EKS-RAN-00497
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00497
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMK1422.19.8E-12715270256
StatusReviewed
Ensembl ProteinENSRNOP00000024227
UniProt AccessionO70150; O08767;
Protein NameCalcium/calmodulin-dependent protein kinase type 1B
Protein Synonyms/Alias CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog;
Gene NamePnck
Gene Synonyms/Alias Pnck;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000017923ENSRNOP00000024227ENSRNOT00000024227
OrganismRattus norvegicus
Functional DescriptionCalcium/calmodulin-dependent protein kinase belonging toa proposed calcium-triggered signaling cascade. In vitro, isoform 1 and isoform 2 phosphorylate CREB1, SYN1/synapsin I. Phosphorylates and activates CAMK1.
Protein Length343
Protein Sequence
(FASTA)
MLLLKKQTED ISSVYEIREK LGSGAFSEVM LAQERGSAHL VALKCIPKKA LRGKEALVEN 60
EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD RIMERGSYTE KDASHLVGQV 120
LGAVSYLHSL GIVHRDLKPE NLLYATPFED SKIMVSDFGL SKIQAGNMLG TACGTPGYVA 180
PELLEQKPYG KAVDVWALGV ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS 240
ESAKDFIRHL LERDPQKRFT CQQALQHLWI SGDAALDRDI LGSVSEQIQK NFARTHWKRA 300
FNATSFLRHI RKLGQSPEGE EASRQGMTRH SHPGLGTSQS PKW 343
Nucleotide Sequence
(FASTA)
ATGCTGCTGC TCAAGAAACA GACGGAGGAC ATCAGCAGTG TCTATGAGAT CCGGGAGAAG 60
CTGGGCTCGG GTGCCTTCTC TGAGGTGATG CTGGCCCAGG AAAGGGGCTC TGCTCATCTT 120
GTGGCCCTCA AGTGCATTCC CAAGAAAGCA CTTCGGGGCA AGGAGGCCCT GGTGGAGAAT 180
GAGATCGCAG TACTCCGCAG GATTAGCCAC CCCAACATTG TGGCTCTGGA GGACGTCCAC 240
GAGAGCCCTT CCCATCTCTA CTTGGCCATG GAGCTGGTAA CAGGTGGTGA ACTGTTTGAC 300
CGAATCATGG AGCGGGGCTC CTACACAGAG AAGGATGCGA GCCACCTTGT AGGGCAGGTC 360
CTTGGTGCTG TCTCCTACCT TCATAGCCTG GGCATCGTGC ACCGGGACCT CAAGCCTGAA 420
AACCTCCTCT ATGCCACACC TTTTGAGGAC TCCAAGATCA TGGTCTCTGA CTTTGGCCTG 480
TCCAAAATTC AAGCTGGCAA CATGCTAGGC ACAGCCTGTG GGACCCCAGG ATATGTGGCC 540
CCAGAGCTCC TGGAGCAGAA ACCCTACGGG AAGGCCGTAG ATGTGTGGGC CCTGGGTGTC 600
ATCTCCTACA TCCTGCTGTG TGGGTACCCC CCCTTCTATG ATGAGAGCGA TCCTGAACTC 660
TTCAGCCAGA TTCTGAGGGC CAGCTACGAG TTTGACTCTC CCTTTTGGGA TGACATCTCA 720
GAATCAGCCA AAGACTTCAT TCGGCACCTT CTGGAACGTG ATCCCCAGAA GAGGTTCACC 780
TGCCAACAGG CCTTACAGCA TCTCTGGATC TCTGGGGATG CAGCCTTGGA CAGGGACATC 840
CTAGGTTCTG TCAGTGAGCA GATCCAGAAG AATTTTGCCA GGACCCACTG GAAGCGTGCA 900
TTCAATGCCA CATCATTCCT ACGTCACATC CGTAAGCTGG GACAGAGCCC AGAGGGTGAG 960
GAGGCCTCCA GGCAGGGTAT GACCCGTCAC AGCCACCCAG GCCTTGGGAC TAGCCAGTCT 1020
CCCAAGTGGT GA 1032
Domain Profile
S: 1     yklkeklGeGafsevlkakekktqkavaikvikkkalkgkeesveneiavlkklkhpniv  60
         y+++eklG+Gafsev++a+e+ +++ va+k+i kkal+gke+ veneiavl++++hpniv
Q: 15    YEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIV  74
         89**********************************************************
S: 61    alkdiyesksklylvlelvtGGelfdrivekgvytekdasevikqvleavkylhelgivh  120
         al+d++es+s+lyl +elvtGGelfdri+e+g+ytekdas+++ qvl av+ylh+lgivh
Q: 75    ALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVH  134
         ************************************************************
S: 121   rdlkPenllylskeedskikiadfGlskleekellktacGtvgyvapevlkqkkyskkvd  180
         rdlkPenlly+++ edski+++dfGlsk++  ++l tacGt+gyvape+l+qk+y+k+vd
Q: 135   RDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVD  194
         ************************************************************
S: 181   vWsiGvityillcGyppfydekeekllekilkgeyefesPyWdeisesakdfikklleld  240
         vW++Gvi+yillcGyppfyde++ +l+++il+++yef+sP+Wd+isesakdfi++lle+d
Q: 195   VWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERD  254
         ************************************************************
S: 241   pekrytieqaledpWi  256
         p+kr+t++qal++ Wi
Q: 255   PQKRFTCQQALQHLWI  270
         ***************8
Domain Sequence
(FASTA)
YEIREKLGSG AFSEVMLAQE RGSAHLVALK CIPKKALRGK EALVENEIAV LRRISHPNIV 60
ALEDVHESPS HLYLAMELVT GGELFDRIME RGSYTEKDAS HLVGQVLGAV SYLHSLGIVH 120
RDLKPENLLY ATPFEDSKIM VSDFGLSKIQ AGNMLGTACG TPGYVAPELL EQKPYGKAVD 180
VWALGVISYI LLCGYPPFYD ESDPELFSQI LRASYEFDSP FWDDISESAK DFIRHLLERD 240
PQKRFTCQQA LQHLWI 256
KeywordAlternative splicing; ATP-binding; Calcium; Calmodulin-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00451
EKS-ANC-00468
EKS-BOT-00483
EKS-CAF-00482
EKS-CAP-00516
EKS-DIO-00104
EKS-FEC-00460
EKS-GOG-00472
EKS-HOS-00491
EKS-ICT-00460
EKS-LOA-00489
EKS-MAM-00481
EKS-MIM-00069
EKS-MOD-00475
EKS-MUM-00514
EKS-MUP-00474
EKS-MYL-00474
EKS-NOL-00131
EKS-ORA-00420
EKS-ORC-00457
EKS-OTG-00489
EKS-PAT-00454
EKS-POA-00132
EKS-PTV-00128
EKS-SAH-00452
EKS-SUS-00422
EKS-XET-00633
Gene Ontology
GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004683; F:calmodulin-dependent protein kinase activity
KEGG
rno:29660;
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013