCCTAC GTCTGCCCAG CCTGAGTGGC TCTGATGGGA TCCCTTATCG AAGTGTCTCT 2760
GAGTGGCTTG AATCCATACG CATGAAGCGC TACATCCTGC ACTTCCGCTC GGCAGGCCTG 2820
GACACCATGG AGTGTGTGCT GGAGCTGACA GCCGAGGACC TGACGCAGAT GGGAATCACA 2880
TTGCCAGGGC ACCAGAAGCG CATTCTCTGC AGTATTCAAG GATTTAAGGA CTGA 2934
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
          +++viG+GefGev++G+l++p++   +vaiktlk++s +  +++fl+ea+i+Gqf+hp+
Q: 626   IVDTVIGEGEFGEVYRGALRIPSQDCKTVAIKTLKDTSPDGYWWNFLREATIMGQFNHPH  685
         5899******************999999********************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         i+rleGv+tk+kp+mi+te+mengald+fl+++++q++  qlv+ml Giasgm+yls ++
Q: 686   ILRLEGVITKRKPIMIITEFMENGALDAFLKEREDQLVPGQLVAMLLGIASGMNYLSGHN  745
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilvn+nl+ckvsdfGl+r l dd + +y+t+ggkipirwtapeaia+r f
Q: 746   YVHRDLAARNILVNQNLCCKVSDFGLTRLL-DDFDGTYETQGGKIPIRWTAPEAIAHRIF  804
         ****************************98.7889*************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         t+asdvws+Giv+wevls+G++py +msnq+v+k+ie+gyrlppp+dcpa ly+lm++cw
Q: 805   TTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCW  864
         ************************************************************
S: 242   qkdraerpkfeqivsi  257
           dra+rp+f q++++
Q: 865   AYDRARRPHFLQLQAH  880
         ************9986
Domain Sequence
(FASTA)
IVDTVIGEGE FGEVYRGALR IPSQDCKTVA IKTLKDTSPD GYWWNFLREA TIMGQFNHPH 60
ILRLEGVITK RKPIMIITEF MENGALDAFL KEREDQLVPG QLVAMLLGIA SGMNYLSGHN 120
YVHRDLAARN ILVNQNLCCK VSDFGLTRLL DDFDGTYETQ GGKIPIRWTA PEAIAHRIFT 180
TASDVWSFGI VMWEVLSFGD KPYGEMSNQE VMKSIEDGYR LPPPVDCPAP LYELMKNCWA 240
YDRARRPHFL QLQAH 255
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00011
EKS-ANC-00010
EKS-BOT-00011
EKS-CAJ-00011
EKS-CAF-00012
EKS-CAP-00009
EKS-EQC-00012
EKS-FEC-00009
EKS-GAG-00011
EKS-GOG-00012
EKS-HOS-00012
EKS-ICT-00011
EKS-LAC-00015
EKS-LOA-00012
EKS-MAM-00010
EKS-MEG-00010
EKS-MOD-00011
EKS-MUM-00012
EKS-MUP-00012
EKS-MYL-00013
EKS-NOL-00011
EKS-OCP-00003
EKS-ORC-00011
EKS-OTG-00012
EKS-PAT-00010
EKS-PES-00009
EKS-POA-00009
EKS-SAH-00009
EKS-SUS-00009
EKS-TAG-00011
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0032862; P:activation of Rho GTPase activity
GO:0030336; P:negative regulation of cell migration
GO:0006469; P:negative regulation of protein kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0051496; P:positive regulation of stress fiber assembly
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
rno:312279;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013