| Tag | Content |
|---|
| EKPD ID | EKS-RAN-00068 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/CDK | 335.6 | 2.7E-100 | 4 | 288 | 285 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000024466 |
| UniProt Accession | Q4KM34; |
| Protein Name | Cyclin-dependent kinase 20 |
| Protein Synonyms/Alias | Cell cycle-related kinase; Cell division protein kinase 20; |
| Gene Name | Cdk20 |
| Gene Synonyms/Alias | Cdk20; Ccrk; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Required for high-level Shh responses in the developingneural tube. Together with BROMI, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). |
| Protein Length | 346 |
Protein Sequence
(FASTA) | | MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGIPNQALR EIKALQEIED 60 | | SQYVVQLKAV FPHGAGFVLA FEFMLSDLAE VVRHAQRPLA PAQVKSYLQM LLKGVAFCHA 120 | | NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGGRLY THQVATRWYR APELLYGARQ 180 | | YDQGVDLWAV GCIMGELLNG SPLFPGENDI EQLCCVLRIL GTPSPRVWPE ITELPDYNKI 240 | | SFKEQAPVPL EEVLPDASHQ ALDLLGQFLL YPPRQRIAAS QALLHQYFFT APLPAHPSEL 300 | | PIPQRPGGPT PKAHPGPPHV HDFHVDRPLE ESLLNPELIR PFIPEG 346 |
|
Nucleotide Sequence
(FASTA) | | ATGGATCAGT ATTGCATCCT CGGTCGCATC GGGGAGGGCG CCCACGGCAT CGTCTTTAAA 60 | | GCCAAGCACG TAGAGACTGG CGAGATCGTT GCCCTCAAGA AGGTGGCCCT GCGGCGGCTG 120 | | GAGGATGGTA TTCCTAACCA GGCCCTCAGG GAAATCAAGG CTCTGCAGGA GATCGAGGAC 180 | | AGTCAATATG TGGTACAGCT GAAGGCTGTG TTCCCACATG GTGCAGGCTT TGTGCTGGCT 240 | | TTCGAGTTTA TGCTGTCGGA CCTGGCGGAG GTGGTGCGCC ATGCCCAGAG GCCACTAGCC 300 | | CCAGCACAGG TTAAGAGCTA CCTGCAGATG CTGCTCAAAG GTGTTGCATT TTGCCATGCC 360 | | AACAACATCG TGCATCGGGA CCTGAAGCCT GCCAACCTGC TCATCAGTGC CTCAGGCCAG 420 | | CTCAAGATAG CTGACTTTGG ACTGGCCCGG GTCTTCTCTC CAGATGGTGG TCGCCTCTAC 480 | | ACACATCAGG TGGCCACCAG GTGGTACCGA GCTCCTGAGC TCCTGTACGG TGCTCGGCAG 540 | | TATGACCAGG GTGTTGACCT ATGGGCTGTA GGCTGTATTA TGGGAGAGCT GTTGAATGGA 600 | | TCCCCCCTAT TCCCGGGAGA AAACGACATT GAACAACTGT GCTGTGTGCT TCGAATCCTG 660 | | GGTACCCCGA GTCCTCGAGT CTGGCCGGAG ATCACAGAGC TGCCTGACTA CAACAAGATC 720 | | TCCTTCAAGG AGCAGGCACC AGTGCCCCTG GAGGAGGTGC TGCCTGATGC CTCTCACCAG 780 | | GCCCTGGACC TGCTGGGTCA GTTCCTCCTT TACCCTCCAC GACAGCGTAT TGCAGCCTCC 840 | | CAGGCCCTTC TGCATCAGTA TTTCTTCACA GCTCCTCTGC CTGCCCATCC GTCTGAGCTG 900 | | CCAATTCCTC AGCGCCCAGG GGGACCCACA CCCAAGGCTC ATCCAGGGCC CCCCCATGTC 960 | | CATGACTTCC ATGTGGATCG TCCTCTTGAG GAGTCACTGT TGAATCCAGA ACTGATCCGG 1020 | | CCCTTCATCC CAGAGGGCTG A 1041 |
|
| Domain Profile | S: 1 yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel.khkn 59 | y l +igeG++g v+kak+ etge+vAlKk++l + ++g+p +alrEi+ l+e+ + ++ | Q: 4 YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQEIeDSQY 63 | 677899*************************************************77899 |
| S: 60 ivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn 119 | +v+L+ v+ + + ++L fef+ +dL++++++ ++ l +++vks+l++ll+g+a++H+n | Q: 64 VVQLKAVFP-HGAGFVLAFEFMLSDLAEVVRHAQR-PLAPAQVKSYLQMLLKGVAFCHAN 121 | *********.99*******************9999.************************ |
| S: 120 kilHRDlKpqNlLiskegklklaDfGlarafssplkt.ytkevvTlwYraPelLlgakeY 178 | +i+HRDlKp+NlLis++g+lk+aDfGlar fs + + yt++v T+wYraPelL+ga++Y | Q: 122 NIVHRDLKPANLLISASGQLKIADFGLARVFSPDGGRlYTHQVATRWYRAPELLYGARQY 181 | *******************************8776544********************** |
| S: 179 stavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ks 237 | ++ vD+W+vgci+ ell+ +plf+g+++i+ql ++++lgtps +vwpe+++lp+y+ s | Q: 182 DQGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPSPRVWPEITELPDYNkIS 241 | *********************************************************88* |
| S: 238 fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf 284 | f+++++ l+e++++++++aldll ++l + p++Ri a++al h+yf | Q: 242 FKEQAPVPLEEVLPDASHQALDLLGQFLLYPPRQRIAASQALLHQYF 288 | **********************************************9 |
|
Domain Sequence
(FASTA) | | YCILGRIGEG AHGIVFKAKH VETGEIVALK KVALRRLEDG IPNQALREIK ALQEIEDSQY 60 | | VVQLKAVFPH GAGFVLAFEF MLSDLAEVVR HAQRPLAPAQ VKSYLQMLLK GVAFCHANNI 120 | | VHRDLKPANL LISASGQLKI ADFGLARVFS PDGGRLYTHQ VATRWYRAPE LLYGARQYDQ 180 | | GVDLWAVGCI MGELLNGSPL FPGENDIEQL CCVLRILGTP SPRVWPEITE LPDYNKISFK 240 | | EQAPVPLEEV LPDASHQALD LLGQFLLYPP RQRIAASQAL LHQYF 285 |
|
| Keyword | ATP-binding; Cell cycle; Cell division; Cell projection; Cilium; Complete proteome; Cytoplasm; Developmental protein; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |