EKS-RAN-00430

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00430

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	478.2	7.4E-144	14	275	262

Status

Unreviewed

Ensembl Protein

ENSRNOP00000062122

UniProt Accession

F1LN68;

Protein Name

Protein Synonyms/Alias

Protein Dapk1;

Gene Name

Dapk1

Gene Synonyms/Alias

Dapk1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000018198	ENSRNOP00000062122	ENSRNOT00000066950

Organism

Rattus norvegicus

Functional Description

Protein Length

1430

Protein Sequence
(FASTA)

MTVFRQENVD DYYDTGEELG SGQFAVVKKC REKSTGLQYA AKFIKKRRTK SSRRGVSRED 60

IEREVSILKE IRHPNVITLH EVYENKTDVI LILELVAGGE LFDFLAEKES LTEEEATEFL 120

KQILSGVYYL HSLQIAHFDL KPENIMLLDR NVPKPRIKII DFGLAHKIDF GNEFKNIFGT 180

PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANVS AVNYDFEEEF 240

FRNTSTLAKD FIRRLLVKDP KKRMTIQDSL QHPWIKPKDT QQALSRKASA VNMEKFKKFA 300

ARKKWKQSVR LISLCQRLSR SFLSRSNMSV ARSDDTLDEE DSFVMKAIIH AINDDNVPGL 360

QHLLGSLSSY DVNQPNKHGT PPLLIAAGCG NIQMLQLLIK RGSRIDVQDK GGSNAIYWAS 420

RHGHVDTLKF LNENKCPLDV KDKSGETALH VAARYGHADV VQLLCSFGSN PDFQDKEEET 480

PLHCAAWHGY YSVARALCEV GCNVNIKNRE GETPLLTASA RGYHDIVECL AEHGADLNAS 540

DKDGHIALHL AVRRCQMEVI KTLLGHGCLV DFQDRHGNTP LHVACKDGSA PIVVALCEAS 600

CNLDISNKYG RTPLHLAANN GILDVVRYLC LMGANVEALT LDGKTAEDLA KAEQHEHVAG 660

LLARLRKDTH RGLFIQQLRP TQNLQPRIKL KLFGHSGSGK STLVESLKCG LLRSFFRRRR 720

PRLSSTNSTR FPPSPLATKP TVSVSINNLY PGCENVSVRS RSMMFEPGLT KGMLEVFVAP 780

SHHLHCSTDD QSTKAIDIQN AYLNGVGDFS VWEFSGNPVY FCCYDYFAAN DPTSIHIIVF 840

SLEEPYEIQL NQVIFWLSFL KSLVSVEEPI AFGGKLKNPL RVVLVATHAD IMNIPRPAGG 900

EFGYDKDTSL LKEIRNRFGN DLHVSNKLFV LDAGASGSKD IKVLRNHLQE IRSQIVSGCP 960

PMTHLCEKII STLPSWRKLN GPNQLMSLQQ FVYDVQDQLN PLASEDDLRR IAQQLHSTGE 1020

INIMQSETVQ DVLLLDPRWL CTNVLGKLLS VETPRALHHY RGRYTMEDIQ RLVPDSDVEE 1080

LLQILDAMDI CARDLSSGTM VDIPALIKTD SLQRSWADEE DEVMVYGGVR IVPVEHLTPF 1140

PCGIFHKVQV NLCRWIHQQS TEGDADIRLW VSGCRIANRG AELLVLLVNH GQGIEVQVRG 1200

LETEKIKCCL LLDSVCSTIE TVMATTLPGL LTVKHYLSPQ QLREHHEPVM VYQPRDFFRA 1260

QTLKESSLTN TMGGYKESFS SITCFGCHDV YSQASLGMDI HASDLSLLTR RKLSRLLDPP 1320

DPMGKDWCLL AMNLGLPDMV AKHNVNTRAS RDFLPSPVHA LLQEWTSYPE STVGILISKL 1380

RELGRRDAAD FLLKASSVFK INLDGNGQEA YASSCNSGTS YNSISSVVSR 1430

Nucleotide Sequence
(FASTA)

ATGACTGTGT TCAGGCAGGA AAACGTGGAC GACTACTACG ACACCGGCGA GGAACTGGGC 60

AGCGGACAGT TCGCCGTTGT GAAGAAATGT CGTGAGAAAA GTACCGGTCT TCAGTATGCG 120

GCCAAGTTCA TCAAGAAAAG GAGGACCAAG TCCAGCCGGC GGGGCGTGAG CCGAGAGGAC 180

ATCGAGCGGG AGGTCAGCAT CCTGAAGGAG ATCCGGCACC CAAACGTCAT CACCCTGCAT 240

GAGGTCTACG AGAACAAGAC AGACGTCATT CTGATCCTGG AGCTTGTTGC AGGAGGCGAG 300

CTGTTTGACT TCCTGGCTGA GAAGGAATCT CTCACTGAAG AAGAAGCAAC CGAGTTCCTC 360

AAGCAGATCC TCAGCGGCGT TTACTACCTG CACTCGCTTC AAATCGCCCA CTTTGACCTG 420

AAGCCGGAAA ACATAATGCT TCTGGATAGA AATGTGCCCA AACCTCGGAT CAAGATCATC 480

GACTTCGGCC TGGCCCATAA AATTGACTTT GGAAATGAAT TCAAAAACAT ATTTGGGACA 540

CCAGAGTTTG TGGCTCCGGA GATCGTCAAC TATGAGCCCC TTGGTCTTGA GGCAGACATG 600

TGGAGCATTG GGGTAATAAC CTATATCCTC CTAAGCGGGG CCTCCCCTTT TCTTGGAGAC 660

ACCAAGCAAG AAACATTAGC GAATGTATCT GCTGTCAACT ATGACTTTGA GGAGGAATTC 720

TTCCGCAACA CCAGTACCCT TGCCAAAGAT TTCATCAGAA GGCTGCTGGT CAAGGATCCA 780

AAGAAGAGGA TGACAATCCA GGACAGTTTG CAGCACCCCT GGATCAAGCC TAAAGACACC 840

CAACAAGCAC TTAGTCGAAA AGCCTCAGCA GTAAACATGG AGAAATTCAA GAAGTTTGCA 900

GCTCGGAAAA AATGGAAACA ATCTGTTCGC TTGATATCAC TGTGCCAAAG ATTATCCAGG 960

TCATTTTTGT CCAGAAGTAA CATGAGCGTT GCCAGGAGCG ATGATACTCT GGATGAGGAA 1020

GACTCCTTTG TGATGAAAGC CATCATTCAT GCCATCAATG ATGACAACGT CCCCGGCCTG 1080

CAGCACCTCC TGGGCTCATT GTCCAGCTAT GATGTCAACC AGCCCAACAA GCACGGGACA 1140

CCTCCATTAC TGATTGCTGC AGGCTGTGGG AATATTCAGA TGTTACAGTT ACTCATAAAA 1200

CGGGGCTCAA GGATCGACGT CCAGGATAAG GGAGGATCCA ATGCTATCTA CTGGGCCTCT 1260

CGGCATGGCC ATGTGGATAC TTTGAAGTTT CTCAATGAGA ACAAATGCCC TTTGGATGTT 1320

AAAGACAAGT CTGGAGAGAC AGCTCTTCAC GTGGCAGCCC GCTATGGCCA TGCAGATGTG 1380

GTTCAACTCT TGTGCAGTTT TGGCTCTAAT CCTGATTTCC AGGACAAGGA AGAGGAAACC 1440

CCCCTGCACT GTGCTGCCTG GCACGGCTAT TACTCCGTGG CTAGAGCTCT TTGTGAAGTT 1500

GGCTGTAACG TGAATATCAA GAACCGGGAG GGAGAGACCC CACTGCTGAC AGCTTCTGCC 1560

AGGGGCTACC ATGACATTGT GGAGTGTCTG GCTGAACATG GAGCTGACCT GAATGCTTCT 1620

GACAAGGATG GGCACATCGC CCTTCATCTT GCTGTGAGGC GCTGTCAGAT GGAGGTCATC 1680

AAGACCCTCC TTGGCCATGG GTGCCTTGTG GATTTCCAGG ATCGGCATGG CAACACCCCC 1740

CTGCATGTGG CCTGCAAAGA TGGGAGCGCG CCCATCGTGG TGGCCCTCTG TGAAGCCAGC 1800

TGCAACCTGG ACATCTCAAA CAAGTATGGT CGGACTCCTC TCCACCTTGC AGCCAACAAC 1860

GGGATCCTAG ATGTGGTCCG CTACCTCTGC CTGATGGGCG CCAACGTGGA GGCTCTGACC 1920

TTGGATGGCA AGACGGCCGA GGACCTCGCC AAGGCAGAGC AGCACGAGCA CGTGGCAGGG 1980

CTCCTGGCAA GACTGCGGAA GGACACACAC CGAGGGCTCT TCATCCAGCA GCTCCGACCC 2040

ACGCAGAATC TCCAGCCCAG AATCAAGCTC AAACTGTTTG GCCACTCGGG ATCGGGGAAA 2100

TCCACACTGG TGGAATCTCT CAAGTGTGGG CTGTTAAGGA GTTTCTTCAG AAGGCGCCGG 2160

CCCAGACTGT CCTCTACCAA CTCCACCCGC TTCCCACCGT CGCCCCTGGC TACTAAGCCA 2220

ACAGTCTCAG TGAGCATTAA CAACCTGTAC CCCGGCTGTG AGAATGTGAG CGTGAGGAGC 2280

CGAAGCATGA TGTTTGAGCC AGGCCTCACC AAAGGGATGC TGGAAGTGTT CGTGGCTCCG 2340

TCTCACCACC TACACTGCTC GACCGATGAC CAGTCCACCA AAGCCATCGA CATCCAGAAT 2400

GCTTACTTGA ACGGAGTTGG TGATTTCAGC GTATGGGAGT TCTCTGGAAA CCCTGTGTAC 2460

TTCTGTTGCT ATGACTACTT CGCCGCCAAC GATCCCACAT CCATCCACAT CATCGTTTTC 2520

AGTCTCGAAG AACCCTATGA GATCCAGCTG AACCAAGTGA TTTTCTGGCT TAGTTTCTTG 2580

AAGTCTCTGG TCTCAGTTGA AGAACCCATA GCATTTGGAG GCAAGCTGAA GAACCCTCTC 2640

CGAGTTGTCC TGGTGGCCAC ACATGCTGAC ATCATGAACA TCCCTCGGCC TGCTGGGGGC 2700

GAGTTTGGAT ATGATAAAGA TACATCCTTG CTGAAAGAGA TCAGGAACAG GTTTGGGAAT 2760

GACCTTCATG TCTCAAATAA GCTGTTTGTG CTGGATGCAG GAGCATCTGG GTCTAAGGAC 2820

ATCAAGGTTC TCCGGAATCA CCTGCAAGAA ATACGGAGTC AGATTGTCTC GGGGTGCCCT 2880

CCCATGACTC ATCTGTGTGA GAAGATCATC TCCACTCTGC CCTCCTGGCG GAAGCTCAAC 2940

GGGCCAAACC AGCTGATGTC GCTCCAGCAG TTTGTGTATG ACGTGCAGGA CCAGCTGAAC 3000

CCCCTGGCCT CCGAGGATGA CCTCAGGCGC ATTGCACAGC AGCTGCACAG CACGGGAGAG 3060

ATCAACATCA TGCAGAGTGA GACAGTGCAG GATGTGTTGC TGCTGGATCC TCGATGGCTC 3120

TGCACCAACG TCCTGGGGAA GCTGCTGTCT GTGGAGACTC CCCGAGCCCT GCACCATTAT 3180

CGGGGCCGCT ACACCATGGA AGATATCCAG CGTCTGGTCC CCGACAGTGA CGTGGAGGAG 3240

CTGCTGCAGA TCCTGGATGC CATGGATATC TGCGCCCGAG ACCTGAGTAG CGGGACTATG 3300

GTGGATATCC CTGCTCTAAT CAAAACAGAC AGCCTGCAGC GCTCCTGGGC CGATGAGGAA 3360

GACGAGGTGA TGGTGTACGG AGGTGTGCGC ATCGTCCCTG TAGAGCACCT CACTCCCTTC 3420

CCCTGTGGCA TCTTTCACAA AGTTCAGGTC AACCTGTGCC GGTGGATCCA CCAGCAGAGC 3480

ACTGAGGGGG ACGCGGACAT CCGTCTGTGG GTGAGCGGCT GCAGGATCGC CAACCGTGGG 3540

GCTGAGTTGC TGGTGCTGCT GGTCAATCAC GGTCAGGGCA TTGAGGTACA GGTGCGTGGA 3600

CTGGAGACCG AGAAGATTAA GTGCTGCCTG CTGCTGGACT CGGTGTGCAG CACCATCGAG 3660

ACTGTCATGG CCACCACCTT GCCAGGGCTG TTGACGGTGA AGCACTACCT GAGCCCCCAG 3720

CAGCTAAGGG AGCATCACGA ACCAGTCATG GTCTACCAGC CCCGGGACTT CTTCCGTGCG 3780

CAGACCCTGA AAGAGAGCTC CCTCACCAAC ACCATGGGAG GGTACAAGGA GAGCTTCAGC 3840

AGCATCACGT GCTTTGGGTG TCACGATGTC TACTCACAGG CCAGTCTTGG CATGGACATC 3900

CATGCATCAG ACCTGAGTCT CCTGACCCGG AGGAAACTGA GTCGTCTTCT TGACCCACCG 3960

GACCCCATGG GGAAGGACTG GTGCCTTCTG GCCATGAACT TGGGCCTCCC GGACATGGTG 4020

GCCAAACACA ACGTCAATAC CAGGGCTTCT AGGGATTTCC TCCCCAGCCC AGTGCATGCC 4080

TTGCTACAGG AATGGACCTC CTACCCTGAG AGCACGGTGG GCATCCTTAT ATCCAAACTT 4140

CGGGAGCTGG GGCGCCGGGA TGCTGCGGAC TTTTTACTGA AGGCCTCCTC TGTGTTCAAG 4200

ATCAACCTTG ACGGCAATGG CCAGGAGGCC TATGCCTCAA GCTGTAACAG TGGCACATCC 4260

TACAATTCCA TAAGCTCAGT GGTGTCCCGG TGA 4293

Domain Profile

S: 2     etgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirs  61

         +tg+elgsG+favv+kcrekstG +yaakf+kkrr+kssrrgvsre+ierev++lkeir

Q: 14    DTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIR-  72

         789********************************************************.

S: 62    epnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhs  121

         +pnvi+lhevyenk+dvililelvaGGelfd+laekesl+eeeate+lkqil+gv+ylhs

Q: 73    HPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILSGVYYLHS  132

         ************************************************************

S: 122   kkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnye  181

          +i+h+dlkPeni+lld++vpk++ik+idfGl++ki+ g+e+k+i+GtPefvaPeivnye

Q: 133   LQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYE  192

         ************************************************************

S: 182   plsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfi  241

         pl+le+dmwsiGvityillsgasPflGdtkqetl+n+savn+df+ee+f+++s+lakdfi

Q: 193   PLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYDFEEEFFRNTSTLAKDFI  252

         ************************************************************

S: 242   rrllvkdpekrltieeclehswl  264

         rrllvkdp+kr+ti+++l+h+w+

Q: 253   RRLLVKDPKKRMTIQDSLQHPWI  275

         **********************8

Domain Sequence
(FASTA)

DTGEELGSGQ FAVVKKCREK STGLQYAAKF IKKRRTKSSR RGVSREDIER EVSILKEIRH 60

PNVITLHEVY ENKTDVILIL ELVAGGELFD FLAEKESLTE EEATEFLKQI LSGVYYLHSL 120

QIAHFDLKPE NIMLLDRNVP KPRIKIIDFG LAHKIDFGNE FKNIFGTPEF VAPEIVNYEP 180

LGLEADMWSI GVITYILLSG ASPFLGDTKQ ETLANVSAVN YDFEEEFFRN TSTLAKDFIR 240

RLLVKDPKKR MTIQDSLQHP WI 262

Keyword

ANK repeat; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0006917	; P:induction of apoptosis
GO:0007243	; P:intracellular protein kinase cascade
GO:2000310	; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR000488	; Death.
IPR020676	; Death-assoc_prot_kinase.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12796	; Ank_2; 3.
PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 9.
SM00005	; DEATH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 7.
PS50017	; DEATH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013