EKS-RAN-00114

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00114

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	392.3	1.4E-117	46	309	264

Status

Unreviewed

Ensembl Protein

ENSRNOP00000044665

UniProt Accession

F1LRI7;

Protein Name

Protein Synonyms/Alias

AP2-associated protein kinase 1;

Gene Name

Aak1

Gene Synonyms/Alias

Aak1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000018317	ENSRNOP00000044665	ENSRNOT00000043082

Organism

Rattus norvegicus

Functional Description

Protein Length

963

Protein Sequence
(FASTA)

MKKFFDSRRE QGSSGLGSGS SGGGGSSSGL GSGYIGRVFG IGRQQVTVDE VLAEGGFALV 60

FLVRTSNGVK CALKRMFVNN EHDLQVCKRE IQIMRDLSGH KNIVGYIDSS INNVSSGDVW 120

EVLILMDFCR GGQVVNLMNQ RLQTGFTENE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 180

NILLHDRGHY VLCDFGSATN KFQNPQAEGV NAVEDEIKKY TTLSYRAPEM VNLYSGKIIT 240

TKADIWALGC LLYKLCYFTL PFGESQVAIC DGSFTIPDNS RYSQDMHCLI RYMLEPDPDK 300

RPDIYQVSYF SFKLLKKECP VPNVQNSPIP TKLPEPVKAS EAAVKKTQPK ARLTDPIPTT 360

ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRATVQPLP QATGPSNQPS LLASVSQPKA 420

QATPSQPLQS SQPKQPQAPP TPQQTPAPQT QGLPTQAQAT PQHQQQLLLK QQQQQQQQQQ 480

QQQPQQPTAP PQPSGTFYQQ QQPQQQQAQT QQFQAVHPAA QQSVTAQFPV VSQGGSQQQL 540

MQNFYQQQQQ QQQQQQQLMA QQAALQQKTA VVVPQPQAQP ATAPQAAAAQ EPAQIQAPAR 600

QQPKVQTTPP PTIQGQKVGS LTPPSSPKTQ RAGHRRILSD VTHSAVFGVP ASKSTQLLHA 660

AAAEASLSKS KSATTTPSGS PRTSQQNVSN ASEGSTWNPF DDDNFSKLTA EELLNKDFAK 720

LGEGKLPEKL GGSAESLIPG FQATQGDAFA TSSFSAGTAE KRKGGQAVDS GIPLLSVSDP 780

FIPLQVPDAP EKLIEGLKSP DTSLLLPDLL PMTDPFGSTS DAVIEKADAA VESLIPGLEP 840

PVAQRLPSHT ESVTSNRTDS LTGEDSLLDC SLLSNPTADL LDEFAPIALS ASTHKAAEDS 900

NLISGFGVAE GSEKVAEDEF DPIPVLITKN TQGGHSRNSS GSSESSLPNL ARSLLLVDQL 960

IDL 963

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TTTTCGACTC CAGGCGGGAG CAGGGGAGCT CTGGCCTGGG TTCGGGCTCC 60

AGCGGAGGAG GGGGCAGCAG CTCAGGCCTG GGCAGTGGCT ACATCGGGAG GGTCTTCGGC 120

ATCGGGAGGC AGCAAGTCAC CGTGGACGAG GTCTTGGCAG AAGGTGGATT CGCTCTCGTC 180

TTTCTGGTGA GAACAAGCAA TGGGGTGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 240

GAGCATGACC TTCAGGTGTG CAAGAGGGAG ATCCAGATCA TGAGGGACCT ATCAGGGCAC 300

AAGAACATTG TGGGCTACAT TGATTCTAGT ATCAACAATG TGAGCAGTGG CGACGTATGG 360

GAAGTTCTCA TTCTCATGGA CTTCTGCAGA GGAGGCCAGG TGGTAAACCT GATGAACCAG 420

CGTCTCCAGA CAGGCTTTAC AGAGAATGAA GTGCTGCAGA TCTTCTGTGA CACCTGTGAG 480

GCTGTGGCCC GCCTGCATCA GTGCAAAACT CCCATTATCC ACCGGGACCT GAAGGTTGAA 540

AATATCCTCT TGCATGACCG AGGCCACTAT GTCTTGTGTG ACTTTGGAAG TGCCACCAAC 600

AAATTCCAGA ATCCACAGGC CGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 660

ACAACGCTCT CCTATCGAGC CCCAGAAATG GTCAACTTGT ACAGTGGCAA AATCATCACC 720

ACGAAGGCAG ATATTTGGGC TCTTGGCTGT TTGTTGTATA AATTATGCTA CTTCACTTTG 780

CCATTTGGGG AGAGCCAGGT GGCAATTTGT GATGGAAGCT TCACAATTCC TGATAACTCT 840

CGATATTCAC AAGATATGCA CTGCCTTATT AGGTATATGT TGGAACCAGA CCCTGACAAA 900

AGGCCGGATA TTTACCAGGT TTCTTACTTC TCATTTAAAC TACTCAAGAA AGAATGCCCA 960

GTTCCAAATG TACAGAATTC TCCCATTCCT ACAAAACTTC CTGAACCAGT GAAAGCCAGT 1020

GAGGCAGCTG TAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 1080

GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC AAACCCCGGA 1140

ATCCTTCCCA TTCAGCCAGC CCTGACTCCT CGTAAGAGGG CCACTGTTCA GCCCCTACCT 1200

CAGGCTACAG GACCCAGCAA TCAGCCTAGC CTTCTAGCCA GTGTTTCCCA GCCTAAAGCC 1260

CAAGCCACGC CCAGTCAACC TCTTCAGTCA TCTCAACCCA AGCAGCCACA AGCTCCACCC 1320

ACCCCACAGC AGACGCCTGC TCCCCAGACC CAGGGTCTGC CCACCCAGGC CCAGGCTACT 1380

CCTCAGCACC AGCAGCAGCT CCTCCTCAAG CAGCAGCAGC AGCAGCAACA GCAGCAGCAG 1440

CAGCAACAGC CACAGCAGCC AACAGCACCA CCACAGCCAT CAGGCACCTT TTACCAGCAG 1500

CAGCAGCCCC AGCAGCAGCA GGCTCAGACT CAGCAGTTTC AGGCAGTGCA TCCAGCAGCC 1560

CAGCAATCAG TCACTGCTCA GTTCCCTGTG GTGTCCCAGG GAGGCTCTCA GCAACAGCTG 1620

ATGCAGAACT TCTACCAGCA GCAGCAGCAG CAGCAACAGC AGCAGCAACA GCTGATGGCT 1680

CAGCAGGCCG CCCTGCAGCA GAAGACTGCT GTGGTAGTAC CACAGCCTCA GGCACAGCCA 1740

GCCACAGCCC CACAGGCAGC TGCTGCCCAG GAGCCTGCGC AGATTCAAGC CCCAGCAAGA 1800

CAACAGCCAA AAGTTCAGAC CACTCCACCT CCAACCATCC AGGGACAGAA AGTTGGCTCT 1860

CTCACTCCTC CATCATCTCC GAAAACCCAA CGTGCTGGGC ACAGGCGGAT TCTCAGTGAT 1920

GTAACCCACA GTGCAGTCTT CGGGGTTCCT GCCAGCAAGT CAACCCAGCT GCTCCACGCG 1980

GCTGCAGCTG AGGCCAGTCT CAGTAAATCT AAGTCTGCAA CCACCACTCC TTCAGGCTCT 2040

CCACGGACTT CCCAGCAGAA TGTCTCTAAT GCTTCCGAAG GCTCCACATG GAATCCTTTT 2100

GATGATGACA ACTTCTCCAA ACTCACGGCT GAAGAGCTGC TGAACAAGGA TTTCGCGAAG 2160

CTTGGGGAAG GAAAGCTTCC TGAGAAGCTT GGAGGCTCTG CAGAGAGTTT GATCCCAGGT 2220

TTCCAGGCAA CACAAGGAGA TGCCTTTGCC ACTTCCTCCT TTTCTGCTGG AACCGCTGAG 2280

AAGAGAAAGG GGGGACAGGC TGTGGATTCT GGCATCCCAC TTCTAAGTGT GTCTGATCCT 2340

TTCATTCCTC TTCAGGTACC TGATGCTCCA GAAAAACTAA TCGAGGGACT CAAATCTCCT 2400

GACACTTCTC TTCTGCTCCC TGACCTCTTG CCTATGACAG ATCCTTTTGG CAGCACTTCC 2460

GATGCTGTGA TTGAAAAAGC TGATGCTGCT GTTGAGAGTC TCATACCTGG GCTGGAGCCA 2520

CCTGTTGCCC AGCGCCTCCC ATCTCACACG GAATCTGTGA CTTCAAACCG CACAGACTCT 2580

CTCACGGGGG AAGACTCTCT CCTTGACTGT TCTCTGCTTT CTAACCCTAC TGCTGACCTT 2640

CTGGACGAGT TTGCCCCCAT AGCACTCTCT GCTTCCACTC ATAAAGCTGC AGAAGATAGT 2700

AATCTCATCT CAGGGTTTGG TGTCGCTGAG GGCTCCGAAA AGGTGGCAGA AGATGAGTTT 2760

GACCCTATTC CTGTACTGAT AACCAAAAAC ACACAAGGTG GGCACTCTAG GAACAGCAGT 2820

GGGAGCTCTG AGTCCAGTCT TCCCAACCTA GCCAGGTCTT TGCTGCTGGT GGATCAGCTC 2880

ATAGACCTGT AG 2892

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfalv+l++ +s+g k+alKr++vn+e+dl+ +krEi+im++lsghkniv

Q: 46    VTVDEVLAEGGFALVFLVR-TSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV  104

         6899***************.99**************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 105   GYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA  163

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++++++ +++++a+++ei+k+tt

Q: 164   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-AEGVNAVEDEIKKYTT  222

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys+++i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 223   LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGSFTIPDNSR  281

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         ys+++++li++mle+dp++Rp+i+qv++

Q: 282   YSQDMHCLIRYMLEPDPDKRPDIYQVSY  309

         **************************87

Domain Sequence
(FASTA)

VTVDEVLAEG GFALVFLVRT SNGVKCALKR MFVNNEHDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINNVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTENEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNKFQNP QAEGVNAVED EIKKYTTLSY 180

RAPEMVNLYS GKIITTKADI WALGCLLYKL CYFTLPFGES QVAICDGSFT IPDNSRYSQD 240

MHCLIRYMLE PDPDKRPDIY QVSY 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013