EKS-RAN-00419
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00419
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR576.13.7E-173580908329
StatusUnreviewed
Ensembl ProteinENSRNOP00000040411
UniProt AccessionD3ZA86;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameCsf1r
Gene Synonyms/Alias Csf1r;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000018414ENSRNOP00000040411ENSRNOT00000049357
OrganismRattus norvegicus
Functional Description
Protein Length978
Protein Sequence
(FASTA)
MELGAPLVLL LATAWHGQGA PVIEPSGPEL VVEPGATVTL RCVSNGSVEW DGPISPYWTL 60
DSESPGSILI TKNATFKNTG TYRCTELEDP MRGSTAIHLY VKDPVRPWNL LAQEVTVFEG 120
QEAVLPCLIT DPTLKDSVSL VREWGRPVSR KTVYSFLPWR GFIIHKAKFL DSHTYMCKAV 180
VNARESTSIG IRLKVNRAHP GPPHIILEPT KLVRIRGEAA QIVCSATHSE VEFNVILKRG 240
DTKLEIPINS DFQDNAYKKV LTLNLNAVDF QDAGIYSCVA NNAAGSNTAT MNFQVVESAY 300
LNLTSEQSLL QEVSVGENLD LTVIADAYPG LQRYNWTYLG PFFEDPHNLE FRTQWTTYSY 360
SFKLHLNRVK PLEAGRYSLM AQNKAGWNNL TFELTLRYPP EVSVTWIPVN GSDVLLCDVS 420
GYPQPNVTWM ECRGHTDRCD EAQASQVWDD TQPEVLSQKP FHRVILQSQL PIGTLKHNMT 480
YVCRAHNNVG NSSQFFRAIS LGQSKQLPDE YLFTPVVVAC ISVMSLLVLL LLLLLYKYKQ 540
KPKYQVRWKI IESYEGNNYT FIDPTQLPYN EKWEFPRNNL QFGKTLGAGA FGKVVEATAF 600
GLGKEDAVLK VAVKMLKSTA HADEKEALMS ELKIMSHLGQ HENIVNLLGA CTHGGPVLVI 660
TEYCCYGDLL NFLRRKAEAM LGPSLSPGQD PEGDSSYKNI HLEKKYVRRD SGFSSQGVDT 720
YVEMRPVSTS SNDSFFKQDL DKEASRPLEL WDLLHFSSQV AQGMAFLASK NCIHRDVAAR 780
NVLLTSGHVA KIGDFGLARD IMNDSNYVVK GNARLPVKWM APESIFDCVY TVQSDVWSYG 840
ILLWEIFSLG LNPYPGILVN NKFYKLVKDG YQMAQPVFAP ENIYSIMQSC WDLEPTKRPT 900
FQQICFLLQE QARLERREQD YANLPSSSSS SSSSSDSGGG SGGSSSEPEE ESSSEHLACC 960
EPGDIAQPLL QPNNYQFC 978
Nucleotide Sequence
(FASTA)
ATGGAGCTGG GGGCTCCTCT GGTCCTGCTG CTGGCCACAG CTTGGCATGG TCAAGGGGCC 60
CCTGTCATCG AGCCTAGTGG CCCAGAGCTG GTTGTAGAGC CAGGTGCAAC AGTGACCCTG 120
CGATGTGTGA GCAATGGCAG TGTGGAATGG GATGGCCCCA TCTCTCCCTA CTGGACCTTG 180
GACTCTGAAT CTCCTGGAAG CATCCTGATC ACAAAAAACG CCACCTTCAA AAACACTGGG 240
ACCTACCGTT GTACTGAGCT TGAAGACCCT ATGCGGGGCA GTACCGCCAT CCACTTGTAC 300
GTCAAAGATC CTGTCCGGCC CTGGAATTTG CTAGCACAGG AGGTGACAGT GTTTGAGGGC 360
CAGGAAGCTG TGCTGCCCTG TCTGATCACT GACCCCACAC TGAAGGACAG TGTCTCACTG 420
GTGAGGGAGT GGGGCAGACC AGTCTCACGC AAAACGGTCT ACTCCTTCTT ACCATGGCGA 480
GGGTTCATTA TCCACAAGGC TAAATTCCTT GACAGTCATA CCTACATGTG CAAGGCTGTT 540
GTGAACGCTA GGGAATCCAC CTCCATTGGC ATCCGGCTTA AGGTGAATCG AGCCCACCCA 600
GGGCCCCCAC ACATCATATT GGAACCTACT AAGCTGGTGA GGATTCGAGG GGAGGCTGCC 660
CAGATCGTGT GCTCGGCCAC TCACTCAGAA GTTGAATTCA ACGTTATCCT CAAACGTGGA 720
GACACCAAGT TGGAAATCCC CATAAACAGT GACTTCCAAG ACAACGCTTA TAAAAAGGTC 780
CTGACTCTTA ACCTCAATGC TGTGGACTTC CAAGATGCTG GCATATATTC CTGTGTGGCC 840
AACAACGCAG CTGGCTCGAA CACGGCCACC ATGAACTTCC AGGTGGTGGA GAGTGCCTAC 900
TTAAACTTGA CCTCTGAGCA GAGCCTCTTG CAGGAGGTGT CTGTGGGTGA GAACCTCGAC 960
CTCACAGTCA TTGCAGATGC CTACCCTGGC CTACAGCGTT ACAACTGGAC CTACCTAGGG 1020
CCGTTCTTTG AAGACCCACA CAATCTTGAG TTTAGAACCC AATGGACCAC ATACAGCTAC 1080
TCATTCAAAC TCCACCTGAA CCGTGTAAAG CCCTTGGAGG CCGGCCGCTA CTCCTTAATG 1140
GCACAAAACA AGGCAGGCTG GAATAATCTG ACCTTTGAGC TCACCCTGCG ATACCCCCCA 1200
GAAGTCAGTG TTACATGGAT ACCTGTGAAC GGCTCTGATG TCCTGCTCTG TGATGTCTCT 1260
GGGTATCCTC AGCCCAACGT GACATGGATG GAGTGCAGGG GCCACACCGA TAGGTGTGAT 1320
GAGGCCCAGG CCTCGCAGGT TTGGGATGAC ACACAACCTG AAGTCCTGAG TCAGAAGCCC 1380
TTCCACAGAG TGATCCTTCA GAGCCAGCTG CCCATTGGGA CCCTAAAGCA CAACATGACT 1440
TATGTTTGCA GAGCCCACAA CAATGTGGGT AACAGCTCCC AGTTCTTCAG GGCCATCTCC 1500
CTAGGACAAA GCAAGCAGCT CCCTGATGAG TACCTGTTCA CTCCAGTGGT GGTGGCCTGT 1560
ATATCTGTCA TGTCTCTGCT GGTACTACTG CTGCTGCTGC TCTTGTACAA GTACAAGCAG 1620
AAGCCGAAAT ATCAGGTGCG CTGGAAGATC ATTGAGAGCT ACGAGGGCAA CAACTACACC 1680
TTCATCGACC CTACCCAGTT GCCCTACAAT GAGAAGTGGG AGTTTCCCCG GAACAACCTG 1740
CAATTTGGTA AGACTCTCGG AGCTGGTGCC TTTGGGAAGG TGGTGGAGGC CACAGCCTTT 1800
GGTCTGGGCA AAGAAGATGC AGTGCTGAAG GTGGCTGTGA AGATGCTCAA GTCCACGGCT 1860
CATGCCGATG AGAAGGAGGC CCTAATGTCA GAACTGAAGA TCATGAGTCA CCTGGGACAG 1920
CATGAGAACA TTGTCAACCT CTTGGGAGCC TGTACTCATG GAGGGCCTGT CCTGGTCATC 1980
ACCGAATACT GCTGCTACGG AGACCTTCTC AACTTCCTTC GAAGGAAGGC CGAGGCTATG 2040
CTGGGACCCA GCCTGAGTCC TGGTCAGGAC CCCGAGGGGG ACTCCAGCTA CAAGAACATC 2100
CACCTGGAGA AGAAATATGT GCGCAGGGAC AGTGGCTTCT CCAGTCAGGG CGTAGATACC 2160
TATGTGGAGA TGAGGCCTGT TTCGACTTCC TCAAATGACT CCTTCTTTAA GCAAGATCTG 2220
GACAAAGAGG CCAGCCGGCC GCTGGAGCTC TGGGACCTGC TTCACTTCTC TAGCCAAGTG 2280
GCTCAGGGCA TGGCTTTCCT TGCTTCTAAA AATTGCATCC ATCGTGATGT AGCTGCTCGA 2340
AATGTGCTGT TGACCAGCGG ACATGTGGCC AAGATTGGGG ACTTTGGGCT GGCTAGGGAC 2400
ATCATGAATG ACTCTAACTA TGTTGTCAAG GGCAATGCCC GCCTGCCTGT AAAGTGGATG 2460
GCCCCAGAGA GCATCTTCGA CTGCGTCTAC ACAGTTCAGA GTGATGTGTG GTCCTACGGC 2520
ATCCTCCTCT GGGAGATTTT CTCACTTGGT CTGAACCCCT ACCCAGGCAT CTTAGTGAAC 2580
AACAAGTTCT ACAAACTGGT GAAGGATGGA TACCAAATGG CCCAGCCTGT ATTTGCACCG 2640
GAGAACATAT ACAGCATCAT GCAGTCCTGC TGGGACCTGG AGCCTACCAA AAGACCTACC 2700
TTCCAGCAGA TCTGCTTCCT CCTCCAGGAA CAGGCCCGAC TGGAGAGGAG AGAGCAGGAC 2760
TATGCTAACC TGCCAAGCAG CAGCAGCAGC AGTAGCAGCA GCAGTGACAG TGGTGGTGGC 2820
AGTGGTGGTA GCAGCAGTGA GCCTGAAGAG GAGAGCTCCA GTGAGCACCT GGCCTGCTGT 2880
GAGCCAGGGG ACATCGCCCA GCCCCTGCTG CAGCCTAACA ACTACCAGTT CTGCTGA 2937
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 580   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  639
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lrrk+e++l  sl+  +++e + ++k+
Q: 640   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGDSSYKN  699
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ ++yv++++    vs+s++d++ +++            l++e
Q: 700   IhLEKKYVRRDSGFSSQGVDTYVEMRP----VSTSSNDSFFKQD------------LDKE  743
         *999***********************....999**99999998............7899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
          s++lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 744   ASRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMN  803
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsnyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv++kf
Q: 804   DSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKF  863
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqp +a+e+iy+imq+cw+ ep+krp+f+q++ ll
Q: 864   YKLVKDGYQMAQPVFAPENIYSIMQSCWDLEPTKRPTFQQICFLL  908
         ******************************************986
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPSLSPGQ DPEGDSSYKN 120
IHLEKKYVRR DSGFSSQGVD TYVEMRPVST SSNDSFFKQD LDKEASRPLE LWDLLHFSSQ 180
VAQGMAFLAS KNCIHRDVAA RNVLLTSGHV AKIGDFGLAR DIMNDSNYVV KGNARLPVKW 240
MAPESIFDCV YTVQSDVWSY GILLWEIFSL GLNPYPGILV NNKFYKLVKD GYQMAQPVFA 300
PENIYSIMQS CWDLEPTKRP TFQQICFLL 329
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0030316; P:osteoclast differentiation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013